allopurinol (BioDeep_00000016915)

   


代谢物信息卡片


1H-Pyrazolo[3,4-d]pyrimidin-4-ol (9CI)

化学式: C5H4N4O (136.03850939999998)
中文名称: 1H-吡唑并[3,4-d]嘧啶-4-醇, 黄嘌呤氧化酶, 别嘌醇, 痛风平,ZYLOPRUNL
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C2C(=NC=NC2=O)NN1
InChI: InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

描述信息

M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AA - Preparations inhibiting uric acid production
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants
C471 - Enzyme Inhibitor > C1637 - Xanthine Oxidase Inhibitor
D000975 - Antioxidants > D016166 - Free Radical Scavengers
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C921 - Uricosuric Agent
D009676 - Noxae > D000963 - Antimetabolites
D004791 - Enzyme Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 2389
[Raw Data] CB202_Allopurinol_pos_50eV_rep000003.txt
[Raw Data] CB202_Allopurinol_pos_40eV_rep000003.txt
[Raw Data] CB202_Allopurinol_pos_30eV_rep000003.txt
[Raw Data] CB202_Allopurinol_pos_20eV_rep000003.txt
[Raw Data] CB202_Allopurinol_pos_10eV_rep000003.txt
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3336
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].

同义名列表

3 个代谢物同义名

1H-Pyrazolo[3,4-d]pyrimidin-4-ol (9CI); Xanthine oxidase; allopurinol



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(6)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fang Congcong, Zhu Xiaoliang, Zhang Yongjian, Q I Huan, Zhang Yingjie. Combination of allopurinol with Dahuang Mudan Tang significantly improve kidney function and alleviate oxidative stress and inflammation of chronic kidney disease stage Ⅰ-Ⅲ patients with hyperuricemia. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):182-187. doi: 10.19852/j.cnki.jtcm.20231121.001. [PMID: 38213253]
  • Jiabao Zhou, Chuanxu Wang, Xuming Zhang, Zhiyuan Wu, Yansheng Wu, Dongdong Li, Jiandong Gao. Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome. Journal of ethnopharmacology. 2023 Dec; 317(?):116777. doi: 10.1016/j.jep.2023.116777. [PMID: 37311502]
  • C-Q Yan, C Liang, Z-R Lan, C Su, S-Y Xiong, Y-X Yang, J-M Chen, S-L Tang, J-S Huang, Z-H Zhang, M-J Luo, Z-H Xiao. Comparison of the efficacy of febuxostat vs. benzbromarone in the treatment of gout: a meta-analysis in Chinese gout patients. European review for medical and pharmacological sciences. 2023 Dec; 27(24):11988-12003. doi: 10.26355/eurrev_202312_34797. [PMID: 38164861]
  • Lucas P Gartzke, Koen D W Hendriks, Femke Hoogstra-Berends, Christian P Joschko, Anne-Lise Strandmoe, Pieter C Vogelaar, Guido Krenning, Robert H Henning. Inhibition of Ferroptosis Enables Safe Rewarming of HEK293 Cells following Cooling in University of Wisconsin Cold Storage Solution. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310939. [PMID: 37446116]
  • Venkateswarlu Korthikunta, Rohit Singh, Rohit Srivastava, Jyotsana Pandey, Atul Srivastava, Upma Chaturvedi, Akansha Mishra, Arvind K Srivastava, Akhilesh K Tamrakar, Narender Tadigoppula. Design, synthesis, and evaluation of benzofuran-based chromenochalcones for antihyperglycemic and antidyslipidemic activities. RSC medicinal chemistry. 2023 Mar; 14(3):470-481. doi: 10.1039/d2md00341d. [PMID: 36970150]
  • Yanfen Niu, Qiang Li, Caixia Tu, Na Li, Lihui Gao, Hua Lin, Zhenyu Wang, Zhihong Zhou, Ling Li. Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo. Journal of natural products. 2023 01; 86(1):24-33. doi: 10.1021/acs.jnatprod.2c00531. [PMID: 36634312]
  • Xin Zhang, Jie Cui, Junling Hou, Wenquan Wang. Research Progress of Natural Active Substances with Uric-Acid-Reducing Activity. Journal of agricultural and food chemistry. 2022 Dec; 70(50):15647-15664. doi: 10.1021/acs.jafc.2c06554. [PMID: 36482671]
  • Na Yang, Bin Cao. Low-dose febuxostat exhibits a superior renal-protective effect and non-inferior safety profile compared to allopurinol in chronic kidney disease patients complicated with hyperuricemia: A double-centre, randomized, controlled study. Journal of clinical pharmacy and therapeutics. 2022 Dec; 47(12):2214-2222. doi: 10.1111/jcpt.13794. [PMID: 36403976]
