Simvastatin (BioDeep_00000016612)
natural product
代谢物信息卡片
2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
化学式: C25H38O5 (418.2719098)
中文名称: 辛伐他汀
谱图信息:
最多检出来源 Helianthus annuus(natural_products) 95.83%
分子结构信息
SMILES: C1[C@H](C=C2[C@]([C@@H]1OC(=O)C(CC)(C)C)([C@@H]([C@H](C=C2)C)CC[C@]3(OC(C[C@@H](C3)O)=O)[H])[H])C
InChI: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
描述信息
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AA - Hmg coa reductase inhibitors
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3144
CONFIDENCE standard compound; INTERNAL_ID 1128
同义名列表
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:9150
- KEGG: C07262
- KEGGdrug: D00434
- PubChem: 54454
- Metlin: METLIN2443
- DrugBank: DB00641
- ChEMBL: CHEMBL1064
- MeSH: Simvastatin
- CAS: 79902-63-9
- MoNA: CCMSLIB00000078292
- MoNA: CCMSLIB00000078291
- MoNA: CCMSLIB00000077126
- MoNA: CCMSLIB00000077125
- MoNA: EQ314406
- MoNA: EQ314405
- MoNA: EQ314404
- MoNA: EQ314403
- MoNA: EQ314402
- MoNA: EQ314401
- MoNA: AU112805
- MoNA: AU112804
- MoNA: AU112803
- MoNA: AU112802
- MoNA: AU112801
- RefMet: Simvastatin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Junna Tanaka, Hiroki Kuwajima, Ryuzaburo Yuki, Yuji Nakayama. Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases.
Cellular signalling.
2024 Jul; 119(?):111172. doi:
10.1016/j.cellsig.2024.111172. [PMID: 38604342] - Haofang Wan, Yihang Lu, Jiehong Yang, Haitong Wan, Li Yu, Ningji Fang, Yu He, Chang Li. Naoxintong capsule remodels gut microbiota and ameliorates early-stage atherosclerosis in apolipoprotein E-deficient mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155662. doi:
10.1016/j.phymed.2024.155662. [PMID: 38728917] - Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia. Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway.
BMC pulmonary medicine.
2024 May; 24(1):224. doi:
10.1186/s12890-024-03014-9. [PMID: 38720270] - Swen Bremer, Eva Weitkemper, Hanns Häberlein, Sebastian Franken. St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism.
Scientific reports.
2024 04; 14(1):9878. doi:
10.1038/s41598-024-60562-0. [PMID: 38684848] - Jihan K Zaki, Santiago G Lago, Benedetta Spadaro, Nitin Rustogi, Shiral S Gangadin, Jiri Benacek, Hemmo A Drexhage, Lot D de Witte, René S Kahn, Iris E C Sommer, Sabine Bahn, Jakub Tomasik. Exploring peripheral biomarkers of response to simvastatin supplementation in schizophrenia.
Schizophrenia research.
2024 Apr; 266(?):66-74. doi:
10.1016/j.schres.2024.02.011. [PMID: 38377869] - Xinyu Zhang, Wei Lin, Shuyue Lei, Siqi Zhang, Yujie Cheng, Xijing Chen, Yang Lu, Di Zhao, Yongjie Zhang, Chaorui Guo. The anti-hyperlipidemic effects of Poria cocos (Schw.) Wolf extract: Modulating cholesterol homeostasis in hepatocytes via PPARα pathway.
Journal of ethnopharmacology.
2024 Mar; 321(?):117532. doi:
10.1016/j.jep.2023.117532. [PMID: 38048892] - Marcin Mateusz Granat, Joanna Eifler-Zydel, Joanna Kolmas. Statins-Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042378. [PMID: 38397055] - Zhirong Ouyang, Muye Ma, Ziwen Zhang, Hongyu Wu, Yongxing Xue, Yuting Jian, Kai Yin, Shaokun Yu, Chunchang Zhao, Wei Guo, Xianfeng Gu. Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Journal of medicinal chemistry.
2024 Jan; 67(1):433-449. doi:
10.1021/acs.jmedchem.3c01634. [PMID: 38112492] - Kaushik Kuche, Vivek Yadav, M Dharshini, Rohan Ghadi, Dasharath Chaudhari, Tushar Date, Sanyog Jain. Synergistic anticancer therapy via ferroptosis using modified bovine serum albumin nanoparticles loaded with sorafenib and simvastatin.
International journal of biological macromolecules.
2023 Dec; 253(Pt 8):127254. doi:
10.1016/j.ijbiomac.2023.127254. [PMID: 37813219] - Bojana Petek, Henrike Häbel, Hong Xu, Marta Villa-Lopez, Irena Kalar, Minh Tuan Hoang, Silvia Maioli, Joana B Pereira, Shayan Mostafaei, Bengt Winblad, Milica Gregoric Kramberger, Maria Eriksdotter, Sara Garcia-Ptacek. Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study.
Alzheimer's research & therapy.
2023 12; 15(1):220. doi:
10.1186/s13195-023-01360-0. [PMID: 38115091] - Qinghai Meng, Ying Chao, Shurui Zhang, Xue Ding, Han Feng, Chenyan Zhang, Bowen Liu, Weijie Zhu, Yu Li, Qichun Zhang, Huangjin Tong, Lixing Wu, Huimin Bian. Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Molecular brain.
