thioridazine (BioDeep_00000016624)
代谢物信息卡片
Thioridazine (oxide)
化学式: C21H26N2S2 (370.1537316)
中文名称: 硫利达嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
InChI: InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
描述信息
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AC - Phenothiazines with piperidine structure
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
同义名列表
2 个代谢物同义名
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:9566
- KEGG: C07133
- KEGGdrug: D00373
- KEGGdrug: D94995
- PubChem: 5452
- Metlin: METLIN2835
- DrugBank: DB00679
- ChEMBL: CHEMBL479
- MeSH: Thioridazine
- CAS: 107388-89-6
- CAS: 50-52-2
- MoNA: MoNA037450
- MoNA: MoNA032940
- MoNA: MoNA032939
- MoNA: MoNA032938
- MoNA: WA000639
- MoNA: WA000638
- MoNA: WA000637
- MoNA: WA000636
- MoNA: WA000635
- MoNA: CO000490
- MoNA: CO000489
- MoNA: CO000488
- MoNA: CO000487
- MoNA: CO000486
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gautam Kumar, Shobhna Kapoor. Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
Bioorganic & medicinal chemistry.
2023 03; 81(?):117212. doi:
10.1016/j.bmc.2023.117212. [PMID: 36804747] - Somayeh Golbaz, Mirzaman Zamanzadeh, Kamyar Yaghmaeian, Ramin Nabizadeh, Nushin Rastkari, Hadi Esfahani. Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-23667-5. [PMID: 36374381] - Sheng Han, Heng Li, Weixiong Chen, Li Yang, Xiankun Tong, Jianping Zuo, Youhong Hu. Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold.
European journal of medicinal chemistry.
2022 Oct; 240(?):114608. doi:
10.1016/j.ejmech.2022.114608. [PMID: 35872393] - Ágota Simon, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Alexandru Stoicu, Alan Dowson, Jack J W A van Loon, Mihail Lucian Pascu. Stability Studies of UV Laser Irradiated Promethazine and Thioridazine after Exposure to Hypergravity Conditions.
Molecules (Basel, Switzerland).
2022 Mar; 27(5):. doi:
10.3390/molecules27051728. [PMID: 35268828] - Tatiana Tozar, Mihai Boni, Ionut R Andrei, Mihail L Pascu, Angela Staicu. High performance thin layer chromatography-densitometry method based on picosecond laser-induced fluorescence for the analysis of thioridazine and its photoproducts.
Journal of chromatography. A.
2021 Oct; 1655(?):462488. doi:
10.1016/j.chroma.2021.462488. [PMID: 34474191] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Michał Otręba, Leon Kośmider, Anna Rzepecka-Stojko. Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review.
European journal of pharmacology.
2020 Nov; 887(?):173553. doi:
10.1016/j.ejphar.2020.173553. [PMID: 32949606] - Tatiana Tozar, Sofia Santos Costa, Ana-Maria Udrea, Viorel Nastasa, Isabel Couto, Miguel Viveiros, Mihail Lucian Pascu, Mihaela Oana Romanitan. Anti-staphylococcal activity and mode of action of thioridazine photoproducts.
Scientific reports.
2020 10; 10(1):18043. doi:
10.1038/s41598-020-74752-z. [PMID: 33093568] - Andréa A S Mendonça, Elda Gonçalves-Santos, Thaiany G Souza-Silva, Kelly J González-Lozano, Ivo S Caldas, Reggiani V Gonçalves, Lívia F Diniz, Rômulo D Novaes. Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
International immunopharmacology.
2020 Aug; 85(?):106611. doi:
10.1016/j.intimp.2020.106611. [PMID: 32447223] - Mike Marvin Ruth, Lian J Pennings, Valerie A C M Koeken, Jodie A Schildkraut, Aria Hashemi, Heiman F L Wertheim, Wouter Hoefsloot, Jakko van Ingen. Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00181-20. [PMID: 32312774] - Aziza El Harchi, Andrew S Butler, Yihong Zhang, Christopher E Dempsey, Jules C Hancox. The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.
Physiological reports.
2020 03; 8(5):e14385. doi:
10.14814/phy2.14385. [PMID: 32147975] - Wenjing Luan, Xiaolei Liu, Xuefei Wang, Yanan An, Yang Wang, Chao Wang, Keshu Shen, Hongyue Xu, Shulin Li, Mingyuan Liu, L U Yu. Inhibition of Drug Resistance of Staphylococcus aureus by Efflux Pump Inhibitor and Autolysis Inducer to Strengthen the Antibacterial Activity of β-lactam Drugs.
Polish journal of microbiology.
