glipizide (BioDeep_00000016635)

   

natural product


代谢物信息卡片


Glipizide (Glucotrol)

化学式: C21H27N5O4S (445.1783662000001)
中文名称: 格列甲嗪
谱图信息: 最多检出来源 Escherichia coli(natural_products) 66.67%

分子结构信息

SMILES: C1(=CC=C(C=C1)CCNC(C2=CN=C(C=N2)C)=O)S(NC(NC3CCCCC3)=O)(=O)=O
InChI: InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007004 - Hypoglycemic Agents
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4274; ORIGINAL_PRECURSOR_SCAN_NO 4271
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4287; ORIGINAL_PRECURSOR_SCAN_NO 4286
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4253; ORIGINAL_PRECURSOR_SCAN_NO 4250
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4272; ORIGINAL_PRECURSOR_SCAN_NO 4269
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4267; ORIGINAL_PRECURSOR_SCAN_NO 4265
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4263; ORIGINAL_PRECURSOR_SCAN_NO 4262
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8486; ORIGINAL_PRECURSOR_SCAN_NO 8483
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8521; ORIGINAL_PRECURSOR_SCAN_NO 8519
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8531; ORIGINAL_PRECURSOR_SCAN_NO 8530
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8569; ORIGINAL_PRECURSOR_SCAN_NO 8565
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8574; ORIGINAL_PRECURSOR_SCAN_NO 8570
CONFIDENCE standard compound; INTERNAL_ID 467; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8577; ORIGINAL_PRECURSOR_SCAN_NO 8573

同义名列表

2 个代谢物同义名

glipizide; Glipizide (Glucotrol)



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Saad Mohammed, Tarique Mahmood, Arshiya Shamim, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Rufaida Waseem, Aditya Singh. Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status. Drug research. 2024 Mar; 74(3):123-132. doi: 10.1055/a-2237-8566. [PMID: 38408478]
  • Xiaojuan Peng, Sisi Chen, Lu Zhong, Yuting Li, Chutian Wu, Lixian Zhong, Weiwei Chen, Jinying Yang, Jiahua Zeng, Shaohui Tang. Cyclocarya paliurus leaves extracts alleviate metabolic phenotypes in Chinese T2DM patients by modulating gut microbiota and metabolites: a clinical randomized controlled trial. Frontiers in endocrinology. 2023; 14(?):1176256. doi: 10.3389/fendo.2023.1176256. [PMID: 37293505]
  • Elza Sundhani, Agung Endro Nugroho, Arief Nurrochmad, Ika Puspitasari, Dita Amalia Prihati, Endang Lukitaningsih. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206901. [PMID: 36296494]
  • Ricardo J Samms, Christine C Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, Andrew C Adams, Muhammad A Abdul-Ghani, Ralph A DeFronzo, Luke Norton. FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes. American journal of physiology. Endocrinology and metabolism. 2022 08; 323(2):E123-E132. doi: 10.1152/ajpendo.00050.2022. [PMID: 35723225]
  • Nam-Tae Kim, Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee. Effects of CYP2C9*3 and *13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects. Archives of pharmacal research. 2022 Feb; 45(2):114-121. doi: 10.1007/s12272-021-01366-y. [PMID: 34952963]
  • Sandeep Rathor, Dinesh Chandra Bhatt. Formulation, Characterization, and Pharmacokinetic Evaluation of Novel Glipizide-phospholipid Nano-complexes with Improved Solubility and Bio-availability. Pharmaceutical nanotechnology. 2022; 10(2):125-136. doi: 10.2174/2211738510666220328151512. [PMID: 35346004]
