Orellanine (BioDeep_00000016910)
代谢物信息卡片
Orellanine
化学式: C10H8N2O6 (252.0382348)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C(=C(C1=O)O)C2=C(C(=O)C=CN2O)O)O
InChI: InChI=1S/C10H8N2O6/c13-5-1-3-11(17)7(9(5)15)8-10(16)6(14)2-4-12(8)18/h1-4,15-18H
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:190273
- KEGG: C19959
- PubChem: 89579
- Metlin: METLIN73453
- ChEMBL: CHEMBL2152646
- CAS: 37338-80-0
- PMhub: MS000092740
- PubChem: 135626425
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 165401 - Cortinarius orellanus: 10.1016/S0021-9673(01)84389-2
- 86073 - Cortinarius rubellus: 10.1016/0041-0101(87)90241-8
- 181881 - Cortinarius speciosissimus: 10.1016/0041-0101(87)90241-8
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shreen D Nusair, Esraa A Zainalabdeen, Osama Y Alshogran, Almuthanna Alkaraki. Evaluation of orellanine-induced toxicity from the mushroom Cortinarius orellanus and the antagonistic effect of Petroselinum crispum.
Toxicon : official journal of the International Society on Toxinology.
2022 Jul; 214(?):1-7. doi:
10.1016/j.toxicon.2022.04.018. [PMID: 35504407] - Deman Najar, Börje Haraldsson, Annika Thorsell, Carina Sihlbom, Jenny Nyström, Kerstin Ebefors. Pharmacokinetic Properties of the Nephrotoxin Orellanine in Rats.
Toxins.
2018 08; 10(8):. doi:
10.3390/toxins10080333. [PMID: 30126099] - Heidi Hedman, Johan Holmdahl, Johan Mölne, Kerstin Ebefors, Börje Haraldsson, Jenny Nyström. Long-term clinical outcome for patients poisoned by the fungal nephrotoxin orellanine.
BMC nephrology.
2017 04; 18(1):121. doi:
10.1186/s12882-017-0533-6. [PMID: 28372584] - Ricardo Jorge Dinis-Oliveira, Mariana Soares, Carolina Rocha-Pereira, Félix Carvalho. Human and experimental toxicology of orellanine.
Human & experimental toxicology.
2016 Sep; 35(9):1016-29. doi:
10.1177/0960327115613845. [PMID: 26553321] - Poojya Anantharam, Dahai Shao, Paula M Imerman, Eric Burrough, Dwayne Schrunk, Tsevelmaa Sedkhuu, Shusheng Tang, Wilson Rumbeiha. Improved Tissue-Based Analytical Test Methods for Orellanine, a Biomarker of Cortinarius Mushroom Intoxication.
Toxins.
2016 05; 8(5):. doi:
10.3390/toxins8050158. [PMID: 27213453] - Dahai Shao, Shusheng Tang, Rosanne A Healy, Paula M Imerman, Dwayne E Schrunk, Wilson K Rumbeiha. A novel orellanine containing mushroom Cortinarius armillatus.
Toxicon : official journal of the International Society on Toxinology.
2016 May; 114(?):65-74. doi:
10.1016/j.toxicon.2016.02.010. [PMID: 26915341] - P Nagaraja, A Thangavelu, H Nair, M Kumwenda. Successful living related kidney transplantation for end-stage renal failure caused by orellanine syndrome.
QJM : monthly journal of the Association of Physicians.
2015 May; 108(5):413-5. doi:
10.1093/qjmed/hcs201. [PMID: 23097388] - Anders Herrmann, Heidi Hedman, Johan Rosén, Daniel Jansson, Börje Haraldsson, Karl-Erik Hellenäs. Analysis of the mushroom nephrotoxin orellanine and its glucosides.
Journal of natural products.
2012 Oct; 75(10):1690-6. doi:
10.1021/np300135k. [PMID: 23046414] - Déborah Talmud, Alain Wynckel, Francis Grossenbacher, Sélim Saad, Jacques Motte, Michel Abély, Christine Pietrement. Four family cases of acute renal failure. Diagnosis: Orellanus syndrome.
Pediatric nephrology (Berlin, Germany).
