fentanyl (BioDeep_00000016620)
代谢物信息卡片
fentanyl
化学式: C22H28N2O (336.2201518)
中文名称: 芬太尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)N(c(c3)cccc3)C(C1)CCN(CCc(c2)cccc2)C1
InChI: InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AB - Phenylpiperidine derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3640
CONFIDENCE standard compound; INTERNAL_ID 1545
同义名列表
1 个代谢物同义名
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:119915
- KEGG: C06998
- KEGGdrug: D00320
- PubChem: 3345
- Metlin: METLIN2695
- DrugBank: DB00813
- ChEMBL: CHEMBL596
- MeSH: Fentanyl
- CAS: 437-38-7
- MoNA: WA001020
- MoNA: WA001019
- MoNA: WA001018
- MoNA: WA001017
- MoNA: WA001016
- MoNA: WA001015
- MoNA: EQ364009
- MoNA: EQ364008
- MoNA: EQ364007
- MoNA: EQ364006
- MoNA: EQ364005
- MoNA: EQ364004
- MoNA: EQ364003
- MoNA: EQ364002
- MoNA: EQ364001
- MoNA: AU154505
- MoNA: AU154504
- MoNA: AU154503
- MoNA: AU154502
- MoNA: AU154501
- RefMet: Fentanyl
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lawrence M Carey, David R Maguire, Charles P France. Effects of Δ⁹-tetrahydrocannabinol (THC), cannabidiol (CBD), and THC/CBD mixtures on fentanyl versus food choice in rhesus monkeys.
Drug and alcohol dependence.
2023 03; 244(?):109787. doi:
10.1016/j.drugalcdep.2023.109787. [PMID: 36753805] - Ling Yang, Hai-Jun Yao, Jian-Shu Ni, Jing Xia, Wei-Hong Chen, Li-Li Hou, Yan Zhao. [Electrophysiological appropriateness technique based on TCM meridian theory for postoperative pain after urethral reconstruction: A real-world study].
Zhonghua nan ke xue = National journal of andrology.
2023 Feb; 29(2):174-180. doi:
". [PMID: 37847090] - Ying Jin, Xiaoshuai Yu, Shen Hu, Lanying Liu, Bin Wang, Yuanling Feng, Yubo Li, Bing Xiong, Liquan Wang. Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial.
American journal of obstetrics & gynecology MFM.
2023 02; 5(2):100826. doi:
10.1016/j.ajogmf.2022.100826. [PMID: 36464237] - Marta Tikhomirov, Paweł Jajor, Tomasz Śniegocki, Błażej Poźniak. Predicting the efficacy of opioid sequestration by intravenous lipid emulsion using biologically relevant in vitro models of drug distribution.
Scientific reports.
2022 11; 12(1):18683. doi:
10.1038/s41598-022-21790-4. [PMID: 36333363] - Tina Lam, Monica J Barratt, Mark Bartlett, Julie Latimer, Marianne Jauncey, Sarah Hiley, Nico Clark, Dimitri Gerostamoulos, Linda Glowacki, Claude Roux, Marie Morelato, Suzanne Nielsen. Infrequent detection of unintentional fentanyl use via urinalysis among people who regularly inject opioids in Sydney and Melbourne, Australia.
Addiction (Abingdon, England).
2022 Aug; 117(8):2331-2337. doi:
10.1111/add.15832. [PMID: 35129225] - Darshan Mehta, Miao Li, Noriko Nakamura, Mani Chidambaram, Xiaobo He, Matthew S Bryant, Ralph Patton, Kelly Davis, Jeffrey Fisher. In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats.
Reproductive toxicology (Elmsford, N.Y.).
2022 08; 111(?):194-203. doi:
10.1016/j.reprotox.2022.06.007. [PMID: 35714934] - Vahid Azimi, Ronald Jackups, Christopher W Farnsworth, Melissa M Budelier. Use of laboratory data for illicit drug use surveillance and identification of socioeconomic risk factors.
Drug and alcohol dependence.
2022 Jul; 236(?):109499. doi:
10.1016/j.drugalcdep.2022.109499. [PMID: 35605528] - S Pesavento, S Bilel, M Murari, R Gottardo, R Arfè, M Tirri, A Panato, F Tagliaro, M Marti. Zebrafish larvae: A new model to study behavioural effects and metabolism of fentanyl, in comparison to a traditional mice model.
Medicine, science, and the law.
2022 Jul; 62(3):188-198. doi:
10.1177/00258024221074568. [PMID: 35040690] - Grace Mahowald, Tahira Khaliq, Sankha Basu, David Griggs, Molly Siegel, Lisa Leffert, Sarah Bernstein, James G Flood, Sacha Uljon. Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC-MS/MS.
The journal of applied laboratory medicine.