  • Amira Abo Bakr, Mohamed Ali, Khairy Ibrahim. Garlic and allopurinol alleviate the apoptotic pathway in rats' brain following exposure to fipronil insecticide. Environmental analysis, health and toxicology. 2022 Dec; 37(4):e2022037-0. doi: 10.5620/eaht.2022037. [PMID: 36916050]
  • Evanthia Bletsa, Stavroula A Paschou, Vasiliki Tsigkou, Panagiota K Stampouloglou, Vasiliki Vasileiou, Georgia N Kassi, Evangelos Oikonomou, Gerasimos Siasos. The effect of allopurinol on cardiovascular outcomes in patients with type 2 diabetes: a systematic review. Hormones (Athens, Greece). 2022 Dec; 21(4):599-610. doi: 10.1007/s42000-022-00403-9. [PMID: 36197637]
  • Diribsa Alemu, Chala Kitila, Weyessa Garedew, LetaTesfaye Jule, Bayissa Badassa, N Nagaprasad, Venkatesh Seenivasan, Abel Saka, Krishnaraj Ramaswamy. Growth, yield, and yield variables of onion (Allium Cepa L.) varieties as influenced by plantspacing at DambiDollo, Western Ethiopia. Scientific reports. 2022 11; 12(1):20563. doi: 10.1038/s41598-022-24993-x. [PMID: 36446874]
  • Zakir Ali, Fakhar Ud Din, Fatima Zahid, Saba Sohail, Basalat Imran, Salman Khan, Maimoona Malik, Alam Zeb, Gul Majid Khan. Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout. BMC pharmacology & toxicology. 2022 11; 23(1):86. doi: 10.1186/s40360-022-00625-y. [PMID: 36443818]
  • Chao Zhang, Ming Zhao, Bei Jiang, Jing Yu, Qiufa Hao, Wenxuan Liu, Zhao Hu, Youming Zhang, Chun Song. Extraction optimization, structural characterization and potential alleviation of hyperuricemia by flavone glycosides from celery seeds. Food & function. 2022 Oct; 13(19):9832-9846. doi: 10.1039/d2fo01715f. [PMID: 36047466]
  • Satoru Mitsuboshi, Takahiro Niimura, Masaya Kanda, Shunsuke Ishida, Yoshito Zamami, Keisuke Ishizawa. Risk of Hematologic Events With Coadministration of Methotrexate and the Breast Cancer Resistance Protein Inhibitor Febuxostat. The Annals of pharmacotherapy. 2022 08; 56(8):910-915. doi: 10.1177/10600280211055794. [PMID: 34726078]
  • Mubin Mustafa Kiyani, Nurain Baig Moghul, Ambreen Javed, Maisra Azhar Butt, Hassan Burair Abbas, Hamza Rehman, Tausif Ahmed Rajput, Syed Ali Imran Bokhari. In Vivo Effects of Orally Administered Different Concentrations of Silver Oxide Nanoparticles in Hyperuricemic Mice. Biological trace element research. 2022 Aug; 200(8):3677-3687. doi: 10.1007/s12011-021-02960-3. [PMID: 34718960]
  • Jian-Hao Deng, Guo-Wei Zhong, Jia-Xing Zhang. Is febuxostat associated with higher risk of cardiovascular death than allopurinol in treating gout or asymptomatic hyperuricemia?. Annals of palliative medicine. 2022 08; 11(8):2789-2791. doi: 10.21037/apm-22-618. [PMID: 35948476]
  • Hayder M Al-Kuraishy, Ali I Al-Gareeb, Marwa S Al-Niemi, Reem M Aljowaie, Saeedah Musaed Almutairi, Athanasios Alexiou, Gaber El-Saber Batiha. The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19. Inflammation. 2022 Aug; 45(4):1651-1667. doi: 10.1007/s10753-022-01648-7. [PMID: 35199285]
  • Jia-Shu Chen, Mu-Xuan Wang, Min-Min Wang, Yu-Kai Zhang, Xu Guo, Ying-Ying Chen, Meng-Qi Zhang, Jin-Yue Sun, Yu-Fa Liu, Chao Liu. Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis. European journal of medicinal chemistry. 2022 Jul; 237(?):114379. doi: 10.1016/j.ejmech.2022.114379. [PMID: 35468514]
  • Ting-Ting Chang, Chih-Hung Chiang, Ching Chen, Su-Chu Lin, Hsin-Jou Lee, Jaw-Wen Chen. Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113139. doi: 10.1016/j.biopha.2022.113139. [PMID: 35623171]
  • Dongmei Liu, Binbin Zhou, Zhen Li, Zhuojun Zhang, Xiaojuan Dai, Zongfei Ji, Huiyong Chen, Ying Sun, Lindi Jiang. Effectiveness of benzbromarone versus febuxostat in gouty patients: a retrospective study. Clinical rheumatology. 2022 Jul; 41(7):2121-2128. doi: 10.1007/s10067-022-06110-5. [PMID: 35229198]
  • F Mariette, V Scarfoglière, M Giot, A Basire, F Rouby, L Daniel, N Jourde-Chiche. [HLA-B58.01 and allopurinol hypersensitivity renal vasculitis in a Chinese patient]. La Revue de medecine interne. 2022 Jul; 43(7):436-439. doi: 10.1016/j.revmed.2022.04.018. [PMID: 35606203]
