phentolamine (BioDeep_00000016598)
代谢物信息卡片
phentolamine
化学式: C17H19N3O (281.1528044)
中文名称: 酚妥拉明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O
InChI: InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
描述信息
C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators > C04AB - Imidazoline derivatives
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction[1][2][3].
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:8081
- KEGG: C07439
- KEGGdrug: D08362
- PubChem: 5775
- Metlin: METLIN1839
- DrugBank: DB00692
- ChEMBL: CHEMBL597
- MeSH: Phentolamine
- CAS: 50-60-2
- medchemexpress: HY-12717
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Qian Liu, Shengwei Wu, Zhenlin Chen, Jin Cai. Phentolamine Protects against Apoptosis and Inflammation in a Neonatal Pneumonia Cell Model Induced by LPS by Regulating the TrkA/Akt Signaling Pathways.
Discovery medicine.
2024 Mar; 36(182):581-590. doi:
10.24976/discov.med.202436182.54. [PMID: 38531798] - Tuhin Mukherjee, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Bijo Mathew, Jasleen Kaur, Ratandeep Kaur, Mayukh Das, Lotfi Aleya, Simona Bungau. Anticipated pharmacological role of Aviptadil on COVID-19.
Environmental science and pollution research international.
2022 Feb; 29(6):8109-8125. doi:
10.1007/s11356-021-17824-5. [PMID: 34846667] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Masahiko Tachi, Naoko Yamaguchi, Shoshiro Okada. Thromboxane A2 in the paraventricular hypothalamic nucleus mediates glucoprivation-induced adrenomedullary outflow.
European journal of pharmacology.
2020 May; 875(?):173034. doi:
10.1016/j.ejphar.2020.173034. [PMID: 32097659] - Alain Couvineau, Rosa P Gomariz, Yossan-Var Tan. Editorial: GPCR in Inflammatory and Cancer Diseases.
Frontiers in endocrinology.
2020; 11(?):588157. doi:
10.3389/fendo.2020.588157. [PMID: 33101216] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Roland von Känel, Nadja Heimgartner, Monika Stutz, Claudia Zuccarella-Hackl, Alexander Hänsel, Ulrike Ehlert, Petra H Wirtz. Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms.
Psychoneuroendocrinology.
2019 07; 105(?):44-50. doi:
10.1016/j.psyneuen.2018.09.018. [PMID: 30318393] - Jie Wen, Xiaojing Li. Effect of Magnesium Sulfate Combined with Phentolamine and Nifedipine for Gestational Hypertension and Serum Levels of LIF and Apelin.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Mar; 29(3):231-234. doi:
10.29271/jcpsp.2019.03.231. [PMID: 30823948] - F B Zanelatto, E V Dias, J M Teixeira, C R Sartori, C A Parada, C H Tambeli. Anti-inflammatory effects of propranolol in the temporomandibular joint of female rats and its contribution to antinociceptive action.
European journal of pain (London, England).
2018 03; 22(3):572-582. doi:
10.1002/ejp.1143. [PMID: 29226500] - Wei Peng, Fei Ding, Yu-Kui Peng, Yong Xie. Biological effects of α-adrenergic phentolamine on erythrocyte hemeprotein: Molecular insights from biorecognition behavior, protein dynamics and flexibility.
Journal of photochemistry and photobiology. B, Biology.
2017 Jun; 171(?):75-84. doi:
10.1016/j.jphotobiol.2017.04.035. [PMID: 28482223] - Shoshiro Okada, Naoko Yamaguchi. Possible role of adrenoceptors in the hypothalamic paraventricular nucleus in corticotropin-releasing factor-induced sympatho-adrenomedullary outflow in rats.
Autonomic neuroscience : basic & clinical.
2017 Mar; 203(?):74-80. doi:
10.1016/j.autneu.2017.01.008. [PMID: 28202248] - Aneta M Bragiel, Di Wang, Tomasz D Pieczonka, Masayuki Shono, Yasuko Ishikawa. Mechanisms Underlying Activation of α₁-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions.