2023 Nov; 16(1):80. doi:
10.1186/s13041-023-01068-0. [PMID: 37986006] - J R Snyman, K R Snyman. A retrospective study: efficacy of an originator versus a generic formulation of simvastatin in patients who suffer from hyperlipidaemia.
Cardiovascular journal of Africa.
2023 Nov; 34(5):264-267. doi:
10.5830/cvja-2022-053. [PMID: 36479888] - Melika Kiani, Fatemeh Moraffah, Fatemeh Khonsari, Bahar Kharazian, Rassoul Dinarvand, Mohammad-Ali Shokrgozar, Fatemeh Atyabi. Co-delivery of simvastatin and microRNA-21 through liposome could accelerates the wound healing process.
Biomaterials advances.
2023 Nov; 154(?):213658. doi:
10.1016/j.bioadv.2023.213658. [PMID: 37866233] - Abdelrahman Y Sherif, Gamaleldin I Harisa, Ahmad A Shahba, Fahd A Nasr, Ehab I Taha, Ali S Alqahtani. Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach.
Drug development research.
2023 11; 84(7):1453-1467. doi:
10.1002/ddr.22097. [PMID: 37519092] - Song-Li Hao, Chun-Lan Zhang, Xiao-Yu Meng. Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
Medicine.
2023 Oct; 102(41):e35152. doi:
10.1097/md.0000000000035152. [PMID: 37832133] - Amanda Jurgelewicz, Rance Nault, Jack Harkema, Timothy R Zacharewski, John J LaPres. Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity.
Scientific reports.
2023 10; 13(1):16598. doi:
10.1038/s41598-023-42972-8. [PMID: 37789023] - Su-Wen Chen, Guo-Liang Yin, Chao-Yuan Song, De-Cheng Meng, Wen-Fei Yu, Xin Zhang, Ya-Nan Feng, Peng-Peng Liang, Feng-Xia Zhang. [Diosgenin alleviates NAFLD induced by a high-fat diet in rats via mTOR/SREBP-1c/HSP60/MCAD/SCAD signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Oct; 48(19):5304-5314. doi:
10.19540/j.cnki.cjcmm.20230601.705. [PMID: 38114120] - Chijun Hou, Xinyue Jiang, Wenjuan Sheng, Yuling Zhang, Qianbei Lin, Shihan Hong, Jiale Zhao, Ting Wang, Xiaohan Ye. Xinmaikang (XMK) tablets alleviate atherosclerosis by regulating the SREBP2-mediated NLRP3/ASC/Caspase-1 signaling pathway.
Journal of ethnopharmacology.
2023 Sep; 319(Pt 2):117240. doi:
10.1016/j.jep.2023.117240. [PMID: 37777030] - Wei Peng, Yufeng Qian, Xuchen Qi. Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin.
Environmental research.
2023 Sep; ?(?):117112. doi:
10.1016/j.envres.2023.117112. [PMID: 37717807] - Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Mónika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti. Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin.
Cell death & disease.
2023 08; 14(8):544. doi:
10.1038/s41419-023-06080-9. [PMID: 37612317] - Alaa Alnoor Alameen, Monerah R Alothman, Mona S Al Wahibi, Ejlal Mohamed Abdullah, Rehab Ali, Mohnad Abdalla, Sndos Z A Fattiny, Rasha Elsayim. Potential Effect of Baobab's Polyphenols as Antihyperlipidemic Agents: In Silico Study.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28166112. [PMID: 37630364] - Alberto E Muñoz, Florencia Pollarsky, Mónica Marino, Mariano Cartier, Carlos Míguez, Enrique G Rodger, Horacio Vázquez, Pablo Salgado, Daniel Álvarez, Gustavo Romero. Baseline Severity and Inflammation Would Influence the Effect of Simvastatin on Clinical Outcomes in Cirrhosis Patients.
Digestive diseases and sciences.
2023 08; 68(8):3442-3450. doi:
10.1007/s10620-023-07969-3. [PMID: 37213003] - Sudhakara Gujjala, Manjunatha Bangeppagari, Venkata Lakshmi Narasimha Prasad Devarakonda, Ramesh Bellamkonda, Ramu Bhadramraju, Srinivasan Kameswaran, Rajendran Ramaswamy, Saralakumari Desireddy. Pleiotropic effects of Salacia reticulata and Simvastatin on oxidative stress and insulin resistance in a rat model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Aug; 164(?):114960. doi:
10.1016/j.biopha.2023.114960. [PMID: 37290186] - Wei Yang, Shuang Wang, Yingying Zhao, Qianming Jiang, Juan J Loor, Yan Tian, Wenwen Fan, Ming Li, Bingbing Zhang, Jie Cao, Chuang Xu. Regulation of cholesterol metabolism during high fatty acid-induced lipid deposition in calf hepatocytes.
Journal of dairy science.
2023 Jul; ?(?):. doi:
10.3168/jds.2022-23136. [PMID: 37419743] - Yuan-Chii Gladys Lee, Fang-Ning Chou, Szu-Yu Tung, Hsiu-Chu Chou, Tsui-Ling Ko, Yang C Fann, Shu-Hui Juan. Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells.
International journal of molecular sciences.