  • Tunlanut Sapankaew, Kunlawat Thadanipon, Narisa Ruenroengbun, Kamolpat Chaiyakittisopon, Atiporn Ingsathit, Pawin Numthavaj, Nathorn Chaiyakunapruk, Gareth McKay, John Attia, Ammarin Thakkinstian. Efficacy and safety of urate-lowering agents in asymptomatic hyperuricemia: systematic review and network meta-analysis of randomized controlled trials. BMC nephrology. 2022 06; 23(1):223. doi: 10.1186/s12882-022-02850-3. [PMID: 35739495]
  • Susanne Johansson, David Han, Thomas Hunt, Karin Björck, Delia Florica, Michael Gillen, Jesse Hall, Fredrik Erlandsson. Pharmacokinetics, pharmacodynamics, and safety of verinurad with and without allopurinol in healthy Asian, Chinese, and non-Asian participants. Pharmacology research & perspectives. 2022 06; 10(3):e00929. doi: 10.1002/prp2.929. [PMID: 35593744]
  • Juan P Ortiz Fragola, Gabriel Cao, Mariano Tumarkin, Marisa Moriondo, Angélica Muller, Martin Sangiorgio, Francisco Azzato, Giuseppe Ambrosio, José Milei. Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock. Journal of cardiovascular pharmacology. 2022 Jun; 79(6):896-903. doi: 10.1097/fjc.0000000000001253. [PMID: 35249963]
  • Özlem Usalan, Ahmet Ziya Şahin, Orhan Özdemir, Mukaddes Cingöz, Celalettin Usalan. Effect of allopurinol drug use on GFR and proteinuria in patients with renal transplant recipients (ADOPTR study). Transplant immunology. 2022 06; 72(?):101560. doi: 10.1016/j.trim.2022.101560. [PMID: 35245661]
  • Krystian Gruszka, Tomasz Drożdż, Wiktoria Wojciechowska, Piotr Jankowski, Michał Terlecki, Magdalena Bijak, Dagmara Hering, Grzegorz Bilo, Dorota Drożdż, Marek Rajzer. Effects of uric acid-lowering therapy in patients with essential arterial hypertension. Blood pressure monitoring. 2022 Jun; 27(3):152-160. doi: 10.1097/mbp.0000000000000578. [PMID: 35120026]
  • P Vikrama Chakravarthi, S Murugesan, A Arivuchelvan, K Sukumar, A Arulmozhi, A Jagadeeswaran. Therapeutic antigout and antioxidant activity of Piper betle L. in gout-induced broilers. British poultry science. 2022 Jun; 63(3):324-331. doi: 10.1080/00071668.2021.1998365. [PMID: 34859728]
  • Nicola Dalbeth, Anthony J Doyle, Karen Billington, Greg D Gamble, Paul Tan, Kieran Latto, Thrishila Parshu Ram, Ravi Narang, Rachel Murdoch, David Bursill, Borislav Mihov, Lisa K Stamp, Anne Horne. Intensive Serum Urate Lowering With Oral Urate-Lowering Therapy for Erosive Gout: A Randomized Double-Blind Controlled Trial. Arthritis & rheumatology (Hoboken, N.J.). 2022 06; 74(6):1059-1069. doi: 10.1002/art.42055. [PMID: 34927391]
  • Yasaman Emad, Nicola Dalbeth, John Weinman, Trudie Chalder, Keith J Petrie. Why Do Patients With Gout Not Take Allopurinol?. The Journal of rheumatology. 2022 06; 49(6):622-626. doi: 10.3899/jrheum.210950. [PMID: 35169055]
  • Jiahe Fan, Shiwei Sun, Chaoyi Lv, Zhizhou Li, Mengru Guo, Yichen Yin, Hui Wang, Wei Wang. Discovery of mycotoxin alternariol as a potential lead compound targeting xanthine oxidase. Chemico-biological interactions. 2022 Jun; 360(?):109948. doi: 10.1016/j.cbi.2022.109948. [PMID: 35430257]
  • Gurpreet Kandav, Dinesh Chandra Bhatt, Shailendra Kumar Singh. Effect of Different Molecular Weights of Chitosan on Formulation and Evaluation of Allopurinol-Loaded Nanoparticles for Kidney Targeting and in Management of Hyperuricemic Nephrolithiasis. AAPS PharmSciTech. 2022 May; 23(5):144. doi: 10.1208/s12249-022-02297-7. [PMID: 35578122]
  • Giovambattista Desideri, Marek Rajzer, Martijn Gerritsen, Michael T Nurmohamed, Cristina Giannattasio, Anne-Kathrin Tausche, Claudio Borghi. Effects of intensive urate lowering therapy with febuxostat in comparison with allopurinol on pulse wave velocity in patients with gout and increased cardiovascular risk: the FORWARD study. European heart journal. Cardiovascular pharmacotherapy. 2022 05; 8(3):236-242. doi: 10.1093/ehjcvp/pvaa144. [PMID: 33410912]
  • Giana Kristy Ramos, David S Goldfarb. Update on Uric Acid and the Kidney. Current rheumatology reports. 2022 05; 24(5):132-138. doi: 10.1007/s11926-022-01069-3. [PMID: 35420373]
  • Xiang Yu, Mingjia Gu, Yiye Zhu, Lixiang Zhang, Wei Kong, Yanqin Zou. Efficacy of Urate-Lowering Therapy in Patients With Chronic Kidney Disease: A Network Meta-Analysis of Randomized Controlled Trials. Clinical therapeutics. 2022 May; 44(5):723-735.e6. doi: 10.1016/j.clinthera.2022.03.014. [PMID: 35610080]