International journal of molecular sciences.
2016 Jun; 17(7):. doi:
10.3390/ijms17071022. [PMID: 27367668] - Matthew A Sparks, Johannes Stegbauer, Daian Chen, Jose A Gomez, Robert C Griffiths, Hooman A Azad, Marcela Herrera, Susan B Gurley, Thomas M Coffman. Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.
Journal of the American Society of Nephrology : JASN.
2015 Dec; 26(12):2953-62. doi:
10.1681/asn.2014080816. [PMID: 25855778] - Kabilan Thanapaalasingham, André S Pollmann, Benjamin Schelew. Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2015 Dec; 62(12):1303-7. doi:
10.1007/s12630-015-0480-2. [PMID: 26362800] - Rosa Adriana Jarillo-Luna, Victor Rivera-Aguilar, Judith Pacheco-Yépez, Marycarmen Godínez-Victoria, Rigoberto Oros-Pantoja, Angel Miliar-García, Rafael Campos-Rodríguez. Nasal IgA secretion in a murine model of acute stress. The possible role of catecholamines.
Journal of neuroimmunology.
2015 Jan; 278(?):223-31. doi:
10.1016/j.jneuroim.2014.11.009. [PMID: 25468772] - Tan Wee Nie, Mohamed Saleem Abdul Shukkoor, Rajesh Sreedharan Nair, Fatimah Khursiah Binti Amiruddin, Shamala Ramasamy. Involvement of opioidergic and serotonergic systems in the analgesic activity of Cissus quadrangularis L. stem extract in mice.
Journal of basic and clinical physiology and pharmacology.
2015 Jan; 26(1):35-41. doi:
10.1515/jbcpp-2014-0035. [PMID: 24810560] - Gde Sasmita J Pande, Nguyen Thao Suong, Peter Bossier, Tom Defoirdt. The catecholamine stress hormones norepinephrine and dopamine increase the virulence of pathogenic Vibrio anguillarum and Vibrio campbellii.
FEMS microbiology ecology.
2014 Dec; 90(3):761-9. doi:
10.1111/1574-6941.12432. [PMID: 25264299] - X Kan, S-L Zheng, C-Y Zhou. UPLC-MS/MS determination of phentolamine in human plasma and its application to a pharmacokinetic study.
Drug research.
2014 Nov; 64(11):607-12. doi:
10.1055/s-0033-1364002. [PMID: 24452521] - Manabu Kitano, Nobuyasu Komasawa, Toshiyuki Sawai, Toshiaki Minami. [Successful anesthetic management of a patient with giant pheochromocytoma using high-dose landiolol hydrochloride].
Masui. The Japanese journal of anesthesiology.
2014 Aug; 63(8):898-900. doi:
NULL. [PMID: 25199327] - Fangjun Wang, Bin Chen, Yang Liu, Faping Tu. [Effect of urapidil combined with phentolamine on hypertension during extracorporeal circulation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2014 Aug; 34(9):1342-6. doi:
NULL. [PMID: 25263372] - Hak Jin Moon, Bong-Soo Lim, Dae-Il Lee, Min Sook Ye, Giseog Lee, Byung-Il Min, Hyunsu Bae, Heung Sik Na, Sun Kwang Kim. Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats.
The journal of physiological sciences : JPS.
2014 Mar; 64(2):151-6. doi:
10.1007/s12576-013-0297-0. [PMID: 24158835] - Tamaki Watanabe, Naoko H Tomioka, Shigekazu Watanabe, Masao Tsuchiya, Makoto Hosoyamada. False in vitro and in vivo elevations of uric acid levels in mouse blood.
Nucleosides, nucleotides & nucleic acids.
2014; 33(4-6):192-8. doi:
10.1080/15257770.2013.865742. [PMID: 24940669] - Feng Wang, Hongyan Cai, Qing Zhao, Tao Xing, Junhui Li, Niansong Wang. Epinephrine evokes renalase secretion via α-adrenoceptor/NF-κB pathways in renal proximal tubular epithelial cells.
Kidney & blood pressure research.
