Goserelin (BioDeep_00000016687)
代谢物信息卡片
Goserelin
化学式: C59H84N18O14 (1268.6414083999998)
中文名称: 戈舍瑞林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
InChI: InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AE - Gonadotropin releasing hormone analogues
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1910 - Gonadotropin-releasing Hormone Analog
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:5523
- KEGG: C07614
- KEGGdrug: D04405
- PubChem: 5311128
- Metlin: METLIN562
- DrugBank: DB00014
- ChEMBL: CHEMBL1201247
- MeSH: Goserelin
- CAS: 1233494-97-7
- CAS: 65807-02-5
- MoNA: FiehnHILIC002742
- MoNA: FiehnHILIC001972
- MoNA: FiehnHILIC001236
- MoNA: FiehnHILIC000401
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nanhui Chen, Zengjun Wang, Ming Chen, Qi Ma, Yi He, Yujie Wang, Xin Li, Mingxing Qiu, Lei Shi, Shaoxing Zhu, Qun Xie, Xiuheng Liu, Benkang Shi, Guowen Lin, Weizhong Yang, Yongbin Liao, Haibin Zhang, Shusheng Wang, Jiexian Li, Shaogang Wang, Lijun Dong, Hui Chen, Jiaju Lu, Yongyi Cheng, Xiaoping Zhang, Lulin Ma, Liqun Zhou, He Wang, Shen Li, Dingwei Ye. Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer.
Cancer biology & medicine.
2024 02; 20(12):. doi:
10.20892/j.issn.2095-3941.2023.0335. [PMID: 38318809] - Chengyuan Gu, Zengjun Wang, Tianxin Lin, Zhiyu Liu, Weiqing Han, Xuhui Zhang, Chao Liang, Hao Liu, Yang Yu, Zhenzhou Xu, Shuang Liu, Jingen Wang, Linghua Jia, Xin Yao, Wenfeng Liao, Cheng Fu, Zhaohui Tan, Guohua He, Guoxi Zhu, Rui Fan, Wenzeng Yang, Xin Chen, Zhizhong Liu, Liqiang Zhong, Benkang Shi, Degang Ding, Shubo Chen, Junli Wei, Xudong Yao, Ming Chen, Zhanpeng Lu, Qun Xie, Zhiquan Hu, Yinhuai Wang, Hongqian Guo, Tiwu Fan, Zhaozhao Liang, Peng Chen, Wei Wang, Tao Xu, Chunsheng Li, Jinchun Xing, Hong Liao, Dalin He, Zhibin Wu, Jiandi Yu, Zhongwen Feng, Mengxiang Yang, Qifeng Dou, Quan Zeng, Yuanwei Li, Xin Gou, Guangchen Zhou, Xiaofeng Wang, Rujian Zhu, Zhonghua Zhang, Bo Zhang, Wanlong Tan, Xueling Qu, Hongliang Sun, Tianyi Gan, Dingwei Ye. Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial.
Chinese medical journal.
2023 May; 136(10):1207-1215. doi:
10.1097/cm9.0000000000002638. [PMID: 37010251] - Tianyang Ren, Jin Chen, Pan Qi, Peifu Xiao, Puxiu Wang. Goserelin/PLGA solid dispersion used to prepare long-acting microspheres with reduced initial release and reduced fluctuation of drug serum concentration in vivo.
International journal of pharmaceutics.
2022 Mar; 615(?):121474. doi:
10.1016/j.ijpharm.2022.121474. [PMID: 35041918] - Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa. Differences in sex hormone recovery profile after cessation of 12-week gonadotropin-releasing hormone antagonist versus agonist therapy.
Andrology.
2022 02; 10(2):270-278. doi:
10.1111/andr.13107. [PMID: 34510814] - Ho Hyun Ryu, Sei Hyun Ahn, Seon Ok Kim, Jeong Eun Kim, Ji Sun Kim, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Hee Jung Shin, Hak Hee Kim, Gyung Yub Gong, Hee Jeong Kim. Comparison of metabolic changes after neoadjuvant endocrine and chemotherapy in ER-positive, HER2-negative breast cancer.
Scientific reports.
2021 05; 11(1):10510. doi:
10.1038/s41598-021-89651-0. [PMID: 34006898] - Yoko Koh, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Hiroshi Kiuchi, Ryoichi Imamura, Yasushi Miyagawa, Norio Nonomura, Motohide Uemura. Failure to achieve castrate level of serum testosterone during luteinizing hormone-releasing hormone agonist therapy in a patient with prostate cancer.
Anti-cancer drugs.
2020 11; 31(10):1099-1102. doi:
10.1097/cad.0000000000000986. [PMID: 32804697] - Ahmad Pourahadi, Saeed Nojavan, Saied Saeed Hosseiny Davarani. Gel-electromembrane extraction of peptides: Determination of five hypothalamic agents in human plasma samples.
Talanta.
2020 Sep; 217(?):121025. doi:
10.1016/j.talanta.2020.121025. [PMID: 32498910] - Joel S Finkelstein, Hang Lee, Sherri-Ann M Burnett-Bowie, Karin Darakananda, Emily C Gentile, David W Goldstein, Sarah H Prizand, Laura M Krivicich, Alexander P Taylor, Kendra E Wulczyn, Benjamin Z Leder, Elaine W Yu. Dose-Response Relationships Between Gonadal Steroids and Bone, Body Composition, and Sexual Function in Aging Men.
