Homidium bromide (BioDeep_00000016749)
代谢物信息卡片
Homidium bromide
化学式: C21H20N3. Br (393.08405000000005)
中文名称: 溴化乙锭(EB)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC[N+]1=C2C=C(C=CC2=C3C=CC(=CC3=C1C4=CC=CC=C4)N)N.[Br-]
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
D004791 - Enzyme Inhibitors
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:4883
- KEGG: C11161
- PubChem: 14710
- Metlin: METLIN68884
- ChEMBL: CHEMBL284328
- MeSH: Ethidium
- CAS: 1239-45-8
- PubChem: 13343
- NIKKAJI: J257.280J
- KNApSAcK: 4883
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anika, Shamsher Singh, Rimpi. Neuroprotective effects of Embelin in an ethidium bromide-induced multiple sclerosis in rats: Modulation of p38 MAPK signaling pathway.
International immunopharmacology.
2024 Mar; 129(?):111639. doi:
10.1016/j.intimp.2024.111639. [PMID: 38335654] - Manish Kumar Gupta, Sanjana Senthilkumar, Latha Rangan. 3, 5-Dihydroxy 4', 7-dimethoxyflavone-DNA interaction study for nucleic acid detection and differential cell staining.
International journal of biological macromolecules.
2024 Mar; 261(Pt 1):129713. doi:
10.1016/j.ijbiomac.2024.129713. [PMID: 38281518] - Ying Liu, Rui Zhu, Xinwei Liu, Dengzhou Li, Mengyu Guo, Bing Fei, Yanying Ren, Xiaojuan You, Yongwei Li. Effect of piperine on the inhibitory potential of MexAB-OprM efflux pump and imipenem resistance in carbapenem-resistant Pseudomonas aeruginosa.
Microbial pathogenesis.
2023 Dec; 185(?):106397. doi:
10.1016/j.micpath.2023.106397. [PMID: 37852553] - Payel Paul, Sarita Sarkar, Debabrata Ghosh Dastidar, Aditya Shukla, Sharmistha Das, Sudipta Chatterjee, Poulomi Chakraborty, Prosun Tribedi. 1, 4-naphthoquinone efficiently facilitates the disintegration of pre-existing biofilm of Staphylococcus aureus through eDNA intercalation.
Folia microbiologica.
2023 Dec; 68(6):843-854. doi:
10.1007/s12223-023-01053-z. [PMID: 37142893] - Dhama Al-Sallami, Amjed Alsultan, Kadhim Hassan Abbas, Simon R Clarke. Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus.
Open veterinary journal.
2023 01; 13(1):42-47. doi:
10.5455/ovj.2023.v13.i1.5. [PMID: 36777436] - Ying Li, Honglin Wen, Xizhen Ge. Opposite motion of the Central Helices of efflux pump KmrA is important for its export efficiency.
Microbial pathogenesis.
2022 Jun; 167(?):105570. doi:
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2022 03; 228(?):111696. doi:
10.1016/j.jinorgbio.2021.111696. [PMID: 35030390] - Dimitrios N Zisimopoulos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, Nikolaos T Panagopoulos, Georgios Salahas, Christos D Georgiou. Detection of superoxide radical in all biological systems by Thin Layer Chromatography.
Archives of biochemistry and biophysics.
2022 02; 716(?):109110. doi:
10.1016/j.abb.2021.109110. [PMID: 34958749] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
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Science advances.
2018 09; 4(9):eaas9365. doi:
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2018 Aug; 32(8):e22174. doi:
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Comparative immunology, microbiology and infectious diseases.
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2015 Sep; 222(?):182-91. doi:
10.1016/j.jviromet.2015.06.014. [PMID: 26129867] - Jaideep B Bharate, Samsher Singh, Abubakar Wani, Sadhana Sharma, Prashant Joshi, Inshad A Khan, Ajay Kumar, Ram A Vishwakarma, Sandip B Bharate. Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump.
Organic & biomolecular chemistry.