  • Monica Santin Zanatta Schindler, Jean Felipe Fossá Calisto, Katiuska Marins, Alissara Regginato, Hemilli Mezzomo, Ana Paula Zanatta, Andre Luiz Radunz, Márcio Paim Mariot, Jacir Dal Magro, Leila Zanatta. Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats. Journal of ethnopharmacology. 2021 Aug; 276(?):114173. doi: 10.1016/j.jep.2021.114173. [PMID: 33932519]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Vasile-Ion Iancu, Roxana-Elena Scutariu, Florentina-Laura Chiriac, Gabriel-Lucian Radu. Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2021; 56(3):310-323. doi: 10.1080/10934529.2021.1873671. [PMID: 33471573]
  • Razique Anwer, Khalid I AlQumaizi, Shafiul Haque, Pallavi Somvanshi, Nazia Ahmad, Saleh M AlOsaimi, Tasneem Fatma. Unravelling the interaction of glipizide with human serum albumin using various spectroscopic techniques and molecular dynamics studies. Journal of biomolecular structure & dynamics. 2021 Jan; 39(1):336-347. doi: 10.1080/07391102.2019.1711195. [PMID: 31900084]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Somasree Ray, Mohua Bera, Uttam Kumar Bhattacharyya, Samarpita Das, Shalmoli Seth, Pallab Kumar Pal, Abdul Aziz. pH Sensitive Interpenetrating Network Bio Containers of Gum Ghatti for Sustained Release of Glipizide. Current drug delivery. 2019; 16(9):849-861. doi: 10.2174/1567201816666191017154719. [PMID: 31625476]
  • Sugandha Chaudhari, Shitalkumar Zambad, Mohammed Ali. Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide. Drug metabolism letters. 2019; 13(1):19-24. doi: 10.2174/1872312812666181106115247. [PMID: 30398126]
  • Clement Lo, Tadashi Toyama, Ying Wang, Jin Lin, Yoichiro Hirakawa, Min Jun, Alan Cass, Carmel M Hawley, Helen Pilmore, Sunil V Badve, Vlado Perkovic, Sophia Zoungas. Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease. The Cochrane database of systematic reviews. 2018 Sep; 9(?):CD011798. doi: 10.1002/14651858.cd011798.pub2. [PMID: 30246878]
  • Rajanikanta Sahu, Tausif Ahmed, Ramchandra Sangana, Ravindra Punde, Bharat Bhusan Subudhi. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study. Journal of pharmaceutical and biomedical analysis. 2018 Mar; 151(?):310-316. doi: 10.1016/j.jpba.2018.01.010. [PMID: 29413979]
  • Adriana M Hung, Edward D Siew, Otis D Wilson, Amy M Perkins, Robert A Greevy, Jeffrey Horner, Khaled Abdel-Kader, Sharidan K Parr, Christianne L Roumie, Marie R Griffin, T Alp Ikizler, Theodore Speroff, Michael E Matheny. Risk of Hypoglycemia Following Hospital Discharge in Patients With Diabetes and Acute Kidney Injury. Diabetes care. 2018 Mar; 41(3):503-512. doi: 10.2337/dc17-1237. [PMID: 29326106]
  • Yanyun Gu, Xiaokai Wang, Junhua Li, Yifei Zhang, Huanzi Zhong, Ruixin Liu, Dongya Zhang, Qiang Feng, Xiaoyan Xie, Jie Hong, Huahui Ren, Wei Liu, Jing Ma, Qing Su, Hongmei Zhang, Jialin Yang, Xiaoling Wang, Xinjie Zhao, Weiqiong Gu, Yufang Bi, Yongde Peng, Xiaoqiang Xu, Huihua Xia, Fang Li, Xun Xu, Huanming Yang, Guowang Xu, Lise Madsen, Karsten Kristiansen, Guang Ning, Weiqing Wang. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nature communications. 2017 11; 8(1):1785. doi: 10.1038/s41467-017-01682-2. [PMID: 29176714]
  • Bo Tan, Aidong Yang, Weian Yuan, Yue Li, Lei Jiang, Jian Jiang, Furong Qiu. Simultaneous determination of glipizide and its four hydroxylated metabolites in human urine using LC-MS/MS and its application in urinary phenotype study. Journal of pharmaceutical and biomedical analysis. 2017 May; 139(?):179-186. doi: 10.1016/j.jpba.2017.03.005. [PMID: 28284082]
  • G Yang, G Zeng, J-P Wu, O Jiang, Y-B Zeng, S-J Huang, J-J Huang, D-Q Wu. Glipizide blocks renal interstitial fibrosis by inhibiting AKT signaling pathway. European review for medical and pharmacological sciences. 2017 02; 21(4):867-872. doi: NULL. [PMID: 28272693]