  • Jie Wei, Hyon K Choi, Tuhina Neogi, Nicola Dalbeth, Robert Terkeltaub, Lisa K Stamp, Houchen Lyu, Natalie McCormick, Jingbo Niu, Chao Zeng, Guanghua Lei, Yuqing Zhang. Allopurinol Initiation and All-Cause Mortality Among Patients With Gout and Concurrent Chronic Kidney Disease : A Population-Based Cohort Study. Annals of internal medicine. 2022 04; 175(4):461-470. doi: 10.7326/m21-2347. [PMID: 35073156]
  • Shaoling Zheng, Pui Y Lee, Yukai Huang, Weiming Deng, Zhixiang Huang, Qidang Huang, Shuyang Chen, Tianwang Li. Clinical characteristics of juvenile gout and treatment response to febuxostat. Annals of the rheumatic diseases. 2022 04; 81(4):599-600. doi: 10.1136/annrheumdis-2021-221762. [PMID: 34930759]
  • Naomi Schlesinger, Lissa Padnick-Silver, Brian LaMoreaux. Enhancing the Response Rate to Recombinant Uricases in Patients with Gout. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2022 Mar; 36(2):95-103. doi: 10.1007/s40259-022-00517-x. [PMID: 35316517]
  • Yuliya Afinogenova, Abhijeet Danve, Tuhina Neogi. Update on gout management: what is old and what is new. Current opinion in rheumatology. 2022 03; 34(2):118-124. doi: 10.1097/bor.0000000000000861. [PMID: 34907116]
  • Juan Salvador García-Maturano, David Eduardo Torres-Ordaz, Miguel Mosqueda-Gutiérrez, Citlallyc Gómez-Ruiz, Aarón Vázquez-Mellado, Alicia Tafoya-Amado, Ingris Peláez-Ballestas, Rubén Burgos-Vargas, Janitzia Vázquez-Mellado. Gout during the SARS-CoV-2 pandemic: increased flares, urate levels and functional improvement. Clinical rheumatology. 2022 Mar; 41(3):811-818. doi: 10.1007/s10067-021-05994-z. [PMID: 34822044]
  • Smriti Juriasingani, Vicky Vo, Masoud Akbari, Jaskiran Grewal, Max Zhang, Jifu Jiang, Aaron Haig, Alp Sener. Supplemental hydrogen sulfide in models of renal transplantation after cardiac death. Canadian journal of surgery. Journal canadien de chirurgie. 2022 Mar; 65(2):E193-E202. doi: 10.1503/cjs.013920. [PMID: 35292525]
  • Ahmed Jamal Abbas Hamad, Claus Rasmussen. [Severe tophaceous gouty arthritis can be treated but is still overlooked in healthcare]. Ugeskrift for laeger. 2022 02; 184(7):. doi: NULL. [PMID: 35179111]
  • Emily Yii Ling Wong, Gabriel Onn Kit Loh, Chen Zhu Goh, Yvonne Tze Fung Tan, Sharon Shi Min Ng, Kian Boon Law, Kit Yee Cheah, Hani Farhana Mohd, Kok Khiang Peh. Sample preparation and quantification of polar drug, allopurinol, in human plasma using LCMSMS. European journal of mass spectrometry (Chichester, England). 2022 Feb; 28(1-2):35-46. doi: 10.1177/14690667221105837. [PMID: 35668610]
  • Takuji Hosoya, Shunya Uchida, Shigeru Shibata, Naoko H Tomioka, Koji Matsumoto, Makoto Hosoyamada. Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice. Journal of the American Society of Nephrology : JASN. 2022 02; 33(2):326-341. doi: 10.1681/asn.2021050616. [PMID: 34799437]
  • Muhammad Riaz, Lina Tariq Al Kury, Noreen Atzaz, Abdullah Alattar, Reem Alshaman, Fawad Ali Shah, Shupeng Li. Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt. Drug design, development and therapy. 2022; 16(?):1159-1170. doi: 10.2147/dddt.s343978. [PMID: 35496367]
  • Masashi Sakuma, Shigeru Toyoda, Takuo Arikawa, Yota Koyabu, Toru Kato, Taichi Adachi, Hideaki Suwa, Jun-Ichi Narita, Koetsu Anraku, Kimihiko Ishimura, Fumitake Yamauchi, Yasunori Sato, Teruo Inoue. Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial. PloS one. 2022 ; 17(1):e0261445. doi: 10.1371/journal.pone.0261445. [PMID: 35077456]
  • Max Y Zhang, George J Dugbartey, Smriti Juriasingani, Masoud Akbari, Winnie Liu, Aaron Haig, Patrick McLeod, Jacqueline Arp, Alp Sener. Sodium thiosulfate-supplemented UW solution protects renal grafts against prolonged cold ischemia-reperfusion injury in a murine model of syngeneic kidney transplantation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112435. doi: 10.1016/j.biopha.2021.112435. [PMID: 34798469]
  • Liudmyla V Khimion, Oleksandr A Burianov, Iryna M Nayshtetik, Svitlana O Rotova, Svitlana I Smiyan, Svitlana V Danyliuk, Viktoriia V Trofanchuk. POSSIBILITIES OF RENOPROTECTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERURICEMIA. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2022; 75(5 pt 1):1059-1063. doi: 10.36740/wlek202205102. [PMID: 35758478]
