clonazepam (BioDeep_00000016599)
代谢物信息卡片
clonazepam
化学式: C15H10ClN3O3 (315.041066)
中文名称: 氯安定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
InChI: InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
描述信息
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AE - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
1 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3756
- KEGG: C06919
- KEGGdrug: D00280
- PubChem: 2802
- Metlin: METLIN1883
- DrugBank: DB01068
- ChEMBL: CHEMBL452
- MeSH: Clonazepam
- CAS: 106955-87-7
- CAS: 1622-61-3
- MoNA: WA002954
- MoNA: WA002953
- MoNA: WA002952
- MoNA: WA002951
- MoNA: WA002950
- MoNA: WA002949
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wei Zhao, Jie Han, Dingbo Tao, Hongliang Zheng. Cerebrotendinous xanthomatosis with tremor as the main manifestation: A case report.
Medicine.
2024 Apr; 103(17):e37976. doi:
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Environmental science and pollution research international.
2023 Apr; 30(20):58156-58168. doi:
10.1007/s11356-023-26669-z. [PMID: 36973629] - Jodi L Nelson, Gregory M Blume, Saurabh K Bansal, Jacqueline R Kaufman, Florence R Woods, Xiaojun Zhang, Jorge C Kattah. Postinfectious SARS-CoV-2 Opsoclonus-Myoclonus-Ataxia Syndrome.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.
2022 06; 42(2):251-255. doi:
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British journal of clinical pharmacology.
2022 05; 88(5):2236-2245. doi:
10.1111/bcp.15152. [PMID: 34811788] - Xiaomeng Zhou, Liang Fang, Xuefei Tong, Ying Xu, Xue Wu. Clinical efficacy of clonazepam in the treatment of status epilepticus.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):891-895. doi:
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Neurology India.
2022 Jan; 70(1):312-314. doi:
10.4103/0028-3886.338670. [PMID: 35263902] - Youjun Yang, Baojia Wang, Zhanqion Zhong, Hanbin Chen, Weijun Ding, Maggie Pui Man Hoi. Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission.
Biochemical pharmacology.
2021 10; 192(?):114711. doi:
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Revista de neurologia.
2021 09; 73(S01):S1-S8. doi:
10.33588/rn.73s01.2021250. [PMID: 34486101] - Behrouz Seyfinejad, Sibel A Ozkan, Abolghasem Jouyban. Ultrasound-assisted electromembrane extraction of clonazepam from plasma and determination using capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Sep; 1181(?):122928. doi:
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Drug development and industrial pharmacy.
2019 Dec; 45(12):1982-1987. doi:
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2019 Oct; 103(?):109754. doi:
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2019 Jun; 43(5):399-405. doi:
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Materials science & engineering. C, Materials for biological applications.
2013 Jan; 33(1):189-95. doi:
10.1016/j.msec.2012.08.029. [PMID: 25428061] - Marta Andres-Mach, Dorota Zolkowska, Beata Barcicka-Klosowska, Agnieszka Haratym-Maj, Magdalena Florek-Luszczki, Jarogniew J Luszczki. Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Dec; 39(2):301-9. doi:
10.1016/j.pnpbp.2012.07.001. [PMID: 22789660] - Mai Shibata, Sachiyo Hashi, Haruka Nakanishi, Satohiro Masuda, Toshiya Katsura, Ikuko Yano. Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring.
Biomedical chromatography : BMC.
2012 Dec; 26(12):1519-28. doi:
10.1002/bmc.2726. [PMID: 22383262] - L W Storhaug, A Enger, K Hjelmeland, E L Øiestad, V Vindenes. Prolonged excretion of 7-aminoclonazepam in urine after repeated ingestion of clonazepam: a case report.
Forensic science international.
2012 Oct; 222(1-3):e33-5. doi:
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L'Encephale.
2012 Sep; 38(4):351-5. doi:
10.1016/j.encep.2011.07.002. [PMID: 22980477] - Charles Mikel, Amadeo J Pesce, Murray Rosenthal, Cameron West. Therapeutic monitoring of benzodiazepines in the management of pain: current limitations of point of care immunoassays suggest testing by mass spectrometry to assure accuracy and improve patient safety.
