Tacalcitol (BioDeep_00000016670)
代谢物信息卡片
(24R)-1α,24-dihydroxyvitamin D3 / (24R)-1α,24-dihydroxycholecalciferol
化学式: C27H44O3 (416.3290274)
中文名称: 他卡西妥
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(CCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)O
InChI: InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25+,26+,27-/m1/s1
描述信息
D018977 - Micronutrients > D014815 - Vitamins > D004100 - Dihydroxycholecalciferols
D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use
D018977 - Micronutrients > D014815 - Vitamins > D006887 - Hydroxycholecalciferols
D000893 - Anti-Inflammatory Agents
D003879 - Dermatologic Agents
Same as: D08554
同义名列表
7 个代谢物同义名
1-alpha,24(R)-Dihydroxyvitamin D3; Tacalcitol; (5Z,7E)-(1S,3R,24S)-9,10-seco-5,7,10(19)-cholestatriene-1,3,24-triol; (24S)-1alpha,24-dihydroxycholecalciferol; (24S)-1alpha,24-dihydroxyvitamin D3; (24R)-1α,24-dihydroxyvitamin D3 / (24R)-1α,24-dihydroxycholecalciferol; (5Z,7E)-(1S,3R,24R)-9,10-seco-5,7,10(19)-cholestatriene-1,3,24-triol
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:32176
- KEGG: C12919
- KEGGdrug: D08554
- PubChem: 5283734
- Metlin: METLIN42193
- DrugBank: DB13689
- ChEMBL: CHEMBL2105611
- LipidMAPS: LMST03020257
- CAS: 57333-96-7
- PubChem: 583308
- NIKKAJI: J240.190H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ewa Maj, Beata Maj, Klaudia Bobak, Michalina Gos, Michał Chodyński, Andrzej Kutner, Joanna Wietrzyk. Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191.
International journal of molecular sciences.
2021 02; 22(5):. doi:
10.3390/ijms22052354. [PMID: 33652978] - Agata Pawlik, Artur Anisiewicz, Beata Filip-Psurska, Marcin Nowak, Eliza Turlej, Justyna Trynda, Joanna Banach, Paweł Gretkierewicz, Joanna Wietrzyk. Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer.
International journal of molecular sciences.
2018 Jul; 19(7):. doi:
10.3390/ijms19072116. [PMID: 30037009] - Kyosuke Satake, Toru Amano, Tadao Okamoto. Low systemic exposure and calcemic effect of calcipotriol/betamethasone ointment in rats with imiquimod-induced psoriasis-like dermatitis.
European journal of pharmacology.
2018 May; 826(?):31-38. doi:
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International journal of oncology.
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Scientific reports.
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2004 Feb; 55(2):165-70. doi:
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The Journal of dermatology.
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European journal of dermatology : EJD.
2002 Nov; 12(6):553-7. doi:
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European journal of dermatology : EJD.
2002 Sep; 12(5):463-8. doi:
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The British journal of dermatology.
2002 Mar; 146(3):414-22. doi:
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Biochemical pharmacology.
2000 Sep; 60(5):701-8. doi:
10.1016/s0006-2952(00)00378-6. [PMID: 10927029] - M Hilbe, T Sydler, L Fischer, H Naegeli. Metastatic calcification in a dog attributable to ingestion of a tacalcitol ointment.
Veterinary pathology.
2000 Sep; 37(5):490-2. doi:
10.1354/vp.37-5-490. [PMID: 11055879] - E A Weinstein, D S Rao, M L Siu-Caldera, K Y Tserng, M R Uskokovic, S Ishizuka, G S Reddy. Isolation and identification of 1alpha-hydroxy-24-oxovitamin D3 and 1alpha,23-dihydroxy-24-oxovitamin D3: metabolites of 1alpha,24(R)-dihydroxyvitamin D3 produced in rat kidney.
Biochemical pharmacology.
1999 Dec; 58(12):1965-73. doi:
10.1016/s0006-2952(99)00293-2. [PMID: 10591152] - N K Veien, J R Bjerke, I Rossmann-Ringdahl, H B Jakobsen. Once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol. A double-blind trial.
The British journal of dermatology.
1997 Oct; 137(4):581-6. doi:
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