2015 May; 13(19):5424-31. doi:
10.1039/c5ob00246j. [PMID: 25865846] - Plamena R Angelova, Mathew H Horrocks, David Klenerman, Sonia Gandhi, Andrey Y Abramov, Mikhail S Shchepinov. Lipid peroxidation is essential for α-synuclein-induced cell death.
Journal of neurochemistry.
2015 May; 133(4):582-9. doi:
10.1111/jnc.13024. [PMID: 25580849] - Lin Bi, Yuan-Hua Yu. Phosphorescent quantum dots/ethidium bromide nanohybrids based on photoinduced electron transfer for DNA detection.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Apr; 140(?):479-83. doi:
10.1016/j.saa.2015.01.014. [PMID: 25638430] - Fabiano B Carvalho, Jessié M Gutierres, Crystiani Bohnert, Adriana M Zago, Fátima H Abdalla, Juliano M Vieira, Heloisa E Palma, Sara M Oliveira, Roselia M Spanevello, Marta M Duarte, Sonia T A Lopes, Graciane Aiello, Marta G Amaral, Ney Luis Pippi, Cinthia M Andrade. Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination.
The Journal of nutritional biochemistry.
2015 Apr; 26(4):378-90. doi:
10.1016/j.jnutbio.2014.11.006. [PMID: 25632845] - Cangman Zhang, Biao Ren, Zongtao Lin, Lingkun Tong, Hong Wang, Shizhong Chen. An analysis method for simultaneous screening of deoxyribonucleic acid-binding active compounds and investigating their mechanisms by ultra-fast liquid chromatography tandem mass spectrometry coupled with fluorescence detection technology.
Journal of chromatography. A.
2015 Feb; 1381(?):160-72. doi:
10.1016/j.chroma.2015.01.019. [PMID: 25616969] - Kathrin Bellmann-Sickert, Tracy A Stone, Bradley E Poulsen, Charles M Deber. Efflux by small multidrug resistance proteins is inhibited by membrane-interactive helix-stapled peptides.
The Journal of biological chemistry.
2015 Jan; 290(3):1752-9. doi:
10.1074/jbc.m114.616185. [PMID: 25425644] - Adam R Brown, Keivan A Ettefagh, Daniel Todd, Patrick S Cole, Joseph M Egan, Daniel H Foil, Tyler N Graf, Bryan D Schindler, Glenn W Kaatz, Nadja B Cech. A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.
PloS one.
2015; 10(5):e0124814. doi:
10.1371/journal.pone.0124814. [PMID: 25961825] - Elena Ogalla, Carmen Claro, María Alvarez de Sotomayor, Maria Dolores Herrera, Rosalia Rodriguez-Rodriguez. Structural, mechanical and myogenic properties of small mesenteric arteries from ApoE KO mice: characterization and effects of virgin olive oil diets.
Atherosclerosis.
2015 Jan; 238(1):55-63. doi:
10.1016/j.atherosclerosis.2014.11.022. [PMID: 25437891] - Monika Mishra, Karishma Tiwari, Sachin Shukla, R Mishra, Vinod P Singh. Synthesis, structural investigation, DNA and protein binding study of some 3d-metal complexes with N'-(phenyl-pyridin-2-yl-methylene)-thiophene-2-carboxylic acid hydrazide.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Nov; 132(?):452-64. doi:
10.1016/j.saa.2014.05.007. [PMID: 24892525] - Ryan L O'Hare Doig, Carole A Bartlett, Ghassan J Maghzal, Magdalena Lam, Michael Archer, Roland Stocker, Melinda Fitzgerald. Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.
Experimental neurology.
2014 Nov; 261(?):136-46. doi:
10.1016/j.expneurol.2014.06.007. [PMID: 24931225] - S Farooq, A-T- Wahab, C D A Fozing, A-U- Rahman, M Iqbal Choudhary. Artonin I inhibits multidrug resistance in Staphylococcus aureus and potentiates the action of inactive antibiotics in vitro.
Journal of applied microbiology.
2014 Oct; 117(4):996-1011. doi:
10.1111/jam.12595. [PMID: 24996035] - Rajpal Sharma, Daniel Nisakar, Shivangi Shivpuri, Munia Ganguli. Contrasting effects of cysteine modification on the transfection efficiency of amphipathic peptides.