  • Saliha Boucheffa, Widad Sobhi, Ayoub Attoui, Serkan Selli, Hasim Kelebek, Abderrahmane Semmeq, Yacine Benguerba. Effect of the main constituents of Pistacia lentiscus leaves against the DPPH radical and xanthine oxidase: experimental and theoretical study. Journal of biomolecular structure & dynamics. 2022; 40(20):9870-9884. doi: 10.1080/07391102.2021.1936182. [PMID: 34114947]
  • Yinfang Gao, Yun Yu, Wan Qin, Nan Fan, Yalin Qi, Huan Chen, Weigang Duan. Uricase-deficient rats with similarly stable serum uric acid to human's are sensitive model animals for studying hyperuricemia. PloS one. 2022; 17(3):e0264696. doi: 10.1371/journal.pone.0264696. [PMID: 35239728]
  • Binbin Wu, Lili Chen, Yuankai Xu, Qingqing Duan, Zhibo Zheng, Zhigui Zheng, Dongyuan He. The Effect of Allopurinol on Renal Outcomes in Patients with Diabetic Kidney Disease: A Systematic Review and Meta-Analysis. Kidney & blood pressure research. 2022; 47(5):291-299. doi: 10.1159/000522248. [PMID: 35130544]
  • Yoon-Young Sung, Dong-Seon Kim. Synergistic Impacts of Alpinia oxyphylla Seed Extract and Allopurinol against Experimental Hyperuricemia. BioMed research international. 2022; 2022(?):2824535. doi: 10.1155/2022/2824535. [PMID: 35726318]
  • Xiaoqing Li, Xiaoxiang Gao, Hui Zhang, Yuanyuan Liu, Md Moklesur Rahman Sarker, Yijing Wu, Xinhua Chen, Chao Zhao. The anti-hyperuricemic effects of green alga Enteromorpha prolifera polysaccharide via regulation of the uric acid transporters in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Dec; 158(?):112630. doi: 10.1016/j.fct.2021.112630. [PMID: 34687833]
  • Satoshi Suzuki, Akiomi Yoshihisa, Tetsuro Yokokawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Akihiro Tsuda, Tatsunori Tsuda, Toshiyuki Ishibashi, Ichiro Konno, Osamu Yamaguchi, Hirofumi Machii, Naoki Nozaki, Takeshi Niizeki, Takuya Miyamoto, Yasuchika Takeishi. Comparison between febuxostat and allopurinol uric acid-lowering therapy in patients with chronic heart failure and hyperuricemia: a multicenter randomized controlled trial. The Journal of international medical research. 2021 Dec; 49(12):3000605211062770. doi: 10.1177/03000605211062770. [PMID: 34914568]
  • Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu. Effects of epigallocatechin-3-gallate combined with ascorbic acid and glycerol on the stability and uric acid-lowering activity of epigallocatechin-3-gallate. Pharmaceutical biology. 2021 Dec; 59(1):157-166. doi: 10.1080/13880209.2021.1878235. [PMID: 33556300]
  • Mariano Andrés, Francisca Sivera, Rachelle Buchbinder, Jordi Pardo Pardo, Loreto Carmona. Dietary supplements for chronic gout. The Cochrane database of systematic reviews. 2021 11; 11(?):CD010156. doi: 10.1002/14651858.cd010156.pub3. [PMID: 34767649]
  • Wona Choi, Yoon-Sik Yang, Dong-Jin Chang, Yeon Woong Chung, HyungMin Kim, Soo Jeong Ko, Sooyoung Yoo, Ji Seon Oh, Dong Yoon Kang, Hyeon-Jong Yang, In Young Choi. Association between the use of allopurinol and risk of increased thyroid-stimulating hormone level. Scientific reports. 2021 10; 11(1):20305. doi: 10.1038/s41598-021-98954-1. [PMID: 34645831]
  • Daniel Hoyer, Carlo Atti, Sebastian Nuding, Alexander Vogt, Daniel G Sedding, Artjom Schott. Toxic Epidermal Necrolysis Caused by Allopurinol: A Serious but Still Underestimated Adverse Reaction. The American journal of case reports. 2021 Oct; 22(?):e932921. doi: 10.12659/ajcr.932921. [PMID: 34634004]
  • M K Chatzis, D Kasabalis, J M Steiner, M N Saridomichelakis, J S Suchodolski, P G Xenoulis. Serum cobalamin concentrations in dogs with leishmaniosis before and during treatment. Comparative immunology, microbiology and infectious diseases. 2021 Oct; 78(?):101686. doi: 10.1016/j.cimid.2021.101686. [PMID: 34153612]
  • Meijiao Wang, Yi Zhang, Min Zhang, Haichang Li, Chengping Wen, Ting Zhao, Zhijun Xie, Jing Sun. The major cardiovascular events of febuxostat versus allopurinol in treating gout or asymptomatic hyperuricemia: a systematic review and meta-analysis. Annals of palliative medicine. 2021 10; 10(10):10327-10337. doi: 10.21037/apm-21-1564. [PMID: 34498481]
