trimipramine (BioDeep_00000016629)

   


代谢物信息卡片


trimipramine

化学式: C20H26N2 (294.2095876)
中文名称: 曲米帕明
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)CC(C)CN(C)C
InChI: InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2861

同义名列表

1 个代谢物同义名

trimipramine



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yasamin Nasiri Khonsari, Shiguo Sun. A novel MIP-ECL sensor based on RGO-CeO2NP/Ru(bpy)32+-chitosan for ultratrace determination of trimipramine. Journal of materials chemistry. B. 2021 01; 9(2):471-478. doi: 10.1039/d0tb01666g. [PMID: 33289771]
  • Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. International journal of molecular sciences. 2019 Oct; 20(21):. doi: 10.3390/ijms20215395. [PMID: 31671916]
  • Christoph Kowalewski, Ekkehard Haen, Christoph Hiemke, Florian Ridders, Katharina Endres, Gerhard Gründer, Michael Paulzen, Georgios Schoretsanitis. Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine. International clinical psychopharmacology. 2019 09; 34(5):241-246. doi: 10.1097/yic.0000000000000268. [PMID: 31094902]
  • Hadi Tabani, Ali Shokri, Shakila Tizro, Saeed Nojavan, Pakorn Varanusupakul, Michal Alexovič. Evaluation of dispersive liquid-liquid microextraction by coupling with green-based agarose gel-electromembrane extraction: An efficient method to the tandem extraction of basic drugs from biological fluids. Talanta. 2019 Jul; 199(?):329-335. doi: 10.1016/j.talanta.2019.02.078. [PMID: 30952267]
  • Maedeh Akhoundian, Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei. A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance. Biosensors & bioelectronics. 2018 Jul; 111(?):27-33. doi: 10.1016/j.bios.2018.03.061. [PMID: 29631160]
  • Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Elham Memarian, Saeed Nojavan. Electromembrane extraction through a virtually rotating supported liquid membrane. Electrophoresis. 2016 Jan; 37(2):339-46. doi: 10.1002/elps.201500296. [PMID: 26462723]
  • Mojtaba Shamsipur, Mehrosadat Mirmohammadi. High performance liquid chromatographic determination of ultra traces of two tricyclic antidepressant drugs imipramine and trimipramine in urine samples after their dispersive liquid-liquid microextraction coupled with response surface optimization. Journal of pharmaceutical and biomedical analysis. 2014 Nov; 100(?):271-278. doi: 10.1016/j.jpba.2014.08.008. [PMID: 25178259]
  • André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry. 2014 Apr; 57(7):3005-10. doi: 10.1021/jm401963n. [PMID: 24601604]
  • Bankim J Sanghavi, Ashwini K Srivastava. Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode. The Analyst. 2013 Mar; 138(5):1395-404. doi: 10.1039/c2an36330e. [PMID: 23324861]
  • Britta Haenisch, Eva Drescher, Lidia Thiemer, Hu Xin, Bruno Giros, Sophie Gautron, Heinz Bönisch. Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3. Naunyn-Schmiedeberg's archives of pharmacology. 2012 Oct; 385(10):1017-23. doi: 10.1007/s00210-012-0781-8. [PMID: 22806583]
  • Ali R Fakhari, Hadi Tabani, Saeed Nojavan, Hamid Abedi. Electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis for the quantification of trimipramine enantiomers. Electrophoresis. 2012 Feb; 33(3):506-15. doi: 10.1002/elps.201100426. [PMID: 22287179]