2022 06; 7(4):854-862. doi:
10.1093/jalm/jfac009. [PMID: 35259249] - Rauane Sousa de Moura, Isabela Plazza Bittar, Janainne Hilbig Gomes, Yan Victor Rodrigues de Oliveira, Gladsthon Divino de Sousa Filho, Glauco Cézar Fragola de Faria Soares, Eliana Martins Lima, Leandro Guimarães Franco. Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy.
BMC veterinary research.
2022 Jun; 18(1):225. doi:
10.1186/s12917-022-03244-1. [PMID: 35701767] - Marthe M Vandeputte, Nick Verougstraete, Donna Walther, Grant C Glatfelter, Jeroen Malfliet, Michael H Baumann, Alain G Verstraete, Christophe P Stove. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass.
Archives of toxicology.
2022 06; 96(6):1865-1880. doi:
10.1007/s00204-022-03294-2. [PMID: 35449307] - Simona Napoletano, Giuseppe Basile, Alfredo Fabrizio Lo Faro, Francesca Negro. New Psychoactive Substances and receding COVID-19 pandemic: really going back to "normal"?.
Acta bio-medica : Atenei Parmensis.
2022 05; 93(2):e2022186. doi:
10.23750/abm.v93i2.13008. [PMID: 35545997] - Erik Olofsen, Marijke Hyke Algera, Laurence Moss, Robert L Dobbins, Geert J Groeneveld, Monique van Velzen, Marieke Niesters, Albert Dahan, Celine M Laffont. Modeling buprenorphine reduction of fentanyl-induced respiratory depression.
JCI insight.
2022 05; 7(9):. doi:
10.1172/jci.insight.156973. [PMID: 35316224] - Suling Zhang, Ziluo Hua, Weixuan Yao, Ting Lü, Dong Zhang, Qingwei Zhao, Jianhong Li, Hongting Zhao. Preparation of bamboo-derived magnetic biochar for solid-phase microextraction of fentanyls from urine.
Journal of separation science.
2022 May; 45(10):1766-1773. doi:
10.1002/jssc.202200049. [PMID: 35261155] - Carly A Baehr, Mariah M Wu, Sujata G Pandit, Jose Arias-Umana, David AuCoin, Marco Pravetoni. Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.
The Journal of pharmacology and experimental therapeutics.
2022 05; 381(2):129-136. doi:
10.1124/jpet.121.001048. [PMID: 35153198] - Namkee G Choi, Bryan Y Choi, Diana M DiNitto, C Nathan Marti, S David Baker. Heroin and fentanyl overdose deaths among cases age 50+ in the National Poison Data System, 2015-2020.
Clinical toxicology (Philadelphia, Pa.).
2022 May; 60(5):639-646. doi:
10.1080/15563650.2021.2016798. [PMID: 34985395] - Dustin L Abbott, Jennifer F Limoges, Kelly J Virkler, Seth J Tracy, Gregory G Sarris. ELISA Screens for Fentanyl in Urine Are Susceptible to False-Positives in High Concentration Methamphetamine Samples.
Journal of analytical toxicology.
2022 Apr; 46(4):457-459. doi:
10.1093/jat/bkab033. [PMID: 33835171] - Lu Li, Xuejiao Yu, Lihong Lyu, Hongbin Duan, Yao Chen, Jing Bian, Zhiru Xu, Li Liu, Yurong Zhang. Determination of Fentanyl, Alpha-Methylfentanyl, Beta-Hydroxyfentanyl and the Metabolite Norfentanyl in Rat Urine by LC-MS-MS.
Journal of analytical toxicology.
2022 Apr; 46(4):421-431. doi:
10.1093/jat/bkab021. [PMID: 33647104] - Vlad Radoi, Gerd Jakobsson, Vinko Palada, Andrej Nikosjkov, Henrik Druid, Lars Terenius, Eva Kosek, Vladana Vukojević. Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation.
Molecules (Basel, Switzerland).
2022 Apr; 27(7):. doi:
10.3390/molecules27072350. [PMID: 35408749] - Dominick Shelton. Fentanyl not detected in routine urine drug screens: case report.
CJEM.
2022 04; 24(3):335-336. doi:
10.1007/s43678-022-00274-4. [PMID: 35138594] - Nestor Nivardo Jiménez-Vargas, Yang Yu, Dane D Jensen, Diana Daeun Bok, Matthew Wisdom, Rocco Latorre, Cintya Lopez, Josue O Jaramillo-Polanco, Claudius Degro, Mabel Guzman-Rodriguez, Quentin Tsang, Zachary Snow, Brian L Schmidt, David E Reed, Alan Edward Lomax, Kara Gross Margolis, Christoph Stein, Nigel W Bunnett, Stephen J Vanner. Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.
Gut.
2022 04; 71(4):695-704. doi:
10.1136/gutjnl-2021-324070. [PMID: 33785555] - Pratik Joshi, Parand R Riley, Rupesh Mishra, Sina Azizi Machekposhti, Roger Narayan. Transdermal Polymeric Microneedle Sensing Platform for Fentanyl Detection in Biofluid.