Clinica chimica acta; international journal of clinical chemistry.
2012 Aug; 413(15-16):1199-202. doi:
10.1016/j.cca.2012.03.017. [PMID: 22484396] - Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood.
Journal of chromatography. A.
2012 Aug; 1249(?):147-54. doi:
10.1016/j.chroma.2012.06.023. [PMID: 22749457] - Seon-Sook Han, Eui-Cheol Nam, Jun Yeon Won, Kang Uk Lee, Wanjoo Chun, Hyun Kyung Choi, Robert Aaron Levine. Clonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba.
Journal of neurology, neurosurgery, and psychiatry.
2012 Aug; 83(8):821-7. doi:
10.1136/jnnp-2012-302273. [PMID: 22626945] - Aasef G Shaikh. A journey of tinnitus: myths, models, membranes and medicines.
Journal of neurology, neurosurgery, and psychiatry.
2012 Aug; 83(8):765-7. doi:
10.1136/jnnp-2012-302823. [PMID: 22696582] - Philippe Delmotte, Binxia Yang, Michael A Thompson, Christina M Pabelick, Y S Prakash, Gary C Sieck. Inflammation alters regional mitochondrial Ca²+ in human airway smooth muscle cells.
American journal of physiology. Cell physiology.
2012 Aug; 303(3):C244-56. doi:
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Epilepsy & behavior : E&B.
2012 Jul; 24(3):319-23. doi:
10.1016/j.yebeh.2012.03.028. [PMID: 22583623] - Mate Fullajtar, Csaba Ferencz. [Designer drug induced psychosis].
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.
2012 Jun; 14(2):137-40. doi:
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Journal of alternative and complementary medicine (New York, N.Y.).
2012 Jun; 18(6):612-21. doi:
10.1089/acm.2010.0778. [PMID: 22784349] - Quan Hong, Ka Qi, Zhe Feng, Zhiyong Huang, Shaoyuan Cui, Liyuan Wang, Bo Fu, Rui Ding, Jurong Yang, Xiangmei Chen, Di Wu. Hyperuricemia induces endothelial dysfunction via mitochondrial Na+/Ca2+ exchanger-mediated mitochondrial calcium overload.
Cell calcium.
2012 May; 51(5):402-10. doi:
10.1016/j.ceca.2012.01.003. [PMID: 22361139] - Yolanda Gonzalez, M Teresa Herrera, Gloria Soldevila, Lourdes Garcia-Garcia, Guadalupe Fabián, E Martha Pérez-Armendariz, Karen Bobadilla, Silvia Guzmán-Beltrán, Eduardo Sada, Martha Torres. High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes.
BMC immunology.
2012 Apr; 13(?):19. doi:
10.1186/1471-2172-13-19. [PMID: 22500980] - P C Rodriguez, M M Satorre, M T Beconi. Effect of two intracellular calcium modulators on sperm motility and heparin-induced capacitation in cryopreserved bovine spermatozoa.
Animal reproduction science.
2012 Apr; 131(3-4):135-42. doi:
10.1016/j.anireprosci.2012.03.015. [PMID: 22516227] - Emmanuel Varesio, J C Yves Le Blanc, Gérard Hopfgartner. Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry.
Analytical and bioanalytical chemistry.
2012 Mar; 402(8):2555-64. doi:
10.1007/s00216-011-5444-y. [PMID: 22006241] - Matthew D Krasowski, Louis E Penrod. Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations.
BMC medical informatics and decision making.
2012 Feb; 12(?):7. doi:
10.1186/1472-6947-12-7. [PMID: 22333264] - Gabriella Inczedy-Farkas, Viktoria Remenyi, Aniko Gal, Zsofia Varga, Petra Balla, Agnes Udvardy-Meszaros, Benjamin Bereznai, Maria Judit Molnar. Psychiatric symptoms of patients with primary mitochondrial DNA disorders.
Behavioral and brain functions : BBF.
2012 Feb; 8(?):9. doi:
10.1186/1744-9081-8-9. [PMID: 22329956] - Anna M Arroyo Plasencia, Lynn M Ballentine, James B Mowry, Louise W Kao. Benzodiazepine-associated atrioventricular block.
American journal of therapeutics.