2014; 39(4):252-9. doi:
10.1159/000355802. [PMID: 25171187] - Chunhua Zhang, Yun-Yun Rui, Yuan-Yuan Zhou, Zhong Ju, Hong-Hong Zhang, Chuang-Ying Hu, Ying Xiao, Guang-Yin Xu. Adrenergic β2-receptors mediates visceral hypersensitivity induced by heterotypic intermittent stress in rats.
PloS one.
2014; 9(4):e94726. doi:
10.1371/journal.pone.0094726. [PMID: 24733123] - Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
10.1093/toxsci/kft205. [PMID: 24052561] - Zachary Barrett-O'Keefe, Melissa A H Witman, John McDaniel, Anette S Fjeldstad, Joel D Trinity, Stephen J Ives, Jamie D Conklin, Van Reese, Sean Runnels, David E Morgan, Mikael Sander, Russell S Richardson, D Walter Wray. Angiotensin II potentiates α-adrenergic vasoconstriction in the elderly.
Clinical science (London, England : 1979).
2013 Mar; 124(6):413-22. doi:
10.1042/cs20120424. [PMID: 22985469] - H Thomas Lee, Joo Yun Kim, Mihwa Kim, Peili Wang, Lieqi Tang, Sara Baroni, Vivette D D'Agati, Gary V Desir. Renalase protects against ischemic AKI.
Journal of the American Society of Nephrology : JASN.
2013 Feb; 24(3):445-55. doi:
10.1681/asn.2012090943. [PMID: 23393318] - Qiang Lin, Feifei Wang, Rong Yang, Xinmin Zheng, Huibao Gao, Ping Zhang. Effect of chronic restraint stress on human colorectal carcinoma growth in mice.
PloS one.
2013; 8(4):e61435. doi:
10.1371/journal.pone.0061435. [PMID: 23585898] - Ulrike Kuebler, Petra H Wirtz, Miho Sakai, Andreas Stemmer, Ulrike Ehlert. Acute stress reduces wound-induced activation of microbicidal potential of ex vivo isolated human monocyte-derived macrophages.
PloS one.
2013; 8(2):e55875. doi:
10.1371/journal.pone.0055875. [PMID: 23431364] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Kazuhisa Honda, Hiroshi Kamisoyama, Taku Uemura, Takashi Yanagi, Noboru Saito, Yohei Kurose, Kunio Sugahara, Kazuo Katoh, Shin Hasegawa. The mechanism underlying the central glucagon-induced hyperglycemia and anorexia in chicks.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2012 Nov; 163(3-4):260-4. doi:
10.1016/j.cbpa.2012.08.005. [PMID: 22909790] - Yan-Fei Mao, You-Lei Zhang, Qi-Hong Yu, Yao-Hao Jiang, Xin-Wei Wang, Yuan Yao, Jun-Long Huang. Chronic restraint stress aggravated arthritic joint swell of rats through regulating nitric oxide production.
Nitric oxide : biology and chemistry.
2012 Oct; 27(3):137-42. doi:
10.1016/j.niox.2012.06.005. [PMID: 22743255] - Yi Luo, Payal Rana, Yvonne Will. Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):346-62. doi:
10.1093/toxsci/kfs208. [PMID: 22700542] - Harvinder Singh Pahwa, Awanish Kumar, Rohit Srivastava, Anurag Rai. Unsuspected pheochromocytoma of the urinary bladder: reminder of an important clinical lesson.
BMJ case reports.
2012 Aug; 2012(?):. doi:
10.1136/bcr-2012-006377. [PMID: 22878991] - Shun-Fan Wu, Yao Yao, Jia Huang, Gong-Yin Ye. Characterization of a β-adrenergic-like octopamine receptor from the rice stem borer (Chilo suppressalis).
The Journal of experimental biology.
2012 Aug; 215(Pt 15):2646-52. doi:
10.1242/jeb.068932. [PMID: 22786641] - Kangbin Zhou, Ujendra Kumar, Violet G Yuen, John H McNeill. The effects of phentolamine on fructose-fed rats.