Biosensors.
2022 Mar; 12(4):. doi:
10.3390/bios12040198. [PMID: 35448258] - Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu. Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine.
Biomolecules.
2022 03; 12(3):. doi:
10.3390/biom12030426. [PMID: 35327617] - Yunjiao Wu, Swantje Völler, Robert B Flint, Sinno H P Simons, Karel Allegaert, Vineta Fellman, Catherijne A J Knibbe. Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study.
Clinical pharmacokinetics.
2022 03; 61(3):401-412. doi:
10.1007/s40262-021-01076-0. [PMID: 34773609] - Minna Guo, Shijiang Liu, Jian Gao, Chuanbao Han, Chun Yang, Cunming Liu. The effects of fentanyl, oxycodone, and butorphanol on gastrointestinal function in patients undergoing laparoscopic hysterectomy: a prospective, double-blind, randomized controlled trial.
BMC anesthesiology.
2022 02; 22(1):53. doi:
10.1186/s12871-022-01594-9. [PMID: 35209847] - Rebecca S Bolinski, Suzan Walters, Elizabeth Salisbury-Afshar, Lawrence J Ouellet, Wiley D Jenkins, Ellen Almirol, Brent Van Ham, Scott Fletcher, Christian Johnson, John A Schneider, Danielle Ompad, Mai T Pho. The Impact of the COVID-19 Pandemic on Drug Use Behaviors, Fentanyl Exposure, and Harm Reduction Service Support among People Who Use Drugs in Rural Settings.
International journal of environmental research and public health.
2022 02; 19(4):. doi:
10.3390/ijerph19042230. [PMID: 35206421] - Kinomi Yomiya. [For the Clinical Use-Clinical Guidelines for Pharmacological Management of Cancer Pain 2020].
Gan to kagaku ryoho. Cancer & chemotherapy.
2022 Feb; 49(2):119-124. doi:
NULL. [PMID: 35249042] - Nissar Shaikh, Mohamad Y Khatib, Mohammad A Al Wraidat, Ahmed S Mohamed, Anood A Al-Assaf, Abdul Gafoor M Tharayil, Ahmad A Abujaber, Abdulqadir J Nashwan. Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl trial).
Medicine.
2022 Jan; 101(4):e28637. doi:
10.1097/md.0000000000028637. [PMID: 35089202] - Marta Katarzyna Choińska, Ivana Šestáková, Vojtěch Hrdlička, Jana Skopalová, Jan Langmaier, Vítězslav Maier, Tomáš Navrátil. Electroanalysis of Fentanyl and Its New Analogs: A Review.
Biosensors.
2022 Jan; 12(1):. doi:
10.3390/bios12010026. [PMID: 35049654] - Marcin Zawadzki, Olga Wachełko, Kaja Tusiewicz, Paweł Szpot. Severe poisoning after smoking a mixture of 4-fluoroisobutyryl fentanyl (4-FiBF) and alpha-pyrolidinoisohexaphenone (α-PiHP).
Journal of forensic and legal medicine.
2022 Jan; 85(?):102287. doi:
10.1016/j.jflm.2021.102287. [PMID: 34798437] - Ju Nyeong Park, Jill Owczarzak, Glenna Urquhart, Miles Morris, Noelle P Weicker, Saba Rouhani, Susan G Sherman. HIV Risk Among Urban and Suburban People Who Inject Drugs: Elevated Risk Among Fentanyl and Cocaine Injectors in Maryland.
AIDS and behavior.
2022 Jan; 26(1):277-283. doi:
10.1007/s10461-021-03381-y. [PMID: 34287755] - Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman. Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase.
Physiology & behavior.
2022 01; 243(?):113630. doi:
10.1016/j.physbeh.2021.113630. [PMID: 34710466] - Heather Skrzypczak, Rachel Reed, Benjamin Brainard, Daniel Sakai, Michele Barletta, Jane Quandt, Carly Smyth, Melanie Ruch, Heather Knych. The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses.
Equine veterinary journal.
2022 Jan; 54(1):153-158. doi:
10.1111/evj.13424. [PMID: 33453066] - Marcela L Machado, Joao H N Soares, Bruno H Pypendop, Natalia Henao-Guerrero, Renato L S Oliveira. Effect of fentanyl, with or without treatment of bradycardia, on the minimum alveolar concentration of isoflurane and cardiovascular function in dogs.
Veterinary anaesthesia and analgesia.
2022 Jan; 49(1):26-35. doi:
10.1016/j.vaa.2021.09.001. [PMID: 34654643] - Jun Zha, Jinping Ni, Shuo Chen, Haijun Feng, Tuanjie Che, Shigang Qiao. Ultrasound Radiomics-Guided Iliac Fascia Block on Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Surgery.