  • Krishna Adeshara, Rashmi Tupe. Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes. Molecular biology reports. 2016 Mar; 43(3):195-205. doi: 10.1007/s11033-016-3947-5. [PMID: 26874852]
  • Walter Korfmacher, Yongyi Luo, Stacy Ho, Wei Sun, Liduo Shen, Jie Wang, Zhongtao Wu, Yang Guo, Gregory Snow, Thomas O'Shea. Utility of capillary microsampling for rat pharmacokinetic studies: Comparison of tail-vein bleed to jugular vein cannula sampling. Journal of pharmacological and toxicological methods. 2015 Nov; 76(?):7-14. doi: 10.1016/j.vascn.2015.07.001. [PMID: 26164093]
  • Ryan Matsuda, Zhao Li, Xiwei Zheng, David S Hage. Analysis of glipizide binding to normal and glycated human serum albumin by high-performance affinity chromatography. Analytical and bioanalytical chemistry. 2015 Jul; 407(18):5309-21. doi: 10.1007/s00216-015-8688-0. [PMID: 25912461]
  • Xiao-Hong Liu, Xing-Min Li, Cheng-Cheng Han, Xiang-Feng Fang, Le Ma. Effects of combined therapy with glipizide and Aralia root bark extract on glycemic control and lipid profiles in patients with type 2 diabetes mellitus. Journal of the science of food and agriculture. 2015 Mar; 95(4):739-44. doi: 10.1002/jsfa.6829. [PMID: 25042995]
  • Xiangjun Qiu, Shuang-li Zheng, Yingfei Wang, Rong Wang, Lei Ye. A rapid and simple UPLC-MS-MS method for determination of glipizide in human plasma and its application to bioequivalence study. Journal of chromatographic science. 2015 Jan; 53(1):85-9. doi: 10.1093/chromsci/bmu023. [PMID: 24771054]
  • C Challier, P Beassoni, C Boetsch, N A García, M A Biasutti, S Criado. Interaction between Human Serum Albumin and antidiabetic compounds and its influence on the O2((1)Δg)-mediated degradation of the protein. Journal of photochemistry and photobiology. B, Biology. 2015 Jan; 142(?):20-8. doi: 10.1016/j.jphotobiol.2014.10.019. [PMID: 25490375]
  • S Del Prato, R Camisasca, C Wilson, P Fleck. Durability of the efficacy and safety of alogliptin compared with glipizide in type 2 diabetes mellitus: a 2-year study. Diabetes, obesity & metabolism. 2014 Dec; 16(12):1239-46. doi: 10.1111/dom.12377. [PMID: 25132212]
  • William Cook, Gianmaria Minervini, Brian Bryzinski, Boaz Hirshberg. Saxagliptin efficacy and safety in patients with type 2 diabetes mellitus stratified by cardiovascular disease history and cardiovascular risk factors: analysis of 3 clinical trials. Postgraduate medicine. 2014 Oct; 126(6):19-32. doi: 10.3810/pgm.2014.10.2818. [PMID: 25414932]
  • Yifei Zhang, Chunxiu Hu, Jie Hong, Jun Zeng, Shenghan Lai, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui, Dajin Zou, Dawang Wang, Hong Li, Chao Liu, Guoting Wu, Jie Shen, Dalong Zhu, Weiqing Wang, Weifeng Shen, Guang Ning, Guowang Xu. Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease. Diabetes care. 2014 Oct; 37(10):2804-12. doi: 10.2337/dc14-0090. [PMID: 25011952]
  • Chea-Ha Kim, Soo-Hyun Park, Yun-Beom Sim, Sung-Su Kim, Su-Jin Kim, Su-Min Lim, Jun-Sub Jung, Hong-Won Suh. Effect of tolbutamide, glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice. Brain research. 2014 May; 1564(?):33-40. doi: 10.1016/j.brainres.2014.03.046. [PMID: 24713348]
  • Nihar Ranjan Pani, Sujata Acharya, Sradhanjali Patra. Development and validation of RP-HPLC method for quantification of glipizide in biological macromolecules. International journal of biological macromolecules. 2014 Apr; 65(?):65-71. doi: 10.1016/j.ijbiomac.2014.01.007. [PMID: 24418334]
  • Bao-Sheng Liu, Shi-Na Cao, Zhi-Yun Li, Bao-Hong Chong. [Modification on the interaction of glipizide with bovine serum albumin by molecular spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu. 2014 Mar; 34(3):762-6. doi: NULL. [PMID: 25208408]