  • Gerile, Chiharu Sogawa, Kazumi Ohyama, Takashi Masuko, Tadashi Kusama, Katsuya Morita, Norio Sogawa, Shigeo Kitayama. Inhibitory action of antidepressants on mouse Betaine/GABA transporter (BGT1) heterologously expressed in cell cultures. International journal of molecular sciences. 2012; 13(3):2578-2589. doi: 10.3390/ijms13032578. [PMID: 22489112]
  • Britta Haenisch, Christoph Hiemke, Heinz Bönisch. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology. 2011 Sep; 217(2):289-95. doi: 10.1007/s00213-011-2281-9. [PMID: 21484238]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • M T Jafari, M Saraji, H Sherafatmand. Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples. Analytical and bioanalytical chemistry. 2011 Apr; 399(10):3555-64. doi: 10.1007/s00216-011-4730-z. [PMID: 21298415]
  • Ruth E Curran, Christopher R J Claxton, Laura Hutchison, Paul J Harradine, Iain J Martin, Peter Littlewood. Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals. 2011 Mar; 39(3):551-7. doi: 10.1124/dmd.110.036988. [PMID: 21098647]
  • Judith Neuwoehner, Beate I Escher. The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model. Aquatic toxicology (Amsterdam, Netherlands). 2011 Jan; 101(1):266-75. doi: 10.1016/j.aquatox.2010.10.008. [PMID: 21084122]
  • Emin Aghayev, Christian Jackowski, Andreas Christe, Michael Thali. Radiopaque stomach contents in postmortem CT in suicidal oral medication intoxication: report of three cases. Journal of forensic and legal medicine. 2010 Apr; 17(3):164-8. doi: 10.1016/j.jflm.2009.10.001. [PMID: 20211459]
  • Britta Haenisch, Heinz Bönisch. Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics. Naunyn-Schmiedeberg's archives of pharmacology. 2010 Jan; 381(1):33-9. doi: 10.1007/s00210-009-0479-8. [PMID: 20012264]
  • Johannes Kornhuber, Lothar Terfloth, Stefan Bleich, Jens Wiltfang, Rainer Rupprecht. Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. European journal of medicinal chemistry. 2009 Jun; 44(6):2667-72. doi: 10.1016/j.ejmech.2008.12.003. [PMID: 19144451]
  • Margareta Reis, Trond Aamo, Olav Spigset, Johan Ahlner. Serum concentrations of antidepressant drugs in a naturalistic setting: compilation based on a large therapeutic drug monitoring database. Therapeutic drug monitoring. 2009 Feb; 31(1):42-56. doi: 10.1097/ftd.0b013e31819114ea. [PMID: 19077925]
  • Xiao-Pen Lee, Chika Hasegawa, Takeshi Kumazawa, Natsuko Shinmen, Yukiko Shoji, Hiroshi Seno, Keizo Sato. Determination of tricyclic antidepressants in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry. Journal of separation science. 2008 Jul; 31(12):2265-71. doi: 10.1002/jssc.200700627. [PMID: 18546392]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • M Flechtner-Mors, C P Jenkinson, A Alt, G Adler, H H Ditschuneit. Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study. Journal of psychiatric research. 2008 Jun; 42(7):578-86. doi: 10.1016/j.jpsychires.2007.06.003. [PMID: 17692337]
  • Annette Thierauf, Reinhard Dettmeyer, Heike Wollersen, Burkhard Madea. Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman. Forensic science international. 2007 Dec; 173(2-3):178-81. doi: 10.1016/j.forsciint.2007.01.001. [PMID: 17317059]
  • Donald F Smith, Bo S Stork, Gregers Wegener, Steen Jakobsen, Dirk Bender, Hélène Audrain, Svend B Jensen, Søren B Hansen, Anders Rodell, Raben Rosenberg. Receptor occupancy of mirtazapine determined by PET in healthy volunteers. Psychopharmacology. 2007 Nov; 195(1):131-8. doi: 10.1007/s00213-007-0877-x. [PMID: 17653532]