Computational and mathematical methods in medicine.
2022; 2022(?):2492667. doi:
10.1155/2022/2492667. [PMID: 35620202] - Laurence M Moss, Marijke Hyke Algera, Robert Dobbins, Frank Gray, Stephanie Strafford, Amy Heath, Monique van Velzen, Jules A A C Heuberger, Marieke Niesters, Erik Olofsen, Celine M Laffont, Albert Dahan, Geert Jan Groeneveld. Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients.
PloS one.
2022; 17(1):e0256752. doi:
10.1371/journal.pone.0256752. [PMID: 35085249] - Juan F Iglesias, Marco Valgimigli, Federico Carbone, Nathalie Lauriers, Pier-Giorgio Masci, Sophie Degrauwe. Comparative effects of fentanyl versus morphine on platelet inhibition induced by ticagrelor in patients with ST-segment elevation myocardial infarction: Full results of the PERSEUS randomized trial.
Cardiology journal.
2022; 29(4):591-600. doi:
10.5603/cj.a2022.0049. [PMID: 35762079] - Raminta Daniulaityte, Sydney M Silverstein, Kylie Getz, Matthew Juhascik, Megan McElhinny, Steven Dudley. Lay knowledge and practices of methamphetamine use to manage opioid-related overdose risks.
The International journal on drug policy.
2022 01; 99(?):103463. doi:
10.1016/j.drugpo.2021.103463. [PMID: 34619443] - Sarah Douglas, Kanna Hayashi, Lindsey Richardson, Kora DeBeck, Thomas Kerr. Social-Structural Predictors of Fentanyl Exposure among Street Involved Youth.
Substance use & misuse.
2022; 57(1):21-26. doi:
10.1080/10826084.2021.1975746. [PMID: 34738494] - Piotr Adamowicz, Karolina Nowak. Blood concentrations of new synthetic opioids.
International journal of legal medicine.
2022 Jan; 136(1):107-122. doi:
10.1007/s00414-021-02729-2. [PMID: 34676457] - Masayoshi Kondo, Makihiko Nagano, Mariko Yoshida, Naoki Yoshida, Naoya Tagui, Masato Yoshida, Kazutoshi Sugaya, Hisamitsu Takase. Physical Compatibility of Nafamostat with Analgesics, Sedatives, and Muscle Relaxants for Treatment of Coronavirus Disease 2019.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2021 Dec; 88(6):533-539. doi:
10.1272/jnms.jnms.2022_89-104. [PMID: 33692301] - Patrick Y Joynt, George Sam Wang. Fentanyl contaminated 'M30' pill overdoses in pediatric patients.
The American journal of emergency medicine.
2021 12; 50(?):811.e3-811.e4. doi:
10.1016/j.ajem.2021.05.035. [PMID: 34030905] - Eiso Hiyama, Shigeki Yamaguchi, Koji Okawa, Fumitaka Hashimoto, Kuniaki Otaka, Takaaki Terahara. An Open-Label Study of the Pharmacokinetics and Tolerability of Once-a-Day Fentanyl Citrate Patch in Japanese Pediatric and Adolescent Patients with Cancer Pain.
Clinical drug investigation.
2021 Dec; 41(12):1087-1098. doi:
10.1007/s40261-021-01097-4. [PMID: 34784012] - Marianne Skov-Skov Bergh, Inger Lise Bogen, Nancy Garibay, Michael H Baumann. Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats.
Psychopharmacology.
2021 Dec; 238(12):3629-3641. doi:
10.1007/s00213-021-05981-x. [PMID: 34613431] - Soroush Moallef, Ekaterina Nosova, Seonaid Nolan, Nadia Fairbairn, Jane Loh, Kanna Hayashi, M-J Milloy. Prevalence and longitudinal correlates of recent exposure to fentanyl among HIV-positive people who use unregulated drugs during a community-wide overdose crisis.
AIDS care.
2021 12; 33(12):1560-1568. doi:
10.1080/09540121.2021.1874272. [PMID: 33764814] - Catherine DiGennaro, Gian-Gabriel P Garcia, Erin J Stringfellow, Sarah Wakeman, Mohammad S Jalali. Changes in characteristics of drug overdose death trends during the COVID-19 pandemic.
The International journal on drug policy.
2021 12; 98(?):103392. doi:
10.1016/j.drugpo.2021.103392. [PMID: 34325184] - Kenneth D Swanson, Rebecca L Shaner, Logan C Krajewski, William A Bragg, Rudolph C Johnson, Elizabeth I Hamelin. Use of Diagnostic Ions for the Detection of Fentanyl Analogs in Human Matrices by LC-QTOF.
Journal of the American Society for Mass Spectrometry.