Canadian journal of physiology and pharmacology.
2012 Aug; 90(8):1075-85. doi:
10.1139/y2012-063. [PMID: 22783820] - Stéphane Balayssac, Véronique Gilard, Chantal Zedde, Robert Martino, Myriam Malet-Martino. Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants.
Journal of pharmaceutical and biomedical analysis.
2012 Apr; 63(?):135-50. doi:
10.1016/j.jpba.2012.01.035. [PMID: 22365331] - Apurva Kumar Ramesh Joshi, Raju Nagaraju, Padmanabhan Sharda Rajini. Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide.
Toxicology.
2012 Mar; 294(1):9-16. doi:
10.1016/j.tox.2012.01.009. [PMID: 22305719] - Danielle L Davison, Lakhmir S Chawla, Leelie Selassie, Rahul Tevar, Christopher Junker, Michael G Seneff. Neurogenic pulmonary edema: successful treatment with IV phentolamine.
Chest.
2012 Mar; 141(3):793-795. doi:
10.1378/chest.11-0789. [PMID: 22396565] - O O Adeyemi, F R Aigbe, O A Badru. The antidiarrhoeal activity of the aqueous root extract of Aristolochia ringens (Vahl.) Aristolochiaceae.
Nigerian quarterly journal of hospital medicine.
2012 Jan; 22(1):29-33. doi:
". [PMID: 23175877] - Jiaming Yang, Paul S P Ip, John H K Yeung, Chun-Tao Che. Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Aug; 18(11):998-1005. doi:
10.1016/j.phymed.2011.02.014. [PMID: 21514126] - Y-R Jin, J Jin, X-X Piao, N G Jin. The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2011 Aug; 23(8):766-e333. doi:
10.1111/j.1365-2982.2011.01704.x. [PMID: 21453412] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - F-P Chuang, M Lakin, S-T Wu, T-L Cha, G-H Sun, D K Montague. Experience with intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: dose considerations.
International journal of impotence research.
2011 Jul; 23(4):146-50. doi:
10.1038/ijir.2011.21. [PMID: 21654813] - Jonathan S Cook, Charity L Sauder, Chester A Ray. Melatonin differentially affects vascular blood flow in humans.
American journal of physiology. Heart and circulatory physiology.
2011 Feb; 300(2):H670-4. doi:
10.1152/ajpheart.00710.2010. [PMID: 21148765] - Ranjani Ramanathan, Philip E Cryer. Adrenergic mediation of hypoglycemia-associated autonomic failure.
Diabetes.
2011 Feb; 60(2):602-6. doi:
10.2337/db10-1374. [PMID: 21270270] - Enitome E Bafor, Upe Sanni, Zuleikha A M Nworgu. In vitro determination of the mechanism of the uterine stimulatory effect of Newbouldia laevis.
Pharmaceutical biology.
2010 Jul; 48(7):808-15. doi:
10.3109/13880200903283673. [PMID: 20645781] - Shintaro Yamaguchi, Hirotaka Shibata, Kazutoshi Miyashita, Isao Kurihara, Ayano Murai-Takeda, Yuko Mitsuishi, Yuichiro Motosugi, Yoshimasa Saito, Koichi Hayashi, Hiroshi Itoh. Gastrointestinal pseudo-obstruction after debulking surgery of malignant pheochromocytoma, improved by intravenous administration of alpha-adrenergic receptor blocker, phentolamine.
Hypertension research : official journal of the Japanese Society of Hypertension.
2010 Jul; 33(7):753-4. doi:
10.1038/hr.2010.75. [PMID: 20505671] - Rafael A Leos, Miranda J Anderson, Xiaochuan Chen, Juliana Pugmire, K Arbor Anderson, Sean W Limesand. Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction.
American journal of physiology. Endocrinology and metabolism.
2010 Apr; 298(4):E770-8. doi:
10.1152/ajpendo.00494.2009. [PMID: 20086198] - U Widegren, R C Hickner, L Jorfeldt, J Henriksson. Muscle blood flow response to mental stress and adrenaline infusion in man: microdialysis ethanol technique compared to (133)Xe clearance and venous occlusion plethysmography.