  • W Chadwick, G Wilson, M van de Venter, W Oelofsen, S Roux. Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?. The Journal of pharmacy and pharmacology. 2007 Jan; 59(1):95-103. doi: 10.1211/jpp.59.1.0013. [PMID: 17227626]
  • H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
  • Tatsuo Shinozuka, Masaru Terada, Einosuke Tanaka. Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method. Forensic science international. 2006 Oct; 162(1-3):108-12. doi: 10.1016/j.forsciint.2006.03.038. [PMID: 16859851]
  • F L Sauvage, J M Gaulier, G Lachâtre, P Marquet. A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum. Therapeutic drug monitoring. 2006 Feb; 28(1):123-30. doi: 10.1097/01.ftd.0000194026.04483.c3. [PMID: 16418706]
  • M Wolfsperger, W Greil. Galactorrhea during treatment with trimipramine. A case report. Pharmacopsychiatry. 2005 Nov; 38(6):326-7. doi: 10.1055/s-2005-916189. [PMID: 16342006]
  • Julia Sachse, Sebastian Härtter, Christoph Hiemke. Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detection. Therapeutic drug monitoring. 2005 Apr; 27(2):158-62. doi: 10.1097/01.ftd.0000150879.36296.4d. [PMID: 15795645]
  • Hubertus Himmerich, Stephany Fulda, Heike E Künzel, Andrea Pfennig, Andrea Dzaja, David E Cummings, Thomas Pollmächer. Ghrelin plasma levels during psychopharmacological treatment. Neuropsychobiology. 2005; 52(1):11-6. doi: 10.1159/000086171. [PMID: 15942258]
  • Pierre Baumann, Sven Ulrich, Gabriel Eckermann, Manfred Gerlach, Hans-Joachim Kuss, Gerd Laux, Bruno Müller-Oerlinghausen, Marie Luise Rao, Peter Riederer, Gerald Zernig, Christoph Hiemke. The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants. Dialogues in clinical neuroscience. 2005; 7(3):231-47. doi: NULL. [PMID: 16156382]
  • D Degner, R Grohmann, S Kropp, E Rüther, S Bender, R R Engel, L G Schmidt. Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP. Pharmacopsychiatry. 2004 Mar; 37 Suppl 1(?):S39-45. doi: 10.1055/s-2004-815509. [PMID: 15052513]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • Ursula Gutteck, Katharina M Rentsch. Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry. Clinical chemistry and laboratory medicine. 2003 Dec; 41(12):1571-9. doi: 10.1515/cclm.2003.240. [PMID: 14708881]
  • B Eisensamer, G Rammes, G Gimpl, M Shapa, U Ferrari, G Hapfelmeier, B Bondy, C Parsons, K Gilling, W Zieglgänsberger, F Holsboer, R Rupprecht. Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Molecular psychiatry. 2003 Nov; 8(12):994-1007. doi: 10.1038/sj.mp.4001314. [PMID: 14647397]
  • Christine Frahnert, Marie Luise Rao, Katja Grasmäder. Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Aug; 794(1):35-47. doi: 10.1016/s1570-0232(03)00393-3. [PMID: 12888196]
  • Yukari Sudoh, Elaine Elliott Cahoon, Peter Gerner, Ging Kuo Wang. Tricyclic antidepressants as long-acting local anesthetics. Pain. 2003 May; 103(1-2):49-55. doi: 10.1016/s0304-3959(02)00375-5. [PMID: 12749958]
  • Manfred Uhr, Markus T Grauer. abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice. Journal of psychiatric research. 2003 May; 37(3):179-85. doi: 10.1016/s0022-3956(03)00022-0. [PMID: 12650738]
  • U Hemmeter, B Annen, R Bischof, U Brüderlin, M Hatzinger, U Rose, E Holsboer-Trachsler. Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine. Pharmacopsychiatry. 2001 Mar; 34(2):50-9. doi: 10.1055/s-2001-15182. [PMID: 11302564]
  • C Hébert, A Habimana, R Elie, T A Reader. Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochemistry international. 2001 Jan; 38(1):63-74. doi: 10.1016/s0197-0186(00)00043-7. [PMID: 10913689]
