isradipine (BioDeep_00000016916)
natural product
代谢物信息卡片
Isradipine (Dynacirc)
化学式: C19H21N3O5 (371.14811360000004)
中文名称: 依拉地平
谱图信息:
最多检出来源 Escherichia coli(natural_products) 94.74%
分子结构信息
SMILES: C1C=C(C2C(C=1)=NON=2)C3C(=C(NC(=C3C(OC(C)C)=O)C)C)C(=O)OC
InChI: InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
2 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6073
- KEGG: C07059
- KEGGdrug: D00349
- PubChem: 3784
- Metlin: METLIN872
- DrugBank: DB00270
- ChEMBL: CHEMBL3211306
- ChEMBL: CHEMBL315436
- ChEMBL: CHEMBL1648
- MeSH: Isradipine
- CAS: 131970-21-3
- CAS: 75695-93-1
- MoNA: FiehnHILIC002782
- MoNA: FiehnHILIC002029
- MoNA: FiehnHILIC001281
- MoNA: FiehnHILIC000457
- MoNA: CCMSLIB00000078230
- MoNA: CCMSLIB00000078229
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tausif Alam, Mohd Asif Ansari, Sanjula Baboota, Javed Ali. Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction.
Drug delivery and translational research.
2022 03; 12(3):577-588. doi:
10.1007/s13346-021-00958-x. [PMID: 33782898] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Charles S Venuto, Luoying Yang, Monica Javidnia, David Oakes, D James Surmeier, Tanya Simuni. Isradipine plasma pharmacokinetics and exposure-response in early Parkinson's disease.
Annals of clinical and translational neurology.
2021 03; 8(3):603-612. doi:
10.1002/acn3.51300. [PMID: 33460320] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Tausif Alam, Saba Khan, Bharti Gaba, Md Faheem Haider, Sanjula Baboota, Javed Ali. Adaptation of Quality by Design-Based Development of Isradipine Nanostructured-Lipid Carrier and Its Evaluation for In Vitro Gut Permeation and In Vivo Solubilization Fate.
Journal of pharmaceutical sciences.
2018 11; 107(11):2914-2926. doi:
10.1016/j.xphs.2018.07.021. [PMID: 30076853] - Jaime N Guzman, Ema Ilijic, Ben Yang, Javier Sanchez-Padilla, David Wokosin, Dan Galtieri, Jyothisri Kondapalli, Paul T Schumacker, D James Surmeier. Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress.
The Journal of clinical investigation.
2018 06; 128(6):2266-2280. doi:
10.1172/jci95898. [PMID: 29708514] - Futoshi Toyoda, Pietro Mesirca, Stefan Dubel, Wei-Guang Ding, Joerg Striessnig, Matteo E Mangoni, Hiroshi Matsuura. CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current.
Scientific reports.
2017 08; 7(1):7869. doi:
10.1038/s41598-017-08191-8. [PMID: 28801600] - Nadine J Ortner, Gabriella Bock, Antonios Dougalis, Maria Kharitonova, Johanna Duda, Simon Hess, Petronel Tuluc, Thomas Pomberger, Nadia Stefanova, Florian Pitterl, Thomas Ciossek, Herbert Oberacher, Henning J Draheim, Peter Kloppenburg, Birgit Liss, Jörg Striessnig. Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2017 07; 37(28):6761-6777. doi:
10.1523/jneurosci.2946-16.2017. [PMID: 28592699] - G Thirupathi, E Swetha, D Narendar. Role of Isradipine Loaded Solid Lipid Nanoparticles on the Pharmacodynamic Effect in Rats.
Drug research.
2017 Mar; 67(3):163-169. doi:
10.1055/s-0042-119947. [PMID: 27992936] - Vikash Kumar, Rajeev Kharb, Hema Chaudhary. Optimization & design of isradipine loaded solid lipid nanobioparticles using rutin by Taguchi methodology.
International journal of biological macromolecules.