Biomaterials.
2014 Aug; 35(24):6563-75. doi:
10.1016/j.biomaterials.2014.04.046. [PMID: 24816284] - Diego V Beckmann, Fabiano B Carvalho, Cinthia M Mazzanti, Rosmarini P Dos Santos, Amanda O Andrades, Graciane Aiello, Angel Rippilinger, Dominguita L Graça, Fátima H Abdalla, Lizielle S Oliveira, Jessié M Gutierres, Maria Rosa C Schetinger, Alexandre Mazzanti. Neuroprotective role of quercetin in locomotor activities and cholinergic neurotransmission in rats experimentally demyelinated with ethidium bromide.
Life sciences.
2014 May; 103(2):79-87. doi:
10.1016/j.lfs.2014.03.033. [PMID: 24727240] - Xia-Bing Fu, Zi-Hua Lin, Hai-Feng Liu, Xue-Yi Le. A new ternary copper(II) complex derived from 2-(2'-pyridyl)benzimidazole and glycylglycine: synthesis, characterization, DNA binding and cleavage, antioxidation and HSA interaction.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Mar; 122(?):22-33. doi:
10.1016/j.saa.2013.11.006. [PMID: 24291450] - Marianthi Zampakou, Natalia Rizeq, Vassilis Tangoulis, Athanasios N Papadopoulos, Franc Perdih, Iztok Turel, George Psomas. Manganese(II) complexes with the non-steroidal anti-inflammatory drug tolfenamic acid: structure and biological perspectives.
Inorganic chemistry.
2014 Feb; 53(4):2040-52. doi:
10.1021/ic4025487. [PMID: 24467343] - Rajnikant Sharma, Sankalp Arya, Supriya Deepak Patil, Atin Sharma, Pradeep Kumar Jain, Naveen Kumar Navani, Ranjana Pathania. Identification of novel regulatory small RNAs in Acinetobacter baumannii.
PloS one.
2014; 9(4):e93833. doi:
10.1371/journal.pone.0093833. [PMID: 24705412] - Fei Zhang, Xiao-Liang Wang, Jing Shi, She-Feng Wang, Yong Yin, Yu-Shun Yang, Wei-Ming Zhang, Hai-Liang Zhu. Synthesis, molecular modeling and biological evaluation of N-benzylidene-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetohydrazide derivatives as potential anticancer agents.
Bioorganic & medicinal chemistry.
2014 Jan; 22(1):468-77. doi:
10.1016/j.bmc.2013.11.004. [PMID: 24286761] - Alexander Hahn, Mara Stevanovic, Oliver Mirus, Iryna Lytvynenko, Klaas Martinus Pos, Enrico Schleiff. The outer membrane TolC-like channel HgdD is part of tripartite resistance-nodulation-cell division (RND) efflux systems conferring multiple-drug resistance in the Cyanobacterium Anabaena sp. PCC7120.
The Journal of biological chemistry.
2013 Oct; 288(43):31192-205. doi:
10.1074/jbc.m113.495598. [PMID: 24014018] - Jin Qiu, Baobing Zhao, Yan Shen, Wang Chen, Yudao Ma, Yuemao Shen. A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition.
European journal of medicinal chemistry.
2013 Oct; 68(?):192-202. doi:
10.1016/j.ejmech.2013.07.020. [PMID: 23974019] - Jakob Kljun, Ioannis Bratsos, Enzo Alessio, George Psomas, Urška Repnik, Miha Butinar, Boris Turk, Iztok Turel. New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium.
Inorganic chemistry.
2013 Aug; 52(15):9039-52. doi:
10.1021/ic401220x. [PMID: 23886077] - Rupak Doshi, Hendrik W van Veen. Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA.
The Journal of biological chemistry.
2013 Jul; 288(30):21638-47. doi:
10.1074/jbc.m113.485714. [PMID: 23766512] - M Abu Mraheil, A Heisig, P Heisig. An improved assay for the detection of alterations in bacterial DNA supercoiling in vivo.
Die Pharmazie.