2011 Mar; 26(3):385-8. doi:
10.1007/s00467-010-1545-7. [PMID: 20514545] - Martin Kirchmair, Reinhold Pöder. Fatal renal failure caused by Cortinarius mushrooms.
Pediatric nephrology (Berlin, Germany).
2011 Mar; 26(3):487-8; author reply 489. doi:
10.1007/s00467-010-1664-1. [PMID: 20927553] - NULL. Erratum.
Clinical nephrology.
2009 Jun; 71(6):727. doi:
10.5414/cnp71727. [PMID: 19473645] - H Frank, T Zilker, M Kirchmair, F Eyer, B Haberl, G Tuerkoglu-Raach, M Wessely, H-J Gröne, U Heemann. Acute renal failure by ingestion of Cortinarius species confounded with psychoactive mushrooms: a case series and literature survey.
Clinical nephrology.
2009 May; 71(5):557-62. doi:
10.5414/cnp71557. [PMID: 19473617] - Ulf A Nilsson, Jenny Nyström, Lisa Buvall, Kerstin Ebefors, Anna Björnson-Granqvist, Johan Holmdahl, Börje Haraldsson. The fungal nephrotoxin orellanine simultaneously increases oxidative stress and down-regulates cellular defenses.
Free radical biology & medicine.
2008 Apr; 44(8):1562-9. doi:
10.1016/j.freeradbiomed.2008.01.017. [PMID: 18279679] - S Gallego Domínguez, M A Suárez Santisteban, J Luengo Alvarez, P González Castillo, I Castellano Cerviño. [Acute renal failure after intake of mushrooms: the orellanus syndrome].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2008; 28(3):351-2. doi:
NULL. [PMID: 18590506] - M Wessely, U Schönermarck, B Raziorrouh, M C Jung, W Samtleben. [Orellanus syndrome: a rare cause of acute renal failure].
Deutsche medizinische Wochenschrift (1946).
2007 Sep; 132(37):1880-2. doi:
10.1055/s-2007-984979. [PMID: 17823878] - Markus Wörnle, Matthias W A Angstwurm, Thomas Sitter. Treatment of intoxication with Cortinarius speciosissimus using an antioxidant therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2004 Apr; 43(4):e3-6. doi:
10.1053/j.ajkd.2003.12.037. [PMID: 15042564] - Christine Karlson-Stiber, Hans Persson. Cytotoxic fungi--an overview.
Toxicon : official journal of the International Society on Toxinology.
2003 Sep; 42(4):339-49. doi:
10.1016/s0041-0101(03)00238-1. [PMID: 14505933] - P Mount, G Harris, R Sinclair, M Finlay, G J Becker. Acute renal failure following ingestion of wild mushrooms.
Internal medicine journal.
2002 Apr; 32(4):187-90. doi:
10.1046/j.1444-0903.2001.00199.x. [PMID: 11951934] - Susanne Münstermann, Hans-Jürgen Heinicke, Marten Kayser, Hubert Nüsslein. [Acute renal failure as a sequela of mushroom poisoning with Cortinarius speciocissimus].
Medizinische Klinik (Munich, Germany : 1983).
2002 Feb; 97(2):96-8. doi:
10.1007/s00063-002-1132-1. [PMID: 11910876] - H Oubrahim, J M Richard, D Cantin-Esnault. Peroxidase-mediated oxidation, a possible pathway for activation of the fungal nephrotoxin orellanine and related compounds. ESR and spin-trapping studies.
Free radical research.
1998 May; 28(5):497-505. doi:
10.3109/10715769809066887. [PMID: 9702530] - K Fulde, J Böhler, E Keller, A W Frahm. Efficiency of haemoperfusion materials at removing the fungal toxin orellanine from human plasma.
Die Pharmazie.
1998 Jan; 53(1):58-9. doi:
NULL. [PMID: 9476259] - B Hölzl, H Regele, M Kirchmair, F Sandhofer. Acute renal failure after ingestion of Cortinarius speciocissimus.
Clinical nephrology.
