Potassium oxonate (BioDeep_00000016894)
代谢物信息卡片
Potassium 2,6-dihydroxytriazinecarboxylate
化学式: C4H2KN3O4 (194.9682392)
中文名称: 氧嗪酸钾
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=NC(=O)NC(=O)N1)C(=O)[O-].[K+]
InChI: /q
描述信息
C471 - Enzyme Inhibitor
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:80230
- KEGG: C15997
- PubChem: 2723920
- Metlin: METLIN71123
- ChEMBL: CHEMBL3184847
- CAS: 2207-75-2
- PubChem: 47205308
- NIKKAJI: J42.695D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xianghao Lin, Xiaojuan Zou, Baifei Hu, Dongyun Sheng, Tianxiang Zhu, Mingzhu Yin, Hui Xia, Haiming Hu, Hongtao Liu. Bi Xie Fen Qing Yin decoction alleviates potassium oxonate and adenine induced-hyperuricemic nephropathy in mice by modulating gut microbiota and intestinal metabolites.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 170(?):116022. doi:
10.1016/j.biopha.2023.116022. [PMID: 38147734] - Yanfen Niu, Qiang Li, Caixia Tu, Na Li, Lihui Gao, Hua Lin, Zhenyu Wang, Zhihong Zhou, Ling Li. Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo.
Journal of natural products.
2023 01; 86(1):24-33. doi:
10.1021/acs.jnatprod.2c00531. [PMID: 36634312] - Hai-Bo Liu, Min Yang, Wan Li, Ting Luo, Yang Wu, Xiang-Yu Huang, Yao-Lei Zhang, Tao Liu, Yong Luo. Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models.
Drug design, development and therapy.
2023; 17(?):2287-2301. doi:
10.2147/dddt.s419130. [PMID: 37551408] - Guangxing Shui, Zheyi Cai, Feng Wang, Ting Chen, Xueyuan Huang, Yun Cai, Xiuhua Mi. Simiao pill inhibits epithelial mesenchymal transition in a mouse model of chronic hyperuricemic nephropathy by inhibiting NLRP3 inflammasome activation.
BMC complementary medicine and therapies.
2022 Oct; 22(1):278. doi:
10.1186/s12906-022-03757-0. [PMID: 36271349] - Barakat M ALRashdi, Hassan A Elgebaly, Mousa O Germoush, Moath M Qarmush, Mona S Azab, Reem S Alruhaimi, Ahmad F Ahmeda, Mohammad H Abukhalil, Emadeldin M Kamel, Hany H Arab, Mohammed A Alzoghaibi, Mohammed F Alotaibi, Ayman M Mahmoud. A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Environmental science and pollution research international.
2022 Sep; 29(42):63520-63532. doi:
10.1007/s11356-022-20274-2. [PMID: 35461413] - Chih-Chiang Wang, You-Liang Li, Po-Yen Chiu, Chun Chen, Hung-Che Chen, Fu-An Chen. Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.
The Journal of veterinary medical science.
2022 Aug; 84(8):1134-1141. doi:
10.1292/jvms.21-0671. [PMID: 35781421] - Bin-Yuan Hu, Yun-Li Zhao, Dan-Yu Ma, Mei-Ling Xiang, Li-Xing Zhao, Xiao-Dong Luo. Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro.
Journal of ethnopharmacology.
2022 May; 290(?):115049. doi:
10.1016/j.jep.2022.115049. [PMID: 35150817] - Jing Tian, Baichuan Wang, Bin Xie, Xinwei Liu, Dapeng Zhou, Xuening Hou, Liangbi Xiang. Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Modern rheumatology.
2022 Jan; 32(1):221-230. doi:
10.1080/14397595.2021.1899569. [PMID: 33705241] - Yu-Zhi Wang, Cong Zhou, Li-Jie Zhu, Xing-Li-Shang He, Lin-Zi Li, Xiang Zheng, Wan-Feng Xu, Ying-Jie Dong, Bo Li, Qiao-Xian Yu, Gui-Yuan Lv, Su-Hong Chen. Effects of Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Fructose and Potassium Oxonate.
Combinatorial chemistry & high throughput screening.