Clinical physiology and functional imaging.
2010 Mar; 30(2):152-61. doi:
10.1111/j.1475-097x.2009.00919.x. [PMID: 20113316] - Akiko Shitara, Akihiko Tanimura, Atsuko Sato, Yosuke Tojyo. Spontaneous oscillations in intracellular Ca(2+) concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Dec; 297(6):G1198-205. doi:
10.1152/ajpgi.00168.2009. [PMID: 19779019] - Xi-Ping Ni, Claudia van Dijk, David Pearce, Michael H Humphreys. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone.
Experimental physiology.
2009 Aug; 94(8):867-76. doi:
10.1113/expphysiol.2009.046748. [PMID: 19429645] - Michael J Ormsbee, Myung Dong Choi, Justin K Medlin, Gabriel H Geyer, Lauren H Trantham, Gabriel S Dubis, Robert C Hickner. Regulation of fat metabolism during resistance exercise in sedentary lean and obese men.
Journal of applied physiology (Bethesda, Md. : 1985).
2009 May; 106(5):1529-37. doi:
10.1152/japplphysiol.91485.2008. [PMID: 19265063] - Jens Mortensen, Uffe Holst, Jørn Skibsted Jakobsen, Frederik Andreasen. Endoluminal norepinephrine inhibits smooth muscle activity of the pig pyeloureter by stimulation of beta-adrenoceptors without side effects.
Basic & clinical pharmacology & toxicology.
2008 Nov; 103(5):455-60. doi:
10.1111/j.1742-7843.2008.00297.x. [PMID: 18713234] - Hiroshi Fukagawa, Mitsuko Hashiguchi, Yuko Ayabe, Taiki Ando, Kumi Nakamura. [Anesthetic management of undiagnosed pheochromocytoma: a case report].
Masui. The Japanese journal of anesthesiology.
2008 Oct; 57(10):1241-4. doi:
NULL. [PMID: 18975540] - Supriya A Bavadekar, Seoung-Soo Hong, Sang-Ii Lee, Duane D Miller, Dennis R Feller. Bioisosteric phentolamine analogs as selective human alpha(2)- versus alpha(1)-adrenoceptor ligands.
European journal of pharmacology.
2008 Aug; 590(1-3):53-60. doi:
10.1016/j.ejphar.2008.05.027. [PMID: 18589415] - Cedric Moro, Fabien Pillard, Isabelle de Glisezinski, Eva Klimcakova, Francois Crampes, Claire Thalamas, Isabelle Harant, Marie-Adeline Marques, Max Lafontan, Michel Berlan. Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men.
American journal of physiology. Endocrinology and metabolism.
2008 Aug; 295(2):E505-13. doi:
10.1152/ajpendo.90227.2008. [PMID: 18559985] - Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Lu Lianyi, Hiroshi Wakiguchi, Kunihiko Yokotani. Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats.
European journal of pharmacology.
2008 Jun; 587(1-3):322-9. doi:
10.1016/j.ejphar.2008.03.005. [PMID: 18423439] - Mieko Yorimitsu, Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Kunihiko Yokotani. Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats.
Life sciences.
2008 Feb; 82(9-10):487-94. doi:
10.1016/j.lfs.2007.12.006. [PMID: 18201726] - G H Wendel, A O M María, J A Guzmán, O Giordano, L E Pelzer. Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.
Fitoterapia.
2008 Jan; 79(1):1-5. doi:
10.1016/j.fitote.2007.05.006. [PMID: 17683879] - Paul A Moore, Elliot V Hersh, Athena S Papas, J Max Goodson, John A Yagiela, Bruce Rutherford, Seigried Rogy, Laura Navalta. Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Anesthesia progress.