The Journal of clinical endocrinology and metabolism.
2020 08; 105(8):. doi:
10.1210/clinem/dgaa318. [PMID: 32480409] - Cicero P Albuquerque, Fatima R Freitas, Ana Elisa M Martinelli, Josefa H Lima, Rafael F Coelho, Carlos V Serrano, Willian C Nahas, Roberto Kalil Filho, Raul C Maranhão. Androgen deprivation therapy improves the in vitro capacity of high-density lipoprotein (HDL) to receive cholesterol and other lipids in patients with prostate carcinoma.
Lipids in health and disease.
2020 Jun; 19(1):133. doi:
10.1186/s12944-020-01305-8. [PMID: 32522195] - Nadia H Mohammed, Anmar Al-Taie, Zahraa Albasry. Evaluation of goserelin effectiveness based on assessment of inflammatory cytokines and symptoms in uterine leiomyoma.
International journal of clinical pharmacy.
2020 Jun; 42(3):931-937. doi:
10.1007/s11096-020-01030-3. [PMID: 32350747] - Jessica E Hawley, Samuel Pan, William D Figg, Zoila A Lopez-Bujanda, Jonathan D Strope, David H Aggen, Matthew C Dallos, Emerson A Lim, Mark N Stein, Jianhua Hu, Charles G Drake. Association between immunosuppressive cytokines and PSA progression in biochemically recurrent prostate cancer treated with intermittent hormonal therapy.
The Prostate.
2020 03; 80(4):336-344. doi:
10.1002/pros.23948. [PMID: 31899823] - John Takyi-Williams, Linnè Erasmus, Rose Hayeshi, Anne Grobler. Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid® formulation, in simulated intestinal fluid.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 180(?):113044. doi:
10.1016/j.jpba.2019.113044. [PMID: 31865209] - Myungsun Shim, Woo Jin Bang, Cheol Young Oh, Yong Seong Lee, Jin Seon Cho. Effectiveness of three different luteinizing hormone-releasing hormone agonists in the chemical castration of patients with prostate cancer: Goserelin versus triptorelin versus leuprolide.
Investigative and clinical urology.
2019 07; 60(4):244-250. doi:
10.4111/icu.2019.60.4.244. [PMID: 31294133] - Katherine N Bachmann, Shi Huang, Hang Lee, Laura E Dichtel, Deepak K Gupta, John C Burnett, Karen K Miller, Thomas J Wang, Joel S Finkelstein. Effect of Testosterone on Natriuretic Peptide Levels.
Journal of the American College of Cardiology.
2019 03; 73(11):1288-1296. doi:
10.1016/j.jacc.2018.12.062. [PMID: 30898204] - Aideen M Campbell, Melanie Morris, Rebecca Gallagher, Ruth Boyd, Hazel Carson, D Paul Harkin, Ewa Wielogorska, Christopher Elliott, Kienan I Savage, Stuart A McIntosh. Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment.
BMJ open.
2018 12; 8(12):e023115. doi:
10.1136/bmjopen-2018-023115. [PMID: 30580266] - Xuechun Hu, Zheng Ding, Zhiwei Hong, Zhichuan Zou, Yuming Feng, Ruilou Zhu, Jinzhao Ma, Xie Ge, Chaojun Li, Bing Yao. Spermatogenesis improved by suppressing the high level of endogenous gonadotropins in idiopathic non-obstructive azoospermia: a case control pilot study.
Reproductive biology and endocrinology : RB&E.
2018 Sep; 16(1):91. doi:
10.1186/s12958-018-0401-7. [PMID: 30243299] - Ming-Yang Chen, Yi-Ying Chen, Hsin-Tzu Tsai, Tzong-Shin Tzai, Mei-Chin Chen, Yuh-Shyan Tsai. Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapy.
Anticancer research.
2017 12; 37(12):6791-6797. doi:
10.21873/anticanres.12139. [PMID: 29187457] - Yang Zhang, Bo-Han Lei, Qing Zou, Qing-Yi Zhu, Zi-Jie Lu, Yue Wang. [Clinical efficacy of integrated traditional Chinese and Western medicine for castration-resistant prostate cancer].
Zhonghua nan ke xue = National journal of andrology.
2017 Oct; 23(10):922-927. doi:
NULL. [PMID: 29727544] - Sibylle Loibl, Nicholas C Turner, Jungsil Ro, Massimo Cristofanilli, Hiroji Iwata, Seock-Ah Im, Norikazu Masuda, Sherene Loi, Fabrice André, Nadia Harbeck, Sunil Verma, Elizabeth Folkerd, Kathy Puyana Theall, Justin Hoffman, Ke Zhang, Cynthia Huang Bartlett, Mitchell Dowsett. Palbociclib Combined with Fulvestrant in Premenopausal Women with Advanced Breast Cancer and Prior Progression on Endocrine Therapy: PALOMA-3 Results.
The oncologist.