2016 Nov; 92(?):338-346. doi:
10.1016/j.ijbiomac.2016.07.020. [PMID: 27392772] - Xaver Koenig, Michael Kovar, Lena Rubi, Agnes K Mike, Peter Lukacs, Vaibhavkumar S Gawali, Hannes Todt, Karlheinz Hilber, Walter Sandtner. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.
Toxicology and applied pharmacology.
2013 Dec; 273(2):259-68. doi:
10.1016/j.taap.2013.05.012. [PMID: 23707769] - X Yu, X Li, G Jiang, X Wang, H C Chang, W H Hsu, Qinglin Li. Isradipine prevents rotenone-induced intracellular calcium rise that accelerates senescence in human neuroblastoma SH-SY5Y cells.
Neuroscience.
2013 Aug; 246(?):243-53. doi:
10.1016/j.neuroscience.2013.04.062. [PMID: 23664925] - Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Zong Zhu Piao, Toi Van Vo, Jun Bom Park, Jisung Lim, Kyung Teak Oh, Yun-Seok Rhee, Beom-Jin Lee. Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion.
International journal of pharmaceutics.
2013 Jun; 450(1-2):79-86. doi:
10.1016/j.ijpharm.2013.04.022. [PMID: 23612354] - Thimmappa S Anekonda, Joseph F Quinn. Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine.
Biochimica et biophysica acta.
2011 Dec; 1812(12):1584-90. doi:
10.1016/j.bbadis.2011.08.013. [PMID: 21925266] - E Ilijic, J N Guzman, D J Surmeier. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.
Neurobiology of disease.
2011 Aug; 43(2):364-71. doi:
10.1016/j.nbd.2011.04.007. [PMID: 21515375] - Thimmappa S Anekonda, Joseph F Quinn, Christopher Harris, Kate Frahler, Teri L Wadsworth, Randall L Woltjer. L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.
Neurobiology of disease.
2011 Jan; 41(1):62-70. doi:
10.1016/j.nbd.2010.08.020. [PMID: 20816785] - Yosuke Miyashita, Do Peterson, Jane M Rees, Joseph T Flynn. Isradipine for treatment of acute hypertension in hospitalized children and adolescents.
Journal of clinical hypertension (Greenwich, Conn.).
2010 Nov; 12(11):850-5. doi:
10.1111/j.1751-7176.2010.00347.x. [PMID: 21054771] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Masayuki Abe, Yoshihiko Ito, Luvsandorj Oyunzul, Tomomi Oki-Fujino, Shizuo Yamada. Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract.
Biological & pharmaceutical bulletin.
2009 Apr; 32(4):646-50. doi:
10.1248/bpb.32.646. [PMID: 19336899] - Adina F Turcu, Jonathan A White, Mark E Kulaga, Myra Skluth, Claudia B Gruss. Calcium channel blocker-associated small bowel angioedema.
Journal of clinical gastroenterology.
2009 Apr; 43(4):338-41. doi:
10.1097/mcg.0b013e31815cf6b9. [PMID: 19077729] - Jin-Hee Park, Yoo-Sin Park, Si-Youn Rhim, Ok-Hwa Jhee, Shin-Hee Kim, Seok-Chul Yang, Min-Ho Lee, Leslie M Shaw, Ju-Seop Kang. Quantification of isradipine in human plasma using LC-MS/MS for pharmacokinetic and bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(1-2):59-64. doi:
10.1016/j.jchromb.2008.11.021. [PMID: 19041284] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Wenbo Zhang, Blanc Star, W R A K J S Rajapaksha, Thomas E Fisher. Dehydration increases L-type Ca(2+) current in rat supraoptic neurons.
The Journal of physiology.
2007 Apr; 580(Pt 1):181-93. doi:
10.1113/jphysiol.2006.126680. [PMID: 17234692] - Jirí Widimský, Jana Sirotiaková. Efficacy and tolerability of rilmenidine compared with isradipine in hypertensive patients with features of metabolic syndrome.