2019 Dec; 68(4):477-491. doi:
10.33073/pjm-2019-047. [PMID: 31880892] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Claes Søndergaard Wassmann, Lars Christian Lund, Mette Thorsing, Sabrina Prehn Lauritzen, Hans Jørn Kolmos, Birgitte Haahr Kallipolitis, Janne Kudsk Klitgaard. Molecular mechanisms of thioridazine resistance in Staphylococcus aureus.
PloS one.
2018; 13(8):e0201767. doi:
10.1371/journal.pone.0201767. [PMID: 30089175] - Jonathan Nzakizwanayo, Paola Scavone, Shirin Jamshidi, Joseph A Hawthorne, Harriet Pelling, Cinzia Dedi, Jonathan P Salvage, Charlotte K Hind, Fergus M Guppy, Lara M Barnes, Bhavik A Patel, Khondaker M Rahman, Mark J Sutton, Brian V Jones. Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis.
Scientific reports.
2017 09; 7(1):12222. doi:
10.1038/s41598-017-12445-w. [PMID: 28939900] - Piotr Skrobecki, Anna Chmielińska, Piotr Bonarek, Piotr Stepien, Anna Wisniewska-Becker, Marta Dziedzicka-Wasylewska, Agnieszka Polit. Sulpiride, Amisulpride, Thioridazine, and Olanzapine: Interaction with Model Membranes. Thermodynamic and Structural Aspects.
ACS chemical neuroscience.
2017 07; 8(7):1543-1553. doi:
10.1021/acschemneuro.7b00057. [PMID: 28375612] - Alireza Asghari, Ebrahim Fahimi, Mohammad Bazregar, Maryam Rajabi, Leila Boutorabi. Rapid determination of some psychotropic drugs in complex matrices by tandem dispersive liquid-liquid microextraction followed by high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):51-59. doi:
10.1016/j.jchromb.2017.03.012. [PMID: 28355580] - Devyani Deshpande, Shashikant Srivastava, Sandirai Musuka, Tawanda Gumbo. Thioridazine as Chemotherapy for Mycobacterium avium Complex Diseases.
Antimicrobial agents and chemotherapy.
2016 08; 60(8):4652-8. doi:
10.1128/aac.02985-15. [PMID: 27216055] - Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
Cardiovascular toxicology.
2016 Apr; 16(2):138-46. doi:
10.1007/s12012-015-9322-2. [PMID: 25822712] - Liang Qi, Li-Min Duan, Xiao-Huan Sun, Jing Zhang, Zhi-Qi Zhang. Simultaneous determination of three banned psychiatric drugs in pig feed and tissue using solid-phase reactor on-line oxidizing and HPLC-fluorescence detection.
Biomedical chromatography : BMC.
2015 Oct; 29(10):1535-40. doi:
10.1002/bmc.3455. [PMID: 25810380] - Jin-Kun Liu, Ya-Juan Hao, Jia-Wei Huang, Xin Li, Hong-Bing Cai, Kang Peng. [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2015 Apr; 35(4):511-5. doi:
. [PMID: 25907934] - Kristina Melkersson, Moira Lewitt, Kerstin Hall. Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.
Neuro endocrinology letters.
2015; 36(5):465-80. doi:
NULL. [PMID: 26707048] - Szymon Dziomba, Michał Biernacki, Ilona Olędzka, Elżbieta Skrzydlewska, Tomasz Bączek, Piotr Kowalski. Repetitive injection field-amplified sample stacking for cationic compounds determination.
Talanta.
2014 Jul; 125(?):1-6. doi:
10.1016/j.talanta.2014.02.045. [PMID: 24840407] - André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
10.1021/jm401963n. [PMID: 24601604] - Mandana Amiri, Shabnam Sohrabnezhad, Azad Rahimi. Nickel (II) incorporated AlPO-5 modified carbon paste electrode for determination of thioridazine in human serum.
Materials science & engineering. C, Materials for biological applications.
2014 Apr; 37(?):342-7. doi:
10.1016/j.msec.2014.01.035. [PMID: 24582258] - K-j Min, B R Seo, Y C Bae, Y H Yoo, T K Kwon. Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L).
Cell death & disease.
2014 Feb; 5(?):e1063. doi:
10.1038/cddis.2014.35. [PMID: 24556678] - Wojciech Kopec, Himanshu Khandelia. Reinforcing the membrane-mediated mechanism of action of the anti-tuberculosis candidate drug thioridazine with molecular simulations.
Journal of computer-aided molecular design.
2014 Feb; 28(2):123-34. doi:
10.1007/s10822-014-9737-z. [PMID: 24577873] - Beth L Hahn, Peter G Sohnle. Effect of thioridazine on experimental cutaneous staphylococcal infections.