2022; 25(8):1294-1303. doi:
10.2174/1386207324666210528114345. [PMID: 34053424] - Guoshu Lin, Qiuxia Yu, Lieqiang Xu, Ziwei Huang, Liting Mai, Linyun Jiang, Ziren Su, Jianhui Xie, Yucui Li, Yuhong Liu, Zhixiu Lin, Jiannan Chen. Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
European journal of pharmacology.
2021 Dec; 912(?):174592. doi:
10.1016/j.ejphar.2021.174592. [PMID: 34699754] - Xia Zhao, Jing Wang, Liying Tang, Pei Li, Jing Ru, Yuzhi Bai. Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Bioengineered.
2021 12; 12(1):589-600. doi:
10.1080/21655979.2021.1882761. [PMID: 33517833] - Jiangchao Zhuang, Xie Zhou, Ting Liu, Shuai Zhang, Falei Yuan, Leifang Zhang, Zuisu Yang, Yan Chen. Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Die Pharmazie.
2021 11; 76(11):551-558. doi:
10.1691/ph.2021.1731. [PMID: 34782040] - Jinfen Chen, Lieqiang Xu, Linyun Jiang, Yulin Wu, Long Wei, Xiaoli Wu, Shihong Xiao, Yuhong Liu, Changjun Gao, Jian Cai, Ziren Su. Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice.
Food & function.
2021 Oct; 12(19):9416-9431. doi:
10.1039/d1fo01830b. [PMID: 34606558] - Yoon-Young Sung, Dong-Seon Kim. Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103323. [PMID: 34684325] - Xiaofen Qi, Haoran Chen, Kaifang Guan, Rongchun Wang, Ying Ma. Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.
Journal of the science of food and agriculture.
2021 Sep; 101(12):4916-4924. doi:
10.1002/jsfa.11135. [PMID: 33543494] - Huilong Xiang, Huan Lei, Ziyuan Liu, Yongjie Liu, Yang Li, Yinsheng Qiu, Lingyun Xu. Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy.
Toxicology and applied pharmacology.
2021 08; 424(?):115594. doi:
10.1016/j.taap.2021.115594. [PMID: 34044073] - Yuanyuan Xu, Xirong Cao, Haoan Zhao, Erlin Yang, Yue Wang, Ni Cheng, Wei Cao. Impact of Camellia japonica Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice.
Nutrients.
2021 Jul; 13(8):. doi:
10.3390/nu13082665. [PMID: 34444825] - Hongling Li, Xuejiao Liu, Mee-Hyun Lee, Haitao Li. Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis.
Journal of food science.
2021 Jul; 86(7):3265-3276. doi:
10.1111/1750-3841.15803. [PMID: 34160066] - Yongmei Li, Zean Zhao, Jian Luo, Yanqing Jiang, Lu Li, Yanyu Chen, Leqi Zhang, Qinghua Huang, Ying Cao, Pingzheng Zhou, Ting Wu, Jianxin Pang. Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 87(?):153585. doi:
10.1016/j.phymed.2021.153585. [PMID: 34044255] - Fei Yang, Wenjun Shi, Liting Wang, Nankun Qin, Chengxiang Wang, Yuying Guo, Guang Xu, Jie Fang, Xue Yu, Qun Ma. Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.
BMC complementary medicine and therapies.
2021 Jun; 21(1):175. doi:
10.1186/s12906-021-03350-x. [PMID: 34172058] - Xiaofei Zhou, Bowei Zhang, Xiuli Zhao, Yongxi Lin, Jin Wang, Xiaowen Wang, Nan Hu, Shuo Wang. Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Food & function.
2021 Jun; 12(12):5637-5649. doi:
10.1039/d0fo03199b. [PMID: 34018499] - Yuchen Tian, Lianzhu Lin, Mouming Zhao, An Peng, Kun Zhao. Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.
Journal of ethnopharmacology.
2021 Apr; 270(?):113808. doi:
10.1016/j.jep.2021.113808. [PMID: 33450289] - Raouia Dhouibi, Hanen Affes, Maryem Ben Salem, Dorsaf Moalla, Rim Marekchi, Slim Charfi, Serria Hammami, Zouheir Sahnoun, Kamel Jamoussi, Khaled Mounir Zeghal, Kamilia Ksouda. Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance.