Current medical research and opinion.
2006 Jul; 22(7):1287-94. doi:
10.1185/030079906x115577. [PMID: 16834827] - T Hattori, P L Wang. Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts.
European journal of medical research.
2006 Mar; 11(3):93-6. doi:
. [PMID: 16751108] - Murat Oz, Alp Alptekin, Yulia Tchugunova, Meral Dinc. Effects of saturated long-chain N-acylethanolamines on voltage-dependent Ca2+ fluxes in rabbit T-tubule membranes.
Archives of biochemistry and biophysics.
2005 Feb; 434(2):344-51. doi:
10.1016/j.abb.2004.11.010. [PMID: 15639235] - Toshimi Hattori, Wang Pao-Li. Rise in intracellular calcium concentration elicited by isradipine in Gin-1 cells.
Pharmacological research.
2005 Feb; 51(2):137-9. doi:
10.1016/j.phrs.2004.04.012. [PMID: 15629258] - Bankole A Johnson, Martin A Javors, Yui-Wing Francis Lam, Lynda T Wells, Mohamed Tiouririne, John D Roache, Nassima Ait-Daoud, Kevin Lawson. Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individuals.
Progress in neuro-psychopharmacology & biological psychiatry.
2005 Jan; 29(1):15-20. doi:
10.1016/j.pnpbp.2004.08.014. [PMID: 15610940] - Kazuyoshi Hirota, David G Lambert. Measurement of [³H]PN200-110 and [¹²⁵I]ω-conotoxin MVIIA binding.
Methods in molecular biology (Clifton, N.J.).
2005; 312(?):147-59. doi:
10.1385/1-59259-949-4:147. [PMID: 21341097] - Gayle M Volk, Lenora J Goss, Vincent R Franceschi. Calcium channels are involved in calcium oxalate crystal formation in specialized cells of Pistia stratiotes L.
Annals of botany.
2004 Jun; 93(6):741-53. doi:
10.1093/aob/mch092. [PMID: 15087302] - Ludwig Baumann, Andrea Gerstner, Xiangang Zong, Martin Biel, Christian Wahl-Schott. Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina.
Investigative ophthalmology & visual science.
2004 Feb; 45(2):708-13. doi:
10.1167/iovs.03-0937. [PMID: 14744918] - Alexandra Koschak, Daniel Reimer, Doris Walter, Jean-Charles Hoda, Thomas Heinzle, Manfred Grabner, Jörg Striessnig. Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003 Jul; 23(14):6041-9. doi:
10.1523/jneurosci.23-14-06041.2003. [PMID: 12853422] - F Belal, A Al-Majed, S Julkhuf. Voltammetric determination of isradipine in dosage forms and spiked human plasma and urine.
Journal of pharmaceutical and biomedical analysis.
2003 Apr; 31(5):989-98. doi:
10.1016/s0731-7085(02)00696-9. [PMID: 12684111] - Per K Christensen, Kamran Akram, Karen B Kønig, Hans-Henrik Parving. Autoregulation of glomerular filtration rate in patients with type 2 diabetes during isradipine therapy.
Diabetes care.
2003 Jan; 26(1):156-62. doi:
10.2337/diacare.26.1.156. [PMID: 12502673] - Michael J Romano, Allyson Gaylor, Charlie J Sang. Life-threatening isradipine poisoning in a child.
Pharmacotherapy.
2002 Jun; 22(6):766-70. doi:
10.1592/phco.22.9.766.34064. [PMID: 12066967] - Alexei V Muravyov, Herbert J Meiselman, Vladimir V Yakusevich, Adrei V Zamishlayev. Effects of antihypertensive therapy on hemorheological profiles in female hypertensive patients with initially low or high whole blood viscosity.
Clinical hemorheology and microcirculation.
