zopiclone (BioDeep_00000016633)
代谢物信息卡片
zopiclone
化学式: C17H17ClN6O3 (388.1050602)
中文名称: 佐匹克隆
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C4)CCN(C4)C(=O)OC(c21)N(c(c3)ncc(Cl)c3)C(=O)c(nccn2)1
InChI: InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CF - Benzodiazepine related drugs
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3643
CONFIDENCE standard compound; INTERNAL_ID 1579
同义名列表
1 个代谢物同义名
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:32315
- KEGG: C12808
- KEGGdrug: D01372
- PubChem: 5735
- Metlin: METLIN3076
- DrugBank: DB01198
- ChEMBL: CHEMBL135400
- CAS: 1169825-88-0
- CAS: 43200-80-2
- MoNA: WA000334
- MoNA: WA000333
- MoNA: WA000332
- MoNA: WA000331
- MoNA: WA000330
- MoNA: WA000329
- MoNA: EQ364309
- MoNA: EQ364308
- MoNA: EQ364307
- MoNA: EQ364306
- MoNA: EQ364305
- MoNA: EQ364304
- MoNA: EQ364303
- MoNA: EQ364302
- MoNA: EQ364301
- MoNA: AU157906
- RefMet: Zopiclone
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yongshuai Jing, Wenjing Cheng, Mingsong Li, Yameng Zhang, Xinyue Pang, Xiaoyue Qiu, Yuguang Zheng, Danshen Zhang, Lanfang Wu. Structural Characterization, Rheological Properties, Antioxidant and Anti-Inflammatory Activities of Polysaccharides from Zingiber officinale.
Plant foods for human nutrition (Dordrecht, Netherlands).
2023 Mar; 78(1):160-165. doi:
10.1007/s11130-022-01033-7. [PMID: 36437417] - Kunihiro Iwamoto, Mari Iwata, Daiji Kambe, Yumiko Imadera, Naoki Tachibana, Yu Kajiyama, Masahiko Ando, Norio Ozaki. Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers.
Psychopharmacology.
2022 Mar; 239(3):841-850. doi:
10.1007/s00213-022-06075-y. [PMID: 35106620] - Tong Wu, Ge Yu, Zhaoxia Li, Guijie Xin. Case report of acute liver injury caused by the eszopiclone in a patient with chronic liver disease.
Medicine.
2021 Jun; 100(25):e26243. doi:
10.1097/md.0000000000026243. [PMID: 34160387] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Szabolcs Sofalvi, Eric S Lavins, Claire K Kaspar, Haley M Michel, Christie L Mitchell-Mata, Marilyn A Huestis, Luigino G Apollonio. Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction.
Journal of analytical toxicology.
2020 Oct; 44(7):708-717. doi:
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2020 Mar; 43(5):946-953. doi:
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Journal of analytical toxicology.
2019 Jun; 43(5):369-377. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2017 Dec; 475(?):147-151. doi:
10.1016/j.cca.2017.10.024. [PMID: 29080688] - C X Shu, D Gong, L P Zhang, J X Zhao. [Progress on Determination and Analysis of Zopiclone in Biological Samples].
Fa yi xue za zhi.
2017 Dec; 33(6):635-639. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2017 Jun; 181(?):148-152. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):230-241. doi:
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International journal of clinical practice.
2015 Nov; 69(11):1275-80. doi:
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2015 Jun; 47(4):392-3. doi:
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BMC geriatrics.
2014 Nov; 14(?):121. doi:
10.1186/1471-2318-14-121. [PMID: 25416480] - Gunnel H Nilsson, Fredrik C Kugelberg, Johan Ahlner, Robert Kronstrand. Quantitative analysis of zopiclone, N-desmethylzopiclone, zopiclone N-oxide and 2-amino-5-chloropyridine in urine using LC-MS-MS.
Journal of analytical toxicology.
2014 Jul; 38(6):327-34. doi:
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European journal of clinical pharmacology.
2014 Mar; 70(3):319-29. doi:
10.1007/s00228-013-1613-6. [PMID: 24337417] - Sabina Strano Rossi, Luca Anzillotti, Erika Castrignanò, Giampietro Frison, Flavio Zancanaro, Marcello Chiarotti. UHPLC-MS/MS and UHPLC-HRMS identification of zolpidem and zopiclone main urinary metabolites and method development for their toxicological determination.