Life sciences.
2021 Mar; 268(?):118998. doi:
10.1016/j.lfs.2020.118998. [PMID: 33417953] - Yanyu Chen, Zean Zhao, Yongmei Li, Yang Yang, Lu Li, Yu Jiang, Cuiting Lin, Ying Cao, Pingzheng Zhou, Yuanxin Tian, Ting Wu, Jianxin Pang. Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jan; 80(?):153374. doi:
10.1016/j.phymed.2020.153374. [PMID: 33075645] - Min Shi, Fan Guo, Dan Liao, Rongshuang Huang, Yuying Feng, Xiaoxi Zeng, Liang Ma, Ping Fu. Pharmacological inhibition of fatty acid-binding protein 4 alleviated kidney inflammation and fibrosis in hyperuricemic nephropathy.
European journal of pharmacology.
2020 Nov; 887(?):173570. doi:
10.1016/j.ejphar.2020.173570. [PMID: 32949603] - Yingchun Zeng, Yu Ma, Zhengyu Yang, Jiamin Mao, Yaxin Zheng. Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract/potassium oxonate-induced hyperuricemic mice.
Drug development and industrial pharmacy.
2020 Sep; 46(9):1550-1557. doi:
10.1080/03639045.2020.1811302. [PMID: 32811191] - Shaoshi Wen, Dan Wang, Haiyang Yu, Mengyang Liu, Qian Chen, Ruixia Bao, Lin Liu, Yi Zhang, Tao Wang. The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
International journal of molecular sciences.
2020 Jul; 21(15):. doi:
10.3390/ijms21155178. [PMID: 32707836] - Arshad Mehmood, Liang Zhao, Muhammad Ishaq, Muhammad Usman, Oumeddour Dounya Zad, Imam Hossain, Rifat Nowshin Raka, Muhammad Naveed, Lei Zhao, Chengtao Wang, Muhammad Nadeem. Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate-induced hyperuricemic mice.
Journal of food biochemistry.
2020 07; 44(7):e13213. doi:
10.1111/jfbc.13213. [PMID: 32347580] - Hui Shi, Xiao Shan Liang, Li Wen Huang, Zhi Gang Luo, Long Tan. [The optimization and assessment of the method for inducing hyperuricemia in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2020 May; 36(3):223-227. doi:
10.12047/j.cjap.5933.2020.049. [PMID: 32981276] - Wen-Hao Xu, Han-Tao Wang, Ying Sun, Zhen-Cheng Xue, Ming-Li Liang, Wei-Ke Su. Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.
The Journal of pharmacy and pharmacology.
2020 Apr; 72(4):551-560. doi:
10.1111/jphp.13222. [PMID: 31910301] - Muhammad Bilal, Saeed Ahmad, Tayyeba Rehman, Waheed Mumtaz Abbasi, Aymen Owais Ghauri, Muhammad Adeel Arshad, Sultan Ayaz, Allah Nawaz. Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.
Pakistan journal of pharmaceutical sciences.
2020 Mar; 33(2):641-649. doi:
NULL. [PMID: 32276910] - Ami Ota-Kontani, Hiroshi Hirata, Masatsune Ogura, Youichi Tsuchiya, Mariko Harada-Shiba. Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin.
Biochemical and biophysical research communications.
2020 01; 521(4):861-867. doi:
10.1016/j.bbrc.2019.10.199. [PMID: 31711647] - Bin Han, Mengjuan Gong, Zhong Li, Yuqin Qiu, Zhongjie Zou. NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats.
Oxidative medicine and cellular longevity.
2020; 2020(?):6943860. doi:
10.1155/2020/6943860. [PMID: 32695259] - Gurpreet Kandav, D C Bhatt, Deepak Kumar Jindal. Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2019 Dec; 27(2):661-671. doi:
10.1007/s40199-019-00300-4. [PMID: 31686374] - Yonger Chen, Cantao Li, Shuni Duan, Xin Yuan, Jian Liang, Shaozhen Hou. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109195. doi:
10.1016/j.biopha.2019.109195. [PMID: 31362244] - Zhichao Zhou, Ya Dong, Hanchi Zhou, Jia Liu, Wei Zhao. MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Biochemical and biophysical research communications.