2017 09; 22(9):1028-1038. doi:
10.1634/theoncologist.2017-0072. [PMID: 28652278] - Shinzaburo Noguchi, Hee Jeong Kim, Anita Jesena, Vani Parmar, Nobuaki Sato, Hwei-Chung Wang, Santi Lokejaroenlarb, Jofel Isidro, Ku Sang Kim, Yohji Itoh, Eisei Shin. Phase 3, open-label, randomized study comparing 3-monthly with monthly goserelin in pre-menopausal women with estrogen receptor-positive advanced breast cancer.
Breast cancer (Tokyo, Japan).
2016 Sep; 23(5):771-9. doi:
10.1007/s12282-015-0637-4. [PMID: 26350351] - Kenta Miki, Hiroshi Sasaki, Masahito Kido, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa. A comparative study on the efficacies of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist in neoadjuvant androgen deprivation therapy combined with transperineal prostate brachytherapy for localized prostate cancer.
BMC cancer.
2016 09; 16(?):708. doi:
10.1186/s12885-016-2737-8. [PMID: 27586506] - Masahiro Nozawa, Isao Hara, Hideyasu Matsuyama, Masayuki Iki, Kazuhiro Nagao, Tsukasa Nishioka, Takahiro Komura, Atsunobu Esa, Shigeya Uejima, Masaaki Imanishi, Yasunari Uekado, Takatoshi Ogawa, Hiroshi Kajikawa, Hirotsugu Uemura. Significance of baseline bone markers on disease progression and survival in hormone-sensitive prostate cancer with bone metastasis.
World journal of urology.
2015 Sep; 33(9):1263-8. doi:
10.1007/s00345-014-1431-1. [PMID: 25354720] - Leonardo O Reis, Fernandes Denardi, Eliney F Faria, Elcio Dias Silva. Correlation Between Testosterone and PSA Kinetics in Metastatic Prostate Cancer Patients Treated With Diverse Chemical Castrations.
American journal of men's health.
2015 Sep; 9(5):430-4. doi:
10.1177/1557988314552468. [PMID: 25294865] - Lili Gong, Shaofen Zhang, Yi Han, Qiqi Long, Shien Zou, Yuankui Cao. Initiation of GnRH agonist treatment on 3-5 days postoperatively in endometriosis patients: a randomized controlled trial.
Journal of clinical pharmacology.
2015 Aug; 55(8):848-53. doi:
10.1002/jcph.485. [PMID: 25694383] - Ji-Ming Chen, Hong-Yan Gao, Yi Ding, Xia Yuan, Qing Wang, Qin Li, Guo-Hua Jiang. Efficacy and safety investigation of Kuntai capsule for the add-back therapy of gonadotropin releasing hormone agonist administration to endometriosis patients: a randomized, double-blind, blank- and tibolone-controlled study.
Chinese medical journal.
2015 Feb; 128(4):427-32. doi:
10.4103/0366-6999.151057. [PMID: 25673440] - Monica Sakai, Daniel B Martinez-Arguelles, Nathan H Patterson, Pierre Chaurand, Vassilios Papadopoulos. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth.
PloS one.
2015; 10(3):e0120670. doi:
10.1371/journal.pone.0120670. [PMID: 25811175] - Chang-Qing Liu, Zi-Xin Qin, Fang-Fang Jiang, Ting Hong, Feng Wang. [Kuntai capsule combined with gonadotropin releasing hormone agonist in treatment of moderate-severe endometriosis: a clinical observation].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2014 Nov; 34(11):1288-91. doi:
NULL. [PMID: 25566615] - Shu Zhang, Jiangbin Han, Guangyi Leng, Xin Di, Chunjie Sha, Xuemei Zhang, Youxin Li, Wanhui Liu. An LC-MS/MS method for the simultaneous determination of goserelin and testosterone in rat plasma for pharmacokinetic and pharmacodynamic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Aug; 965(?):183-9. doi:
10.1016/j.jchromb.2014.06.028. [PMID: 25038408] - Alexander V Uihlein, Joel S Finkelstein, Hang Lee, Benjamin Z Leder. FSH suppression does not affect bone turnover in eugonadal men.
The Journal of clinical endocrinology and metabolism.
2014 Jul; 99(7):2510-5. doi:
10.1210/jc.2013-3246. [PMID: 24646101] - Luis Daverede, Christy Ralph, Satinder P Jagdev, Ioannis Trigonis, Sebastian Trainor, Patricia Harnden, Michael Weston, Alan Paul, Naveen S Vasudev. Metastatic castrate-resistant prostate cancer with a late, complete and durable response to docetaxel chemotherapy: a case report.
Journal of medical case reports.
2014 Apr; 8(?):122. doi:
10.1186/1752-1947-8-122. [PMID: 24717107] - Peyman Hadji, Annette Kauka, May Ziller, Katrin Birkholz, Monika Baier, Mathias Muth, Peter Kann. Effect of adjuvant endocrine therapy on hormonal levels in premenopausal women with breast cancer: the ProBONE II study.
Breast cancer research and treatment.
2014 Apr; 144(2):343-51. doi:
10.1007/s10549-014-2860-7. [PMID: 24519387] - Thine Hvid, Kamilla Winding, Anders Rinnov, Thomas Dejgaard, Carsten Thomsen, Peter Iversen, Klaus Brasso, Kari J Mikines, Gerrit van Hall, Birgitte Lindegaard, Thomas P J Solomon, Bente K Pedersen. Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy.
