triamterene (BioDeep_00000016627)

   

natural product


代谢物信息卡片


Triamterene (JP18/USP/INN)

化学式: C12H11N7 (253.10758859999999)
中文名称: 氨苯蝶啶
谱图信息: 最多检出来源 Escherichia coli(natural_products) 92%

分子结构信息

SMILES: C1(=NC2=C(C(=N1)N)N=C(C(=N2)N)C3=CC=CC=C3)N
InChI: InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

描述信息

D049990 - Membrane Transport Modulators > D026941 - Sodium Channel Blockers > D062686 - Epithelial Sodium Channel Blockers
C - Cardiovascular system > C03 - Diuretics > C03D - Aldosterone antagonists and other potassium-sparing agents
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49186 - Potassium-Sparing Diuretic
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
Therapeutic category: 2133
CONFIDENCE standard compound; INTERNAL_ID 638; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6193; ORIGINAL_PRECURSOR_SCAN_NO 6191
CONFIDENCE standard compound; INTERNAL_ID 638; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6227; ORIGINAL_PRECURSOR_SCAN_NO 6226
CONFIDENCE standard compound; INTERNAL_ID 638; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6223; ORIGINAL_PRECURSOR_SCAN_NO 6220
CONFIDENCE standard compound; INTERNAL_ID 638; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6239; ORIGINAL_PRECURSOR_SCAN_NO 6237
CONFIDENCE standard compound; INTERNAL_ID 638; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6243; ORIGINAL_PRECURSOR_SCAN_NO 6241
CONFIDENCE standard compound; INTERNAL_ID 638; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6249; ORIGINAL_PRECURSOR_SCAN_NO 6248
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3637
CONFIDENCE standard compound; INTERNAL_ID 1109