2021 Dec; 32(12):2852-2859. doi:
10.1021/jasms.1c00267. [PMID: 34793156] - Justin K Niles, Jeffrey Gudin, Alana M Vivolo-Kantor, R Matthew Gladden, Desiree Mustaquim, Puja Seth, Harvey W Kaufman. Notes from the Field: Testing for Nonprescribed Fentanyl and Percentage of Positive Test Results Among Patients with Opioid Use Disorder - United States, 2019-2020.
MMWR. Morbidity and mortality weekly report.
2021 11; 70(47):1649-1651. doi:
10.15585/mmwr.mm7047a4. [PMID: 34818316] - Sara Shum, Danny D Shen, Nina Isoherranen. Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling.
Drug metabolism and disposition: the biological fate of chemicals.
2021 11; 49(11):1003-1015. doi:
10.1124/dmd.121.000612. [PMID: 34407992] - M Eugenia Socias, Cameron Grant, Kanna Hayashi, Geoff Bardwell, Mary Clare Kennedy, M-J Milloy, Thomas Kerr. The use of diverted pharmaceutical opioids is associated with reduced risk of fentanyl exposure among people using unregulated drugs in Vancouver, Canada.
Drug and alcohol dependence.
2021 11; 228(?):109109. doi:
10.1016/j.drugalcdep.2021.109109. [PMID: 34601278] - Ryan R Cook, Randy Torralva, Caroline King, Paula J Lum, Hansel Tookes, Canyon Foot, Pamela Vergara-Rodriguez, Allan Rodriguez, Laura Fanucchi, Gregory M Lucas, Elizabeth N Waddell, P Todd Korthuis. Associations between fentanyl use and initiation, persistence, and retention on medications for opioid use disorder among people living with uncontrolled HIV disease.
Drug and alcohol dependence.
2021 11; 228(?):109077. doi:
10.1016/j.drugalcdep.2021.109077. [PMID: 34600253] - Samantha Young, Kanna Hayashi, Cameron Grant, M J Milloy, Kora DeBeck, Evan Wood, Nadia Fairbairn. Buprenorphine/naloxone associated with a reduced odds of fentanyl exposure among a cohort of people who use drugs in Vancouver, Canada.
Drug and alcohol dependence.
2021 11; 228(?):109006. doi:
10.1016/j.drugalcdep.2021.109006. [PMID: 34509737] - Grace K Mahowald, Tahira P Khaliq, David Griggs, Mi O, James G Flood, Sacha Uljon. Comparison of Oral Fluid and Urine for Detection of Fentanyl Use Using Liquid Chromatography with Tandem Mass Spectrometry.
The journal of applied laboratory medicine.
2021 11; 6(6):1533-1540. doi:
10.1093/jalm/jfab068. [PMID: 34327523] - Noa Katz Shroitman, Einat Peles, Sharona Even-Tov, Shaul Schreiber, Oren Tene. False-positive fentanyl screening kit results during treatment with long term injectable risperidone (Risperdal-Consta).
Psychiatry research.
2021 11; 305(?):114246. doi:
10.1016/j.psychres.2021.114246. [PMID: 34717208] - Tao Feng, Si Zeng, Jie Ding, Gong Chen, Bin Wang, Daguo Wang, Xueli Li, Kunfeng Wang. Comparative analysis of the effects of opioids in angiogenesis.
BMC anesthesiology.
2021 10; 21(1):257. doi:
10.1186/s12871-021-01475-7. [PMID: 34702181] - Jin Qiu, Mian Xie. Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies.
Medicine.
2021 Oct; 100(42):e27409. doi:
10.1097/md.0000000000027409. [PMID: 34678869] - Boxin Zhang, Xingwei Hou, Cheng Zhen, Alan X Wang. Sub-Part-Per-Billion Level Sensing of Fentanyl Residues from Wastewater Using Portable Surface-Enhanced Raman Scattering Sensing.
Biosensors.
2021 Oct; 11(10):. doi:
10.3390/bios11100370. [PMID: 34677326] - Marius Bogdan Novac, Lidia Boldeanu, Luciana Teodora Rotaru, Anda Lorena Dijmărescu, Mircea Sebastian Şerbănescu, Lucreţiu Radu, Simona Daniela Neamţu, Alina Maria Vîlcea, Mihaela Niculescu, Cecil Sorin Mirea, Mihail Virgil Boldeanu, Maria Magdalena Manolea. The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.
2021 Oct; 62(4):961-969. doi:
10.47162/rjme.62.4.08. [PMID: 35673815] - Alex J Krotulski, Donna M Papsun, Sara E Walton, Barry K Logan. Metonitazene in the United States-Forensic toxicology assessment of a potent new synthetic opioid using liquid chromatography mass spectrometry.
Drug testing and analysis.
2021 Oct; 13(10):1697-1711. doi:
10.1002/dta.3115. [PMID: 34137194] - Warren R Korn, Matthew D Stone, Kaddie L Haviland, Joanne M Toohey, Douglas F Stickle. High prevalence of xylazine among fentanyl screen-positive urines from hospitalized patients, Philadelphia, 2021.