  • Ling He, Prachi Wickremasingha, James Lee, Ben Tao, Jeanne Mendell-Harary, Joseph Walker, Douglas Wight. The effects of colesevelam HCl on the single-dose pharmacokinetics of glimepiride, extended-release glipizide, and olmesartan medoxomil. Journal of clinical pharmacology. 2014 Jan; 54(1):61-9. doi: 10.1002/jcph.180. [PMID: 24019110]
  • Y Bi, G Y Tong, H J Yang, M Y Cai, J H Ma, J Liang, B Xin, H Miao, Z H Peng, D L Zhu. The beneficial effect of metformin on β-cell function in non-obese Chinese subjects with newly diagnosed type 2 diabetes. Diabetes/metabolism research and reviews. 2013 Nov; 29(8):664-72. doi: 10.1002/dmrr.2443. [PMID: 23955995]
  • Li Wu, Hai-Yan Li, Xian-Zhen Yin, Ying Li, Jian-Xiu Chen, Rong-feng Hu, Ji-Wen Zhang. [Applicability of a natural swelling matrix as the propellant of osmotic pump tablets]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Aug; 48(8):1319-24. doi: ". [PMID: 24187843]
  • Rupinder Kaur, Muhammad Afzal, Imran Kazmi, Iqbal Ahamd, Zubair Ahmed, Babar Ali, Sayeed Ahmad, Firoz Anwar. Polypharmacy (herbal and synthetic drug combination): a novel approach in the treatment of type-2 diabetes and its complications in rats. Journal of natural medicines. 2013 Jul; 67(3):662-71. doi: 10.1007/s11418-012-0720-5. [PMID: 23151907]
  • Juan Camilo Arjona Ferreira, Michel Marre, Nir Barzilai, Hua Guo, Gregory T Golm, Christine McCrary Sisk, Keith D Kaufman, Barry J Goldstein. Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency. Diabetes care. 2013 May; 36(5):1067-73. doi: 10.2337/dc12-1365. [PMID: 23248197]
  • M Nauck, S Del Prato. [SGLT-2-inhibitor dapagliflozin: new treatment approach for diabetes type 2--new achievements, but also new questions!]. Deutsche medizinische Wochenschrift (1946). 2013 Apr; 138 Suppl 1(?):S4-5. doi: 10.1055/s-0032-1305325. [PMID: 23529569]
  • Ning Li, Ying Deng, Feng Qin, Jia Yu, Famei Li. Simultaneous quantification of metformin and glipizide in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2013 Feb; 27(2):191-6. doi: 10.1002/bmc.2768. [PMID: 22763773]
  • Paramita Dey, Sabyasachi Maiti, Biswanath Sa. Novel etherified locust bean gum-alginate hydrogels for controlled release of glipizide. Journal of biomaterials science. Polymer edition. 2013; 24(6):663-83. doi: 10.1080/09205063.2012.703950. [PMID: 23565908]
  • C Rosak, T Forst. [Glycosuria with SGLT-2 inhibitors--a new treatment approach for type 2 diabetes mellitus]. MMW Fortschritte der Medizin. 2012 Dec; 154 Suppl 4(?):95-101. doi: NULL. [PMID: 23326927]
  • Greg L Plosker. Dapagliflozin: a review of its use in type 2 diabetes mellitus. Drugs. 2012 Dec; 72(17):2289-312. doi: 10.2165/11209910-000000000-00000. [PMID: 23170914]
  • Tina M Binz, Nicholas Villani, Hugo Neels, Serge Schneider. Rapid extraction, identification and quantification of oral hypoglycaemic drugs in serum and hair using LC-MS/MS. Forensic science international. 2012 Nov; 223(1-3):119-24. doi: 10.1016/j.forsciint.2012.08.014. [PMID: 22940189]
  • Rajesh Kulkarni, Nathan Yumibe, Zhongyi Wang, Xin Zhang, Cheng Cai Tang, Kenneth Ruterbories, Amy Cox, Robyn McCain, Gregory T Knipp. Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs. Journal of pharmaceutical sciences. 2012 Nov; 101(11):4327-36. doi: 10.1002/jps.23292. [PMID: 22899546]
  • Sudipta Basu, Abdul Basit, Selvan Ravindran, Vandana B Patel, Subrahmanyam Vangala, Hitesh Patel. Split calibration curve: an approach to avoid repeat analysis of the samples exceeding ULOQ. Bioanalysis. 2012 Oct; 4(19):2375-89. doi: 10.4155/bio.12.219. [PMID: 23088464]