2023 Jun; 24(11):. doi:
10.3390/ijms24119738. [PMID: 37298689] - Kensuke Kitsugi, Hidenao Noritake, Moe Matsumoto, Tomohiko Hanaoka, Masahiro Umemura, Maho Yamashita, Shingo Takatori, Jun Ito, Kazuyoshi Ohta, Takeshi Chida, Takafumi Suda, Kazuhito Kawata. Simvastatin inhibits hepatic stellate cells activation by regulating the ferroptosis signaling pathway.
Biochimica et biophysica acta. Molecular basis of disease.
2023 May; ?(?):166750. doi:
10.1016/j.bbadis.2023.166750. [PMID: 37268254] - Grazyna Lietzau, Waldemar Sienkiewicz, Zbigniew Karwacki, Jerzy Dziewiątkowski, Jerzy Kaleczyc, Przemysław Kowiański. The Effect of Simvastatin on the Dynamics of NF-κB-Regulated Neurodegenerative and Neuroprotective Processes in the Acute Phase of Ischemic Stroke.
Molecular neurobiology.
2023 May; ?(?):. doi:
10.1007/s12035-023-03371-2. [PMID: 37204689] - Khaled Mahmoud, Mahmoud Teaima, Yasmeen Attia, Mohamed El-Nabarawi, Shady Swidan. Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal transition in hepatocellular carcinoma: role of PTEN/AKT signaling.
Expert opinion on drug delivery.
2023 May; ?(?):. doi:
10.1080/17425247.2023.2216451. [PMID: 37208857] - So Min Lee, You Mee Ahn, Seong-Hwan Park, Sarah Shin, Jeeyoun Jung. Reshaping the gut microbiome and bile acid composition by Gyejibongnyeong-hwan ameliorates western diet-induced dyslipidemia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 May; 163(?):114826. doi:
10.1016/j.biopha.2023.114826. [PMID: 37148862] - Megan M Sperry, Tomiko T Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E Carlson, Ronald J Wong, Idit Kosti, Brian L Le, James Logue, Holly Hammond, Matthew Frieman, David K Stevenson, Donald E Ingber, Marina Sirota, Richard Novak. Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.
PLoS computational biology.
2023 05; 19(5):e1011050. doi:
10.1371/journal.pcbi.1011050. [PMID: 37146076] - Routong Yang, Junhui Wu, Huan Yu, Siyue Wang, Hongbo Chen, Mengying Wang, Xueying Qin, Tao Wu, Yiqun Wu, Yonghua Hu. Is statin therapy after ischaemic stroke associated with increased intracerebral hemorrhage? The association may be dependent on intensity of statin therapy.
International journal of stroke : official journal of the International Stroke Society.
2023 Apr; ?(?):17474930231172623. doi:
10.1177/17474930231172623. [PMID: 37070670] - Evelyn Andrades, Agustí Toll, Gustavo Deza, Sonia Segura, Ramón Gimeno, Guadalupe Espadas, Eduard Sabidó, Noemí Haro, Óscar J Pozo, Marta Bódalo, Paloma Torres, Ramon M Pujol, Inmaculada Hernández-Muñoz. Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway.
Life science alliance.
2023 Apr; 6(4):. doi:
10.26508/lsa.202201692. [PMID: 36732018] - Xuehan Qiao, Zhangmin Hu, Fen Xiong, Yufei Yang, Chen Peng, Deqiang Wang, Xiaoqin Li. Lipid metabolism reprogramming in tumor-associated macrophages and implications for therapy.
Lipids in health and disease.
2023 Mar; 22(1):45. doi:
10.1186/s12944-023-01807-1. [PMID: 37004014] - Sana Khan, Noorul Hasan, Saba Khan, Mymoona Akhtar, Mohammad Akhtar, Abul Kalam Najmi. Exploring effects of Simvastatin on coagulation mediators to alleviate the advancement of high cholesterol diet triggered neurodegeneration.
Journal of biochemical and molecular toxicology.
2023 Mar; ?(?):e23342. doi:
10.1002/jbt.23342. [PMID: 36992618] - Youngjoo Lee, Soo-Hyun Lee, Geon Kook Lee, Eun Jin Lim, Ji-Youn Han. A randomized Phase II Study of Irinotecan Plus Cisplatin with or without Simvastatin in ever Smokers with Extended Disease Small Cell Lung Cancer.
Cancer research and treatment.
2023 Mar; ?(?):. doi:
10.4143/crt.2023.283. [PMID: 36960628] - Ruxandra Busuioc, Gabriel Ștefan, Simona Stancu, Adrian Zugravu, Gabriel Mircescu. Nephrotic Syndrome and Statin Therapy: An Outcome Analysis.
Medicina (Kaunas, Lithuania).
2023 Mar; 59(3):. doi:
10.3390/medicina59030512. [PMID: 36984513] - Shuwen Xu, Zhiyong Wu, Gaofeng Cai, Yue Zhang, Song Peng, Lina Jiao, Zhenguang Liu, Yang Yang, Deyun Wang. Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in mice.
Vaccine.
2023 03; 41(10):1684-1693. doi:
10.1016/j.vaccine.2023.01.069. [PMID: 36754767] - Tarique Anwar, James Sinnett-Smith, Yi-Ping Jin, Elaine F Reed, Enrique Rozengurt. Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA Class I Molecules in Endothelial Cells: Role of YAP Multisite Phosphorylation.
Journal of immunology (Baltimore, Md. : 1950).