  • Alanna Weisman, George A Tomlinson, Lorraine L Lipscombe, Amit X Garg, Bruce A Perkins, David Z I Cherney, Gillian A Hawker. Allopurinol and Renal Outcomes in Adults With and Without Type 2 Diabetes: A Retrospective, Population-Based Cohort Study and Propensity Score Analysis. Canadian journal of diabetes. 2021 Oct; 45(7):641-649.e4. doi: 10.1016/j.jcjd.2021.01.005. [PMID: 33714662]
  • Krishna Gopal Chattaraj, Sandip Paul. Underlying Mechanisms of Allopurinol in Eliminating Renal Toxicity Induced by Melamine-Uric Acid Complex Formation: A Computational Study. Chemical research in toxicology. 2021 09; 34(9):2054-2069. doi: 10.1021/acs.chemrestox.1c00145. [PMID: 34410109]
  • Qianling Liu, Wenwen Hou, Yang Shen, Sumei Zhao. Allopurinol-induced acute kidney injury and DRESS syndrome without eosinophilia: A case report. Clinical nephrology. 2021 09; 96(3):188-190. doi: 10.5414/cn110594. [PMID: 34338190]
  • Tarek Barbar, Insara Jaffer Sathick. Tumor Lysis Syndrome. Advances in chronic kidney disease. 2021 09; 28(5):438-446.e1. doi: 10.1053/j.ackd.2021.09.007. [PMID: 35190110]
  • Melonie K Sriranganathan, Ophir Vinik, Jordi Pardo Pardo, Claire Bombardier, Christopher J Edwards. Interventions for tophi in gout. The Cochrane database of systematic reviews. 2021 08; 8(?):CD010069. doi: 10.1002/14651858.cd010069.pub3. [PMID: 34379791]
  • Robert J Fontana, Yi-Ju Li, Elizabeth Phillips, Naba Saeed, Huiman Barnhart, David Kleiner, Jay Hoofnagle. Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles. Liver international : official journal of the International Association for the Study of the Liver. 2021 08; 41(8):1884-1893. doi: 10.1111/liv.14903. [PMID: 33899326]
  • Angelo L Gaffo, David A Calhoun, Elizabeth J Rahn, Suzanne Oparil, Peng Li, Tanja Dudenbostel, Daniel I Feig, David T Redden, Paul Muntner, Phillip J Foster, Stephanie R Biggers-Clark, Amy Mudano, Sebastian E Sattui, Michael B Saddekni, S Louis Bridges, Kenneth G Saag. Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial. Arthritis & rheumatology (Hoboken, N.J.). 2021 08; 73(8):1514-1522. doi: 10.1002/art.41749. [PMID: 33779064]
  • Sascha Grzella, Jannik Hinzmann, Nina Pillokeit, Thorsten Lengenfeld, Hans-Martin Vaihinger, Panagiota Zgoura, Timm H Westhoff, Richard Viebahn, Peter Schenker. Impact of Histidine-Tryptophan-Ketoglutarate Versus University of Wisconsin Solution on the Outcome of Pancreas Transplant With Cold Ischemic Time ≥12 Hours: A Retrospective Study. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2021 08; 19(8):842-848. doi: 10.6002/ect.2020.0544. [PMID: 34142940]
  • Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. The journal of trauma and acute care surgery. 2021 08; 91(2S Suppl 2):S89-S98. doi: 10.1097/ta.0000000000003259. [PMID: 33938511]
  • Milan Hromadka, Jan Opatrny, Roman Miklik, David Suchy, Jan Bruthans, Josef Jirak, Richard Rokyta, Otto Mayer. Uricemia in the acute phase of myocardial infarction and its relation to long-term mortality risk. Journal of comparative effectiveness research. 2021 08; 10(12):979-988. doi: 10.2217/cer-2021-0082. [PMID: 34114471]
  • Pankit Vachhani, Jeffrey Baron, Craig W Freyer, Austin Miller, Meir Wetzler, James E Thompson, Elizabeth A Griffiths, Eunice S Wang. A phase 2 trial of single low doses of rasburicase for treatment of hyperuricemia in adult patients with acute leukemia. Leukemia research. 2021 08; 107(?):106588. doi: 10.1016/j.leukres.2021.106588. [PMID: 33957371]
  • Huilong Xiang, Huan Lei, Ziyuan Liu, Yongjie Liu, Yang Li, Yinsheng Qiu, Lingyun Xu. Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy. Toxicology and applied pharmacology. 2021 08; 424(?):115594. doi: 10.1016/j.taap.2021.115594. [PMID: 34044073]
  • Torsten R Goesch, Nancy A Wilson, Weifeng Zeng, Bret M Verhoven, Weixiong Zhong, Maya M Coumbe Gitter, William E Fahl. Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats. Biomolecules. 2021 07; 11(7):. doi: 10.3390/biom11071054. [PMID: 34356678]