  • Asish Biswas, Suparna Chatterjee, Rama Chowdhury, Sangita Sen, Dipak Sarkar, Mitali Chatterjee, Jayasree Das. Antidiabetic effect of seeds of Strychnos potatorum Linn. in a streptozotocin-induced model of diabetes. Acta poloniae pharmaceutica. 2012 Sep; 69(5):939-43. doi: ". [PMID: 23061291]
  • T R S Satheeshmanikandan, V Sridhar, V V S Kanthikiran, V V S Swaroopkumar, K Mukkanti. Liquid chromatography - tandem mass spectrometry for the simultaneous quantitation of glipizide, cilostazol and its active metabolite 3, 4-dehydro-cilostazol in rat plasma: application for a pharmacokinetic study. Arzneimittel-Forschung. 2012 Sep; 62(9):425-32. doi: 10.1055/s-0032-1316374. [PMID: 22821721]
  • D F Pereira, V D Kappel, L H Cazarolli, A A Boligon, M L Athayde, S M Guesser, E L Da Silva, F R M B Silva. Influence of the traditional Brazilian drink Ilex paraguariensis tea on glucose homeostasis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Jul; 19(10):868-77. doi: 10.1016/j.phymed.2012.05.008. [PMID: 22795927]
  • Nasser Mikhail. Use of dipeptidyl peptidase-4 inhibitors for the treatment of patients with type 2 diabetes mellitus and chronic kidney disease. Postgraduate medicine. 2012 Jul; 124(4):138-44. doi: 10.3810/pgm.2012.07.2575. [PMID: 22913902]
  • Yanni Teng, Haibo Song, Fanlong Bu, Chunmin Wei, Wenjing Zhao, Rui Zhang, Guiyan Yuan, Xiaoyan Liu, Benjie Wang, Ruichen Guo. Determination of the active metabolite of moguisteine in human plasma and urine by LC-ESI-MS method and its application in pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jun; 899(?):31-5. doi: 10.1016/j.jchromb.2012.04.033. [PMID: 22626894]
  • Virginia D Kappel, Danielle F Pereira, Luisa H Cazarolli, Samantha M Guesser, Carlos H Blum da Silva, Eloir P Schenkel, Flávio H Reginatto, Fátima R M B Silva. Short and long-term effects of Baccharis articulata on glucose homeostasis. Molecules (Basel, Switzerland). 2012 Jun; 17(6):6754-68. doi: 10.3390/molecules17066754. [PMID: 22664465]
  • Jing Lu, Youping Liu, Xin Wang, Shaojie Wang, Xin Di. Development and validation of a rapid high-performance liquid chromatography-tandem mass spectrometry method for the determination of WJ-38, a novel aldose reductase inhibitor, in rat plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 893-894(?):29-33. doi: 10.1016/j.jchromb.2012.02.024. [PMID: 22425386]
  • Richard Engbersen, Rosalinde Masereeuw, Miriam A van Gestel, Helene L M Siero, Miek M Moons, Paul Smits, Frans G M Russel. Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels. European journal of pharmacology. 2012 Apr; 681(1-3):75-9. doi: 10.1016/j.ejphar.2012.02.006. [PMID: 22366200]
  • Holger Rehmann. Epac2: a sulfonylurea receptor?. Biochemical Society transactions. 2012 Feb; 40(1):6-10. doi: 10.1042/bst20110640. [PMID: 22260657]
  • Hui Dong, Nan Wang, Li Zhao, Fuer Lu. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):591654. doi: 10.1155/2012/591654. [PMID: 23118793]
  • Nalinee Poolsup, Naeti Suksomboon, Wanwaree Setwiwattanakul. Efficacy of various antidiabetic agents as add-on treatments to metformin in type 2 diabetes mellitus: systematic review and meta-analysis. ISRN endocrinology. 2012; 2012(?):798146. doi: 10.5402/2012/798146. [PMID: 22619731]
  • Majambu Mbikay. Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review. Frontiers in pharmacology. 2012; 3(?):24. doi: 10.3389/fphar.2012.00024. [PMID: 22403543]
  • Man-Wo Tsang. The management of type 2 diabetic patients with hypoglycaemic agents. ISRN endocrinology. 2012; 2012(?):478120. doi: 10.5402/2012/478120. [PMID: 22645689]