1997 Oct; 48(4):260-2. doi:
NULL. [PMID: 9352162] - S Horn, J H Horina, G J Krejs, H Holzer, M Ratschek. End-stage renal failure from mushroom poisoning with Cortinarius orellanus: report of four cases and review of the literature.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1997 Aug; 30(2):282-6. doi:
10.1016/s0272-6386(97)90066-4. [PMID: 9261043] - H Oubrahim, J M Richard, D Cantin-Esnault, F Seigle-Murandi, F Trécourt. Novel methods for identification and quantification of the mushroom nephrotoxin orellanine. Thin-layer chromatography and electrophoresis screening of mushrooms with electron spin resonance determination of the toxin.
Journal of chromatography. A.
1997 Jan; 758(1):145-57. doi:
10.1016/s0021-9673(96)00695-4. [PMID: 9181972] - M Rohrmoser, M Kirchmair, E Feifel, A Valli, R Corradini, E Pohanka, A Rosenkranz, R Pöder. Orellanine poisoning: rapid detection of the fungal toxin in renal biopsy material.
Journal of toxicology. Clinical toxicology.
1997; 35(1):63-6. doi:
10.3109/15563659709001167. [PMID: 9022654] - J M Richard, E E Creppy, J L Benoit-Guyod, G Dirheimer. Orellanine inhibits protein synthesis in Madin-Darby canine kidney cells, in rat liver mitochondria, and in vitro: indication for its activation prior to in vitro inhibition.
Toxicology.
1991 Mar; 67(1):53-62. doi:
10.1016/0300-483x(91)90163-u. [PMID: 1708173] - N Delpech, S Rapior, P Donnadieu, A P Cozette, J P Ortiz, G Huchard. [Voluntary poisoning by Cortinarius orellanus: usefulness of an original early treatment after determination of orellanine in the biological fluids and tissues].
Nephrologie.
1991; 12(2):63-6. doi:
NULL. [PMID: 1944757] - N Delpech, S Rapior, A P Cozette, J P Ortiz, P Donnadieu, C Andary, G Huchard. [Outcome of acute renal failure caused by voluntary ingestion of Cortinarius orellanus].
Presse medicale (Paris, France : 1983).
1990 Jan; 19(3):122-4. doi:
NULL. [PMID: 2137588] - S Rapior, N Delpech, C Andary, G Huchard. Intoxication by Cortinarius orellanus: detection and assay of orellanine in biological fluids and renal biopsies.
Mycopathologia.
1989 Dec; 108(3):155-61. doi:
10.1007/bf00436220. [PMID: 2615804] - C Ruedl, G Gstraunthaler, M Moser. Differential inhibitory action of the fungal toxin orellanine on alkaline phosphatase isoenzymes.
Biochimica et biophysica acta.
1989 May; 991(2):280-3. doi:
10.1016/0304-4165(89)90117-7. [PMID: 2566329] - J M Richard, J Louis, D Cantin. Nephrotoxicity of orellanine, a toxin from the mushroom Cortinarius orellanus.
Archives of toxicology.
1988; 62(2-3):242-5. doi:
10.1007/bf00570151. [PMID: 3196164] - C Heufler, G Felmayer, H Prast. Investigations on the mode of action of the fungus toxin orellanine on renal cell cultures.
Agents and actions.
1987 Jun; 21(1-2):203-8. doi:
10.1007/bf01974943. [PMID: 3630855] - J Holmdahl, J Ahlmén, S Bergek, S Lundberg, S A Persson. Isolation and nephrotoxic studies of orellanine from the mushroom Cortinarius speciosissimus.
Toxicon : official journal of the International Society on Toxinology.
1987; 25(2):195-9. doi:
10.1016/0041-0101(87)90241-8. [PMID: 3576636] - J M Richard, P Ravanel, D Cantin. Phytotoxicity of orellanine, a mushroom toxin.
Toxicon : official journal of the International Society on Toxinology.
1987; 25(3):350-4. doi:
10.1016/0041-0101(87)90264-9. [PMID: 3590215] - R Flammer. [Orellanus syndrome: tubular atrophy following mushroom ingestion].
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.
1985 Sep; 74(37):985-7. doi:
NULL. [PMID: 4059737] - T Schumacher, K Høiland. Mushroom poisoning caused by species of the genus Cortinarius Fries.
Archives of toxicology.
1983 Jun; 53(2):87-106. doi:
10.1007/bf00302720. [PMID: 6349583]