Endocrine-related cancer.
2013 Oct; 20(5):621-32. doi:
10.1530/erc-12-0393. [PMID: 23744766] - H Yang, X Zong, Y Yu, G Shao, L Zhang, C Qian, Y Bian, X Xu, W Sun, X Meng, X Ding, D Chen, D Zou, S Xie, Y Zheng, J Zhang, X He, C Sun, X Yu, J Ni. Combined effects of goserelin and tamoxifen on estradiol level, breast density, and endometrial thickness in premenopausal and perimenopausal women with early-stage hormone receptor-positive breast cancer: a randomised controlled clinical trial.
British journal of cancer.
2013 Aug; 109(3):582-8. doi:
10.1038/bjc.2013.324. [PMID: 23860520] - Osamu Ishizuka, Osamu Nishizawa, Shuji Nishizawa, Tomoya Satoh, Masahisa Wajiki, Hideo Kiyokawa, Yoshihiro Inoue, Shinya Kobayashi, Hiroya Mizusawa, Tatsuo Nakagawa. Comparison of efficacy and safety of 1- and 3-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer.
International journal of clinical oncology.
2013 Jun; 18(3):524-30. doi:
10.1007/s10147-012-0413-9. [PMID: 22552359] - Priti Tomar, Neeti Jain, Vinod Kumar Dixit. Nanoparticulate delivery of LHRH analogue for the treatment of prostate cancer.
Pharmaceutical development and technology.
2013 May; 18(3):645-52. doi:
10.3109/10837450.2012.663389. [PMID: 22380019] - James P Dean, Cynthia C Sprenger, Junxiang Wan, Kathleen Haugk, William J Ellis, Daniel W Lin, John M Corman, Bruce L Dalkin, Elahe Mostaghel, Peter S Nelson, Pinchas Cohen, Bruce Montgomery, Stephen R Plymate. Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation.
The Journal of clinical endocrinology and metabolism.
2013 May; 98(5):E820-8. doi:
10.1210/jc.2012-3856. [PMID: 23533230] - Ying Zhang, Jing Xin Ding, Xiang Tao, Zhi Ying Lu, Jia Jia Wang, Wei Wei Feng, Ke Qin Hua. Goserelin can inhibit ovarian cancer proliferation and simultaneously protect ovarian function from cisplatin: an in vitro and in vivo study.
Journal of chemotherapy (Florence, Italy).
2013 Apr; 25(2):96-103. doi:
10.1179/1973947813y.0000000069. [PMID: 23684357] - Adnan Aydiner, Leyla Kilic, Ibrahim Yildiz, Serkan Keskin, Fatma Sen, Seden Kucucuk, Hasan Karanlik, Mahmut Muslumanoglu, Abdullah Igci. Two different formulations with equivalent effect? Comparison of serum estradiol suppression with monthly goserelin and trimonthly leuprolide in breast cancer patients.
Medical oncology (Northwood, London, England).
2013 Mar; 30(1):354. doi:
10.1007/s12032-012-0354-1. [PMID: 23275115] - Karol Axcrona, Sirpa Aaltomaa, Carlos Martins da Silva, Haluk Ozen, Jan-Erik Damber, László B Tankó, Enrico Colli, Peter Klarskov. Androgen deprivation therapy for volume reduction, lower urinary tract symptom relief and quality of life improvement in patients with prostate cancer: degarelix vs goserelin plus bicalutamide.
BJU international.
2012 Dec; 110(11):1721-8. doi:
10.1111/j.1464-410x.2012.11107.x. [PMID: 22500884] - Neil P Evans, Jane E Robinson, Hans W Erhard, Erik Ropstad, Lynne M Fleming, Ira Ronit Hebold Haraldsen. Development of psychophysiological motoric reactivity is influenced by peripubertal pharmacological inhibition of gonadotropin releasing hormone action--results of an ovine model.
Psychoneuroendocrinology.
2012 Nov; 37(11):1876-84. doi:
10.1016/j.psyneuen.2012.03.020. [PMID: 22534405] - Noboru Hara, Itsuhiro Takizawa, Etsuko Isahaya, Tsutomu Nishiyama, Tatsuhiko Hoshii, Fumio Ishizaki, Kota Takahashi. Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer.
Urologic oncology.
2012 Sep; 30(5):596-601. doi:
10.1016/j.urolonc.2010.11.001. [PMID: 21458314] - Élcio Dias Silva, Ubirajara Ferreira, Wagner Matheus, Eliney F Faria, Gustavo D Silva, Minori Saito, Auro A S de Souza, Azuil Laranjo, Otavio Clark, Luis Alberto Magna, Lísias Nogueira Castilho, Leonardo Oliveira Reis. Goserelin versus leuprolide in the chemical castration of patients with prostate cancer.
International urology and nephrology.
2012 Aug; 44(4):1039-44. doi:
10.1007/s11255-012-0134-z. [PMID: 22315155] - Selmo Geber, Augusto H F Brandão, Marcos Sampaio. Effects of estradiol and FSH on leptin levels in women with suppressed pituitary.