  • Edward C Chao. Dapagliflozin: an evidence-based review of its potential in the treatment of type-2 diabetes. Core evidence. 2012; 7(?):21-8. doi: 10.2147/ce.s16359. [PMID: 22701099]
  • Amy C Keller, Jun Ma, Adam Kavalier, Kan He, Anne-Marie B Brillantes, Edward J Kennelly. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Dec; 19(1):32-7. doi: 10.1016/j.phymed.2011.06.019. [PMID: 22133295]
  • Rachel A Skoff, Nancee V Waterbury, Robert F Shaw, Jason A Egge, Matthew Cantrell. Glycemic control and hypoglycemia in Veterans Health Administration patients converted from glyburide to glipizide. Journal of managed care pharmacy : JMCP. 2011 Nov; 17(9):664-71. doi: 10.18553/jmcp.2011.17.9.664. [PMID: 22050391]
  • Li Wang, Xin Sun, Liang Du, Qiang Yuan, Honghao Li, Haoming Tian, Youping Li. Effects and patient compliance of sustained-release versus immediate-release glipizides in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Journal of evidence-based medicine. 2011 Nov; 4(4):232-41. doi: 10.1111/j.1756-5391.2011.01158.x. [PMID: 23672754]
  • Efrat Gil, Iveta Mintsman, Efrat Wolfowitz. [Munchausen syndrome in an extreme form of factitious disorder]. Harefuah. 2011 Oct; 150(10):778-9, 815, 814. doi: NULL. [PMID: 22111121]
  • Hyun Jeong Jeon, Tae Keun Oh. Comparison of vildagliptin-metformin and glimepiride-metformin treatments in type 2 diabetic patients. Diabetes & metabolism journal. 2011 Oct; 35(5):529-35. doi: 10.4093/dmj.2011.35.5.529. [PMID: 22111045]
  • Violet Kasabri, Fatma U Afifi, Imad Hamdan. Evaluation of the acute antihyperglycemic effects of four selected indigenous plants from Jordan used in traditional medicine. Pharmaceutical biology. 2011 Jul; 49(7):687-95. doi: 10.3109/13880209.2010.539619. [PMID: 21639682]
  • Hanzhou Feng, Wei Chen, Chunyan Zhu. Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins. International archives of medicine. 2011 Jun; 4(1):18. doi: 10.1186/1755-7682-4-18. [PMID: 21658246]
  • Won Jun Kim, Cheol-Young Park, Eun Haeng Jeong, Jeong Youn Seo, Ji Soo Seol, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim. Retrospective analysis on the efficacy, safety and treatment failure group of sitagliptin for mean 10-month duration. Diabetes & metabolism journal. 2011 Jun; 35(3):290-7. doi: 10.4093/dmj.2011.35.3.290. [PMID: 21785750]
  • J Joya-Galeana, M Fernandez, A Cervera, S Reyna, S Ghosh, C Triplitt, N Musi, R A DeFronzo, E Cersosimo. Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects. Diabetes/metabolism research and reviews. 2011 May; 27(4):373-82. doi: 10.1002/dmrr.1185. [PMID: 21309063]
  • Li Li, Fanhua Meng, Jifen Guo, Lu Sun, Nengjiang Yu, Yimin Zhao. Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 May; 879(15-16):1033-7. doi: 10.1016/j.jchromb.2011.02.021. [PMID: 21482203]
  • Cornelius Hess, Frank Musshoff, Burkhard Madea. Simultaneous identification and validated quantification of 11 oral hypoglycaemic drugs in plasma by electrospray ionisation liquid chromatography-mass spectrometry. Analytical and bioanalytical chemistry. 2011 Apr; 400(1):33-41. doi: 10.1007/s00216-011-4698-8. [PMID: 21327875]
  • Anthony W Tolcher, Leonard J Appleman, Geoffrey I Shapiro, Alain C Mita, Frank Cihon, Arthur Mazzu, Pavur R Sundaresan. A phase I open-label study evaluating the cardiovascular safety of sorafenib in patients with advanced cancer. Cancer chemotherapy and pharmacology. 2011 Apr; 67(4):751-64. doi: 10.1007/s00280-010-1372-3. [PMID: 20521052]