同义名列表

3 个代谢物同义名

Triamterene (JP18/USP/INN); Dyrenium (TN); triamterene



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ahmed A Khorshed, Mohamed M Elsutohy, Abobakr A Mohamed, Mohamed Oraby. HPTLC Method for the Ultrasensitive Detection of Triamterene in Plasma. Journal of chromatographic science. 2022 Mar; 60(3):267-273. doi: 10.1093/chromsci/bmab076. [PMID: 34128052]
  • Bernhard N Bohnert, Daniel Essigke, Andrea Janessa, Jonas C Schneider, Matthias Wörn, M Zaher Kalo, Mengyun Xiao, Lingsi Kong, Kingsley Omage, Jörg Hennenlotter, Bastian Amend, Andreas L Birkenfeld, Ferruh Artunc. Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na+ channel in the mouse kidney. American journal of physiology. Renal physiology. 2021 10; 321(4):F480-F493. doi: 10.1152/ajprenal.00199.2021. [PMID: 34423678]
  • Daniel Essigke, Alexandr V Ilyaskin, Matthias Wörn, Bernhard N Bohnert, Mengyun Xiao, Christoph Daniel, Kerstin Amann, Andreas L Birkenfeld, Roman Szabo, Thomas H Bugge, Christoph Korbmacher, Ferruh Artunc. Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice. Acta physiologica (Oxford, England). 2021 05; 232(1):e13640. doi: 10.1111/apha.13640. [PMID: 33650216]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Wen Shen, Mohammed Alshehri, Sameer Desale, Christopher Wilcox. The Effect of Amiloride on Proteinuria in Patients with Proteinuric Kidney Disease. American journal of nephrology. 2021; 52(5):368-377. doi: 10.1159/000515809. [PMID: 33957621]
  • Nichole Orr-Burks, Jackelyn Murray, Kyle V Todd, Abhijeet Bakre, Ralph A Tripp. Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro. PloS one. 2021; 16(10):e0259129. doi: 10.1371/journal.pone.0259129. [PMID: 34714852]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ahmed A Khorshed, Mohamed Khairy, Craig E Banks. Electrochemical determination of antihypertensive drugs by employing costless and portable unmodified screen-printed electrodes. Talanta. 2019 Jun; 198(?):447-456. doi: 10.1016/j.talanta.2019.01.117. [PMID: 30876585]
  • Neda Hosseinpour Moghadam, Sadegh Salehzadeh, Hamid Tanzadehpanah, Massoud Saidijam, Jamshid Karimi, Sadegh Khazalpour. In vitro cytotoxicity and DNA/HSA interaction study of triamterene using molecular modelling and multi-spectroscopic methods. Journal of biomolecular structure & dynamics. 2019 Jun; 37(9):2242-2253. doi: 10.1080/07391102.2018.1489305. [PMID: 30043689]
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  • Xian-Hua Wang, Li-Fu Xie, Qian Dong, Hao-Long Liu, Yan-Ping Huang, Zhao-Sheng Liu. Synthesis of monodisperse molecularly imprinted microspheres with multi-recognition ability via precipitation polymerization for the selective extraction of cyromazine, melamine, triamterene and trimethoprim. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Dec; 1007(?):127-31. doi: 10.1016/j.jchromb.2015.11.009. [PMID: 26595796]
  • Jing Li, Zhanchen Guo, Xu Zhao, Yuhua Ma, Ping Han, Shun Feng. [Simultaneous determination of four drugs for kidney diseases in urine by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2015 Nov; 33(11):1210-3. doi: 10.3724/sp.j.1123.2015.07022. [PMID: 26939369]
  • Nawar Dalila, Jürgen Brockmöller, Mladen Vassilev Tzvetkov, Markus Schirmer, Martin Haubrock, Stefan Viktor Vormfelde. Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs. Pharmacogenomics. 2015 Jan; 16(2):115-27. doi: 10.2217/pgs.14.163. [PMID: 25616098]
  • Samih H Nasr, Dawn S Milliner, Thomas D Wooldridge, Sanjeev Sethi. Triamterene crystalline nephropathy. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2014 Jan; 63(1):148-52. doi: 10.1053/j.ajkd.2013.06.023. [PMID: 23958399]
  • Yoko Nishimura, Yuji Morikawa, Chiaki Kondo, Yutaka Tonomura, Ryou Fukushima, Mikinori Torii, Takeki Uehara. Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies. Journal of applied toxicology : JAT. 2013 Oct; 33(10):1120-30. doi: 10.1002/jat.2867. [PMID: 23558518]
  • Xiao-Yun Zhao, Hong-Wu Zhang, Zhen-Jie Liang, Ya-Ping Shu, Yong Liang. Selective recognition of Triamterene in biological samples by molecularly imprinted monolithic column with a pseudo template employed. Journal of separation science. 2013 May; 36(9-10):1501-8. doi: 10.1002/jssc.201201104. [PMID: 23424016]
  • Hadir M Maher, Rasha M Youssef, Eman I El-Kimary, Ekram M Hassan, Magda A Barary. Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination. Journal of pharmaceutical and biomedical analysis. 2012 Mar; 61(?):78-85. doi: 10.1016/j.jpba.2011.11.032. [PMID: 22197154]
  • Yiqun Wu, Yonghua Hu, Xun Tang, Liu He, Tao Ren, Qiushan Tao, Xueying Qin, Ningling Sun, Hongyi Wang, Weihua Cao, Tao Wu, Siyan Zhan, Jin Wang, Weihua Chen, Liming Li. Long-term efficacy and tolerability of a fixed-dose combination of antihypertensive agents: an open-label surveillance study in China. Clinical drug investigation. 2011 Nov; 31(11):769-77. doi: 10.1007/bf03256917. [PMID: 21671689]
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  • Yasuo Kohjimoto, Yumiko Sasaki, Isao Hara. [Clinical strategies for prevention of drug-induced urinary calculi]. Clinical calcium. 2011 Oct; 21(10):1457-63. doi: clica111014571463. [PMID: 21960230]
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  • Tony Antoniou, Tara Gomes, Muhammad M Mamdani, Zhan Yao, Chelsea Hellings, Amit X Garg, Matthew A Weir, David N Juurlink. Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study. BMJ (Clinical research ed.). 2011 Sep; 343(?):d5228. doi: 10.1136/bmj.d5228. [PMID: 21911446]
  • Kang Nyeong Lee, Oh Young Lee, Myung-Gyu Choi, Seok Reyol Choi, Dong Ho Lee, Yong Chan Lee, Tae Nyeun Kim, Suck Chei Choi, Jong Sun Rew, Sang-Yong Seol. Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. Journal of Korean medical science. 2011 Aug; 26(8):1074-80. doi: 10.3346/jkms.2011.26.8.1074. [PMID: 21860559]
  • Z Khawaja, C S Wilcox. Role of the kidneys in resistant hypertension. International journal of hypertension. 2011 Mar; 2011(?):143471. doi: 10.4061/2011/143471. [PMID: 21461391]
  • Hang Li, Junting He, Qin Liu, Zhaohui Huo, Si Liang, Yong Liang. Simultaneous analysis of hydrochlorothiazide, triamterene and reserpine in rat plasma by high performance liquid chromatography and tandem solid-phase extraction. Journal of separation science. 2011 Mar; 34(5):542-7. doi: 10.1002/jssc.201000754. [PMID: 21344645]
  • Mehrdad Hamidi, Mohammad-Ali Shahbazi, Kourosh Azimi. Bioequivalence evaluation of a triamterene-hydrochlorothiazide generic product: a new bioequivalence index for fixed-dose combinations. Regulatory toxicology and pharmacology : RTP. 2011 Feb; 59(1):149-56. doi: 10.1016/j.yrtph.2010.12.006. [PMID: 21193005]
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  • Ihn Suk Lee, Seul Young Kim, Hye Won Jang, Min Kyeong Kim, Ju Hee Lee, Yun Hyeong Lee, Young Suk Jo. Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism. Journal of Korean medical science. 2010 Sep; 25(9):1379-83. doi: 10.3346/jkms.2010.25.9.1379. [PMID: 20808686]
  • Shih-Hua Lin, Sung-Sen Yang, Tom Chau. A practical approach to genetic hypokalemia. Electrolyte & blood pressure : E & BP. 2010 Jun; 8(1):38-50. doi: 10.5049/ebp.2010.8.1.38. [PMID: 21468196]
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  • Chiaki Kondo, Yohsuke Minowa, Takeki Uehara, Yasushi Okuno, Noriyuki Nakatsu, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology. 2009 Nov; 265(1-2):15-26. doi: 10.1016/j.tox.2009.09.003. [PMID: 19761811]
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