droperidol (BioDeep_00000016614)

   


代谢物信息卡片


droperidol

化学式: C22H22FN3O2 (379.1695964)
中文名称: 氟哌利多
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1ccc2c(c1)nc(n2C3=CCN(CC3)CCCC(=O)c4ccc(cc4)F)O
InChI: InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C323 - Butyrophenone
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; INTERNAL_ID 1207
INTERNAL_ID 1207; CONFIDENCE standard compound
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3679
Droperidol is a butyrophenone-type Dopamine-2 receptor antagonist.

同义名列表

2 个代谢物同义名

droperidol; Dehydrobenzperidol



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Carl M Truesdale, Michael C Soulen, Timothy W I Clark, Jeffrey I Mondschein, Eric Wehrenberg-Klee, S Bruce Malkowicz, Alan J Wein, Thomas J Guzzo, S William Stavropoulos. Percutaneous computed tomography-guided renal mass radiofrequency ablation versus cryoablation: doses of sedation medication used. Journal of vascular and interventional radiology : JVIR. 2013 Mar; 24(3):347-50. doi: 10.1016/j.jvir.2012.11.022. [PMID: 23433410]
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  • Krzysztof Helewski, Grazyna Kowalczyk-Ziomek, Eugeniusz Czecior, Grzegorz Wyrobiec, Marzena Harabin-Slowinska, Malgorzata Juszko-Piekut, Bogumila Braczkowska, Jadwiga Josko. Protective effect of intermittent clamping of the portal triad in the rat liver on liver ischemia-reperfusion injury. Hepatitis monthly. 2011 Jun; 11(6):445-51. doi: ". [PMID: 22087176]
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  • Jean-Claude Alvarez, Beny Charbit, Stanislas Grassin-Delyle, Jean-Louis Demolis, Christian Funck-Brentano, Emuri Abe. Human plasma quantification of droperidol and ondansetron used in preventing postoperative nausea and vomiting with a LC/ESI/MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jan; 879(2):186-90. doi: 10.1016/j.jchromb.2010.12.001. [PMID: 21185793]
  • Johnique Billups, Cynthia Jones, Tanise L Jackson, Seth Y Ablordeppey, Shawn D Spencer. Simultaneous RP-HPLC-DAD quantification of bromocriptine, haloperidol and its diazepane structural analog in rat plasma with droperidol as internal standard for application to drug-interaction pharmacokinetics. Biomedical chromatography : BMC. 2010 Jul; 24(7):699-705. doi: 10.1002/bmc.1349. [PMID: 19908205]
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  • Yasuhiko Higashi, Miyuki Kitahara, Youichi Fujii. Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection. Biomedical chromatography : BMC. 2006 Feb; 20(2):166-72. doi: 10.1002/bmc.547. [PMID: 16034821]
  • Jian-guo Xia, Jian Peng, Hong Xiao, Jia Zhang, Jian-bin Sun. [Effect of intravenous patient-controlled intravenous analgesia with small dose of ketamine during shock stage on cytokine balance in patients with severe burn]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2006 Jan; 18(1):32-5. doi: NULL. [PMID: 16464383]
  • Shinji Nakamura, Tomoki Nishiyama, Kazuo Hanaoka. [Anesthesia for argon plasma coagulation therapy through the tracheostomy site]. Masui. The Japanese journal of anesthesiology. 2005 Nov; 54(11):1286-7. doi: NULL. [PMID: 16296370]
  • Karine Titier, Pierre-Olivier Girodet, Hélène Verdoux, Mathieu Molimard, Bernard Bégaud, Wilhelm Haverkamp, Malcolm Lader, Nicholas Moore. Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death. Drug safety. 2005; 28(1):35-51. doi: 10.2165/00002018-200528010-00003. [PMID: 15649104]
  • P Gimeno Fernández, J A Pérez Andújar, J Gómez Nieto, E Domínguez Nieto. [Rhabdomyolysis in transplantation patients]. Revista espanola de anestesiologia y reanimacion. 2003 Jun; 50(6):307-8. doi: NULL. [PMID: 12940222]
  • A González Gil, J C Illera, G Silván, M Illera. Effects of the anaesthetic/tranquillizer treatments on selected plasma biochemical parameters in NZW rabbits. Laboratory animals. 2003 Apr; 37(2):155-61. doi: 10.1258/00236770360563804. [PMID: 12689427]
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  • Gilles Rioufol, Sylvia Pietri, Marcel Culcasi, Joseph Loufoua, Patrick Staat, Calin Pop, Katy Drieu, Michel Ovize. Ginkgo biloba extract EGb 761 attenuates myocardial stunning in the pig heart. Basic research in cardiology. 2003 Feb; 98(1):59-68. doi: 10.1007/s00395-003-0380-4. [PMID: 12494270]
  • Yachiyo Tabuchi, Yoshihiro Takamitsu. [Perioperative management for nephrectomy using combined spinal-epidural anesthesia with sedation in a patient with cerebral palsy under maintenance hemodialysis]. Masui. The Japanese journal of anesthesiology. 2002 Nov; 51(11):1268-71. doi: NULL. [PMID: 12481458]
  • V V Bol'shakov, A V Sapozhkov, S V Denisova. [Effect of droperidol and tramadol combination on the hemostasis in rabbits]. Eksperimental'naia i klinicheskaia farmakologiia. 2002 Sep; 65(5):50-2. doi: NULL. [PMID: 12596516]
  • Taiki Shigeyama, Tadao Yanagidani. [Droperidol causes multifocal ventricular dysrhythmias]. Masui. The Japanese journal of anesthesiology. 2002 Jan; 51(1):53-5. doi: NULL. [PMID: 11840665]
  • G Colmenarejo, A Alvarez-Pedraglio, J L Lavandera. Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry. 2001 Dec; 44(25):4370-8. doi: 10.1021/jm010960b. [PMID: 11728183]
  • A González Gil, J C Illera, G Silván, M Illera. Plasma glucocorticoid concentrations after fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anaesthesia in New Zealand white rabbits. The Veterinary record. 2001 Jun; 148(25):784-6. doi: 10.1136/vr.148.25.784. [PMID: 11465268]
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  • J C Illera, A González Gil, G Silván, M Illera. The effects of different anaesthetic treatments on the adreno-cortical functions and glucose levels in NZW rabbits. Journal of physiology and biochemistry. 2000 Dec; 56(4):329-36. doi: 10.1007/bf03179801. [PMID: 11321527]
  • X Gao, C Jiang, H Yan. [Clinical observation on operation of cerebral speech area under combined acupuncture-drug anesthesia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2000 Oct; 20(10):731-2. doi: ". [PMID: 11938805]
  • B Drolet, S Zhang, D Deschênes, J Rail, S Nadeau, Z Zhou, C T January, J Turgeon. Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current. Journal of cardiovascular electrophysiology. 1999 Dec; 10(12):1597-604. doi: 10.1111/j.1540-8167.1999.tb00224.x. [PMID: 10636190]
  • A Kudoh, A Matsuki. Middle latency auditory evoked potentials during total intravenous anesthesia with droperidol, ketamine and fentanyl. Clinical EEG (electroencephalography). 1999 Apr; 30(2):79-83. doi: 10.1177/155005949903000210. [PMID: 10358788]
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