troglitazone (BioDeep_00000016630)

   

Antitumor activity


代谢物信息卡片


5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazlidinedione

化学式: C24H27NO5S (441.1609852000001)
中文名称: 曲格列酮
谱图信息: 最多检出来源 Viridiplantae(plant) 66.67%

分子结构信息

SMILES: CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
InChI: InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BG - Thiazolidinediones
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
D007004 - Hypoglycemic Agents
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5234; ORIGINAL_PRECURSOR_SCAN_NO 5232
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5241; ORIGINAL_PRECURSOR_SCAN_NO 5238
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5206; ORIGINAL_PRECURSOR_SCAN_NO 5205
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5244; ORIGINAL_PRECURSOR_SCAN_NO 5241
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5240; ORIGINAL_PRECURSOR_SCAN_NO 5238
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5233; ORIGINAL_PRECURSOR_SCAN_NO 5232
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9800; ORIGINAL_PRECURSOR_SCAN_NO 9795
CONFIDENCE standard compound; INTERNAL_ID 701; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9806; ORIGINAL_PRECURSOR_SCAN_NO 9803
Troglitazone is an orally active PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes.

同义名列表

3 个代谢物同义名

troglitazone; 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazlidinedione; CS-045



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
  • Hong Wei, Albert P Li. Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone. Drug metabolism and disposition: the biological fate of chemicals. 2022 02; 50(2):140-149. doi: 10.1124/dmd.121.000645. [PMID: 34750194]
  • Jiafeng Duan, Chunmei Hu, Qiujuan Zhang, Jin Zhu. Exploration of the Effects of TGF-β Pathway-Based Pituitary Tumor of Rats on GH3 Cell Line after Intervention with Different Concentrations of TGZ. Contrast media & molecular imaging. 2022; 2022(?):7445042. doi: 10.1155/2022/7445042. [PMID: 36072638]
  • Aozora Nagaoka, Makoto Sakurai, Katsuyoshi Kamiie, Atsuko Masumi. Sorghum (Sorghum bicolor) Extract-Induced Adipogenesis Is Independent of PPARγ Ser273 Phosphorylation in 3T3-L1 Adipocytes. Biological & pharmaceutical bulletin. 2022; 45(5):659-663. doi: 10.1248/bpb.b22-00087. [PMID: 35491170]
  • Ji-Hong Moon, Jeong-Min Hong, Sang-Youel Park. The antidiabetic drug troglitazone protects against PrP (106‑126)‑induced neurotoxicity via the PPARγ‑autophagy pathway in neuronal cells. Molecular medicine reports. 2021 06; 23(6):. doi: 10.3892/mmr.2021.12069. [PMID: 33846779]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell biology and toxicology. 2021 04; 37(2):151-175. doi: 10.1007/s10565-020-09537-1. [PMID: 32535746]
  • Seungchan An, Gyudong Kim, Hyun Jin Kim, Sungjin Ahn, Hyun Young Kim, Hyejin Ko, Young Eum Hyun, Mai Nguyen, Juri Jeong, Zijing Liu, Jinhe Han, Hongseok Choi, Jinha Yu, Ji Won Kim, Hyuk Woo Lee, Kenneth A Jacobson, Won Jea Cho, Young-Mi Kim, Keon Wook Kang, Minsoo Noh, Lak Shin Jeong. Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators. Journal of medicinal chemistry. 2020 12; 63(24):16012-16027. doi: 10.1021/acs.jmedchem.0c01874. [PMID: 33325691]
  • Satoshi Ito, Hidetaka Kamimura, Yousuke Yamamoto, Hiroyuki Chijiwa, Takeshi Okuzono, Hiroshi Suemizu, Hiroshi Yamazaki. Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling. Drug metabolism and pharmacokinetics. 2020 Dec; 35(6):505-514. doi: 10.1016/j.dmpk.2020.07.004. [PMID: 32962912]
  • Emiko Yoda, Keiko Hachisu, Hiroshi Kuwata, Yoshihito Nakatani, Shuntaro Hara. Gene Deletion of Calcium-Independent Phospholipase A2γ (iPLA2γ) Suppresses Adipogenic Differentiation of Mouse Embryonic Fibroblasts. Biological & pharmaceutical bulletin. 2020; 43(9):1375-1381. doi: 10.1248/bpb.b20-00321. [PMID: 32879212]