2019 09; 517(3):413-420. doi:
10.1016/j.bbrc.2019.07.114. [PMID: 31378369] - Young-Sil Lee, Yoon-Young Sung, Heung Joo Yuk, Eunjung Son, SeonJoo Lee, Jin Soo Kim, Dong-Seon Kim. Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Sep; 62(?):152975. doi:
10.1016/j.phymed.2019.152975. [PMID: 31181404] - Tong-Hua Yang, De-Xiu Yan, Xiao-Yan Huang, Bo Hou, Yun-Bao Ma, Hua Peng, Xue-Mei Zhang, Ji-Jun Chen, Chang-An Geng. Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Phytochemistry.
2019 Aug; 164(?):228-235. doi:
10.1016/j.phytochem.2019.05.019. [PMID: 31181354] - Yung-Tsung Chau, Hsin-Yuan Chen, Po-Han Lin, Shih-Min Hsia. Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate.
Marine drugs.
2019 06; 17(6):. doi:
10.3390/md17060343. [PMID: 31185695] - Guoyan Liang, Yichu Nie, Yunbing Chang, Shixing Zeng, Changxiang Liang, Xiaoqing Zheng, Dan Xiao, Shiqiang Zhan, Qiujian Zheng. Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jun; 59(?):152772. doi:
10.1016/j.phymed.2018.11.032. [PMID: 31005813] - Fei Yang, Mingyu Liu, Nankun Qin, Shuangshuang Li, Mengqi Yu, Chengxiang Wang, Qun Ma. Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats.
Lipids in health and disease.
2019 May; 18(1):112. doi:
10.1186/s12944-019-1054-z. [PMID: 31077208] - Wenjun You, Jie Wang, Yaowu Zou, Kui Che, Xu Hou, Honghua Fei, Yangang Wang. Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice.
The Journal of international medical research.
2019 May; 47(5):1927-1935. doi:
10.1177/0300060519831182. [PMID: 30832523] - Jianbiao Yao, Houhong He, Jin Xue, Jianfang Wang, Huihui Jin, Jian Wu, Jiangning Hu, Ruwei Wang, Kenny Kuchta. Mori Ramulus (Chin.Ph.)-the Dried Twigs of Morus alba L./Part 1: Discovery of Two Novel Coumarin Glycosides from the Anti-Hyperuricemic Ethanol Extract.
Molecules (Basel, Switzerland).
2019 Feb; 24(3):. doi:
10.3390/molecules24030629. [PMID: 30754654] - Akio Nakashima, Atsushi Yamauchi, Junichi Matsumoto, Shinya Dohgu, Fuyuko Takata, Mitsuhisa Koga, Jiro Fukae, Yoshio Tsuboi, Yasufumi Kataoka. Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Behavioural pharmacology.
2019 02; 30(1):89-94. doi:
10.1097/fbp.0000000000000413. [PMID: 29847340] - Naixin Liu, Ying Wang, Meifeng Yang, Wenxin Bian, Lin Zeng, Saige Yin, Ziqian Xiong, Yan Hu, Siyuan Wang, Buliang Meng, Jun Sun, Xinwang Yang. New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.
Journal of agricultural and food chemistry.
2019 Jan; 67(1):220-228. doi:
10.1021/acs.jafc.8b05879. [PMID: 30562028] - Dool-Ri Oh, Jong Ro Kim, Chul Yung Choi, Chan-Hun Choi, Chang-Su Na, Bok Yun Kang, Seon-Jong Kim, Young Ran Kim. Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.
BMC complementary and alternative medicine.
2019 Jan; 19(1):10. doi:
10.1186/s12906-018-2415-2. [PMID: 30621705] - Guoqiang Zhang, Yanrong Ma, Dali Xi, Zhi Rao, Xiaohan Sun, Xin'an Wu. Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.
Biopharmaceutics & drug disposition.