2013 Jul; 68(7):541-8. doi:
". [PMID: 23923635] - Qin-Fang Zhang, Wen-Jing Yi, Bing Wang, Ji Zhang, Laifeng Ren, Qian-Ming Chen, Liandi Guo, Xiao-Qi Yu. Linear polycations by ring-opening polymerization as non-viral gene delivery vectors.
Biomaterials.
2013 Jul; 34(21):5391-401. doi:
10.1016/j.biomaterials.2013.03.083. [PMID: 23582685] - Marianthi Zampakou, Melpomeni Akrivou, Eleni G Andreadou, Catherine P Raptopoulou, Vassilis Psycharis, Anastasia A Pantazaki, George Psomas. Structure, antimicrobial activity, DNA- and albumin-binding of manganese(II) complexes with the quinolone antimicrobial agents oxolinic acid and enrofloxacin.
Journal of inorganic biochemistry.
2013 Apr; 121(?):88-99. doi:
10.1016/j.jinorgbio.2012.12.013. [PMID: 23353085] - Zhiling Song, Hong Wang, Biao Ren, Baobao Zhang, Yuki Hashi, Shizhong Chen. On-line study of flavonoids of Trollius chinensis Bunge binding to DNA with ethidium bromide using a novel combination of chromatographic, mass spectrometric and fluorescence techniques.
Journal of chromatography. A.
2013 Mar; 1282(?):102-12. doi:
10.1016/j.chroma.2013.01.060. [PMID: 23411144] - R J Aitken, T B Smith, T Lord, L Kuczera, A J Koppers, N Naumovski, H Connaughton, M A Baker, G N De Iuliis. On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid.
Andrology.
2013 Mar; 1(2):192-205. doi:
10.1111/j.2047-2927.2012.00056.x. [PMID: 23316012] - Anna Byczkowska, Anita Kunikowska, Andrzej Kaźmierczak. Determination of ACC-induced cell-programmed death in roots of Vicia faba ssp. minor seedlings by acridine orange and ethidium bromide staining.
Protoplasma.
2013 Feb; 250(1):121-8. doi:
10.1007/s00709-012-0383-9. [PMID: 22350735] - Jun-Jie Koh, Shengxiang Qiu, Hanxun Zou, Rajamani Lakshminarayanan, Jianguo Li, Xiaojun Zhou, Charles Tang, Padmanabhan Saraswathi, Chandra Verma, Donald T H Tan, Ai Ling Tan, Shouping Liu, Roger W Beuerman. Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting.
Biochimica et biophysica acta.
2013 Feb; 1828(2):834-44. doi:
10.1016/j.bbamem.2012.09.004. [PMID: 22982495] - María Del Carmen García-Rodríguez, Megumi Monserrat Carvente-Juárez, Mario Agustín Altamirano-Lozano. Antigenotoxic and apoptotic activity of green tea polyphenol extracts on hexavalent chromium-induced DNA damage in peripheral blood of CD-1 mice: analysis with differential acridine orange/ethidium bromide staining.
Oxidative medicine and cellular longevity.
2013; 2013(?):486419. doi:
10.1155/2013/486419. [PMID: 24363823] - Yuji Ishibashi, Takanori Matsui, Keisuke Ohta, Ryuichiro Tanoue, Masayoshi Takeuchi, Katsuhiko Asanuma, Kei Fukami, Seiya Okuda, Kei-ichiro Nakamura, Sho-ichi Yamagishi. PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation.
Microvascular research.
2013 Jan; 85(?):54-8. doi:
10.1016/j.mvr.2012.10.007. [PMID: 23108227] - Shagun Arora, Shristhi Goyal, Jay Balani, Simran Tandon. Enhanced antiproliferative effects of aqueous extracts of some medicinal mushrooms on colon cancer cells.
International journal of medicinal mushrooms.
2013; 15(3):301-14. doi:
10.1615/intjmedmushr.v15.i3.70. [PMID: 23662617] - Adriana M Ojeda-Sana, Victoria Repetto, Silvia Moreno. Carnosic acid is an efflux pumps modulator by dissipation of the membrane potential in Enterococcus faecalis and Staphylococcus aureus.
World journal of microbiology & biotechnology.