Reproductive biology and endocrinology : RB&E.
2012 Jun; 10(?):45. doi:
10.1186/1477-7827-10-45. [PMID: 22703959] - Ben-Shian Huang, Kok-Min Seow, Kuan-Hao Tsui, Chen-Yu Huang, Yen-Feng Lu, Peng-Hui Wang. Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist: long-term follow-up in a series of nine patients.
Taiwanese journal of obstetrics & gynecology.
2012 Jun; 51(2):212-6. doi:
10.1016/j.tjog.2012.04.008. [PMID: 22795096] - Vanessa Battisti, Liési D K Maders, Margarete D Bagatini, Luiz Gustavo B Reetz, Juarez Chiesa, Iara E Battisti, Jamile F Gonçalves, Marta M F Duarte, Maria R C Schetinger, Vera M Morsch. Oxidative stress and antioxidant status in prostate cancer patients: relation to Gleason score, treatment and bone metastasis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2011 Oct; 65(7):516-24. doi:
10.1016/j.biopha.2011.06.003. [PMID: 21993000] - Chikako Nishihara, Katsuyuki Kuratsukuri, Tomoaki Tanaka, Hidenori Kawashima, Tatsuya Nakatani. [Successful combined treatment with maximal androgen blockade (MAB), intra arterial chemotherapy and radiation for advanced prostatic ductal adenocarcinoma : report of two cases].
Hinyokika kiyo. Acta urologica Japonica.
2011 Apr; 57(4):209-12. doi:
NULL. [PMID: 21646853] - Kazumasa Torimoto, Shoji Samma, Yoriaki Kagebayashi, Yoshitomo Chihara, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto, Yoshihiko Hirao. The effects of androgen deprivation therapy on lipid metabolism and body composition in Japanese patients with prostate cancer.
Japanese journal of clinical oncology.
2011 Apr; 41(4):577-81. doi:
10.1093/jjco/hyr005. [PMID: 21297122] - A Dahlman, A Edsjö, C Halldén, J L Persson, S W Fine, H Lilja, W Gerald, A Bjartell. Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3.
Prostate cancer and prostatic diseases.
2010 Dec; 13(4):369-75. doi:
10.1038/pcan.2010.25. [PMID: 20680031] - J Banzo, M A Ubieto, E Prats, P Razola, L Tardin, A Andrés, A Santapau, A Parra. [¹⁸F-FDG PET-CT in cytomegalovirus-induced mononucleosis].
Revista espanola de medicina nuclear.
2010 Nov; 29(6):304-7. doi:
10.1016/j.remn.2010.03.008. [PMID: 20869792] - Itsuhiro Takizawa, Noboru Hara, Tsutomu Nishiyama, Etsuko Isahaya, Tatsuhiko Hoshii, Kota Takahashi. Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer.
The Journal of urology.
2010 Nov; 184(5):1971-6. doi:
10.1016/j.juro.2010.06.115. [PMID: 20884032] - Itsuhiro Takizawa, Tsutomu Nishiyama, Noboru Hara, Etsuko Isahaya, Tatsuhiko Hoshii, Kota Takahashi. Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy: Tumor malignant potential and androgen milieu.
The Prostate.
2010 Sep; 70(13):1395-401. doi:
10.1002/pros.21174. [PMID: 20687212] - Min Kyung Kim, Tae Ho Lee, Joon Hyuk Suh, Han Young Eom, Jung Won Min, Hyesun Yeom, Unyong Kim, Hyung Joon Jung, Kyung Hoi Cha, Yong Seok Choi, Jeong-Rok Youm, Sang Beom Han. Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of goserelin in rabbit plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Aug; 878(24):2235-42. doi:
10.1016/j.jchromb.2010.06.031. [PMID: 20655813] - M Aydin, S Oktar, Z Yonden, O H Ozturk, B Yilmaz. Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats.
Cell biochemistry and function.
2010 Jun; 28(4):293-9. doi:
10.1002/cbf.1656. [PMID: 20517893] - Kenji Kawamura. [Can serum testosterone level measurement extend the intervals of administration of a long-acting LHRH agonist ?].
Hinyokika kiyo. Acta urologica Japonica.
2010 Jun; 56(6):301-4. doi:
. [PMID: 20610920] - Qi-qi Long, Shao-fen Zhang, Yi Han, Hang Chen, Xue-lian Li, Ke-qin Hua, Wei-guo Hu. [Clinical efficacy and safety of gonadotropin releasing hormone agonist combined with estrogen-dydrogesteronea in treatment of endometriosis].
Zhonghua fu chan ke za zhi.
2010 Apr; 45(4):247-51. doi:
. [PMID: 20646533] - Massimo Perachino, Valerio Cavalli, Fabio Bravi. Testosterone levels in patients with metastatic prostate cancer treated with luteinizing hormone-releasing hormone therapy: prognostic significance?.
BJU international.
2010 Mar; 105(5):648-51. doi:
10.1111/j.1464-410x.2009.08814.x. [PMID: 19747358] - Etsuko Isahaya, Noboru Hara, Tsutomu Nishiyama, Tatsuhiko Hoshii, Itsuhiro Takizawa, Kota Takahashi. Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis.
The Prostate.