  • Soon Ae Kim, Woo Ho Shim, Eun Hae Lee, Young Mi Lee, Sun Hee Beom, Eun Sook Kim, Jeong Seon Yoo, Ji Sun Nam, Min Ho Cho, Jong Suk Park, Chul Woo Ahn, Kyung Rae Kim. Predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus. Diabetes & metabolism journal. 2011 Apr; 35(2):159-65. doi: 10.4093/dmj.2011.35.2.159. [PMID: 21738898]
  • Robert S Rosenson, Dawn M Carlson, Maureen T Kelly, Carolyn M Setze, Boaz Hirshberg, James C Stolzenbach, Laura A Williams. Achievement of lipid targets with the combination of rosuvastatin and fenofibric Acid in patients with type 2 diabetes mellitus. Cardiovascular drugs and therapy. 2011 Feb; 25(1):47-57. doi: 10.1007/s10557-010-6273-5. [PMID: 21174145]
  • Violet Kasabri, Fatma U Afifi, Imad Hamdan. In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine. Journal of ethnopharmacology. 2011 Jan; 133(2):888-96. doi: 10.1016/j.jep.2010.11.025. [PMID: 21093568]
  • Priyanka Gunasekara, Manjula Hettiarachchi, Chandrani Liyanage, Sarath Lekamwasam. Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. Diabetes, metabolic syndrome and obesity : targets and therapy. 2011 Jan; 4(?):53-60. doi: 10.2147/dmso.s16691. [PMID: 21448322]
  • Phuong-Thu T Pham, Phuong-Mai T Pham, Son V Pham, Phuong-Anh T Pham, Phuong-Chi T Pham. New onset diabetes after transplantation (NODAT): an overview. Diabetes, metabolic syndrome and obesity : targets and therapy. 2011; 4(?):175-86. doi: 10.2147/dmso.s19027. [PMID: 21760734]
  • Sunil Kumar, Naveen Kunaparaju, S William Zito, Michael A Barletta. Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and insulin levels in the Zucker diabetic rat model. Journal of complementary & integrative medicine. 2011 Jan; 8(?):. doi: 10.2202/1553-3840.1538. [PMID: 22754929]
  • Bruce P Burnett, Lakshmi Pillai, Alessandra Bitto, Francesco Squadrito, Robert M Levy. Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women. International journal of women's health. 2011; 3(?):139-50. doi: 10.2147/ijwh.s19309. [PMID: 21792336]
  • S Prashanth, A Anil Kumar, B Madhu, N Rama, J Vidya Sagar. Pharmacokinetic and pharmacodynamic drug interactions of carbamazepine and glibenclamide in healthy albino Wistar rats. Journal of pharmacology & pharmacotherapeutics. 2011 Jan; 2(1):7-10. doi: 10.4103/0976-500x.77083. [PMID: 21701639]
  • Jaipaul Singh, Emmanuel Cumming, Gunasekar Manoharan, Huba Kalasz, Ernest Adeghate. Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions. The open medicinal chemistry journal. 2011; 5(Suppl 2):70-7. doi: 10.2174/1874104501105010070. [PMID: 21966327]
  • Karunanidhi S Lakshmi, Tirumala Rajesh. Separation and quantification of eight antidiabetic drugs on a high-performance liquid chromatography: its application to human plasma assay. ISRN pharmaceutics. 2011; 2011(?):521353. doi: 10.5402/2011/521353. [PMID: 22389851]
  • Offie P Soldin, Sarah H Chung, Donald R Mattison. Sex differences in drug disposition. Journal of biomedicine & biotechnology. 2011; 2011(?):187103. doi: 10.1155/2011/187103. [PMID: 21403873]
  • Zeinab A Issa, Mira S Zantout, Sami T Azar. Multiple myeloma and diabetes. ISRN endocrinology. 2011; 2011(?):815013. doi: 10.5402/2011/815013. [PMID: 22363889]
  • Anne Flint, Khalil Nazzal, Pawel Jagielski, Charlotte Hindsberger, Milan Zdravkovic. Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide. British journal of clinical pharmacology. 2010 Dec; 70(6):807-14. doi: 10.1111/j.1365-2125.2010.03762.x. [PMID: 21175436]
  • Kristen Kulasa, Steven Edelman. Saxagliptin: the evidence for its place in the treatment of type 2 diabetes mellitus. Core evidence. 2010 Oct; 5(?):23-37. doi: 10.2147/ce.s8006. [PMID: 21042540]