In vivo (Athens, Greece).
2014 Jan; 28(1):33-8. doi:
NULL. [PMID: 24425833] - Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
10.1093/toxsci/kft205. [PMID: 24052561] - Ana M Chamoun-Emanuelli, Eve-Isabelle Pecheur, Rudo L Simeon, Da Huang, Paul S Cremer, Zhilei Chen. Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.
Antimicrobial agents and chemotherapy.
2013 Jun; 57(6):2571-81. doi:
10.1128/aac.02593-12. [PMID: 23529728] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Shen-Chieh Chang, Mong-Liang Lu, Yue-Chi Wang, Fang-Wei Lin, Shu-Huei Huang, Pei-Hsin Kuo, Hsiu-O Ho, Tzu-Hua Wu. Combined therapy with thioridazine decreases plasma levels of quetiapine inTaiwanese schizophrenic patients.
Therapeutic drug monitoring.
2012 Jun; 34(3):345-8. doi:
10.1097/ftd.0b013e31825479cc. [PMID: 22569350] - Heidi Kidron, Gloria Wissel, Nenad Manevski, Marika Häkli, Raimo A Ketola, Moshe Finel, Marjo Yliperttula, Henri Xhaard, Arto Urtti. Impact of probe compound in MRP2 vesicular transport assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 May; 46(1-2):100-5. doi:
10.1016/j.ejps.2012.02.016. [PMID: 22406294] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Mihail-Lucian Pascu, Viorel Nastasa, Adriana Smarandache, Andra Militaru, Ana Martins, Miguel Viveiros, Mihai Boni, Ionut Relu Andrei, Alexandru Pascu, Angela Staicu, Joseph Molnar, Seamus Fanning, Leonard Amaral. Direct modification of bioactive phenothiazines by exposure to laser radiation.
Recent patents on anti-infective drug discovery.
2011 May; 6(2):147-57. doi:
10.2174/157489111796064515. [PMID: 21517738] - Jakko van Ingen. The broad-spectrum antimycobacterial activities of phenothiazines, InVitro: somewhere in all of this there may be patentable potentials.
Recent patents on anti-infective drug discovery.
2011 May; 6(2):104-9. doi:
10.2174/157489111796064623. [PMID: 21517740] - Olga Wesołowska, Krystyna Michalak, Andrzej B Hendrich. Direct visualization of phase separation induced by phenothiazine-type antipsychotic drugs in model lipid membranes.
Molecular membrane biology.
2011 Feb; 28(2):103-14. doi:
10.3109/09687688.2010.533706. [PMID: 21190429] - Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Feb; 39(2):312-21. doi:
10.1124/dmd.110.036095. [PMID: 21071520] - Iida Peltonen, Pekka T Männistö. Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase.
Basic & clinical pharmacology & toxicology.
2011 Jan; 108(1):46-54. doi:
10.1111/j.1742-7843.2010.00626.x. [PMID: 20825390] - Hao-Jie Zhu, David I Appel, Yuri K Peterson, Zichao Wang, John S Markowitz. Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions.
Toxicology.
2010 Apr; 270(2-3):59-65. doi:
10.1016/j.tox.2010.01.009. [PMID: 20097249] - Viktoria Hancock, Malin Dahl, Rebecca Munk Vejborg, Per Klemm. Dietary plant components ellagic acid and tannic acid inhibit Escherichia coli biofilm formation.
Journal of medical microbiology.
2010 Apr; 59(Pt 4):496-498. doi:
10.1099/jmm.0.013680-0. [PMID: 19959627] - Michael Margulis, Steve Sorota, Inhou Chu, Anthony Soares, Tony Priestley, Amin A Nomeir. Protein binding-dependent decreases in hERG channel blocker potency assessed by whole-cell voltage clamp in serum.
Journal of cardiovascular pharmacology.
2010 Apr; 55(4):368-76. doi:
10.1097/fjc.0b013e3181d2ce39. [PMID: 20125032] - Asish Dasgupta, Sayanti Mukherjee, Shaswati Chaki, Sujata G Dastidar, Oliver Hendricks, Jørn B Christensen, Jette E Kristiansen, Leonard Amaral. Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74.
International journal of antimicrobial agents.
2010 Feb; 35(2):174-6. doi:
10.1016/j.ijantimicag.2009.09.027. [PMID: 20005679] - Markus Fridén, Susanne Winiwarter, Gunilla Jerndal, Ola Bengtsson, Hong Wan, Ulf Bredberg, Margareta Hammarlund-Udenaes, Madeleine Antonsson. Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Journal of medicinal chemistry.