2023 Mar; ?(?):. doi:
10.4049/jimmunol.2200568. [PMID: 36881871] - Walter Oliver, Robert P Giugliano. Benefit of Combination Ezetimibe/Simvastatin Among High-Risk Populations: Lessons from the IMPROVE-IT Trial.
Current atherosclerosis reports.
2023 03; 25(3):85-93. doi:
10.1007/s11883-023-01084-4. [PMID: 36763180] - A Rašković, N Martić, D Zaklan, N Duborija-Kovačević, M Vujčić, B Andrejić-Višnjić, I Čapo, R Mijović, M Krga, N Pavlović, D Prodanović, P Arsenović, O Horvat. Antihyperlipidemic potential of dietary supplementation with carnosine in high-fat diet-fed rats.
European review for medical and pharmacological sciences.
2023 02; 27(3):1083-1094. doi:
10.26355/eurrev_202302_31211. [PMID: 36808356] - M Ishrat Husain, Imran B Chaudhry, Ameer B Khoso, Tayyeba Kiran, Nawaz Khan, Farooq Ahmad, John Hodsoll, M Omair Husain, Haider A Naqvi, Asad T Nizami, Nasim Chaudhry, Hazrat A Khan, Fareed Minhas, Jeffrey H Meyer, Moin A Ansari, Benoit H Mulsant, Nusrat Husain, Allan H Young. Effect of Adjunctive Simvastatin on Depressive Symptoms Among Adults With Treatment-Resistant Depression: A Randomized Clinical Trial.
JAMA network open.
2023 02; 6(2):e230147. doi:
10.1001/jamanetworkopen.2023.0147. [PMID: 36808239] - Fatemeh Karami, Saeed Saber-Samandari. Synthesis and characterization of a novel hydrogel based on carboxymethyl chitosan/sodium alginate with the ability to release simvastatin for chronic wound healing.
Biomedical materials (Bristol, England).
2023 01; 18(2):. doi:
10.1088/1748-605x/acb0a3. [PMID: 36603225] - Darko Ciric, Tamara Kravic-Stevovic, Vladimir Bumbasirevic, Sasa Petricevic, Sofija Jovanovic, Vladimir Trajkovic, Tamara Martinovic. Effects of metformin and simvastatin treatment on ultrastructural features of liver macrophages in HFD mice.
Ultrastructural pathology.
2023 Jan; 47(1):1-11. doi:
10.1080/01913123.2022.2156639. [PMID: 36520527] - Xinya Huang, Hai Gao, Wenli Zhang, Jianping Liu, Qiqi Zhang. Regulating the Size of Simvastatin-loaded Discoidal Reconstituted Highdensity Lipoprotein: Preparation, Characterization, and Investigation of Cellular Cholesterol Efflux.
Current drug delivery.
2023; 20(5):629-641. doi:
10.2174/1567201819666220414120901. [PMID: 35430991] - Ezgi Şaman, Martina Cebova, Andrej Barta, Martina Koneracka, Vlasta Zavisova, Anita Eckstein-Andicsova, Martin Danko, Jaroslav Mosnacek, Olga Pechanova. Combined Therapy with Simvastatin- and Coenzyme-Q10-Loaded Nanoparticles Upregulates the Akt-eNOS Pathway in Experimental Metabolic Syndrome.
International journal of molecular sciences.
2022 Dec; 24(1):. doi:
10.3390/ijms24010276. [PMID: 36613727] - Janani Balraj, Thandeeswaran Murugesan, Anand Raj Dhanapal, Vidhya Kalieswaran, Karunyadevi Jairaman, Govindaraju Archunan, Angayarkanni Jayaraman. Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity.
Biotechnology and applied biochemistry.
2022 Dec; ?(?):. doi:
10.1002/bab.2429. [PMID: 36524308] - Rachmawati Rachmawati, Rinaldi Idroes, Eko Suhartono, Nur Balqis Maulydia, Darusman Darusman. In Silico and In Vitro Analysis of Tacca Tubers (Tacca leontopetaloides) from Banyak Island, Aceh Singkil Regency, Indonesia, as Antihypercholesterolemia Agents.
Molecules (Basel, Switzerland).
2022 Dec; 27(23):. doi:
10.3390/molecules27238605. [PMID: 36500698] - Shafaq, Tasleem Akhtar, Hafiz Muhammad Ishaq, Muhammad Shahzad. Pharmacological effects of Artocarpus lakoocha methanol extract on inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway.
Pharmaceutical biology.
2022 Dec; 60(1):840-845. doi:
10.1080/13880209.2022.2063346. [PMID: 35588395] - Engi Seif E Shaker, Sherihan H Allam, Maaly M Mabrouk, Nashwa M Elgharbawy, Shady Fikry Abdel Salaam. Simvastatin and non-segmental vitiligo: A new potential treatment option?.
Dermatologic therapy.
2022 12; 35(12):e15969. doi:
10.1111/dth.15969. [PMID: 36346030] - Zoe White, Zeren Sun, Elodie Sauge, Dan Cox, Graham Donen, Dmitri Pechkovsky, Volker Straub, Gordon A Francis, Pascal Bernatchez. Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice.
Skeletal muscle.