2002; 26(2):125-35. doi:
NULL. [PMID: 12082261] - Arlin B Blood, Yu Zhao, Wen Long, Lubo Zhang, Lawrence D Longo. L-type Ca2+ channels in fetal and adult ovine cerebral arteries.
American journal of physiology. Regulatory, integrative and comparative physiology.
2002 Jan; 282(1):R131-8. doi:
10.1152/ajpregu.00318.2001. [PMID: 11742831] - A Scholze, T D Plant, A C Dolphin, B Nürnberg. Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
Molecular endocrinology (Baltimore, Md.).
2001 Jul; 15(7):1211-21. doi:
10.1210/mend.15.7.0666. [PMID: 11435619] - L Valencia, M Bidet, S Martial, E Sanchez, E Melendez, M Tauc, C Poujeol, D Martin, M D Namorado, J L Reyes, P Poujeol. Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
American journal of physiology. Cell physiology.
2001 May; 280(5):C1193-203. doi:
10.1152/ajpcell.2001.280.5.c1193. [PMID: 11287333] - C Bracht, X W Yan, H P Brunner-LaRocca, G Sütsch, F W Amann, W Kiowski. Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia.
Journal of hypertension.
2001 May; 19(5):899-905. doi:
10.1097/00004872-200105000-00010. [PMID: 11393673] - L J Petersen, J R Petersen, U Talleruphuus, M L Møller, S D Ladefoged, J Mehlsen, H A Jensen. A randomized and double-blind comparison of isradipine and spirapril as monotherapy and in combination on the decline in renal function in patients with chronic renal failure and hypertension.
Clinical nephrology.
2001 May; 55(5):375-83. doi:
NULL. [PMID: 11393383] - R Vajna, U Klöckner, A Pereverzev, M Weiergräber, X Chen, G Miljanich, N Klugbauer, J Hescheler, E Perez-Reyes, T Schneider. Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1.
European journal of biochemistry.
2001 Feb; 268(4):1066-75. doi:
10.1046/j.1432-1327.2001.01969.x. [PMID: 11179973] - Y Tanaka, S Ando. Age-related changes in the subtypes of voltage-dependent calcium channels in rat brain cortical synapses.
Neuroscience research.
2001 Feb; 39(2):213-20. doi:
10.1016/s0168-0102(00)00212-1. [PMID: 11223467] - P J Darby, C Y Kwan, E E Daniel. Caveolae from canine airway smooth muscle contain the necessary components for a role in Ca(2+) handling.
American journal of physiology. Lung cellular and molecular physiology.
2000 Dec; 279(6):L1226-35. doi:
10.1152/ajplung.2000.279.6.l1226. [PMID: 11076813] - K Takamura, F Kusu, H Abdel-Wadood, N El-Rabbat, G Saleh, I Refaat. Redox properties of isradipine and its electrochemical detection in the HPLC determination of the compound in human serum.
Biomedical chromatography : BMC.
2000 Nov; 14(7):453-8. doi:
10.1002/1099-0801(200011)14:7<453::aid-bmc5>3.0.co;2-7. [PMID: 11113923] - I C van Riemsdijk, P G Mulder, J W de Fijter, J A Bruijn, J P van Hooff, A J Hoitsma, A M Tegzess, W Weimar. Addition of isradipine (Lomir) results in a better renal function after kidney transplantation: a double-blind, randomized, placebo-controlled, multi-center study.
Transplantation.
2000 Jul; 70(1):122-6. doi:
NULL. [PMID: 10919587] - S Uchida, S Yamada, Y Deguchi, M Yamamoto, R Kimura. In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain.
Pharmaceutical research.
2000 Jul; 17(7):844-50. doi:
10.1023/a:1007512426420. [PMID: 10990204] - S S Rakov, V A Betekhtina. [Protein markers in evaluation of nephroprotective effects of antihypertensive drugs in patients with arterial hypertension].
Klinicheskaia laboratornaia diagnostika.