2019 Jan; 40(1):3-11. doi:
10.1002/bdd.2164. [PMID: 30488476] - Heung Joo Yuk, Young-Sil Lee, Hyung Won Ryu, Seung-Hyung Kim, Dong-Seon Kim. Effects of Toona sinensis Leaf Extract and Its Chemical Constituents on Xanthine Oxidase Activity and Serum Uric Acid Levels in Potassium Oxonate-Induced Hyperuricemic Rats.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123254. [PMID: 30544886] - Rui Zhang, Shaoying Zhan, Shuyi Li, Zhenzhou Zhu, Jingren He, Jose M Lorenzo, Francisco J Barba. Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice.
Food & function.
2018 Nov; 9(11):5778-5790. doi:
10.1039/c8fo01480a. [PMID: 30327809] - Tianqiao Yong, Dan Li, Muxia Li, Danling Liang, Xue Diao, Chenling Deng, Shaodan Chen, Yizhen Xie, Diling Chen, Dan Zuo. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
Molecules (Basel, Switzerland).
2018 Oct; 23(10):. doi:
10.3390/molecules23102671. [PMID: 30336599] - Hua Yang, Wenwei Bai, Lihui Gao, Jun Jiang, Yingxi Tang, Yanfen Niu, Hua Lin, Ling Li. Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Journal of pharmacological sciences.
2018 Jun; 137(2):154-161. doi:
10.1016/j.jphs.2018.05.008. [PMID: 29934052] - Xiaoran Liu, Ya Li, Zhixin Li, Xiaomin Wei, Yanjie Ma, Peng Cheng, Rui Jiao, Jinzhi Fang, Yun Xing, Jiali Tang, Min Wang, Taiming Li. A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
International journal of biological macromolecules.
2018 Jun; 112(?):537-547. doi:
10.1016/j.ijbiomac.2018.01.171. [PMID: 29382583] - Kang Wang, Lei Hu, Jian-Kang Chen. RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 May; 101(?):617-626. doi:
10.1016/j.biopha.2018.02.010. [PMID: 29518608] - Yi Zhang, Lijun Jin, Jinchang Liu, Wei Wang, Haiyang Yu, Jian Li, Qian Chen, Tao Wang. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Journal of ethnopharmacology.
2018 Mar; 214(?):29-36. doi:
10.1016/j.jep.2017.12.004. [PMID: 29233733] - Siti Sarwani Putri Mohamed Isa, Abdulwali Ablat, Jamaludin Mohamad. The Antioxidant and Xanthine Oxidase Inhibitory Activity of Plumeria rubra Flowers.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020400. [PMID: 29438299] - Qibiao Su, Hua Su, Zhihuan Nong, Dongmei Li, Laiyou Wang, Shifeng Chu, Lizhen Liao, Jie Zhao, Xianbiao Zeng, Qikang Ya, Fei He, Wenjie Lu, Baowei Wei, Guining Wei, Naihong Chen. Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats.
Kidney & blood pressure research.
2018; 43(1):220-233. doi:
10.1159/000487675. [PMID: 29490297] - Hui Wang, Ying Peng, Tingjian Zhang, Qunsheng Lan, Huimin Zhao, Wenbao Wang, Yufei Zhao, Xu Wang, Jianxin Pang, Shaojie Wang, Jiang Zheng. Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity.
Drug metabolism and disposition: the biological fate of chemicals.
2017 12; 45(12):1354-1363. doi:
10.1124/dmd.117.077818. [PMID: 29021351] - Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity.
Journal of gastroenterology and hepatology.
2017 Nov; 32(11):1839-1845. doi:
10.1111/jgh.13785. [PMID: 28295549] - Dong-Hong Tang, You-Song Ye, Chen-Yun Wang, Zhe-Li Li, Hong Zheng, Kai-Li Ma. Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).
Experimental animals.
2017 Aug; 66(3):209-216. doi:
10.1538/expanim.16-0096. [PMID: 28302963] - Lvyi Chen, Zhou Lan. Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway.
Food & function.
2017 May; 8(5):1785-1792. doi:
10.1039/c6fo01561a. [PMID: 28428988] - Hong-Jian Zhang, Ling-Nan Li, Jie Zhou, Qin-Qin Yang, Pei-Gang Liu, Pan Xu, Wei-Qing Liang, Lin Cheng, Ying-Qi Zhang, Jin-Bao Pu, Yi-Juan Hu. Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.