2010 Feb; 70(2):155-61. doi:
10.1002/pros.21047. [PMID: 19760629] - David S Yee, William T Lowrance, James A Eastham, Alexandra C Maschino, Angel M Cronin, Farhang Rabbani. Long-term follow-up of 3-month neoadjuvant hormone therapy before radical prostatectomy in a randomized trial.
BJU international.
2010 Jan; 105(2):185-90. doi:
10.1111/j.1464-410x.2009.08698.x. [PMID: 19594741] - Kristine Lossl, Anne Loft, Nina L C Freiesleben, Susanne Bangsbøll, Claus Yding Andersen, Anette T Pedersen, Dorthe Hartwell, Anders Nyboe Andersen. Combined down-regulation by aromatase inhibitor and GnRH-agonist in IVF patients with endometriomas-A pilot study.
European journal of obstetrics, gynecology, and reproductive biology.
2009 May; 144(1):48-53. doi:
10.1016/j.ejogrb.2009.02.001. [PMID: 19261371] - Frances Mouat, Paul L Hofman, Craig Jefferies, Alistair Jan Gunn, Wayne S Cutfield. Initial growth deceleration during GnRH analogue therapy for precocious puberty.
Clinical endocrinology.
2009 May; 70(5):751-6. doi:
10.1111/j.1365-2265.2008.03433.x. [PMID: 19178517] - William D Figg, Maha H Hussain, James L Gulley, Philip M Arlen, Jeanny B Aragon-Ching, Daniel P Petrylak, Celestia S Higano, Seth M Steinberg, Gurkamal S Chatta, Howard Parnes, John J Wright, Oliver Sartor, William L Dahut. A double-blind randomized crossover study of oral thalidomide versus placebo for androgen dependent prostate cancer treated with intermittent androgen ablation.
The Journal of urology.
2009 Mar; 181(3):1104-13; discussion 1113. doi:
10.1016/j.juro.2008.11.026. [PMID: 19167733] - Mehmet Agirbasli, Oytun A Baykan, Ali Tekin, Feridun Sengor, Altug A Cincin, Muzaffer Demir, Douglas E Vaughan. Short term effects of GnRH agonists on plasma fibrinolytic balance in patients with advanced prostate cancer.
Journal of thrombosis and thrombolysis.
2009 Feb; 27(2):172-4. doi:
10.1007/s11239-007-0188-4. [PMID: 18183354] - James L Gulley, Jeanny B Aragon-Ching, Seth M Steinberg, Maha H Hussain, Oliver Sartor, Celestia S Higano, Daniel P Petrylak, Gurkamal S Chatta, Philip M Arlen, William D Figg, William L Dahut. Kinetics of serum androgen normalization and factors associated with testosterone reserve after limited androgen deprivation therapy for nonmetastatic prostate cancer.
The Journal of urology.
2008 Oct; 180(4):1432-7; discussion 1437. doi:
10.1016/j.juro.2008.06.017. [PMID: 18710748] - Paul R Hutson, Kurt Oettel, Jeff Douglas, Mark Ritter, Ed Messing, Mary Jane Staab, Dona Alberti, Dorthea Horvath, George Wilding. Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test.
Cancer chemotherapy and pharmacology.
2008 Aug; 62(3):373-7. doi:
10.1007/s00280-007-0613-6. [PMID: 17922273] - Shih-Tsung Huang, Ming-Li Hsieh. Evaluation of resistance index in patients with prostate cancer.
Anticancer research.
2008 Jul; 28(4A):1985-8. doi:
NULL. [PMID: 18649736] - Gary W Bong, Harry S Clarke, Wanda C Hancock, Thomas E Keane. Serum testosterone recovery after cessation of long-term luteinizing hormone-releasing hormone agonist in patients with prostate cancer.
Urology.
2008 Jun; 71(6):1177-80. doi:
10.1016/j.urology.2007.09.066. [PMID: 18279929] - A C van Bon, W M Wiersinga. Goserelin-induced transient thyrotoxicosis in a hypothyroid woman on L-thyroxine replacement.
The Netherlands journal of medicine.
2008 Jun; 66(6):256-8. doi:
. [PMID: 18689910] - Yasuhisa Fujii, Junji Yonese, Satoru Kawakami, Shinya Yamamoto, Yuhei Okubo, Iwao Fukui. Equivalent and sufficient effects of leuprolide acetate and goserelin acetate to suppress serum testosterone levels in patients with prostate cancer.
BJU international.
2008 May; 101(9):1096-100. doi:
10.1111/j.1464-410x.2007.07374.x. [PMID: 18190637] - Tsutomu Nishiyama, Toshihiko Ikarashi, Yutaka Hashimoto, Koichi Wako, Kota Takahashi. The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score.
The Journal of urology.
2007 Oct; 178(4 Pt 1):1282-8; discussion 1288. doi:
10.1016/j.juro.2007.05.138. [PMID: 17698092] - Jason P Mansell, Allen J Bailey, Sarah J Yarram. Could bone tissue be a target for luteinizing hormone/chorionic gonadotropin?.
Molecular and cellular endocrinology.
