Trandolapril (BioDeep_00000016625)
代谢物信息卡片
化学式: C24H34N2O5 (430.24675940000003)
中文名称: 群多普利, 苯那非普利特甲基酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O
InChI: InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
描述信息
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:9649
- KEGG: C07154
- KEGGdrug: D00383
- PubChem: 5484727
- Metlin: METLIN2887
- DrugBank: DB00519
- ChEMBL: CHEMBL1519
- CAS: 87679-37-6
- CAS: 118194-41-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Emrah Gün, Mahmut Çiçek, Mustafa Kafalı, Hüsnü Demir, İlknur Arslan, Tanıl Kendirli. Use of Intravenous Lipid Emulsion Therapy and Insulin in a Case of Tarka Intoxication.
WMJ : official publication of the State Medical Society of Wisconsin.
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Scientific reports.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 May; 22(5):1314-22. doi:
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Therapeutics and clinical risk management.
2007 Mar; 3(1):119-31. doi:
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Clinical therapeutics.
2007 Feb; 29(2):305-15. doi:
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Diabetes/metabolism research and reviews.
2007 Feb; 23(2):100-10. doi:
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Kidney & blood pressure research.
2007; 30(3):182-6. doi:
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American journal of nephrology.
2007; 27(5):522-9. doi:
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Vascular health and risk management.
2007; 3(6):937-45. doi:
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Vascular health and risk management.
2007; 3(6):901-8. doi:
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Diabetes care.
2006 Dec; 29(12):2592-7. doi:
10.2337/dc06-1373
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European journal of heart failure.
2006 Oct; 8(6):577-84. doi:
10.1016/j.ejheart.2005.11.017
. [PMID: 16678485] - Patricio López-Jaramillo, Lina P Pradilla, Vicente Lahera, Federico A Silva Sieger, Christian F Rueda-Clausen, Gustavo A Márquez. A randomized, double blind, cross-over, placebo-controlled clinical trial to assess the effects of Candesartan on the insulin sensitivity on non diabetic, non hypertense subjects with dysglyce mia and abdominal obesity. 'ARAMIA'.
Trials.
2006 Sep; 7(?):28. doi:
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Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2006 Aug; 21(122):174-5; discussion 176. doi:
NULL
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Implementation science : IS.
2006 May; 1(?):11. doi:
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Journal of clinical pharmacy and therapeutics.
2006 Apr; 31(2):139-47. doi:
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. [PMID: 16635047] - Giuseppe Remuzzi, Manuel Macia, Piero Ruggenenti. Prevention and treatment of diabetic renal disease in type 2 diabetes: the BENEDICT study.
Journal of the American Society of Nephrology : JASN.
2006 Apr; 17(4 Suppl 2):S90-7. doi:
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Clinical research in cardiology : official journal of the German Cardiac Society.
2006 Feb; 95(2):61-7. doi:
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BMC clinical pharmacology.
2006 Jan; 6(?):1. doi:
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Rapid communications in mass spectrometry : RCM.
2006; 20(24):3709-16. doi:
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Cardiovascular drug reviews.
2006; 24(1):33-50. doi:
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Internal medicine (Tokyo, Japan).
2006; 45(4):193-8. doi:
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Medical hypotheses.
2006; 66(3):476-85. doi:
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. [PMID: 16298493] - Mensura Ascerić, Nedzad Mulabegović, Sabina Nuhbegović, Alma Nadarević, Muamera Mujcinagić-Vrabac. Antihypertensive treatment in patients with end-stage renal disease.
Bosnian journal of basic medical sciences.
2005 Nov; 5(4):22-5. doi:
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Current opinion in nephrology and hypertension.
2005 Sep; 14(5):453-9. doi:
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Medizinische Klinik (Munich, Germany : 1983).
2005 Aug; 100(8):471-7. doi:
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Journal of clinical hypertension (Greenwich, Conn.).
2005 Aug; 7(8 Suppl 2):2-4. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 May; 45(5):866-74. doi:
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. [PMID: 15861352] - Wiesław Bryl, Anna Miczke, Paweł Bogdański, Magdalena Kujawska-Luczak, Maciej Cymerys, Danuta Pupek-Musialik, Olga Trojnarska. [Assessment of blood pressure and endothelin-1 plasma concentration in young, hypertensive patients after treatment with angiotensin converting enzyme inhibitor].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2005 May; 18(107):524-6. doi:
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. [PMID: 16161947] - Alexander Logan. BENEDICT in the treatment of hypertension.
Current hypertension reports.
2005 Apr; 7(2):121-3. doi:
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. [PMID: 15748536] - Y Kanno, H Okada, Y Yamaji, Y Nakazato, H Suzuki. Angiotensin-converting-enzyme inhibitors slow renal decline in IgA nephropathy, independent of tubulointerstitial fibrosis at presentation.