Clinica chimica acta; international journal of clinical chemistry.
2021 Oct; 521(?):151-154. doi:
10.1016/j.cca.2021.07.010. [PMID: 34265257] - Soumen Chakraborty, Jeffrey F DiBerto, Abdelfattah Faouzi, Sarah M Bernhard, Anna M Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N F Nelson, Wesley B Asher, Shainnel O Eans, Lisa L Wilson, Satyanarayana M Chintala, Marta Filizola, Richard M van Rijn, Elyssa B Margolis, Bryan L Roth, Jay P McLaughlin, Tao Che, Dalibor Sames, Jonathan A Javitch, Susruta Majumdar. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
Journal of medicinal chemistry.
2021 09; 64(18):13873-13892. doi:
10.1021/acs.jmedchem.1c01273. [PMID: 34505767] - Robert Kronstrand, Anna Åstrand, Shimpei Watanabe, Henrik Gréen, Svante Vikingsson. Circumstances, Postmortem Findings, Blood Concentrations and Metabolism in a Series of Methoxyacetylfentanyl-Related Deaths.
Journal of analytical toxicology.
2021 Sep; 45(8):760-771. doi:
10.1093/jat/bkab053. [PMID: 34009362] - Emily Biggar, Kristi Papamihali, Pascale Leclerc, Elaine Hyshka, Brittany Graham, Marliss Taylor, Doris Payer, Bridget Maloney-Hall, Jane A Buxton. Towards cross-Canada monitoring of the unregulated street drug supply.
BMC public health.
2021 09; 21(1):1678. doi:
10.1186/s12889-021-11757-x. [PMID: 34525994] - Sidnee L Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R Butelman, Mary Jeanne Kreek, Thomas E Prisinzano. Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent.
Journal of biomedical science.
2021 Sep; 28(1):62. doi:
10.1186/s12929-021-00758-y. [PMID: 34503531] - Aymen A Al-Qurain, Desmond B Williams, Lorraine Mackenzie, Michael S Roberts, Michael D Wiese. Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 203(?):114171. doi:
10.1016/j.jpba.2021.114171. [PMID: 34087551] - Amadeo Pesce, Raymond Sundyhanata, Dennis Ritz, Richard Thomas, Gregory Ackerman, Katie Bollman. Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients.
Annals of clinical and laboratory science.
2021 Sep; 51(5):694-697. doi:
. [PMID: 34686512] - John J Mariani, Amy L Mahony, Samuel C Podell, Daniel J Brooks, Christina Brezing, Sean X Luo, Nasir H Naqvi, Frances R Levin. Open-label trial of a single-day induction onto buprenorphine extended-release injection for users of heroin and fentanyl.
The American journal on addictions.
2021 09; 30(5):470-476. doi:
10.1111/ajad.13193. [PMID: 34223681] - Brendan Saloner, Penn Whitley, Leah LaRue, Eric Dawson, Angela Huskey. Polysubstance Use Among Patients Treated With Buprenorphine From a National Urine Drug Test Database.
JAMA network open.
2021 09; 4(9):e2123019. doi:
10.1001/jamanetworkopen.2021.23019. [PMID: 34505888] - V Vohra, A M King, E Jacobs, C Aaron. Death associated with brorphine, an emerging novel synthetic opioid.
Clinical toxicology (Philadelphia, Pa.).
2021 09; 59(9):851-852. doi:
10.1080/15563650.2021.1879111. [PMID: 33522844] - Kanna Hayashi, Evan Wood, Huiru Dong, Jane A Buxton, Nadia Fairbairn, Kora DeBeck, M-J Milloy, Thomas Kerr. Awareness of fentanyl exposure and the associated overdose risks among people who inject drugs in a Canadian setting.
Drug and alcohol review.
2021 09; 40(6):964-973. doi:
10.1111/dar.13261. [PMID: 33604968] - Eleonora Amante, Eugenio Alladio, Rebecca Rizzo, Daniele Di Corcia, Pierre Negri, Lia Visintin, Michela Guglielmotto, Elena Tamagno, Marco Vincenti, Alberto Salomone. Untargeted Metabolomics in Forensic Toxicology: A New Approach for the Detection of Fentanyl Intake in Urine Samples.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164990. [PMID: 34443578] - Christopher Faulkner, Nora H de Leeuw. Predicting the Membrane Permeability of Fentanyl and Its Analogues by Molecular Dynamics Simulations.
The journal of physical chemistry. B.
2021 08; 125(30):8443-8449. doi:
10.1021/acs.jpcb.1c05438. [PMID: 34286980] - Michael Levine, Frank Lovecchio. New Designer Drugs.
Emergency medicine clinics of North America.