  • Beatriz Prieto-Moure, Dolores Cejalvo-Lapeña, Mariola Belda-Antolí, Carolina Padrón-Sanz, José Miguel Lloris-Cejalvo, José Miguel Lloris-Carsí. Combination Therapy of Allopurinol and Dantrolene and Its Role In The Prevention of Experimental Ischemia Reperfusion Injury Of The Small Intestine. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2021 Jul; 34(7):800-807. doi: 10.1080/08941939.2019.1696904. [PMID: 31906750]
  • A Jeyaruban, W Hoy, A Cameron, H Healy, Z Wang, J Zhang, A Mallett. Hyperuricaemia, gout and allopurinol in the CKD Queensland registry. Journal of nephrology. 2021 06; 34(3):753-762. doi: 10.1007/s40620-020-00937-4. [PMID: 33439469]
  • Shadan Li, Zhongli Huang, Xiaowei Li, Youguang Zhao, Xin Jiang, Yang Wen, Hao Luo, Liang Wang, Qiunong Guan, Irina Cafeeva, Donald E Brooks, Christopher Y C Nguan, Jayachandran N Kizhakkedathu, Caigan Du. Evaluation of hyperbranched polyglycerol for cold perfusion and storage of donor kidneys in a pig model of kidney autotransplantation. Journal of biomedical materials research. Part B, Applied biomaterials. 2021 06; 109(6):853-863. doi: 10.1002/jbm.b.34750. [PMID: 33098184]
  • In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong. Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. Scientific reports. 2021 05; 11(1):9894. doi: 10.1038/s41598-021-88872-7. [PMID: 33972568]
  • Tsugumichi Sato, Ching-Lan Cheng, Heung-Woo Park, Yea-Huei Kao Yang, Min-Suk Yang, Mizuki Fujita, Yuji Kumagai, Masahiro Tohkin, Yoshiro Saito, Kimie Sai. Real-world evidence of population differences in allopurinol-related severe cutaneous adverse reactions in East Asians: A population-based cohort study. Clinical and translational science. 2021 05; 14(3):1002-1014. doi: 10.1111/cts.12964. [PMID: 33382928]
  • Jacob Joseph, Anna Giczewska, Brooke Alhanti, Amrita K Cheema, Diane E Handy, Douglas L Mann, Joseph Loscalzo, Michael M Givertz. Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure. Journal of physiology and biochemistry. 2021 May; 77(2):295-304. doi: 10.1007/s13105-021-00797-x. [PMID: 33595776]
  • John Elmer Cabang Quilisadio, Evelyn Osio Salido, Ester Gonzales Penserga. Achievement of the target serum urate level among patients with gout treated with allopurinol or febuxostat in an arthritis clinic in the Philippines. Modern rheumatology. 2021 May; 31(3):755-761. doi: 10.1080/14397595.2020.1800557. [PMID: 32701037]
  • Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell biology and toxicology. 2021 04; 37(2):151-175. doi: 10.1007/s10565-020-09537-1. [PMID: 32535746]
  • Hebatallah M Essam, Heba M Mohamed. Developing, optimizing, and assessing a green electrophoretic method for determination of benzbromarone and allopurinol with its active metabolite in biological and pharmaceutical matrices. Journal of separation science. 2021 Apr; 44(7):1461-1470. doi: 10.1002/jssc.202000934. [PMID: 33527723]
  • Christian Philipp Selinger, Aileen Fraser, Paul Collins, Melanie Gunn, Thean Soon Chew, Georgina Kerry, Kamal V Patel, Maya Roysam, Klaartje Bel Kok, Aaron Bancil, Veronica Hall, Rachel Cooney, Lyn Smith, Helen Steed, Jonathan Segal, Alexandra Kent, Jimmy Limdi, Shaji Sebastian. Impact of the coronavirus infectious disease (COVID-19) pandemic on the provision of inflammatory bowel disease (IBD) antenatal care and outcomes of pregnancies in women with IBD. BMJ open gastroenterology. 2021 03; 8(1):. doi: 10.1136/bmjgast-2021-000603. [PMID: 33753426]
  • See Y Choi, Seung W Choi, Sunggun Lee, Min W So, Ji S Oh, Doo-Ho Lim. Efficacy and tolerability of febuxostat in gout patients on dialysis. Internal medicine journal. 2021 Mar; 51(3):348-354. doi: 10.1111/imj.14776. [PMID: 32043690]
  • Jun Xia Zhang, Xue Lin, Jinxiu Xu, Feng Tang. Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2021 Mar; 129(4):314-321. doi: 10.1055/a-1023-6710. [PMID: 31683330]
  • Takuya Nihei, Hideyuki Sato, Satomi Onoue. Biopharmaceutical characterization of a novel sustained-release formulation of allopurinol with reduced nephrotoxicity. Biopharmaceutics & drug disposition. 2021 Mar; 42(2-3):78-84. doi: 10.1002/bdd.2260. [PMID: 33400825]