Journal of ethnopharmacology.
2017 May; 203(?):304-311. doi:
10.1016/j.jep.2017.03.057. [PMID: 28390941] - Zhen Jing Li, Zhuan Li, Xiao Ying Dong, Lai Feng Lu, Chang Lu Wang. Hypouricemic and nephroprotective effects of total flavonoids from the residue of supercritical CO2 extraction of Humulus lupulus in potassium oxonate-induced mice.
Pakistan journal of pharmaceutical sciences.
2017 Mar; 30(2):493-497. doi:
NULL. [PMID: 28649075] - Tianqiao Yong, Minglong Zhang, Diling Chen, Ou Shuai, Shaodan Chen, Jiyan Su, Chunwei Jiao, Delong Feng, Yizhen Xie. Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine.
Journal of ethnopharmacology.
2016 Dec; 194(?):403-411. doi:
10.1016/j.jep.2016.10.001. [PMID: 27717908] - In-Soo Yoon, Dae-Hun Park, Sung-Hwan Ki, Seung-Sik Cho. Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
The Journal of pharmacy and pharmacology.
2016 Dec; 68(12):1597-1603. doi:
10.1111/jphp.12626. [PMID: 27696407] - Long Hongyan, Wu Suling, Zhu Weina, Zhang Yajie, Ruan Jie. Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):1930-1936. doi:
10.1016/j.biopha.2016.11.009. [PMID: 27863839] - Jhih-Jia Jhang, Jia-Wei Ong, Chi-Cheng Lu, Chin-Lin Hsu, Jia-Hong Lin, Jiunn-Wang Liao, Gow-Chin Yen. Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo.
Food & function.
2016 Oct; 7(10):4239-4246. doi:
10.1039/c6fo00822d. [PMID: 27713960] - Ming Wang, Jing Zhao, Nan Zhang, Jianghua Chen. Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Oct; 83(?):975-988. doi:
10.1016/j.biopha.2016.07.025. [PMID: 27522260] - Yanfen Niu, Jia Liu, Hai-Yang Liu, Li-Hui Gao, Guo-Hua Feng, Xu Liu, Ling Li. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
Pharmaceutical biology.
2016 Sep; 54(9):1680-6. doi:
10.3109/13880209.2015.1120322. [PMID: 26916555] - Huipin Li, Mouming Zhao, Guowan Su, Lianzhu Lin, Yong Wang. Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor.
Journal of agricultural and food chemistry.
2016 Jun; 64(23):4725-34. doi:
10.1021/acs.jafc.6b01094. [PMID: 27181598] - Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka. Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice.
Journal of radiation research.
2016 Jun; 57(3):250-7. doi:
10.1093/jrr/rrw014. [PMID: 27021217] - Wu Hui, Yuan Yongliang, Chen Yongde, Lu Guo, Lan Li, Yang Zhonglin, Ji Hui, Hu Qinghua. Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3.
Planta medica.
2016 Mar; 82(4):289-297. doi:
10.1055/s-0035-1558212. [PMID: 26584455] - Tetsuya Taniguchi, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga, Kazuhiro Saitoh. Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor.
The Journal of pharmacy and pharmacology.
2016 Jan; 68(1):76-83. doi:
10.1111/jphp.12490. [PMID: 26589240] - Fangfang Zhu, Lian Yin, Leilei Ji, Fan Yang, Guangji Zhang, Le Shi, Li Xu. Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An in vivo and in vitro study.
International immunopharmacology.
2016 Jan; 30(?):36-42. doi:
10.1016/j.intimp.2015.11.010. [PMID: 26637956] - Gang Chen, Ming-Liang Tan, Kai-Kai Li, Ping-Chung Leung, Chun-Hay Ko. Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice.
Journal of ethnopharmacology.
2015 Dec; 175(?):14-20. doi:
10.1016/j.jep.2015.08.043. [PMID: 26344851] - Yu-Tang Tung, Lei-Chen Lin, Ya-Ling Liu, Shang-Tse Ho, Chi-Yang Lin, Hsiao-Li Chuang, Chien-Chao Chiu, Chi-Chang Huang, Jyh-Horng Wu. Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice.