2013 Jan; 29(1):137-44. doi:
10.1007/s11274-012-1166-3. [PMID: 22961443] - Valentina Gallo, Oleksii A Skorokhod, Evelin Schwarzer, Paolo Arese. Simultaneous determination of phagocytosis of Plasmodium falciparum-parasitized and non-parasitized red blood cells by flow cytometry.
Malaria journal.
2012 Dec; 11(?):428. doi:
10.1186/1475-2875-11-428. [PMID: 23259636] - Petra Živec, Franc Perdih, Iztok Turel, Gerald Giester, George Psomas. Different types of copper complexes with the quinolone antimicrobial drugs ofloxacin and norfloxacin: structure, DNA- and albumin-binding.
Journal of inorganic biochemistry.
2012 Dec; 117(?):35-47. doi:
10.1016/j.jinorgbio.2012.08.008. [PMID: 23078773] - G M Pires-Santos, K G Santana-Anjos, M A Vannier-Santos. Optimization of Entamoeba histolytica culturing in vitro.
Experimental parasitology.
2012 Dec; 132(4):561-5. doi:
10.1016/j.exppara.2012.09.011. [PMID: 23026453] - Alexander Hahn, Mara Stevanovic, Oliver Mirus, Enrico Schleiff. The TolC-like protein HgdD of the cyanobacterium Anabaena sp. PCC 7120 is involved in secondary metabolite export and antibiotic resistance.
The Journal of biological chemistry.
2012 Nov; 287(49):41126-38. doi:
10.1074/jbc.m112.396010. [PMID: 23071120] - Shalini Minocha, Russell J Mumper. Effect of carbon coating on the physico-chemical properties and toxicity of copper and nickel nanoparticles.
Small (Weinheim an der Bergstrasse, Germany).
2012 Nov; 8(21):3289-99. doi:
10.1002/smll.201200478. [PMID: 22837153] - Illkyu-O Lee, Mario T Kratz, Stephan H Schirmer, Magnus Baumhäkel, Michael Böhm. The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein E-deficient mice.
The Journal of pharmacology and experimental therapeutics.
2012 Nov; 343(2):253-7. doi:
10.1124/jpet.112.194837. [PMID: 22837011] - Sudipta Nandi, Parimal Routh, Rama K Layek, Arun K Nandi. Ethidium bromide-adsorbed graphene templates as a platform for preferential sensing of DNA.
Biomacromolecules.
2012 Oct; 13(10):3181-8. doi:
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Bioelectrochemistry (Amsterdam, Netherlands).
2012 Oct; 87(?):226-9. doi:
10.1016/j.bioelechem.2012.02.006. [PMID: 22425286] - Somendu K Roy, Sonika Pahwa, Hemraj Nandanwar, Sanjay M Jachak. Phenylpropanoids of Alpinia galanga as efflux pump inhibitors in Mycobacterium smegmatis mc² 155.
Fitoterapia.
2012 Oct; 83(7):1248-55. doi:
10.1016/j.fitote.2012.06.008. [PMID: 22735598] - Isabelle Passagne, Marie Morille, Marine Rousset, Igor Pujalté, Béatrice L'azou. Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells.
Toxicology.
2012 Sep; 299(2-3):112-24. doi:
10.1016/j.tox.2012.05.010. [PMID: 22627296] - Evropi Chalkidou, Franc Perdih, Iztok Turel, Dimitris P Kessissoglou, George Psomas. Copper(II) complexes with antimicrobial drug flumequine: structure and biological evaluation.
Journal of inorganic biochemistry.
2012 Aug; 113(?):55-65. doi:
10.1016/j.jinorgbio.2012.03.005. [PMID: 22694822] - Evangelia S Koumousi, Marianthi Zampakou, Catherine P Raptopoulou, Vassilis Psycharis, Christine M Beavers, Simon J Teat, George Psomas, Theocharis C Stamatatos. First palladium(II) and platinum(II) complexes from employment of 2,6-diacetylpyridine dioxime: synthesis, structural and spectroscopic characterization, and biological evaluation.
Inorganic chemistry.
2012 Jul; 51(14):7699-710. doi:
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