  • C B Eap, S Bender, M Gastpar, W Fischer, C Haarmann, K Powell, M Jonzier-Perey, N Cochard, P Baumann. Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients. Therapeutic drug monitoring. 2000 Apr; 22(2):209-14. doi: 10.1097/00007691-200004000-00012. [PMID: 10774635]
  • C Quiñones-Torrelo, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. Journal of medicinal chemistry. 1999 Aug; 42(16):3154-62. doi: 10.1021/jm9910369. [PMID: 10447960]
  • M Tatsumi, K Groshan, R D Blakely, E Richelson. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European journal of pharmacology. 1997 Dec; 340(2-3):249-58. doi: 10.1016/s0014-2999(97)01393-9. [PMID: 9537821]
  • J Liu, J T Stewart. Quantitation of trimipramine enantiomers in human serum by enantioselective high-performance liquid chromatography and mixed-mode disc solid-phase extraction. Journal of chromatography. B, Biomedical sciences and applications. 1997 Oct; 700(1-2):175-82. doi: 10.1016/s0378-4347(97)00324-1. [PMID: 9390727]
  • F König, M Wolfersdorf, M Löble, S Wössner, B Hauger. Trimipramine and maprotiline plasma levels during combined treatment with moclobemide in therapy-resistant depression. Pharmacopsychiatry. 1997 Jul; 30(4):125-7. doi: 10.1055/s-2007-979497. [PMID: 9271778]
  • K E Fattinger, K M Rentsch, P J Meier, H Dazzi, S Krähenbühl. Safety of liver donation after fatal intoxication with the tricyclic antidepressant trimipramine. Transplantation. 1996 Nov; 62(9):1259-62. doi: 10.1097/00007890-199611150-00014. [PMID: 8932268]
  • A Sonntag, B Rothe, J Guldner, A Yassouridis, F Holsboer, A Steiger. Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression. Depression. 1996; 4(1):1-13. doi: 10.1002/(sici)1522-7162(1996)4:1<1::aid-depr1>3.0.co;2-s. [PMID: 9160649]
  • J P Jaffrézou, Kevin Gang Chen, G E Durán, C Muller, C Bordier, G Laurent, B I Sikic, T Levade. Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance. Biochimica et biophysica acta. 1995 04; 1266(1):1-8. doi: 10.1016/0167-4889(94)00219-5. [PMID: 7718613]
  • A J Remy, D Larrey, G P Pageaux, J Ribstein, J Ramos, H Michel. Cross hepatotoxicity between tricyclic antidepressants and phenothiazines. European journal of gastroenterology & hepatology. 1995 Apr; 7(4):373-6. doi: NULL. [PMID: 7600146]
  • D Marisavljević, D Bosković, M Petrović, M Colović, N Radosević-Radojković, V Jovanovitsh. [Clinico-pathological characteristics, response to therapy and survival of patients with bone marrow infiltration by Hodgkin's lymphoma]. Srpski arhiv za celokupno lekarstvo. 1995 Mar; 123(3-4):68-72. doi: NULL. [PMID: 16296226]
  • C Lartigue-Mattei, M J Galmier, J L Chabard, E Beyssac, J M Aiache. Determination of oxeladin in human plasma by gas chromatography--mass spectrometry. Biomedical chromatography : BMC. 1995 Jan; 9(1):32-5. doi: 10.1002/bmc.1130090107. [PMID: 7734931]
  • E Seifritz, E Holsboer-Trachsler, U Hemmeter, C B Eap, P Baumann. Increased trimipramine plasma levels during fluvoxamine comedication. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 1994 Mar; 4(1):15-20. doi: 10.1016/0924-977x(94)90310-7. [PMID: 8204992]
  • C B Eap, L Koeb, P Baumann. Determination of trimipramine and its demethylated and hydroxylated metabolites in plasma by gas chromatography-mass spectrometry. Journal of chromatography. 1994 Jan; 652(1):97-103. doi: 10.1016/0378-4347(93)e0366-x. [PMID: 8014234]