Drug testing and analysis.
2014 Mar; 6(3):226-33. doi:
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Analytical and bioanalytical chemistry.
2014 Jan; 406(3):803-18. doi:
10.1007/s00216-013-7513-x. [PMID: 24309624] - Naren Gunja. The clinical and forensic toxicology of Z-drugs.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2013 Jun; 9(2):155-62. doi:
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2012 Dec; 22(4):154-9. doi:
NULL. [PMID: 23271584] - R N El-Shaheny, A Alattas, J J Nasr, N El-Enany, F Belal. Simultaneous determination of zopiclone and its degradation product and main impurity (2-amino-5-chloropyridine) by micellar liquid chromatography with time-programmed fluorescence detection: preliminary investigation for biological monitoring.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 907(?):49-55. doi:
10.1016/j.jchromb.2012.08.034. [PMID: 22999478] - Stephanie J Marin, Mark Roberts, Michelle Wood, Gwendolyn A McMillin. Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma.
Journal of analytical toxicology.
2012 Sep; 36(7):472-6. doi:
10.1093/jat/bks059. [PMID: 22833647] - Zi-ru Cheng, Li-ming Chen, Ming-hua Zhang. [Determination of zopiclone in serum by gas chromatographic method].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2012 Apr; 30(4):314-5. doi:
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Journal of pharmaceutical and biomedical analysis.
2011 Nov; 56(3):582-91. doi:
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Analytical and bioanalytical chemistry.
2011 Sep; 401(4):1341-52. doi:
10.1007/s00216-011-5187-9. [PMID: 21773738] - Milena Araújo Tonon, Valquíria A P Jabor, Pierina Sueli Bonato. Enantioselective analysis of zopiclone and its metabolites in plasma by liquid chromatography/tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2011 Jul; 400(10):3517-25. doi:
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Journal of chromatography. A.
2011 May; 1218(20):3111-7. doi:
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Forensic science international.
2011 Apr; 207(1-3):35-9. doi:
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Sleep medicine reviews.
2010 Aug; 14(4):259-67. doi:
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Methods in molecular biology (Clifton, N.J.).
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Journal of analytical toxicology.
2009 Oct; 33(8):486-90. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Sep; 877(25):2652-7. doi:
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2009 Aug; 52(15):4844-52. doi:
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Colloids and surfaces. B, Biointerfaces.
2009 Jun; 71(1):79-83. doi:
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Clinical toxicology (Philadelphia, Pa.).
2008 Dec; 46(10):1099-100. doi:
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2008 Jul; 36(7):1385-405. doi:
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Psychopharmacology.
2008 May; 197(4):591-600. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 864(1-2):137-48. doi:
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2007; 24(12):1045-59. doi:
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Drug and alcohol review.
2007 Jan; 26(1):83-5. doi:
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European journal of clinical pharmacology.
2006 Aug; 62(8):645-51. doi:
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Biomedical chromatography : BMC.
2006 Aug; 20(8):794-9. doi:
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Clinical chemistry.
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Clinical therapeutics.
2006 Apr; 28(4):491-516. doi:
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Journal of analytical toxicology.
2005 Oct; 29(7):616-26. doi:
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European journal of pharmacology.
2005 Sep; 519(3):223-30. doi:
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Journal of pharmacological sciences.
2003 Oct; 93(2):204-9. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):88-101. doi:
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Biomedical chromatography : BMC.
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Therapeutic drug monitoring.
2002 Jun; 24(3):410-6. doi:
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Se pu = Chinese journal of chromatography.
2002 May; 20(3):256-8. doi:
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Sleep.
2002 Mar; 25(2):224-31. doi:
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The Journal of pharmacy and pharmacology.
2002 Mar; 54(3):335-40. doi:
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The Annals of pharmacotherapy.
2001 Nov; 35(11):1378-80. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2001 May; 25(4):825-33. doi:
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Acta physiologica Hungarica.
2001; 88(2):139-44. doi:
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Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
2000 Aug; 20(3):123-30. doi:
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