BMC complementary and alternative medicine.
2015 Dec; 15(?):423. doi:
10.1186/s12906-015-0950-7. [PMID: 26627882] - Long Zhang, Hong Tian Li, Lin Lin Wang, Howard Trachtman, Leonardo Trasande, Pei Xin Wang, Jian Meng Liu. Melamine Nephrotoxicity is Mediated by Hyperuricemia.
Biomedical and environmental sciences : BES.
2015 Dec; 28(12):904-12. doi:
10.3967/bes2015.124. [PMID: 26777910] - Pi-Yong Hou, Chao Mi, Yi He, Jun Zhang, Shu-Qing Wang, Fei Yu, Samantha Anderson, Yan-Wen Zhang, Xiao-Hui Wu. Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice.
Fitoterapia.
2015 Sep; 105(?):43-8. doi:
10.1016/j.fitote.2015.06.002. [PMID: 26051087] - Nandani Darshika Kodithuwakku, Yi-dong Feng, Yan-yan Zhang, Min Pan, Wei-rong Fang, Yun-man Li. The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice.
Journal of ethnopharmacology.
2015 Apr; 163(?):278-89. doi:
10.1016/j.jep.2015.01.013. [PMID: 25614106] - Ming-Xing Wang, Yang-Liu Liu, Ying Yang, Dong-Mei Zhang, Ling-Dong Kong. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
European journal of pharmacology.
2015 Jan; 747(?):59-70. doi:
10.1016/j.ejphar.2014.11.035. [PMID: 25499818] - Yongping Guo, Qian Jiang, Dingkun Gui, Niansong Wang. Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 37(4):1491-502. doi:
10.1159/000438517. [PMID: 26509423] - Hua Yang, Lihui Gao, Yanfen Niu, Yuanfang Zhou, Hua Lin, Jing Jiang, Xiangfu Kong, Xu Liu, Ling Li. Mangiferin Inhibits Renal Urate Reabsorption by Modulating Urate Transporters in Experimental Hyperuricemia.
Biological & pharmaceutical bulletin.
2015; 38(10):1591-8. doi:
10.1248/bpb.b15-00402. [PMID: 26228630] - Li Ma, Song Zhang, Ying Yuan, Jianhua Gao. Hypouricemic actions of exopolysaccharide produced by Cordyceps militaris in potassium oxonate-induced hyperuricemic mice.
Current microbiology.
2014 Dec; 69(6):852-7. doi:
10.1007/s00284-014-0666-9. [PMID: 25086583] - Xiao-Hui Wu, Chong-Zhi Wang, Jun Zhang, Shu-Qing Wang, Lide Han, Yan-Wen Zhang, Chun-Su Yuan. Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model.
Phytotherapy research : PTR.
2014 Dec; 28(12):1822-8. doi:
10.1002/ptr.5207. [PMID: 25098402] - Xiao-Hui Wu, Jin-Lan Ruan, Jun Zhang, Shu-Qing Wang, Yan-Wen Zhang. Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice.
Journal of ethnopharmacology.
2014 Nov; 157(?):201-5. doi:
10.1016/j.jep.2014.09.034. [PMID: 25267580] - Junxia Su, Yuhui Wei, Minglong Liu, Tianxi Liu, Jianhua Li, Yuanchun Ji, Jianping Liang. Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Archives of pharmacal research.
2014 Oct; 37(10):1336-44. doi:
10.1007/s12272-014-0413-6. [PMID: 24866061] - Shi-xiang Hou, Wen-jing Zhu, Ming-qun Pang, Joseph Jeffry, Lan-lan Zhou. Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Feb; 64(?):57-64. doi:
10.1016/j.fct.2013.11.022. [PMID: 24287205] - Xiao-Hui Wu, Chun-Hao Yu, Chun-Feng Zhang, Samantha Anderson, Yan-Wen Zhang. Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
The American journal of Chinese medicine.
2014; 42(1):257-9. doi:
10.1142/s0192415x14200018. [PMID: 24467548] - Qing-Hua Hu, Ji-Xiao Zhu, Jing Ji, Lin-Lin Wei, Ming-Xing Miao, Hui Ji. Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3.