  • J Degen, E Wölke, M Seiberling, P Pintar, G Höxter, H B Steinhauer, W Fischer. [Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure]. Medizinische Klinik (Munich, Germany : 1983). 1993 Mar; 88(3):129-33, 171. doi: NULL. [PMID: 8474401]
  • N Jourdil, B Pinteur, F Vincent, C Marka, G Bessard. Simultaneous determination of trimipramine and desmethyl- and hydroxytrimipramine in plasma and red blood cells by capillary gas chromatography with nitrogen-selective detection. Journal of chromatography. 1993 Mar; 613(1):59-65. doi: 10.1016/0378-4347(93)80197-c. [PMID: 8458903]
  • P J Taylor, B G Charles, R Norris, P Salm, P J Ravenscroft. Measurement of dothiepin and its major metabolites in plasma by high-performance liquid chromatography. Journal of chromatography. 1992 Oct; 581(1):152-5. doi: 10.1016/0378-4347(92)80460-8. [PMID: 1430000]
  • C B Eap, L Koeb, E Holsboer-Trachsler, P Baumann. Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolites. Therapeutic drug monitoring. 1992 Oct; 14(5):380-5. doi: 10.1097/00007691-199210000-00007. [PMID: 1448845]
  • I Magureanu, G Schmitt, H Joachim. [Suicide with chloroquine combined with maprotiline and trimipramine]. Archiv fur Kriminologie. 1992 Sep; 190(3-4):82-7. doi: . [PMID: 1444709]
  • C B Eap, S Laurian, A Souche, L Koeb, P Reymond, T Buclin, P Baumann. Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjects. Neuropsychobiology. 1992; 25(4):214-20. doi: 10.1159/000118840. [PMID: 1454163]
  • E Holsboer-Trachsler, R Stohler, M Hatzinger. Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression. Psychiatry research. 1991 Aug; 38(2):163-71. doi: 10.1016/0165-1781(91)90041-m. [PMID: 1661430]
  • A A Gulaid, G A Jahn, C Maslen, M J Dennis. Simultaneous determination of trimipramine and its major metabolites by high-performance liquid chromatography. Journal of chromatography. 1991 May; 566(1):228-33. doi: 10.1016/0378-4347(91)80128-y. [PMID: 1885716]
  • M S Hussain, R T Coutts, G B Baker, R G Micetich, M Daneshtalab. Metabolism of antidepressants: urinary metabolites of trimipramine in the rat. Progress in neuro-psychopharmacology & biological psychiatry. 1991; 15(2):285-9. doi: 10.1016/0278-5846(91)90094-h. [PMID: 1871330]
  • I Saenz de Tejada, J C Ware, R Blanco, J T Pittard, P W Nadig, K M Azadzoi, R J Krane, I Goldstein. Pathophysiology of prolonged penile erection associated with trazodone use. The Journal of urology. 1991 Jan; 145(1):60-4. doi: 10.1016/s0022-5347(17)38247-2. [PMID: 1984101]
  • R T Coutts, M S Hussain, R G Micetich, M Daneshtalab, G B Baker. The metabolism of trimipramine in the rat. Biomedical & environmental mass spectrometry. 1990 Dec; 19(13):793-806. doi: 10.1002/bms.1200191303. [PMID: 2099870]
  • M N Musa. Nonlinear kinetics of trimipramine in depressed patients. Journal of clinical pharmacology. 1989 Aug; 29(8):746-7. doi: 10.1002/j.1552-4604.1989.tb03410.x. [PMID: 2778096]
  • A M Bougerolle, J L Chabard, M Jbilou, G Dordain, A Eschalier, O Aumaitre, J Gaillot, J J Piron, J Petit, J A Berger. Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man. European journal of drug metabolism and pharmacokinetics. 1989 Apr; 14(2):139-44. doi: 10.1007/bf03190854. [PMID: 2591418]
  • W F Boyer, J P Feighner. Plasma trimipramine levels. The Journal of clinical psychiatry. 1989 Mar; 50(3):108-9. doi: NULL. [PMID: 2925597]