2009 Oct; 52(20):6233-43. doi:
10.1021/jm901036q. [PMID: 19764786] - Pedro Dorado, Eva M Peñas-LLedó, Alfredo de la Rubia, Adrián LLerena. Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.
Pharmacogenomics.
2009 Jul; 10(7):1083-9. doi:
10.2217/pgs.09.57. [PMID: 19604081] - Johannes Kornhuber, Lothar Terfloth, Stefan Bleich, Jens Wiltfang, Rainer Rupprecht. Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors.
European journal of medicinal chemistry.
2009 Jun; 44(6):2667-72. doi:
10.1016/j.ejmech.2008.12.003. [PMID: 19144451] - Marcin Kolaczkowski, Anna Kolaczkowska, Noboru Motohashi, Krystyna Michalak. New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.
Antimicrobial agents and chemotherapy.
2009 Apr; 53(4):1516-27. doi:
10.1128/aac.00956-08. [PMID: 19188399] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
10.1021/jm801441s. [PMID: 19256501] - Chaomei Xiong, Jinlan Ruan, Yaling Cai, Ying Tang. Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
2009 Feb; 49(2):572-8. doi:
10.1016/j.jpba.2008.11.036. [PMID: 19135820] - R H K Thanacoody, A K Daly, J G Reilly, I N Ferrier, S H L Thomas. Factors affecting drug concentrations and QT interval during thioridazine therapy.
Clinical pharmacology and therapeutics.
2007 Nov; 82(5):555-65. doi:
10.1038/sj.clpt.6100195. [PMID: 17460606] - I S M Salih, R H K Thanacoody, G A McKay, S H L Thomas. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses.
Clinical pharmacology and therapeutics.
2007 Nov; 82(5):548-54. doi:
10.1038/sj.clpt.6100194. [PMID: 17410120] - Pedro Dorado, Roland Berecz, Eva M Peñas-Lledó, Alfredo de la Rubia, Adrián Llerena. No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients.
European journal of clinical pharmacology.
2007 May; 63(5):527-8. doi:
10.1007/s00228-007-0284-6. [PMID: 17345072] - Leonard Amaral, Miguel Viveiros, Jette E Kristiansen. 'Non-Antibiotics': alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries.
Current drug targets.
2006 Jul; 7(7):887-91. doi:
10.2174/138945006777709539. [PMID: 16842219] - Alexander N Katchman, John Koerner, Toshimasa Tosaka, Raymond L Woosley, Steven N Ebert. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.
The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1098-106. doi:
10.1124/jpet.105.093393. [PMID: 16278312] - Luciana de Matos Alves Pinto, Sônia Valéria Pinheiro Malheiros, Antônio Carlos Senges Lino, Eneida de Paula, Maria Angélica Perillo. Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface.
Biophysical chemistry.
2006 Feb; 119(3):247-55. doi:
10.1016/j.bpc.2005.09.006. [PMID: 16233945] - Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation.
The Journal of toxicological sciences.
2005 Aug; 30(3):239-47. doi:
10.2131/jts.30.239. [PMID: 16141657] - David N Bailey, John R Briggs. The effect of lovastatin and thioridazine on the degradation of cocaine in human serum in vitro.
Therapeutic drug monitoring.
2005 Apr; 27(2):168-70. doi:
10.1097/01.ftd.0000151187.68593.12. [PMID: 15795647] - Chiara Bastianon, Roberta Zanoni, Giorgia Miolo, Sergio Caffieri, Elena Reddi. Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine.
The international journal of biochemistry & cell biology.
2005 Apr; 37(4):901-8. doi:
10.1016/j.biocel.2004.11.016. [PMID: 15694848] - Hiroshi Sawada, Kenji Takami, Satoru Asahi. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):282-92. doi:
10.1093/toxsci/kfh264. [PMID: 15342952] - Cristiane Masetto de Gaitani, Alexandre Souto Martinez, Pierina Sueli Bonato. Degradation and configurational changes of thioridazine 2-sulfoxide.
Journal of pharmaceutical and biomedical analysis.
2004 Nov; 36(3):601-7. doi:
10.1016/j.jpba.2004.07.011. [PMID: 15522536] - Miroslav Ravic, Steve Warrington, Malcolm Boyce, Kate Dunn, Atholl Johnston. Repeated dosing with donepezil does not affect the safety, tolerability or pharmacokinetics of single-dose thioridazine in young volunteers.
British journal of clinical pharmacology.
2004 Nov; 58 Suppl 1(?):34-40. doi:
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The American journal of psychiatry.
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2004 Feb; 24(1):62-9. doi:
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European journal of clinical pharmacology.
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