2022 11; 12(1):25. doi:
10.1186/s13395-022-00308-6. [PMID: 36447272] - Mandana AmeliMojarad, Melika AmeliMojarad, Alireza Pourmadian. Simvastatin Therapy Increased miR-150-5p
Expression in the Patients with Type 2 Diabetes and COVID-19.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2022 Nov; 56(6):685-691. doi:
10.33594/000000590. [PMID: 36426391] - Yang-Xi Hu, Hong-Min You, Rong-Fang Zhu, Yu-Lai Liang, Fang-Fang Li, Yong-Wen Qin, Xian-Xian Zhao, Chun Liang, Qing Jing. Establishment of a lipid metabolism disorder model in ApoEb mutant zebrafish.
Atherosclerosis.
2022 11; 361(?):18-29. doi:
10.1016/j.atherosclerosis.2022.10.008. [PMID: 36306655] - Y J Sheng, Q Q Jiang, L Liu, S Cheng, H R Li, S W Li, S L Huang, Y D Li, J Q Yuan, Y F Ping, J Dong. [Characteristics and regulatory mechanisms of lipid metabolism remodeling after malignant transformation of glioma-associated macrophages].
Zhonghua yi xue za zhi.
2022 Oct; 102(39):3134-3142. doi:
10.3760/cma.j.cn112137-20220127-00203. [PMID: 36274598] - Qiqi Tang, Beibei Liang, Lisha Zhang, Xuhui Li, Hengyu Li, Wei Jing, Yingjie Jiang, Felix Zhou, Jian Zhang, Yanchun Meng, Xinhua Yang, Hao Yang, Gang Huang, Jian Zhao. Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
Scientific reports.
2022 10; 12(1):17350. doi:
10.1038/s41598-022-22410-x. [PMID: 36253427] - Aleksandra Bartkowiak, Ewa Nazaruk, Ewa Gajda, Marlena Godlewska, Damian Gaweł, Elżbieta Jabłonowska, Renata Bilewicz. Simvastatin Coadministration Modulates the Electrostatically Driven Incorporation of Doxorubicin into Model Lipid and Cell Membranes.
ACS biomaterials science & engineering.
2022 Oct; 8(10):4354-4364. doi:
10.1021/acsbiomaterials.2c00724. [PMID: 36173110] - Chutimon Termkwancharoen, Wachirawadee Malakul, Amnat Phetrungnapha, Sakara Tunsophon. Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats.
Nutrients.
2022 Oct; 14(19):. doi:
10.3390/nu14194120. [PMID: 36235772] - José Guedes da Silva Júnior, Hallysson Douglas Andrade de Araújo, Ismael Gomes da Rocha, Jacinto Costa da Silva Neto, Ronaldo Nascimento Oliveira, Shalom Pôrto de Oliveira Assis, Vera Lúcia de Menezes Lima. Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance.
Chemistry & biodiversity.
2022 Oct; 19(10):e202200119. doi:
10.1002/cbdv.202200119. [PMID: 36094678] - Mohamed S Othman, Azza M Khaled, Ghada M Aleid, Mohamed A Fareid, Reda A Hameed, Mohamed S Abdelfattah, Doaa Ezz Aldin, Ahmed E Abdel Moneim. Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats.
Environmental science and pollution research international.
2022 Oct; 29(49):75043-75056. doi:
10.1007/s11356-022-21092-2. [PMID: 35648345] - Ying Han, Yuanyuan Ma, Junwei Tong, Jingpu Zhang, Changqin Hu. Systems assessment of statins hazard: Integrating in silico prediction, developmental toxicity profile and transcriptomics in zebrafish.
Ecotoxicology and environmental safety.
2022 Sep; 243(?):113981. doi:
10.1016/j.ecoenv.2022.113981. [PMID: 36029576] - Jianbo Zhang, Na Hao, Wei Li, Qianwei Chen, Zhi Chen, Hua Feng, Yao Wu, Xia Shi. Simvastatin upregulates lipoxin A4 and accelerates neuroinflammation resolution after intracerebral hemorrhage.
Current neurovascular research.
2022 Sep; ?(?):. doi:
10.2174/1567202619666220913124627. [PMID: 36100985] - Che-Wei Lin, Chih-Yun Lee, Sung-Yen Lin, Lin Kang, Yin-Chih Fu, Chung-Hwan Chen, Chih-Kuang Wang. Bone-Targeting Nanoparticles of a Dendritic (Aspartic acid)3-Functionalized PEG-PLGA Biopolymer Encapsulating Simvastatin for the Treatment of Osteoporosis in Rat Models.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810530. [PMID: 36142447] - Satyawan B Jadhav, Ryan L Crass, Sunny Chapel, Michael Kerschnitzki, William J Sasiela, Maurice G Emery, Benny M Amore, P Hugh R Barrett, Gerald F Watts, Alberico L Catapano. Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
European heart journal. Cardiovascular pharmacotherapy.
2022 Sep; 8(6):578-586. doi:
10.1093/ehjcvp/pvab064. [PMID: 34448822] - Emma Rose McGlone, T Bertie Ansell, Cecilia Dunsterville, Wanling Song, David Carling, Alejandra Tomas, Stephen R Bloom, Mark S P Sansom, Tricia Tan, Ben Jones. Hepatocyte cholesterol content modulates glucagon receptor signalling.
Molecular metabolism.
2022 09; 63(?):101530. doi:
10.1016/j.molmet.2022.101530. [PMID: 35718339] - Sadia Afrin, Malak El Sabeh, Mariko Miyashita-Ishiwata, Natasha Charewycz, Bhuchitra Singh, Mostafa A Borahay. Simvastatin reduces plasma membrane caveolae and caveolin-1 in uterine leiomyomas.