  • G Forzy, L Convain, C Vittu, M Henniaux. [Tricyclic antidepressants and therapeutic monitoring. An experience with trimipramine]. Annales pharmaceutiques francaises. 1989; 47(5):276-82. doi: NULL. [PMID: 2637647]
  • A Steiger, O Benkert, S Wöhrmann, D Steinseifer, F Holsboer. Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls. Neuropsychobiology. 1989; 21(2):71-5. doi: 10.1159/000118555. [PMID: 2515468]
  • M Wiegand, M Berger. Action of trimipramine on sleep and pituitary hormone secretion. Drugs. 1989; 38 Suppl 1(?):35-42; discussion 49. doi: 10.2165/00003495-198900381-00009. [PMID: 2612388]
  • H Maurer. Metabolism of trimipramine in man. Arzneimittel-Forschung. 1989 Jan; 39(1):101-3. doi: NULL. [PMID: 2719736]
  • A M Bougerolle, J L Chabard, M Jbilou, H Bargnoux, J Petit, J A Berger, G Dordain. Simultaneous determination of trimipramine and its demethylated metabolites in plasma by gas chromatography-mass spectrometry. Journal of chromatography. 1988 Dec; 434(1):232-8. doi: 10.1016/0378-4347(88)80081-1. [PMID: 3243820]
  • C Köppel, J Tenczer. Gas chromatographic-mass spectrometric study of the urinary metabolism of trimipramine. Journal of chromatography. 1988 Sep; 431(1):197-202. doi: 10.1016/s0378-4347(00)83085-6. [PMID: 3235531]
  • R C Mihail, J M Crowley, B E Walden, J Fishburne, J E Reinwall, J T Zajtchuk. The tricyclic trimipramine in the treatment of subjective tinnitus. The Annals of otology, rhinology, and laryngology. 1988 Mar; 97(2 Pt 1):120-3. doi: 10.1177/000348948809700204. [PMID: 3355041]
  • G M Simpson, E H Pi, L Gross, D Baron, M November. Plasma levels and therapeutic response with trimipramine treatment of endogenous depression. The Journal of clinical psychiatry. 1988 Mar; 49(3):113-6. doi: NULL. [PMID: 3279023]
  • G Cournoyer, C de Montigny, J Ouellette, R Langlois, R Elie, G Caille, P le Morvan. A comparative double-blind controlled study of trimipramine and amitriptyline in major depression: lack of correlation with 5-hydroxytryptamine reuptake blockade. Journal of clinical psychopharmacology. 1987 Dec; 7(6):385-93. doi: NULL. [PMID: 3323262]
  • A D Fraser, A F Isner, R A Perry. Distribution of trimipramine and its major metabolites in a fatal overdose case. Journal of analytical toxicology. 1987 Jul; 11(4):168-70. doi: 10.1093/jat/11.4.168. [PMID: 3626529]
  • U V Cunha. Antidepressants: their uses in nonpsychiatric disorders of aging. Geriatrics. 1986 Oct; 41(10):63-7, 70. doi: NULL. [PMID: 3758682]
  • J D Leighton, R J Walker, K L Lynn. Trimipramine-induced acute renal failure. The New Zealand medical journal. 1986 Apr; 99(799):248. doi: NULL. [PMID: 3458072]
  • R Pok Phak, T Conquy, F Gouezo, A Viala, F Grimaldi. Determination of metapramine, imipramine, trimipramine and their major metabolites in plasma by reversed-phase column liquid chromatography. Journal of chromatography. 1986 Mar; 375(2):339-47. doi: 10.1016/s0378-4347(00)83726-3. [PMID: 3700559]
  • A Häusler, K Hauser, J B Meeker. Effects of subchronic administration of psychoactive substances on the circadian rhythm of urinary corticosterone excretion in rats. Psychoneuroendocrinology. 1985; 10(4):421-9. doi: 10.1016/0306-4530(85)90081-2. [PMID: 3878973]
  • R F Suckow, T B Cooper. Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection. Journal of pharmaceutical sciences. 1984 Dec; 73(12):1745-8. doi: 10.1002/jps.2600731221. [PMID: 6527248]