Molecules (Basel, Switzerland).
2013 Jul; 18(8):8976-93. doi:
10.3390/molecules18088976. [PMID: 23899832] - Zhi-xiang Zhuang, Hong Zhu, Ji Wang, Min-gao Zhu, Hui Wang, Wang-yang Pu, Hua-hui Bian, Lei Chen, Hong Zhang. Pharmacokinetic evaluation of novel oral fluorouracil antitumor drug S-1 in Chinese cancer patients.
Acta pharmacologica Sinica.
2013 Apr; 34(4):570-80. doi:
10.1038/aps.2012.169. [PMID: 23396375] - Cássia R Silva, Janaina K Fröhlich, Sara M Oliveira, Thaíssa N Cabreira, Mateus F Rossato, Gabriela Trevisan, Amanda L Froeder, Guilherme V Bochi, Rafael N Moresco, Margareth L Athayde, Juliano Ferreira. The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
Journal of ethnopharmacology.
2013 Jan; 145(1):205-13. doi:
10.1016/j.jep.2012.10.054. [PMID: 23127654] - Li-Tao Yi, Jing Li, Dong-Xue Su, Jing-Fang Dong, Cheng-Fu Li. Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.
Pharmaceutical biology.
2012 Nov; 50(11):1423-7. doi:
10.3109/13880209.2012.683115. [PMID: 22856880] - Yun-Wei Shi, Cai-Ping Wang, Xing Wang, Yuan-Li Zhang, Lei Liu, Ru-Wei Wang, Jian-Feng Ye, Lin-Shui Hu, Ling-Dong Kong. Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice.
Journal of ethnopharmacology.
2012 Oct; 143(3):896-904. doi:
10.1016/j.jep.2012.08.023. [PMID: 22967667] - He-ying Liu, Li Ding, Yong Yu, Yan Chu, He Zhu. [Pharmacokinetics of S-1 capsule in patients with advanced gastric cancer].
Yao xue xue bao = Acta pharmaceutica Sinica.
2012 Oct; 47(10):1363-9. doi:
NULL. [PMID: 23289150] - Yun-Wei Shi, Cai-Ping Wang, Lei Liu, Yang-Liu Liu, Xing Wang, Ye Hong, Zhen Li, Ling-Dong Kong. Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
Molecular nutrition & food research.
2012 Sep; 56(9):1433-44. doi:
10.1002/mnfr.201100828. [PMID: 22865646] - Yanfen Niu, Wei Lu, Lihui Gao, Hua Lin, Xu Liu, Ling Li. Reducing effect of mangiferin on serum uric acid levels in mice.
Pharmaceutical biology.
2012 Sep; 50(9):1177-82. doi:
10.3109/13880209.2012.663763. [PMID: 22881143] - Maíra Ribeiro de Souza, Carmen Aparecida de Paula, Michelle Luciane Pereira de Resende, Andrea Grabe-Guimarães, José Dias de Souza Filho, Dênia Antunes Saúde-Guimarães. Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
Journal of ethnopharmacology.
2012 Aug; 142(3):845-50. doi:
10.1016/j.jep.2012.06.012. [PMID: 22732730] - Qing-Hua Hu, Xian Zhang, Xing Wang, Rui-Qing Jiao, Ling-Dong Kong. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.
European journal of nutrition.
2012 Aug; 51(5):593-606. doi:
10.1007/s00394-011-0243-y. [PMID: 21909718] - Jian Hua, Ping Huang, Chong-Mei Zhu, Xiao Yuan, Chen-Huan Yu. Anti-hyperuricemic and nephroprotective effects of Modified Simiao Decoction in hyperuricemic mice.
Journal of ethnopharmacology.
2012 Jun; 142(1):248-52. doi:
10.1016/j.jep.2012.04.052. [PMID: 22575704] - Jian-Mei Li, Xian Zhang, Xing Wang, Yong-Chang Xie, Ling-Dong Kong. Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.
European journal of pharmacology.
2011 Sep; 666(1-3):196-204. doi:
10.1016/j.ejphar.2011.05.021. [PMID: 21620826]