2007 Apr; 269(1-2):99-106. doi:
10.1016/j.mce.2006.06.016. [PMID: 17368927] - Sherri-Ann M Burnett-Bowie, Natalia Mendoza, Benjamin Z Leder. Effects of gonadal steroid withdrawal on serum phosphate and FGF-23 levels in men.
Bone.
2007 Apr; 40(4):913-8. doi:
10.1016/j.bone.2006.10.016. [PMID: 17157573] - Michael F Sarosdy. Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapy.
Cancer.
2007 Feb; 109(3):536-41. doi:
10.1002/cncr.22438. [PMID: 17183557] - Thue Kvorning, Marianne Andersen, Kim Brixen, Peter Schjerling, Charlotte Suetta, Klavs Madsen. Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans.
The Journal of physiology.
2007 Jan; 578(Pt 2):579-93. doi:
10.1113/jphysiol.2006.122671. [PMID: 17095559] - K-P Brüssow, F Schneider, A Tuchscherer, J Rátky, R R Kraeling, W Kanitz. Luteinizing hormone release after administration of the gonadotropin-releasing hormone agonist Fertilan (goserelin) for synchronization of ovulation in pigs.
Journal of animal science.
2007 Jan; 85(1):129-37. doi:
10.2527/jas.2006-281. [PMID: 17179548] - Qimin He, Tommy Fornander, Hemming Johansson, Ulla Johansson, Guo Zhu Hu, Lars-Erik Rutqvist, Sven Skog. Thymidine kinase 1 in serum predicts increased risk of distant or loco-regional recurrence following surgery in patients with early breast cancer.
Anticancer research.
2006 Nov; 26(6C):4753-9. doi:
NULL. [PMID: 17214336] - Vedang Murthy, Andrew R Norman, Mehdi Shahidi, Christopher C Parker, Alan Horwich, Robert A Huddart, Arsha Bange, David P Dearnaley. Recovery of serum testosterone after neoadjuvant androgen deprivation therapy and radical radiotherapy in localized prostate cancer.
BJU international.
2006 Mar; 97(3):476-9. doi:
10.1111/j.1464-410x.2006.06013.x. [PMID: 16469011] - A Mueller, H Binder, S Cupisti, I Hoffmann, M W Beckmann, R Dittrich. Effects on the male endocrine system of long-term treatment with gonadotropin-releasing hormone agonists and estrogens in male-to-female transsexuals.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2006 Mar; 38(3):183-7. doi:
10.1055/s-2006-925198. [PMID: 16673210] - Hideaki Miyake, Mototsugu Muramaki, Toshifumi Kurahashi, Kazuki Yamanaka, Isao Hara, Masato Fujisawa. Enhanced expression of heat shock protein 27 following neoadjuvant hormonal therapy is associated with poor clinical outcome in patients undergoing radical prostatectomy for prostate cancer.
Anticancer research.
2006 Mar; 26(2B):1583-7. doi:
NULL. [PMID: 16619575] - Tomofumi Ohsako, Yutaka Yamamoto, Teru Kawazoe, Katsuhiko Inoue, Norihide Nagamoto, Yasushi Yoshida, Osamu Nakahara, Namiko Sakamoto, Hirotaka Iwase. [Two cases of stage IV breast cancer with severe hypercalcemia].
Gan to kagaku ryoho. Cancer & chemotherapy.
2006 Feb; 33(2):223-6. doi:
NULL. [PMID: 16484860] - Hideaki Miyake, Iori Sakai, Taka-Aki Inoue, Isao Hara, Masato Fujisawa. The limited significance of a longer duration of neoadjuvant hormonal therapy prior to radical prostatectomy for high-risk prostate cancer in Japanese men.
Urologia internationalis.
2006; 77(2):122-6. doi:
10.1159/000093904. [PMID: 16888415] - Ahmet Kiper, Orhan Yiğitbasi, Abdurrahim Imamoglu, Can Tuygun, Celaleddin Turan. The prognostic importance of prostate specific antigen in the monitorisation of patients undergoing maximum androgen blockade for metastatic prostate cancer.
International urology and nephrology.
2006; 38(3-4):571-6. doi:
10.1007/s11255-006-0096-0. [PMID: 17171425] - A Nikolov, E Tiufekchieva, V Novachkov, I Karag'ozov. [Using GnRH-agonists (Zoladex) in the treatment of genital endometriosis].
Akusherstvo i ginekologiia.
2006; 45(4):13-20. doi:
NULL. [PMID: 16889194] - Salma Aslam Kundi, Saleem Wazir, Saleem Afzal, Naeema Afzal, Iftikhar Qayum, Mary L Forsling. Release of vasopressin during suppression of oestrous cycle in rat by zoladex and hypovolemic challenge.
Journal of Ayub Medical College, Abbottabad : JAMC.
2005 Oct; 17(4):63-6. doi:
NULL. [PMID: 16599040] - Sophie D Fosså. [Are all LH-RH analogues equally effective in prostate cancer?].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.
2005 Sep; 125(18):2493-5. doi:
. [PMID: 16186869] - Valerie A Jenkins, David J Bloomfield, Valerie M Shilling, Trudi L Edginton. Does neoadjuvant hormone therapy for early prostate cancer affect cognition? Results from a pilot study.
BJU international.