  • G Caille, P du Souich, J Spenard, Y Lacasse, M Vezina. Pharmacokinetic and clinical parameters of zopiclone and trimipramine when administered simultaneously to volunteers. Biopharmaceutics & drug disposition. 1984 Apr; 5(2):117-25. doi: 10.1002/bdd.2510050205. [PMID: 6743780]
  • D R Abernethy, D J Greenblatt, R I Shader. Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection. Clinical pharmacology and therapeutics. 1984 Mar; 35(3):348-53. doi: 10.1038/clpt.1984.42. [PMID: 6697642]
  • R K Ries, D A Gilbert, W Katon. Tricyclic antidepressant therapy for peptic ulcer disease. Archives of internal medicine. 1984 Mar; 144(3):566-9. doi: NULL. [PMID: 6367680]
  • M Lewis, J Kallenbach, C Germond, M Zaltzman, F Muller, J Steyn, S Zwi. Survival following massive overdose of adrenergic blocking agents (acebutolol and labetalol). European heart journal. 1983 May; 4(5):328-32. doi: 10.1093/oxfordjournals.eurheartj.a061469. [PMID: 6617679]
  • K Valnes, S Wetterhus, J Myren, P Arva, S Larsen. Comparative study of cimetidine and trimipramine in the short-term treatment of duodenal and gastric ulcer. Scandinavian journal of gastroenterology. 1983 Jan; 18(1):33-8. doi: 10.3109/00365528309181555. [PMID: 6372066]
  • O Flaten, T Bohman, J Myren. Serum concentration of pancreatic polypeptide after infusion of histamine and the effect of cimetidine, trimipramine, and atropine in man. Scandinavian journal of gastroenterology. 1981; 16(8):989-91. doi: 10.3109/00365528109181016. [PMID: 7336140]
  • G Caillé, J G Besner, Y Lacasse, M Vézina. Pharmacokinetic characteristics of two different formulations of trimipramine determined with a new GLC method. Biopharmaceutics & drug disposition. 1980 Apr; 1(4):187-94. doi: 10.1002/bdd.2510010406. [PMID: 7448347]
  • K Valnes, S Wetterhus, E Ellekjaer, L Halvorsen, N Hovdenak, S Larsen, O E Skaug, M Tønder, J Myren. Trimipramine in the treatment of duodenal ulcer. A multicenter, open study. Scandinavian journal of gastroenterology. Supplement. 1980; 58(?):65-70. doi: NULL. [PMID: 6929096]
  • K Valnes, O E Skaug, S Larsen, J Myren. Trimipramine and duodenal ulcer. Scandinavian journal of gastroenterology. Supplement. 1980; 58(?):71-8. doi: NULL. [PMID: 6929097]
  • J Myren, E Schrumpf, T Bohman, O E Skaug, S Larsen. Serum concentration of trimipramine (Surmontil) and gastric secretion of acid and pepsin following peroral administration of the drug in healthy humans. Scandinavian journal of gastroenterology. 1979; 14(2):237-40. doi: 10.3109/00365527909179876. [PMID: 373073]
  • T Bohman, E Schrumpf, J Myren, O P Foss. The effect of TRIMIPRAMINE (Surmontil) on the stimulated gastric secretion and serum gastrin concentration in healthy students. Scandinavian journal of gastroenterology. Supplement. 1978; 48(?):7-49. doi: NULL. [PMID: 27861]
  • T Bohmann, E Schrumpf, J Myren. The effect of trimipramine (Surmontil) on gastric secretion and the serum gastrin release in healthy young students. Scandinavian journal of gastroenterology. Supplement. 1977; 43(?):7-17. doi: NULL. [PMID: 323962]
  • Z Frenkel, G Simu, Z Uray. [Principal 17-ketosteroid fractions and the microscopic appearance of the adrenal glands, the pituitary, and the testicles in guinea pigs exposed to radiation and protected by neurotropic substances]. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression. 1975; 16(1):35-42. doi: NULL. [PMID: 1232797]