2012 Jan; 19(1):e48-52. doi:
10.1097/mjt.0b013e3181dcf572. [PMID: 20535011] - Simin Dashti-Khavidaki, Nastaran Chamani, Hossein Khalili, Azita Hajhossein Talasaz, Farokhlegha Ahmadi, Mahboob Lessan-Pezeshki, Padideh Ghaeli, Shirin Dalili, Abbas Alimadadi. Comparing effects of clonazepam and zolpidem on sleep quality of patients on maintenance hemodialysis.
Iranian journal of kidney diseases.
2011 Nov; 5(6):404-9. doi:
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Cellular signalling.
2011 Nov; 23(11):1777-84. doi:
10.1016/j.cellsig.2011.06.012. [PMID: 21740965] - Qing Chang, Hongying Ma, Fangjie Wang, Honglian Ou, Ming Zou. [Determination of 10 sedative-hypnotics in human plasma using pulse splitless injection technique and gas chromatography-mass spectrometry].
Se pu = Chinese journal of chromatography.
2011 Nov; 29(11):1082-6. doi:
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The Analyst.
2011 Sep; 136(18):3753-7. doi:
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Organic & biomolecular chemistry.
2011 Aug; 9(16):5737-47. doi:
10.1039/c1ob05210a. [PMID: 21717023] - Conrad W Liang, Sarah J Diamond, Daniel S Hagg. Lipid rescue of massive verapamil overdose: a case report.
Journal of medical case reports.
2011 Aug; 5(?):399. doi:
10.1186/1752-1947-5-399. [PMID: 21854635] - Boby Varkey Maramattom, Anu Jacob. N-methyl D-aspartate receptor encephalitis: A new addition to the spectrum of autoimmune encephalitis.
Annals of Indian Academy of Neurology.
2011 Jul; 14(3):153-7. doi:
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Drug development and industrial pharmacy.
2011 Jul; 37(7):809-14. doi:
10.3109/03639045.2010.545069. [PMID: 21247373] - Hugues Beaufrère, Javier Nevarez, Lorrie Gaschen, Kirk Ryan, Rodney Schnellbacher, Thomas Tully. Diagnosis of presumed acute ischemic stroke and associated seizure management in a Congo African grey parrot.
Journal of the American Veterinary Medical Association.
2011 Jul; 239(1):122-8. doi:
10.2460/javma.239.1.122. [PMID: 21718205] - Yosuke Suzuki, Hiroki Itoh, Tomohide Abe, Fumihiro Nishimura, Yuhki Sato, Masaharu Takeyama. No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy.
The Journal of pharmacy and pharmacology.
2011 Jul; 63(7):976-81. doi:
10.1111/j.2042-7158.2011.01282.x. [PMID: 21635265] - Yi Chang, Yu-Wan Lin, Su-Jane Wang. Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
10.1007/s00210-011-0630-1. [PMID: 21541760] - Angèle Consoli, Karine Ronen, Isabelle An-Gourfinkel, Martine Barbeau, Donata Marra, Nathalie Costedoat-Chalumeau, Delphine Montefiore, Philippe Maksud, Olivier Bonnot, Adrien Didelot, Zahir Amoura, Marie Vidailhet, David Cohen. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report.
Child and adolescent psychiatry and mental health.
2011 May; 5(1):15. doi:
10.1186/1753-2000-5-15. [PMID: 21569502] - Robert J Gasperini, Xu Hou, Helena Parkington, Harry Coleman, David W Klaver, Adele J Vincent, Lisa C Foa, David H Small. TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons.
Molecular neurodegeneration.
2011 Mar; 6(1):19. doi:
10.1186/1750-1326-6-19. [PMID: 21375738] - Hiromichi Naito, Masaharu Nagae, Shuji Okahara, Hiroki Maeyama, Daisuke Okada, Shingo Hagioka, Naoki Morimoto. [Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report].
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2011 Mar; 24(1):35-8. doi:
. [PMID: 21485121] - Sharareh Eskandari, Jaleh Varshosaz, Mohsen Minaiyan, Majid Tabbakhian. Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: in vivo pharmacodynamic studies using rat electroshock model.
International journal of nanomedicine.
2011; 6(?):363-71. doi:
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