2005 Jul; 96(1):48-53. doi:
10.1111/j.1464-410x.2005.05565.x. [PMID: 15963119] - James L Gulley, William D Figg, Seth M Steinberg, Jane Carter, Oliver Sartor, Celestia S Higano, Daniel P Petrylak, Gerkamal Chatta, Maha H Hussain, William L Dahut. A prospective analysis of the time to normalization of serum androgens following 6 months of androgen deprivation therapy in patients on a randomized phase III clinical trial using limited hormonal therapy.
The Journal of urology.
2005 May; 173(5):1567-71. doi:
10.1097/01.ju.0000154780.72631.85. [PMID: 15821487] - Arif Hussain, Nancy Dawson, Pradip Amin, Christine Engstrom, Brenda Dorsey, Eliot Siegel, Chuanfa Guo. Docetaxel followed by hormone therapy in men experiencing increasing prostate-specific antigen after primary local treatments for prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2005 Apr; 23(12):2789-96. doi:
10.1200/jco.2005.07.152. [PMID: 15837994] - M Sugiono, M H Winkler, A A Okeke, M Benney, D A Gillatt. Bicalutamide vs cyproterone acetate in preventing flare with LHRH analogue therapy for prostate cancer--a pilot study.
Prostate cancer and prostatic diseases.
2005; 8(1):91-4. doi:
10.1038/sj.pcan.4500784. [PMID: 15711607] - Susan M Cheer, Greg L Plosker, Dene Simpson, Antona J Wagstaff. Goserelin: a review of its use in the treatment of early breast cancer in premenopausal and perimenopausal women.
Drugs.
2005; 65(18):2639-55. doi:
10.2165/00003495-200565180-00011. [PMID: 16392882] - Norman R Zinner, Mohamed Bidair, Arthur Centeno, Kevin Tomera. Similar frequency of testosterone surge after repeat injections of goserelin (Zoladex) 3.6 mg and 10.8 mg: results of a randomized open-label trial.
Urology.
2004 Dec; 64(6):1177-81. doi:
10.1016/j.urology.2004.07.033. [PMID: 15596193] - Nilo Bozzini, Marcos L Messina, Rodrigo Borsari, Sandro G Hilário, José A Pinotti. Comparative study of different dosages of goserelin in size reduction of myomatous uteri.
The Journal of the American Association of Gynecologic Laparoscopists.
2004 Nov; 11(4):462-3. doi:
10.1016/s1074-3804(05)60075-8. [PMID: 15701186] - Ken Morimoto, Masae Koh. [Postoperative changes in serum lipid levels of breast cancer and adjuvant chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2004 Oct; 31(10):1517-24. doi:
. [PMID: 15508443] - Navjeet Gandhok, Oliver Sartor. Unexpected response of hormone-refractory prostate cancer to treatment with an antileukemic chemotherapy regimen.
Urology.
2004 Oct; 64(4):807-9. doi:
10.1016/j.urology.2004.05.042. [PMID: 15491730] - Terrence H Diamond, Joseph Bucci, John H Kersley, Peter Aslan, William B Lynch, Carl Bryant. Osteoporosis and spinal fractures in men with prostate cancer: risk factors and effects of androgen deprivation therapy.
The Journal of urology.
2004 Aug; 172(2):529-32. doi:
10.1097/01.ju.0000130508.61020.66. [PMID: 15247721] - Toshiki Kijima, Tetsuo Okuno, Yasuyuki Sakai, Mamoru Wakui. [A case of seminal vesicle cyst due to the obstruction of the ejaculatory duct: possible association with prostate cancer].
Hinyokika kiyo. Acta urologica Japonica.
2004 Feb; 50(2):123-5. doi:
NULL. [PMID: 15101171] - Alkan Hacer Iynem, Ayşe Zeynep Alademir, Can Obek, Ali Riza Kural, Dildar Konukoğlu, Tülay Akçay. The effect of prostate cancer and antiandrogenic therapy on lipid peroxidation and antioxidant systems.
International urology and nephrology.
2004; 36(1):57-62. doi:
10.1023/b:urol.0000032676.31470.b2. [PMID: 15338676] - Sophie Michalet, Philippe Favreau, Reto Stöcklin. Profiling and in vivo quantification of proteins by high resolution mass spectrometry: the example of goserelin, an analogue of luteinizing hormone-releasing hormone.
Clinical chemistry and laboratory medicine.
2003 Dec; 41(12):1589-98. doi:
10.1515/cclm.2003.242. [PMID: 14708883] - Husnu Celik, Ahmet Ayar, Nermin Kilic. Effects of goserelin administration before myomectomy on plasma homocysteine levels in patients with symptomatic uterine leiomyomata.
Fertility and sterility.
2003 Oct; 80(4):1060-1. doi:
10.1016/s0015-0282(03)01159-2. [PMID: 14556836] - Vincent Martin, Suzanne Wernke, Karen Mandell, Willie Zoma, Judy Bean, Susan Pinney, James Liu, Nabih Ramadan, Robert Rebar. Medical oophorectomy with and without estrogen add-back therapy in the prevention of migraine headache.
Headache.
2003 Apr; 43(4):309-21. doi:
10.1046/j.1526-4610.2003.03065.x. [PMID: 12656701]