  • Subhadeep Banerjee, Indrani Talukdar, Arnab Banerjee, Arnav Gupta, Advait Balaji, Raviprasad Aduri. Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments. Journal of biosciences. 2019 Dec; 44(6):. doi: 10.1007/s12038-019-9962-7. [PMID: 31894131]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Vivek Krishnan, Padmamalini Baskaran, Baskaran Thyagarajan. Troglitazone activates TRPV1 and causes deacetylation of PPARγ in 3T3-L1 cells. Biochimica et biophysica acta. Molecular basis of disease. 2019 02; 1865(2):445-453. doi: 10.1016/j.bbadis.2018.11.004. [PMID: 30496795]
  • Hyo-Kyung Bae, Bae-Dong Jung, Seunghyung Lee, Choon-Keun Park, Boo-Keun Yang, Hee-Tae Cheong. Correlation of spontaneous adipocyte generation with osteogenic differentiation of porcine skin-derived stem cells. Journal of veterinary science. 2019 Jan; 20(1):16-26. doi: 10.4142/jvs.2019.20.1.16. [PMID: 30481989]
  • Sae On Kim, Yujia Han, Sungjin Ahn, Seungchan An, Jeayoung C Shin, Hyunjung Choi, Hyoung-June Kim, Nok Hyun Park, Yong-Jin Kim, Sun Hee Jin, Ho Sik Rho, Minsoo Noh. Kojyl cinnamate esters are peroxisome proliferator-activated receptor α/γ dual agonists. Bioorganic & medicinal chemistry. 2018 11; 26(21):5654-5663. doi: 10.1016/j.bmc.2018.10.010. [PMID: 30352713]
  • Lijiao Geng, Tao Zhang, Wei Liu, Yong Chen. Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells. Yonsei medical journal. 2018 Nov; 59(9):1096-1106. doi: 10.3349/ymj.2018.59.9.1096. [PMID: 30328325]
  • Wen-Bin Zhong, Yuan-Chin Tsai, Li-Han Chin, Jen-Ho Tseng, Li-Wen Tang, Steve Horng, Yu-Ching Fan, Sung-Po Hsu. A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model. International journal of molecular sciences. 2018 06; 19(7):. doi: 10.3390/ijms19071834. [PMID: 29932104]
  • Anika Engel, Thorsten Buhrke, Stefanie Kasper, Anne-Cathrin Behr, Albert Braeuning, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ. Toxicology letters. 2018 May; 287(?):83-91. doi: 10.1016/j.toxlet.2018.02.006. [PMID: 29421333]
  • Steven Cepa, David Potter, Lisa Wong, Leah Schutt, Jacqueline Tarrant, Jodie Pang, Xiaolin Zhang, Roxanne Andaya, Laurent Salphati, Yingqing Ran, Le An, Ryan Morgan, Jonathan Maher. Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition. Toxicology and applied pharmacology. 2018 01; 338(?):204-213. doi: 10.1016/j.taap.2017.11.007. [PMID: 29146462]
  • Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li, Marianna Kulka. Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator-activated receptor γ activator-mediated inhibition of dendritic cells. International journal of immunopathology and pharmacology. 2018 Jan; 32(?):2058738418787739. doi: 10.1177/2058738418787739. [PMID: 30014756]
  • Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito. Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. The Journal of toxicological sciences. 2018; 43(5):339-351. doi: 10.2131/jts.43.339. [PMID: 29743445]
  • Emily W Y Tung, Vian Peshdary, Remi Gagné, Andrea Rowan-Carroll, Carole L Yauk, Adéle Boudreau, Ella Atlas. Adipogenic Effects and Gene Expression Profiling of Firemaster® 550 Components in Human Primary Preadipocytes. Environmental health perspectives. 2017 09; 125(9):097013. doi: 10.1289/ehp1318. [PMID: 28934090]
  • Jinha Yu, Seyeon Ahn, Hee Jin Kim, Moonyoung Lee, Sungjin Ahn, Jungmin Kim, Sun Hee Jin, Eunyoung Lee, Gyudong Kim, Jae Hoon Cheong, Kenneth A Jacobson, Lak Shin Jeong, Minsoo Noh. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential. Journal of medicinal chemistry. 2017 09; 60(17):7459-7475. doi: 10.1021/acs.jmedchem.7b00805. [PMID: 28799755]
  • Michelle M Angrish, Charlene A McQueen, Elaine Cohen-Hubal, Maribel Bruno, Yue Ge, Brian N Chorley. Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicological sciences : an official journal of the Society of Toxicology. 2017 09; 159(1):159-169. doi: 10.1093/toxsci/kfx121. [PMID: 28903485]
  • Yaofeng Cheng, Shenjue Chen, Chris Freeden, Weiqi Chen, Yueping Zhang, Pamela Abraham, David M Nelson, W Griffith Humphreys, Jinping Gan, Yurong Lai. Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):385-394. doi: 10.1124/jpet.117.242370. [PMID: 28645914]