2021 Aug; 39(3):677-687. doi:
10.1016/j.emc.2021.04.013. [PMID: 34215409] - Marta Tikhomirov, Tomasz Śniegocki, Błażej Poźniak. Lipemia in the Plasma Sample Affects Fentanyl Measurements by Means of HPLC-MS2 after Liquid-Liquid Extraction.
Molecules (Basel, Switzerland).
2021 Jul; 26(15):. doi:
10.3390/molecules26154514. [PMID: 34361667] - Hao Wang, Zhaolin Xue, Yuxuan Wu, John Gilmore, Lu Wang, Laura Fabris. Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs with a Portable Raman Module.
Analytical chemistry.
2021 07; 93(27):9373-9382. doi:
10.1021/acs.analchem.1c00792. [PMID: 34191499] - A Di Trana, N La Maida. New Psychoactive Substances consumption and their monito- ring during Covid-19 pandemic.
La Clinica terapeutica.
2021 Jul; 172(4):271-272. doi:
10.7417/ct.2021.2330. [PMID: 34247209] - Jie Zhou, Laura Curd, Lauren R L Lohmer, Natalie Delpratt, Joachim Ossig, Frank Schippers, Thomas Stoehr, Virginia D Schmith. A population pharmacodynamic Markov mixed-effects model for determining remimazolam-induced sedation when co-administered with fentanyl in procedural sedation.
Clinical and translational science.
2021 07; 14(4):1554-1565. doi:
10.1111/cts.13023. [PMID: 33768731] - Daniel Ciccarone. The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis.
Current opinion in psychiatry.
2021 07; 34(4):344-350. doi:
10.1097/yco.0000000000000717. [PMID: 33965972] - Antti Valtola, Maisa Laakso, Henriikka Hakomäki, Brian J Anderson, Hannu Kokki, Veli-Pekka Ranta, Valtteri Rinne, Merja Kokki. Intranasal Fentanyl for Intervention-Associated Breakthrough Pain After Cardiac Surgery.
Clinical pharmacokinetics.
2021 07; 60(7):907-919. doi:
10.1007/s40262-021-01002-4. [PMID: 33686630] - Jian Guo, Weigang Zhu, Qinye Shi, Fangping Bao, Jianhong Xu. Effect of surgical pleth index-guided analgesia versus conventional analgesia techniques on fentanyl consumption under multimodal analgesia in laparoscopic cholecystectomy: a prospective, randomized and controlled study.
BMC anesthesiology.
2021 06; 21(1):167. doi:
10.1186/s12871-021-01366-x. [PMID: 34088270] - Thomas R Kosten, Ismene L Petrakis. The Hidden Epidemic of Opioid Overdoses During the Coronavirus Disease 2019 Pandemic.
JAMA psychiatry.
2021 06; 78(6):585-586. doi:
10.1001/jamapsychiatry.2020.4148. [PMID: 33377967] - G Mannocchi, F Pirani, M Gottardi, A Sirignano, F P Busardò, G Ricci. Determination of nine new fentanyl analogues and metabolites in consumers' urine by ultra-high-performance liquid chromatography-tandem mass spectrometry.
European review for medical and pharmacological sciences.
2021 Jun; 25(12):4394-4399. doi:
10.26355/eurrev_202106_26149. [PMID: 34227074] - Kamil J Polok, Ilona Nowak-Kózka, Jakub Fronczek, Wojciech Szczeklik. Concentrations of fentanyl before and after initiation of continuous venovenous haemodialysis in septic patients with acute kidney injury: A prospective observational study.
European journal of anaesthesiology.
2021 06; 38(6):669-671. doi:
10.1097/eja.0000000000001392. [PMID: 33967260] - Neeraj Chhabra, Lum Rizvanolli, Arkady Rasin, Granger Marsden, Keiki Hinami, Steven E Aks. A cross-sectional analysis of fentanyl analog exposures among living patients.
The American journal of drug and alcohol abuse.
2021 05; 47(3):344-349. doi:
10.1080/00952990.2021.1891420. [PMID: 33798014] - Julia Zubiago, Meghan Murphy, Rubeen Guardado, Denise Daudelin, Dustin Patil, Alysse Wurcel. Increased HIV testing in people who use drugs hospitalized in the first wave of the COVID-19 pandemic.
Journal of substance abuse treatment.
2021 05; 124(?):108266. doi:
10.1016/j.jsat.2020.108266. [PMID: 33771274] - Robert J Brosnan, Bruno H Pypendop. Evaluation of whether acepromazine maleate causes fentanyl to decrease the minimum alveolar concentration of isoflurane in cats.
American journal of veterinary research.
2021 May; 82(5):352-357. doi:
10.2460/ajvr.82.5.352. [PMID: 33904805] - Lindsay Mackay, Thomas Kerr, Nadia Fairbairn, Cameron Grant, M-J Milloy, Kanna Hayashi. The relationship between opioid agonist therapy satisfaction and fentanyl exposure in a Canadian setting.