2000 Jul; ?(7):3-7. doi:
NULL. [PMID: 10981385] - M L De Rosa, G Maddaluno, F Lionetti, U Di Palma, L Albanese, P Cardace, A Baiano, C Vigorito. Effects of enalapril and isradipine alone and in combination on blood pressure, renal function and echocardiographic parameters in mild hypertension.
International journal of cardiology.
2000 Jun; 74(1):77-84. doi:
10.1016/s0167-5273(00)00249-7. [PMID: 10854683] - S J Taler, S C Textor, V J Canzanello, L Schwartz, M K Porayko, R H Wiesner, R A Krom. Hypertension after liver transplantation: a predictive role for pretreatment hemodynamics and effects of isradipine on the systemic and renal circulations.
American journal of hypertension.
2000 Mar; 13(3):231-9. doi:
10.1016/s0895-7061(99)00171-5. [PMID: 10777026] - I Sihm, K Thygesen, L R Krusell, O Lederballe. Long-term renal and cardiovascular effects of antihypertensive treatment regimens based upon isradipine, perindopril and thiazide.
Blood pressure.
2000; 9(6):346-54. doi:
10.1080/080370500300000932. [PMID: 11212064] - R Handrock, R Rao-Schymanski, N Klugbauer, F Hofmann, S Herzig. Dihydropyridine enantiomers block recombinant L-type Ca2+ channels by two different mechanisms.
The Journal of physiology.
1999 Nov; 521 Pt 1(?):31-42. doi:
10.1111/j.1469-7793.1999.00031.x. [PMID: 10562332] - S Yamada, S Uchida, A Urayama, R Kimura. In vivo receptor occupancy and plasma concentration of pranidipine, a potent and long-acting dihydropyridine calcium antagonist.
Pharmacology.
1999 Oct; 59(4):171-82. doi:
10.1159/000028318. [PMID: 10474077] - J T Backman, J S Wang, X Wen, K T Kivistö, P J Neuvonen. Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam.
Clinical pharmacology and therapeutics.
1999 Oct; 66(4):401-7. doi:
10.1053/cp.1999.v66.a101461. [PMID: 10546924] - H M Laivuori, M Laakso, M J Tikkanen, B Cacciatore, R O Ylikorkala, R J Kaaja. Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia.
Journal of hypertension.
1999 Aug; 17(8):1189-94. doi:
10.1097/00004872-199917080-00019. [PMID: 10466475] - C M Nzerue. Calcium antagonists and renal disease.
Kidney international.
1999 May; 55(5):2074. doi:
10.1046/j.1523-1755.1999.00501.x. [PMID: 10231475] - T V Morugova, D N Lazareva. [The metabolic effects of isradipine, ramipril, Ednit and beta-adrenoblockers in patients with non-insulin-dependent diabetes mellitus and arterial hypertension].
Eksperimental'naia i klinicheskaia farmakologiia.
1999 Mar; 62(2):39-42. doi:
NULL. [PMID: 10340128] - L P Jacob, D Malhotra, L Chan, J I Shapiro. Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1999 Feb; 33(2):301-3. doi:
10.1016/s0272-6386(99)70304-5. [PMID: 10023642] - J Shohat, C Wittenberg, A Erman, J Rosenfeld, G Boner. Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension.
Scandinavian journal of urology and nephrology.
1999 Feb; 33(1):57-62. doi:
10.1080/003655999750016294. [PMID: 10100366] - A Yildiz, M S Sever, A Türkmen, T Ecder, S Türk, V Akkaya, E Ark. Interaction between cyclosporine A and verapamil, felodipine, and isradipine.
Nephron.
1999 Jan; 81(1):117-8. doi:
10.1159/000045262. [PMID: 9884436] - R P Byington, C D Furberg, T E Craven, M Pahor, J R Sowers. Isradipine in prediabetic hypertensive subjects.
Diabetes care.