Life sciences.
2022 Sep; 304(?):120708. doi:
10.1016/j.lfs.2022.120708. [PMID: 35705139] - Sanaa A Ahmed, Mahmoud H Abd El Reheem, Dalia A Elbahy. l-Carnitine ameliorates the osteoporotic changes and protects against simvastatin induced myotoxicity and hepatotoxicity in glucocorticoid-induced osteoporosis in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Aug; 152(?):113221. doi:
10.1016/j.biopha.2022.113221. [PMID: 35671582] - Nils Tore Vethe, Einar Husebye, Anders M Andersen, Stein Bergan, Oscar Kristiansen, Morten W Fagerland, John Munkhaugen. Monitoring Simvastatin Adherence in Patients With Coronary Heart Disease: A Proof-of-Concept Study Based on Pharmacokinetic Measurements in Blood Plasma.
Therapeutic drug monitoring.
2022 Aug; 44(4):558-567. doi:
10.1097/ftd.0000000000000992. [PMID: 35482468] - Tsung-Hui Wu, I-Te Lee, Low-Tone Ho, Wayne H-H Sheu, Chii-Min Hwu. Combined lipid goal attainment in patients with type 2 diabetes and dyslipidemia: A head-to-head comparative trial of statins.
Journal of the Chinese Medical Association : JCMA.
2022 08; 85(8):831-838. doi:
10.1097/jcma.0000000000000765. [PMID: 35727095] - Trang Thi Nguyen, Heejin Kim, Tran Xuan Ngoc Huy, Wongi Min, Hujang Lee, Alisha Wehdnesday Bernardo Reyes, Johnhwa Lee, Suk Kim. Simvastatin Inhibits Brucella abortus Invasion into RAW 264.7 Cells through Suppression of the Mevalonate Pathway and Promotes Host Immunity during Infection in a Mouse Model.
International journal of molecular sciences.
2022 Jul; 23(15):. doi:
10.3390/ijms23158337. [PMID: 35955474] - Hye-Lin Kim, You Mee Ahn, So Min Lee, Chang-Seob Seo, Seong-Hwan Park, Ok-Sun Bang, Jeeyoun Jung. Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice.
Nutrients.
2022 Jul; 14(14):. doi:
10.3390/nu14142929. [PMID: 35889886] - Mengran Wang, Haowei Li, Jiaxin Tang, Yue Xi, Shiyi Chen, Ming Liu. Effect of simvastatin on osteogenesis of the extremity bones in aging rats.
Connective tissue research.
2022 Jul; ?(?):1-11. doi:
10.1080/03008207.2022.2094790. [PMID: 35816110] - João Pedro Ferreira, Francisco Vasques-Nóvoa, Diana Ferrão, Francisca Saraiva, Inês Falcão-Pires, João Sérgio Neves, Abhinav Sharma, Patrick Rossignol, Faiez Zannad, Adelino Leite-Moreira. Fenofibrate and Heart Failure Outcomes in Patients With Type 2 Diabetes: Analysis From ACCORD.
Diabetes care.
2022 07; 45(7):1584-1591. doi:
10.2337/dc21-1977. [PMID: 35320363] - Narendra Kumar Pandey, Sachin Kumar Singh, Bimlesh Kumar, Monica Gulati, Sukriti Vishwas, Rubiya Khursheed, Harish Dureja, Dinesh Kumar Chellappan, Niraj Kumar Jha, Ankur Sharma, Saurabh Kumar Jha, Piyush Kumar Gupta, Saurabh Gupta, Gaurav Gupta, Parteek Prasher, Kamal Dua. Expanding arsenal against diabetes mellitus through nanoformulations loaded with glimepiride and simvastatin: A comparative study.
Environmental science and pollution research international.
2022 Jul; 29(34):51976-51988. doi:
10.1007/s11356-022-19371-z. [PMID: 35254621] - Sijia Liu, Jiawei Lin, Rui Ding, Xiangping Nie. Simvastatin as an emerging pollutant on non-target aquatic invertebrates: effects on antioxidant-related genes in Daphnia magna.
Environmental science and pollution research international.
2022 Jul; 29(34):52248-52262. doi:
10.1007/s11356-022-19466-7. [PMID: 35258724] - Hetong Li, Yu Gou, Faming Tian, Qiangqiang Lian, Yunpeng Hu, Liu Zhang. The combined anti-osteoporotic effects of simvastatin and exercise in ovariectomized mice fed a high-fat diet.
Experimental gerontology.
2022 07; 164(?):111794. doi:
10.1016/j.exger.2022.111794. [PMID: 35421557] - Yi Ming Gong, Xing Wang, Song Liu, Xue Chun Hu, Yan Xu, Tao Huang. Simvastatin inhibits prostatic hyperplasia in rats with metabolic syndrome.
International urology and nephrology.
2022 Jun; ?(?):. doi:
10.1007/s11255-022-03227-z. [PMID: 35691993] - Ferran Trias, Xavier Pintó, Emili Corbella, Manuel Suárez-Tembra, Antonio Ruíz-García, José Luis Díaz-Díaz, Elena Sánchez-Ruíz-Granado, Itziar Sarasa, Raul Martínez-Porqueras, Maria Angeles Rodríguez-Sánchez, Xavier Corbella. Differences in the diabetogenic effect of statins in patients with prediabetes. The PRELIPID study.