  • Anika Engel, Thorsten Buhrke, Francine Imber, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR. Toxicology letters. 2017 Aug; 277(?):54-63. doi: 10.1016/j.toxlet.2017.05.028. [PMID: 28571686]
  • Guang-Hui Chen, Zhi Luo, Feng Chen, Xi Shi, Yu-Feng Song, Wen-Jing You, Xu Liu. PPARα, PPARγ and SREBP-1 pathways mediated waterborne iron (Fe)-induced reduction in hepatic lipid deposition of javelin goby Synechogobius hasta. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2017 Jul; 197(?):8-18. doi: 10.1016/j.cbpc.2017.04.003. [PMID: 28411055]
  • Yoshio Tsujino. A New Agonist for Peroxisome Proliferation-activated Receptor γ (PPARγ), Fraglide-1 from Zhenjiang Fragrant Vinegar: Screening and Characterization Based on Cell Culture Experiments. Journal of oleo science. 2017 Jun; 66(6):615-622. doi: 10.5650/jos.ess16253. [PMID: 28515383]
  • Brenton R Ware, Michael McVay, Wendy Y Sunada, Salman R Khetani. Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling. Toxicological sciences : an official journal of the Society of Toxicology. 2017 06; 157(2):387-398. doi: 10.1093/toxsci/kfx059. [PMID: 28369597]
  • Emily W Y Tung, Shaimaa Ahmed, Vian Peshdary, Ella Atlas. Firemaster® 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Pparγ) on the adipocyte protein 2 (aP2) promoter. PloS one. 2017; 12(4):e0175855. doi: 10.1371/journal.pone.0175855. [PMID: 28437481]
  • Dale B Bosco, Mark D Roycik, Yonghao Jin, Martin A Schwartz, Ty J Lively, Diego A R Zorio, Qing-Xiang Amy Sang. A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis. PloS one. 2017; 12(2):e0172925. doi: 10.1371/journal.pone.0172925. [PMID: 28234995]
  • Xiaojuan Wan, Songbo Wang, Jingren Xu, Lu Zhuang, Kongping Xing, Mengyuan Zhang, Xiaotong Zhu, Lina Wang, Ping Gao, Qianyun Xi, Jiajie Sun, Yongliang Zhang, Tiejun Li, Gang Shu, Qingyan Jiang. Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation. PloS one. 2017; 12(3):e0173174. doi: 10.1371/journal.pone.0173174. [PMID: 28257428]
  • Audrey Berthe, Stéphane Flament, Stéphanie Grandemange, Marie Zaffino, Michel Boisbrun, Sabine Mazerbourg. Δ2-Troglitazone promotes cytostatic rather than pro-apoptotic effects in breast cancer cells cultured in high serum conditions. Cell cycle (Georgetown, Tex.). 2016 Dec; 15(24):3402-3412. doi: 10.1080/15384101.2016.1245248. [PMID: 27753533]
  • Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki. Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs. Bioorganic & medicinal chemistry letters. 2016 11; 26(22):5411-5417. doi: 10.1016/j.bmcl.2016.10.033. [PMID: 27777006]
  • Y Li, T Zhang, Q Huang, Y Sun, X Chang, H Zhang, Y Zhu, X Han. Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise. Endocrine. 2016 Nov; 54(2):383-395. doi: 10.1007/s12020-016-0979-5. [PMID: 27160820]
  • Xin Zhou, Luc R A Rougée, David W Bedwell, Jeff W Cramer, Michael A Mohutsky, Nathan A Calvert, Richard D Moulton, Kenneth C Cassidy, Nathan P Yumibe, Lisa A Adams, Kenneth J Ruterbories. Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats. Drug metabolism and disposition: the biological fate of chemicals. 2016 08; 44(8):1184-92. doi: 10.1124/dmd.116.070623. [PMID: 27217490]
  • Cheng-Hung Chuang, Chiao-Lin Yeh, Shu-Lan Yeh, En-Shyh Lin, Li-Yu Wang, Ying-Hsuna Wang. Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms. The Journal of nutritional biochemistry. 2016 07; 33(?):45-53. doi: 10.1016/j.jnutbio.2016.03.011. [PMID: 27260467]
  • Jonathan G Boucher, Shaimaa Ahmed, Ella Atlas. Bisphenol S Induces Adipogenesis in Primary Human Preadipocytes From Female Donors. Endocrinology. 2016 Apr; 157(4):1397-407. doi: 10.1210/en.2015-1872. [PMID: 27003841]
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  • Fátima O Martins, Teresa C Delgado, Joana Viegas, Joana M Gaspar, Donald K Scott, Robert M O'Doherty, M Paula Macedo, John G Jones. Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia. British journal of pharmacology. 2016 Jan; 173(2):267-78. doi: 10.1111/bph.13362. [PMID: 26447327]
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