1998 Dec; 21(12):2103-10. doi:
10.2337/diacare.21.12.2103. [PMID: 9839101] - A I Neĭmark, V N Zhukov, A V Fidirkin. [Use of isradipine and lipostabil for protection of the kidney during extracorporeal lithotripsy].
Urologiia i nefrologiia.
1998 Nov; ?(6):19-21. doi:
NULL. [PMID: 10051821] - B M Cheung, C P Lau, B Z Wu. Amlodipine, felodipine, and isradipine in the treatment of Chinese patients with mild-to-moderate hypertension.
Clinical therapeutics.
1998 Nov; 20(6):1159-69. doi:
10.1016/s0149-2918(98)80111-2. [PMID: 9916609] - S Gaur, M E Morton, G P Frick, H M Goodman. Growth hormone regulates the distribution of L-type calcium channels in rat adipocyte membranes.
The American journal of physiology.
1998 08; 275(2):C505-14. doi:
10.1152/ajpcell.1998.275.2.c505. [PMID: 9688605] - A V Muravyov, L G Zaitsev, A A Muravyov, V V Yakusevich, A M Sirotkina. Effects of Ramipril and Isradipin on hemorheological profiles in patients with arterial hypertension.
Clinical hemorheology and microcirculation.
1998 Jul; 18(2-3):185-90. doi:
NULL. [PMID: 9699040] - K H Yin, S C Koh, P Malcus, S SvenMontan, A Biswas, S Arulkumaran, S S Ratnam. Preeclampsia: haemostatic status and the short-term effects of methyldopa and isradipine therapy.
The journal of obstetrics and gynaecology research.
1998 Jun; 24(3):231-8. doi:
10.1111/j.1447-0756.1998.tb00080.x. [PMID: 9714995] - N Kanaya, M Matsumoto, S Kawana, H Tsuchida, H Kimura, A Miyamoto, H Ohshika, A Namiki. Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1998 Jun; 45(6):584-91. doi:
10.1007/bf03012714. [PMID: 9669017] - H S Rask, H R Angelo, H R Christensen. Enantioselective determination of isradipine in human serum using chiral stationary phase liquid chromatography and gas chromatography with nitrogen selective detection.
Chirality.
1998; 10(9):808-12. doi:
10.1002/(sici)1520-636x(1998)10:9<808::aid-chir6>3.0.co;2-h. [PMID: 9839430] - M Wysocki, O K Andersson, B Persson, U Bagge. Vasoconstriction during acute hypervolemic hemodilution in hypertensive patients is not prevented by calcium blockade.
Angiology.
1998 Jan; 49(1):41-8. doi:
10.1177/000331979804900105. [PMID: 9456163] - A Smith, J McPherson, M Taylor, A Mason, S Carney, A Gillies. Pro-haemorrhagic effects of calcium antagonists: a comparison of isradipine and atenolol on ex vivo platelet function in hypertensive subjects.
Journal of human hypertension.
1997 Dec; 11(12):783-8. doi:
10.1038/sj.jhh.1000449. [PMID: 9468004] - K Allikmets, T Parik, R Teesalu. Increased urinary cGMP and decreased albumin excretion with isradipine treatment in essential hypertension.
Cardiovascular drugs and therapy.
1997 Nov; 11(5):651-2. doi:
10.1023/a:1007782807263. [PMID: 9493703] - K Ahmed, B Michael, J F Burke. Effects of isradipine on renal hemodynamics in renal transplant patients treated with cyclosporine.
Clinical nephrology.
1997 Nov; 48(5):307-10. doi:
NULL. [PMID: 9403215] - K Allikmets, T Parik, R Teesalu. Antihypertensive and renal effects of isradipine in essential hypertension: focus on renin system activity.
Angiology.
1997 Nov; 48(11):977-83. doi:
10.1177/000331979704801107. [PMID: 9373050] - H Ito, N Klugbauer, F Hofmann. Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel.
Molecular pharmacology.