Medicina clinica.
2022 06; 158(11):531-539. doi:
10.1016/j.medcli.2021.06.018. [PMID: 34517987] - Andrew James Boyle, Peter Ferris, Ian Bradbury, John Conlon, Manu Shankar-Hari, Angela J Rogers, Cecilia M O'Kane, Daniel F McAuley. Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial.
Critical care (London, England).
2022 06; 26(1):164. doi:
10.1186/s13054-022-04025-w. [PMID: 35672834] - Valerie J Page, Leiv Otto Watne, Amanda Heslegrave, Allan Clark, Daniel F McAuley, Robert D Sanders, Henrik Zetterberg. Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients.
EBioMedicine.
2022 Jun; 80(?):104043. doi:
10.1016/j.ebiom.2022.104043. [PMID: 35533500] - Andrzej Teisseyre, Mateusz Chmielarz, Anna Uryga, Kamila Środa-Pomianek, Anna Palko-Łabuz. Co-Application of Statin and Flavonoids as an Effective Strategy to Reduce the Activity of Voltage-Gated Potassium Channels Kv1.3 and Induce Apoptosis in Human Leukemic T Cell Line Jurkat.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103227. [PMID: 35630703] - Jianhua He, Xiaoju Zhou, Fengfei Xu, Hongliang He, Shuangyan Ma, Xinyue Liu, Mengyuan Zhang, Wenli Zhang, Jianping Liu. Anchoring β-CD on simvastatin-loaded rHDL for selective cholesterol crystals dissolution and enhanced anti-inflammatory effects in macrophage/foam cells.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2022 May; 174(?):144-154. doi:
10.1016/j.ejpb.2022.04.005. [PMID: 35447349] - Luis Ramudo-Cela, Sara Santana-Martínez, Maite García-Ramos, Mariano Bergamino, Diego García-Giustiniani, Paula Vélez-Vieitez, Jose Luis Hernández-Hernández, Carmen García-Ibarbia, Pablo González-Bustos, Patricia Ruíz-Martín, Jaime González-Lozano, Luis Santomé-Collazo, Andrea Grana-Fernandez, Pablo Cabaleiro-Cerviño, Martín Ortíz, Lorenzo Monserrat-Iglesias. Combining familial hypercholesterolemia and statin genetic studies as a strategy for the implementation of pharmacogenomics. A multidisciplinary approach.
The pharmacogenomics journal.
2022 05; 22(3):180-187. doi:
10.1038/s41397-022-00274-8. [PMID: 35361995] - Andrew R English, Bodhayan Prasad, Declan H McGuigan, Geraldine Horigan, Maurice O'Kane, Anthony J Bjourson, Priyank Shukla, Catriona Kelly, Paula L McClean. Simvastatin is associated with superior lipid and glycaemic control to atorvastatin and reduced levels of incident Type 2 diabetes, in men and women, in the UK Biobank.
Endocrinology, diabetes & metabolism.
2022 05; 5(3):e00326. doi:
10.1002/edm2.326. [PMID: 35243827] - Elisa Pose, Elsa Solà, Juan J Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit, Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T Ma, Marta Carol, Manuel Morales-Ruiz, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G Abraldes, Patrick S Kamath, Mark M Davis, Pere Ginès. Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
Hepatology communications.
2022 05; 6(5):1100-1112. doi:
10.1002/hep4.1881. [PMID: 34964311] - Lei Tian, Rongmei Liu, Zhiwei Zhou, Xiaofang Xu, Su Feng, Ariel Kushmaro, Robert S Marks, Dan Wang, Qun Sun. Probiotic Characteristics of Lactiplantibacillus Plantarum N-1 and Its Cholesterol-Lowering Effect in Hypercholesterolemic Rats.
Probiotics and antimicrobial proteins.
2022 04; 14(2):337-348. doi:
10.1007/s12602-021-09886-1. [PMID: 35064922] - Dorien Groenendaal-van de Meent, Martin den Adel, Virginie Kerbusch, Jan van Dijk, Tomohisa Shibata, Kota Kato, Marloes Schaddelee. Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open-Label, 1-Sequence, Crossover Studies.
Clinical pharmacology in drug development.
2022 04; 11(4):486-501. doi:
10.1002/cpdd.1076. [PMID: 35182045] - Elisenda Climent, Ana M Bea, David Benaiges, Ángel Brea-Hernando, Xavier Pintó, Manuel Suárez-Tembra, Verónica Perea, Núria Plana, Francisco Blanco-Vaca, Juan Pedro-Botet. LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry.
Cardiovascular drugs and therapy.
2022 04; 36(2):301-308. doi:
10.1007/s10557-020-07137-z. [PMID: 33555511] - Ivana Semova, Amy E Levenson, Joanna Krawczyk, Kevin Bullock, Mary E Gearing, Alisha V Ling, Kathryn A Williams, Ji Miao, Stuart S Adamson, Dong-Ju Shin, Satyapal Chahar, Mark J Graham, Rosanne M Crooke, Lee R Hagey, David Vicent, Sarah D de Ferranti, Srividya Kidambi, Clary B Clish, Sudha B Biddinger. Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids.
Circulation.