  • Thomas Minor, Charlotte von Horn. Reduction of Renal Preservation/Reperfusion Injury by Controlled Hyperthermia During Ex Vivo Machine Perfusion. Clinical and translational science. 2021 03; 14(2):544-549. doi: 10.1111/cts.12906. [PMID: 33108687]
  • Kazuki Yoshida, Hyon K Choi, Daniel H Solomon. Medications for gout and its comorbidities: mutual benefits?. Current opinion in rheumatology. 2021 03; 33(2):145-154. doi: 10.1097/bor.0000000000000784. [PMID: 33399398]
  • Lonnie Pyne, Michael Walsh. Allopurinol: Good for Gout But Not for Preventing Loss of Kidney Function. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 03; 77(3):459-461. doi: 10.1053/j.ajkd.2020.09.001. [PMID: 32920152]
  • Ryan S Hsi, Phyllis L Yan, David S Goldfarb, Ada Egbuji, Yajuan Si, Vahakn Shahinian, John M Hollingsworth. Comparison of Selective Versus Empiric Pharmacologic Preventative Therapy With Kidney Stone Recurrence. Urology. 2021 03; 149(?):81-88. doi: 10.1016/j.urology.2020.11.054. [PMID: 33352163]
  • Meida Fan, Jian Liu, Bingcheng Zhao, Xinyu Wu, Xuefeng Li, Jieruo Gu, Naomi Schlesinger. Comparison of efficacy and safety of urate-lowering therapies for hyperuricemic patients with gout: a meta-analysis of randomized, controlled trials. Clinical rheumatology. 2021 Feb; 40(2):683-692. doi: 10.1007/s10067-020-05272-4. [PMID: 32654080]
  • Julie De Beule, Steffen Fieuws, Diethard Monbaliu, Maarten Naesens, Mauricio Sainz-Barriga, Ben Sprangers, Dirk Kuypers, Jacques Pirenne, Ina Jochmans. The effect of IGL-1 preservation solution on outcome after kidney transplantation: A retrospective single-center analysis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2021 02; 21(2):830-837. doi: 10.1111/ajt.16302. [PMID: 32888364]
  • Corinne Vanucci-Bacqué, Florence Bedos-Belval. Anti-inflammatory activity of naturally occuring diarylheptanoids - A review. Bioorganic & medicinal chemistry. 2021 02; 31(?):115971. doi: 10.1016/j.bmc.2020.115971. [PMID: 33422907]
  • Ichiro Hisatome, Peili Li, Junichiro Miake, Fikri Taufiq, Endang Mahati, Nani Maharani, Sulistiyati Bayu Utami, Masanari Kuwabara, Udin Bahrudin, Haruaki Ninomiya. Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　- Japanese Guideline on the Management of Asymptomatic Hyperuricemia. Circulation journal : official journal of the Japanese Circulation Society. 2021 01; 85(2):130-138. doi: 10.1253/circj.cj-20-0406. [PMID: 33342914]
  • Mateusz Winder, Aleksander J Owczarek, Małgorzata Mossakowska, Katarzyna Broczek, Tomasz Grodzicki, Łukasz Wierucki, Jerzy Chudek. Prevalence of Hyperuricemia and the Use of Allopurinol in Older Poles-Results from a Population-Based PolSenior Study. International journal of environmental research and public health. 2021 01; 18(2):. doi: 10.3390/ijerph18020387. [PMID: 33419128]
  • Khalid A M Attia, Ahmed El-Olemy, Sherif Ramzy, Ahmed H Abdelazim, Mohamed A Hasan, Mahmoud K M Omar, Mohamed Shahin. Application of different spectrofluorimetric methods for determination of lesinurad and allopurinol in pharmaceutical preparation and human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Jan; 244(?):118871. doi: 10.1016/j.saa.2020.118871. [PMID: 32889340]
  • Kimio Watanabe, Masaaki Nakayama, Tae Yamamoto, Gen Yamada, Hiroshi Sato, Mariko Miyazaki, Sadayoshi Ito. Different clinical impact of hyperuricemia according to etiologies of chronic kidney disease: Gonryo Study. PloS one. 2021; 16(3):e0249240. doi: 10.1371/journal.pone.0249240. [PMID: 33765101]
  • Eman H Nadwa, George N B Morcos, Nagwan M Salama, Amani N Shafik. Comparing the Effects of Febuxostat and Allopurinol in an Animal Model of Metabolic Syndrome. Pharmacology. 2021; 106(9-10):564-572. doi: 10.1159/000516495. [PMID: 34182567]
  • Jürgen Floege, Richard J Johnson. Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?. Kidney international. 2021 01; 99(1):14-16. doi: 10.1016/j.kint.2020.10.022. [PMID: 33390225]
  • AbdelAal Mohammed, Mohamed A Marie, Dina O Abdulazim, Mohammed Hassan, Olfat Shaker, Ghada Ayeldeen, Mona M Salem, Usama A Sharaf El Din. Serum Urate Lowering Therapy Using Allopurinol Improves Serum 25 Hydroxy Vitamin D in Stage 3-5 CKD Patients: A Pilot Study. Nephron. 2021; 145(2):133-136. doi: 10.1159/000512340. [PMID: 33378761]