1997 Oct; 52(4):735-40. doi:
10.1124/mol.52.4.735. [PMID: 9380037] - M R Weir, P S Hall, M T Behrens, J M Flack. Salt and blood pressure responses to calcium antagonism in hypertensive patients.
Hypertension (Dallas, Tex. : 1979).
1997 Sep; 30(3 Pt 1):422-7. doi:
10.1161/01.hyp.30.3.422. [PMID: 9314427] - K Yamanaga, H Shinyama, T Akira, M Iwamoto, T Uchida, N Nakamura, Y Kagitani. AE0047-mediated calcium channel blocking in vascular smooth muscles.
General pharmacology.
1997 Sep; 29(3):337-43. doi:
10.1016/s0306-3623(96)00515-0. [PMID: 9378237] - R G O'Neil, J M Reid, R L Williams, N J Karin. Expression of dihydropyridine binding sites in renal epithelial cells.
Biochemical and biophysical research communications.
1997 Aug; 237(1):41-5. doi:
10.1006/bbrc.1997.7071. [PMID: 9266826] - C A Gurnett, R Felix, K P Campbell. Extracellular interaction of the voltage-dependent Ca2+ channel alpha2delta and alpha1 subunits.
The Journal of biological chemistry.
1997 Jul; 272(29):18508-12. doi:
10.1074/jbc.272.29.18508. [PMID: 9218497] - A Guasch, M Parham, C F Zayas, O Campbell, C Nzerue, E Macon. Contrasting effects of calcium channel blockade versus converting enzyme inhibition on proteinuria in African Americans with non-insulin-dependent diabetes mellitus and nephropathy.
Journal of the American Society of Nephrology : JASN.
1997 May; 8(5):793-8. doi:
10.1681/asn.v85793. [PMID: 9176849] - E R Maccariello, V Genelhu de Abreu Fagundes, E A Francischetti. The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy.
American journal of hypertension.
1997 May; 10(5 Pt 1):541-5. doi:
10.1016/s0895-7061(97)00029-0. [PMID: 9160765] - N Bowling, W E Bloomquist, M L Cohen, H U Bryant, H W Cole, D E Magee, E R Rowley, C J Vlahos. Effects of prolonged ethinyl estradiol treatment on calcium channel binding and in vivo calcium-mediated hemodynamic responses in ovariectomized rats.
The Journal of pharmacology and experimental therapeutics.
1997 Apr; 281(1):218-25. doi:
NULL. [PMID: 9103500] - K K Borowicz, M Gasior, Z Kleinrok, S J Czuczwar. Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
European journal of pharmacology.
1997 Mar; 323(1):45-51. doi:
10.1016/s0014-2999(97)00020-4. [PMID: 9105875] - P M Roekaerts, C J Lawrence, F W Prinzen, S de Lange. Alleviation of the peripheral hemodynamic effects of dexmedetomidine by the calcium channel blocker isradipine.
Acta anaesthesiologica Scandinavica.
1997 Mar; 41(3):364-70. doi:
10.1111/j.1399-6576.1997.tb04700.x. [PMID: 9113181] - E Kvaszová, L Turecký, A Viktorínová. [The effect of isradipine on lipid parameters in calcinosis in rats induced by vitamin D3].
Bratislavske lekarske listy.
1997 Feb; 98(2):91-6. doi:
NULL. [PMID: 9264815] - M Tomkowiak, P Guerrier, S Krantic. Meiosis reinitiation of mussel oocytes involves L-type voltage-gated calcium channel.
Journal of cellular biochemistry.
1997 Jan; 64(1):152-60. doi:
10.1002/(sici)1097-4644(199701)64:1<152::aid-jcb17>3.0.co;2-n. [PMID: 9015763] - N Futrakul, C Pochanugool, V Sitprija, V Singkhwa, P Futrakul, S Yenrudi, R Sensirivatana, D Watana, M Poshyachinda. Renal dysfunction in glomerulonephropathy associated with rapid onset renal failure.