2022 03; 145(13):969-982. doi:
10.1161/circulationaha.120.045373. [PMID: 35193378] - Franciele Aline Bruinsmann, Aline de Cristo Soares Alves, Amanda de Fraga Dias, Luiz Fernando Lopes Silva, Fernanda Visioli, Adriana Raffin Pohlmann, Fabrício Figueiró, Fabio Sonvico, Silvia Stanisçuaski Guterres. Nose-to-brain delivery of simvastatin mediated by chitosan-coated lipid-core nanocapsules allows for the treatment of glioblastoma in vivo.
International journal of pharmaceutics.
2022 Mar; 616(?):121563. doi:
10.1016/j.ijpharm.2022.121563. [PMID: 35151819] - Wencui Yin, Reem I Al-Wabli, Mohamed W Attwa, A F M Motiur Rahman, Adnan A Kadi. Detection and characterization of simvastatin and its metabolites in rat tissues and biological fluids using MALDI high resolution mass spectrometry approach.
Scientific reports.
2022 03; 12(1):4757. doi:
10.1038/s41598-022-08804-x. [PMID: 35306510] - Jing Wei, Yuhang Huan, Ziqi Heng, Chenyang Zhao, Lulu Jia, Yuncui Yu, Youhe Gao. Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury.
Journal of proteomics.
2022 03; 254(?):104477. doi:
10.1016/j.jprot.2021.104477. [PMID: 34990819] - Siruo Zhang, Lu Yuan, Huan Li, Lei Han, Wanghui Jing, Xiaokang Wu, Shakir Ullah, Ruina Liu, Yonghong Wu, Jiru Xu. The Novel Interplay between Commensal Gut Bacteria and Metabolites in Diet-Induced Hyperlipidemic Rats Treated with Simvastatin.
Journal of proteome research.
2022 03; 21(3):808-821. doi:
10.1021/acs.jproteome.1c00252. [PMID: 34365791] - Thomas E Williams, Katherine P Holdsworth, Jennifer M Nicholas, Arman Eshaghi, Theodora Katsanouli, Henrietta Wellington, Amanda Heslegrave, Henrik Zetterberg, Chris Frost, Jeremy Chataway. Assessing Neurofilaments as Biomarkers of Neuroprotection in Progressive Multiple Sclerosis: From the MS-STAT Randomized Controlled Trial.
Neurology(R) neuroimmunology & neuroinflammation.
2022 03; 9(2):. doi:
10.1212/nxi.0000000000001130. [PMID: 35031587] - Zhen Zhou, Andrea J Curtis, Michael E Ernst, Joanne Ryan, Sophia Zoungas, Rory Wolfe, John J McNeil, Anne M Murray, Christopher M Reid, Enayet K Chowdhury, Robyn L Woods, Andrew M Tonkin, Mark R Nelson. Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults.
European journal of clinical pharmacology.
2022 Mar; 78(3):467-476. doi:
10.1007/s00228-021-03239-1. [PMID: 34698889] - Yu Zhang, Jian He, Xiao Tang, Zunjian Zhang, Yuan Tian. A validated LC-MS/MS method for simultaneous quantification of simvastatin and simvastatin acid in beagle plasma: Application to an absolute bioavailability study.
Biomedical chromatography : BMC.
2022 Mar; 36(3):e5290. doi:
10.1002/bmc.5290. [PMID: 34854096] - Mitja Pohlen, Jurij Aguiar Zdovc, Jurij Trontelj, Janez Mravljak, Mirjam Gosenca Matjaž, Iztok Grabnar, Tomaž Snoj, Rok Dreu. Relative bioavailability enhancement of simvastatin via dry emulsion systems: Comparison of spray drying and fluid bed layering technology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2022 Mar; 172(?):228-239. doi:
10.1016/j.ejpb.2021.12.004. [PMID: 34942336] - Eunjin Bae, Mi-Yeon Yu, Jong-Joo Moon, Ji-Eun Kim, Saram Lee, Sang-Woong Han, Dong-Jun Park, Yon-Su Kim, Seung-Hee Yang. Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy.
Cells.
2022 02; 11(5):. doi:
10.3390/cells11050762. [PMID: 35269384] - Evelyn Nunes Goulart da Silva Pereira, Beatriz Peres de Araujo, Karine Lino Rodrigues, Raquel Rangel Silvares, Carolina Souza Machado Martins, Edgar Eduardo Ilaquita Flores, Caroline Fernandes-Santos, Anissa Daliry. Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress.
Nutrients.
2022 Feb; 14(3):. doi:
10.3390/nu14030716. [PMID: 35277075] - Anja Birk Kuhlman, Lise Bluhme Mikkelsen, Signe Regnersgaard, Sophie Heinrichsen, Frederikke Hyldahl Nielsen, Jacob Frandsen, Patrick Orlando, Sonia Silvestri, Steen Larsen, Jørn Wulff Helge, Flemming Dela. The effect of 8 weeks of physical training on muscle performance and maximal fat oxidation rates in patients treated with simvastatin and coenzyme Q10 supplementation.
The Journal of physiology.
2022 02; 600(3):569-581. doi:
10.1113/jp281475. [PMID: 34891216] - Feng Zhang, Hong-Xin Li, Tian-Tian Zhang, Yuan Xiong, Hao-Nan Wang, Zhen-Hui Lu, Lei Xiong, Yu-Qi He, Guang-Bo Ge. Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans.
Chemico-biological interactions.
2022 Jan; 351(?):109744. doi:
10.1016/j.cbi.2021.109744. [PMID: 34774545]