  • P Srirangam, Sagar J Vidya. Modulation of the p-glycoproein-mediated intestinal secretion of glibenclamide: in vitro and in vivo assessments. Journal of young pharmacists : JYP. 2010 Oct; 2(4):379-83. doi: 10.4103/0975-1483.71632. [PMID: 21264098]
  • T Tirkkonen, P Heikkilä, R Huupponen, K Laine. Potential CYP2C9-mediated drug-drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide. Journal of internal medicine. 2010 Oct; 268(4):359-66. doi: 10.1111/j.1365-2796.2010.02257.x. [PMID: 20698928]
  • Charles J Fasano, Adam K Rowden, Gerald F O'Malley, Elizabeth Aguilera, Kennon Heard. Quantitative insulin and C-peptide levels among ED patients with sulfonylurea-induced hypoglycemia-a prospective case series. The American journal of emergency medicine. 2010 Oct; 28(8):952-5. doi: 10.1016/j.ajem.2009.08.025. [PMID: 20887914]
  • Gemma Brufau, Matthias J Bahr, Bart Staels, Thierry Claudel, Johann Ockenga, Klaus Hw Böker, Elizabeth J Murphy, Kris Prado, Frans Stellaard, Michael P Manns, Folkert Kuipers, Uwe Jf Tietge. Plasma bile acids are not associated with energy metabolism in humans. Nutrition & metabolism. 2010 Sep; 7(?):73. doi: 10.1186/1743-7075-7-73. [PMID: 20815878]
  • Qing Li, Lian Li, Shao-Jin Wang, Ya-Ping Luo, Cui-Ping An, Ling Ma, Hui-Ru Mi, Jing-Kun Song. [Effect of electroacupuncture on lipid metabolism in metabolic syndrome]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2010 Sep; 30(9):713-6. doi: ". [PMID: 20886788]
  • L Romayne Kurukulasuriya, James R Sowers. Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors. Cardiovascular diabetology. 2010 Aug; 9(?):45. doi: 10.1186/1475-2840-9-45. [PMID: 20804556]
  • James E Foley, Jens Jordan. Weight neutrality with the DPP-4 inhibitor, vildagliptin: mechanistic basis and clinical experience. Vascular health and risk management. 2010 Aug; 6(?):541-8. doi: 10.2147/vhrm.s10952. [PMID: 20730070]
  • S Panda, K Lahiri. Seronegative necrolytic acral erythema: a distinct clinical subset?. Indian journal of dermatology. 2010 Jul; 55(3):259-61. doi: 10.4103/0019-5154.70676. [PMID: 21063519]
  • Diana M Sobieraj, Craig W Freyer. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. The Annals of pharmacotherapy. 2010 Jul; 44(7-8):1334-7. doi: 10.1345/aph.1p148. [PMID: 20516361]
  • Sabyasachi Maiti, Paramita Dey, Arunava Banik, Biswanath Sa, Somasree Ray, Santanu Kaity. Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide. Drug delivery. 2010 Jul; 17(5):288-300. doi: 10.3109/10717541003706265. [PMID: 20350054]
  • S S Engel, D E Williams-Herman, G T Golm, R J Clay, S V Machotka, K D Kaufman, B J Goldstein. Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis. International journal of clinical practice. 2010 Jun; 64(7):984-90. doi: 10.1111/j.1742-1241.2010.02382.x. [PMID: 20412332]
  • Morali D Sharma. Role of saxagliptin as monotherapy or adjunct therapy in the treatment of type 2 diabetes. Therapeutics and clinical risk management. 2010 May; 6(?):233-7. doi: 10.2147/tcrm.s7679. [PMID: 20526441]
  • Alex Avdeef, Kin Y Tam. How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?. Journal of medicinal chemistry. 2010 May; 53(9):3566-84. doi: 10.1021/jm901846t. [PMID: 20373811]
  • Robert G Moses. Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an update. Diabetes, metabolic syndrome and obesity : targets and therapy. 2010 May; 3(?):145-54. doi: 10.2147/dmsott.s6621. [PMID: 21437084]
  • Husam Ghanim, Kelly Korzeniewski, Chang Ling Sia, Sanaa Abuaysheh, Teekam Lohano, Ajay Chaudhuri, Paresh Dandona. Suppressive effect of insulin infusion on chemokines and chemokine receptors. Diabetes care. 2010 May; 33(5):1103-8. doi: 10.2337/dc09-2193. [PMID: 20200310]