Addiction science & clinical practice.
2021 04; 16(1):26. doi:
10.1186/s13722-021-00234-w. [PMID: 33910630] - Siqingaowa Han, Chen Zhang, Shuang Lin, Xuanyu Sha, Wuliji Hasi. Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Apr; 251(?):119463. doi:
10.1016/j.saa.2021.119463. [PMID: 33493937] - Kari M Midthun, Lewis S Nelson, Barry K Logan. Levamisole-a Toxic Adulterant in Illicit Drug Preparations: a Review.
Therapeutic drug monitoring.
2021 04; 43(2):221-228. doi:
10.1097/ftd.0000000000000851. [PMID: 33298746] - Todd Kerensky, Marc LaRochelle, Shu-Ling Fan, Sarah Kosakowski, Kristin Wason, Alexander Y Walley. Non-prescription Fentanyl Positive Toxicology: Prevalence, Positive Predictive Value of Fentanyl Immunoassay Screening, and Description of Co-substance Use.
Journal of addiction medicine.
2021 04; 15(2):150-154. doi:
10.1097/adm.0000000000000723. [PMID: 32909981] - Marianne Skov-Skov Bergh, Åse Marit Leere Øiestad, Michael H Baumann, Inger Lise Bogen. Selectivity and sensitivity of urine fentanyl test strips to detect fentanyl analogues in illicit drugs.
The International journal on drug policy.
2021 04; 90(?):103065. doi:
10.1016/j.drugpo.2020.103065. [PMID: 33333419] - Joseph J Palamar, Austin Le, Thomas H Carr, Linda B Cottler. Shifts in drug seizures in the United States during the COVID-19 pandemic.
Drug and alcohol dependence.
2021 04; 221(?):108580. doi:
10.1016/j.drugalcdep.2021.108580. [PMID: 33674175] - Kristen A Morin, Shreedhar Acharya, Joseph K Eibl, David C Marsh. Evidence of increased Fentanyl use during the COVID-19 pandemic among opioid agonist treatment patients in Ontario, Canada.
The International journal on drug policy.
2021 04; 90(?):103088. doi:
10.1016/j.drugpo.2020.103088. [PMID: 33385974] - Sin Yin Lim, Jamie L Miller, Emilie Henry, Rebecca Heltsley, Sukyung Woo, Peter N Johnson. Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children.
Pharmacotherapy.
2021 04; 41(4):359-369. doi:
10.1002/phar.2515. [PMID: 33604895] - Tracy-Lynn E Lockwood, Alexandra Vervoordt, Marya Lieberman. High concentrations of illicit stimulants and cutting agents cause false positives on fentanyl test strips.
Harm reduction journal.
2021 03; 18(1):30. doi:
10.1186/s12954-021-00478-4. [PMID: 33750405] - Marijke Hyke Algera, Erik Olofsen, Laurence Moss, Robert L Dobbins, Marieke Niesters, Monique van Velzen, Geert Jan Groeneveld, Jules Heuberger, Celine M Laffont, Albert Dahan. Tolerance to Opioid-Induced Respiratory Depression in Chronic High-Dose Opioid Users: A Model-Based Comparison With Opioid-Naïve Individuals.
Clinical pharmacology and therapeutics.
2021 03; 109(3):637-645. doi:
10.1002/cpt.2027. [PMID: 32865832] - Daniel J Angelini, Tracey D Biggs, Amber M Prugh, Jessica A Smith, Jennifer A Hanburger, Bob Llano, Raquel Avelar, Angela Ellis, Brady Lusk, Abdallah Malik Naanaa, Edward Sisco, Jennifer W Sekowski. The use of lateral flow immunoassays for the detection of fentanyl in seized drug samples and postmortem urine.
Journal of forensic sciences.
2021 Mar; 66(2):758-765. doi:
10.1111/1556-4029.14631. [PMID: 33275295] - Sheng Feng, Theodore J Rutledge, Maureen Manzoni, Thuan Le, JoAnn Gardiner, Michael Milone, Leslie Shaw, Ping Wang. Performance of Two Fentanyl Immunoassays against a Liquid Chromatography-Tandem Mass Spectrometry Method.
Journal of analytical toxicology.
2021 Feb; 45(2):117-123. doi:
10.1093/jat/bkaa053. [PMID: 32435812] - Adrianna N Masterson, Sumon Hati, Greta Ren, Thakshila Liyanage, Nicholas E Manicke, John V Goodpaster, Rajesh Sardar. Enhancing Nonfouling and Sensitivity of Surface-Enhanced Raman Scattering Substrates for Potent Drug Analysis in Blood Plasma via Fabrication of a Flexible Plasmonic Patch.
Analytical chemistry.
2021 02; 93(4):2578-2588. doi:
10.1021/acs.analchem.0c04643. [PMID: 33432809]