Renal failure.
1997 Jan; 19(1):77-84. doi:
10.3109/08860229709026262. [PMID: 9044454] - P Mollard, O Kah. Spontaneous and gonadotropin-releasing hormone-stimulated cytosolic calcium rises in individual goldfish gonadotrophs.
Cell calcium.
1996 Nov; 20(5):415-24. doi:
10.1016/s0143-4160(96)90004-4. [PMID: 8955556] - C Arsac, C Raymond, N Martin-Moutot, B Dargent, F Couraud, J Pouget, M Seagar. Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum.
Annals of neurology.
1996 Nov; 40(5):695-700. doi:
10.1002/ana.410400504. [PMID: 8957009] - A Zanchetti. Trials investigating the anti-atherosclerotic effects of antihypertensive drugs.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1996 Sep; 14(2):S77-80; discussion S80. doi:
10.1097/00004872-199609002-00015. [PMID: 8934382] - M J Maher, L D Dworkin. Calcium antagonists in the treatment of hypertension: special clinical considerations.
Current opinion in nephrology and hypertension.
1996 Sep; 5(5):437-41. doi:
10.1097/00041552-199609000-00010. [PMID: 8937813] - H Sinzinger, G Lupattelli, H Kritz, P Fitscha, J O'Grady. Prostaglandin I2-mediated upregulation of 125I-LDL-receptor binding by isradipine in normo- and hypercholesterolemic rabbits in vivo.
Prostaglandins.
1996 Aug; 52(2):77-91. doi:
10.1016/0090-6980(96)00054-8. [PMID: 8880894] - A M van Rhee, J L Jiang, N Melman, M E Olah, G L Stiles, K A Jacobson. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
Journal of medicinal chemistry.
1996 Jul; 39(15):2980-9. doi:
10.1021/jm9600205. [PMID: 8709132] - L La Civita, D Giuggioli, M G Del Chicca, G Longombardo, G Pasero, C Ferri. Effect of isradipine on endothelin-1 plasma concentrations in patients with Raynaud's phenomenon.
Annals of the rheumatic diseases.
1996 May; 55(5):331-2. doi:
10.1136/ard.55.5.331-b. [PMID: 8660111] - G Ranieri, V Filitti, A Andriani, M V Bonfantino, G Lamontanara, A Cavallo, M Milani, R De Cesaris. Effects of isradipine sustained release on platelet function and fibrinolysis in essential hypertensives with or without other risk factors.
Cardiovascular drugs and therapy.
1996 May; 10(2):119-23. doi:
10.1007/bf00823589. [PMID: 8842503] - A Zanchetti. Antiatherosclerotic effects of antihypertensive drugs: recent evidence and ongoing trials.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1996 Apr; 18(3-4):489-99. doi:
10.3109/10641969609088979. [PMID: 8743037] - H Shi, N J Severs, H Robenek. Effects of calcium on the migration and recruitment of macrophages and macrophage-derived foam cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1996 Mar; 10(4):491-501. doi:
10.1096/fasebj.10.4.8647348. [PMID: 8647348] - K Abbott, A Smith, G L Bakris. Effects of dihydropyridine calcium antagonists on albuminuria in patients with diabetes.
Journal of clinical pharmacology.
1996 Mar; 36(3):274-9. doi:
10.1002/j.1552-4604.1996.tb04199.x. [PMID: 8690823] - J N Skepper, C T Kappagoda. The effect of isradipine administration on existing fatty streaks in the cholesterol-fed rabbit: a morphometric study.
Atherosclerosis.
1996 Jan; 119(2):247-60. doi:
10.1016/0021-9150(95)05643-2. [PMID: 8808501] - R M Touyz, E L Schiffrin. Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin.
American journal of hypertension.
1995 Dec; 8(12 Pt 1):1214-21. doi:
10.1016/0895-7061(95)00249-9. [PMID: 8998256]