QJM : monthly journal of the Association of Physicians.
2005 Mar; 98(3):199-203. doi:
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. [PMID: 15728401] - Sabine C Wolf, Gabriele Sauter, Teut Risler, Bernhard R Brehm. Effects of combined endothelin and angiotensin II antagonism on growth factor-induced proliferation of vascular smooth muscle cells isolated from uremic rats.
Renal failure.
2005; 27(4):465-74. doi:
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. [PMID: 16060137] - Cipy Hofman, Efraim Gabai, Edna Peleg, Klaus Munter, Talma Rosenthal. Endothelin A antagonist LU-135252 and trandolapril in the treatment of the Cohen-Rosenthal diabetic hypertensive rat.
Blood pressure.
2005; 14(2):114-9. doi:
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. [PMID: 16036489] - Atsuhisa Sato, Koichi Hayashi, Takao Saruta. Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease.
American journal of hypertension.
2005 Jan; 18(1):44-9. doi:
10.1016/j.amjhyper.2004.06.029
. [PMID: 15691616] - Marta Prieto, Ana Rodríguez-Peña, Miguel Arévalo, Juan V Rivas, Annette Düwel, Nélida Eleno, Rafael J Sánchez, Ana I Morales, José M López-Novoa, Fernando Pérez-Barriocanal. Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal fibrosis induced by renal mass reduction.
Kidney & blood pressure research.
2005; 28(1):32-40. doi:
10.1159/000081439
. [PMID: 15475654] - Ulrich P Jorde, Timothy J Vittorio, Clarito A Dimayuga, Shunichi Homma, Adel Rizkala, Thierry H Le Jemtel, Stuart D Katz. Comparison of suppression of the circulating and vascular renin-angiotensin system by enalapril versus trandolapril in chronic heart failure.
The American journal of cardiology.
2004 Dec; 94(12):1501-5. doi:
10.1016/j.amjcard.2004.08.027
. [PMID: 15589004] - Eugene Braunwald, Michael J Domanski, Sarah E Fowler, Nancy L Geller, Bernard J Gersh, Judith Hsia, Marc A Pfeffer, Madeline M Rice, Yves D Rosenberg, Jean L Rouleau. Angiotensin-converting-enzyme inhibition in stable coronary artery disease.
The New England journal of medicine.
2004 Nov; 351(20):2058-68. doi:
10.1056/nejmoa042739
. [PMID: 15531767] - Charlotte Kragelund, Ole Snorgaard, Lars Køber, Bruno Bengtsson, Michael Ottesen, Søren Højberg, Claus Olesen, Jens-Jørgen Kjaergaard, Jan Carlsen, Christian Torp-Petersen. Hyperinsulinaemia is associated with increased long-term mortality following acute myocardial infarction in non-diabetic patients.
European heart journal.
2004 Nov; 25(21):1891-7. doi:
10.1016/j.ehj.2004.07.033
. [PMID: 15522467] - Naoyuki Nakao, Hachiro Seno, Hirotake Kasuga, Takanobu Toriyama, Hirohisa Kawahara, Masafumi Fukagawa. Effects of combination treatment with losartan and trandolapril on office and ambulatory blood pressures in non-diabetic renal disease: a COOPERATE-ABP substudy.
American journal of nephrology.
2004 Sep; 24(5):543-8. doi:
10.1159/000081953
. [PMID: 15528874] - Lawrence G Hunsicker. Emerging trends for prevention and treatment of diabetic nephropathy: blockade of the RAAS and BP control.
Journal of managed care pharmacy : JMCP.
2004 Sep; 10(5 Suppl A):S12-7. doi:
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. [PMID: 15369420] - Alberto Francisco Rubio-Guerra, Adalberto Arceo-Navarro, German Vargas-Ayala, Leticia Rodriguez-Lopez, Jose Juan Lozano-Nuevo, Carlos Treviño Gomez-Harper. The effect of trandolapril and its fixed-dose combination with verapamil on proteinuria in normotensive adults with type 2 diabetes.
Diabetes care.
2004 Jul; 27(7):1688-91. doi:
10.2337/diacare.27.7.1688
. [PMID: 15220247] - Yoshihiro Takamitsu. [Therapeutic strategy for patients with stable-stage chronic kidney failure].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.
2004 Mar; 93(3):477-82. doi:
10.2169/naika.93.477
. [PMID: 15052806] - Tomoaki Yamaguchi, Takashi Ida, Masazumi Hiraga, Kazuhiko Oishi, Masaatsu K Uchida, Hirotoshi Echizen. [Effects of angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase inhibitors, amlodipine and epalrestat on cultured basilar artery smooth muscle cell proliferation].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2004 Mar; 124(3):159-63. doi:
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