2008; 55(2):40-8. doi:
10.2344/0003-3006(2008)55[40:polwef]2.0.co;2. [PMID: 18547152] - Jan Polak, Cédric Moro, David Bessière, Jindra Hejnova, Marie A Marquès, Magda Bajzova, Max Lafontan, Francois Crampes, Michel Berlan, Vladimir Stich. Acute exposure to long-chain fatty acids impairs {alpha}2-adrenergic receptor-mediated antilipolysis in human adipose tissue.
Journal of lipid research.
2007 Oct; 48(10):2236-46. doi:
10.1194/jlr.m700253-jlr200. [PMID: 17625217] - Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Takashi Yokoi, Seiji Maeda, Hirofumi Tanaka. Systemic alpha-adrenergic and nitric oxide inhibition on basal limb blood flow: effects of endurance training in middle-aged and older adults.
American journal of physiology. Heart and circulatory physiology.
2007 Sep; 293(3):H1466-72. doi:
10.1152/ajpheart.00273.2007. [PMID: 17496216] - Oddbjørn Haugen, Marit Farstad, Venny Kvalheim, Stig Hammersborg, Paul Husby. Intraoperative fluid balance during cardiopulmonary bypass: effects of different mean arterial pressures.
Perfusion.
2007 Jul; 22(4):273-8. doi:
10.1177/0267659107084148. [PMID: 18181516] - Elena Grossini, Claudio Molinari, David A S G Mary, Ezio Ghigo, Gianni Bona, Giovanni Vacca. Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs.
Endocrinology.
2007 Feb; 148(2):806-12. doi:
10.1210/en.2006-1230. [PMID: 17110424] - G M G Sundkvist, P Hjemdahl, T Kahan, A Melcher. Mechanisms of exercise-induced ST-segment depression in patients without typical angina pectoris.
Journal of internal medicine.
2007 Feb; 261(2):148-58. doi:
10.1111/j.1365-2796.2006.01751.x. [PMID: 17241180] - Cédric Moro, Jan Polak, Jindra Hejnova, Eva Klimcakova, François Crampes, Vladimir Stich, Max Lafontan, Michel Berlan. Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise.
American journal of physiology. Endocrinology and metabolism.
2006 May; 290(5):E864-9. doi:
10.1152/ajpendo.00348.2005. [PMID: 16291573] - Nga Cao, John M Haynes, Sabatino Ventura. Saw palmetto is an indirectly acting sympathomimetic in the rat-isolated prostate gland.
The Prostate.
2006 Feb; 66(2):115-23. doi:
10.1002/pros.20322. [PMID: 16114061] - E Grossini, C Molinari, A Battaglia, D A S G Mary, F Ribichini, N Surico, G Vacca. Human placental lactogen decreases regional blood flow in anesthetized pigs.
Journal of vascular research.
2006; 43(2):205-13. doi:
10.1159/000090950. [PMID: 16410683] - J Polak, C Moro, E Klimcakova, J Hejnova, M Majercik, N Viguerie, D Langin, M Lafontan, V Stich, M Berlan. Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects.
Diabetologia.
2005 Dec; 48(12):2631-40. doi:
10.1007/s00125-005-0003-8. [PMID: 16273345] - Seoung-Soo Hong, Supriya A Bavadekar, Sang-Il Lee, Popat N Patil, S G Lalchandani, Dennis R Feller, Duane D Miller. Bioisosteric phentolamine analogs as potent alpha-adrenergic antagonists.
Bioorganic & medicinal chemistry letters.
2005 Nov; 15(21):4691-5. doi:
10.1016/j.bmcl.2005.07.083. [PMID: 16153828] - Yuming Huang, Weibing Liu. Flow-injection chemiluminescence determination of phentolamine based on its enhancing effect on the luminol-potassium ferricyanide system.
Journal of pharmaceutical and biomedical analysis.
2005 Jul; 38(3):537-42. doi:
10.1016/j.jpba.2005.01.027. [PMID: 15925257] - Ya-Li Luo, Jun-Wei Zeng, Mei Yu, Yu-Ling Wei, Song-Yi Qu, Wei Li, Tian-Zhen Zheng. Effect of rhubarb on contractile response of gallbladder smooth muscle strips isolated from guinea pigs.
World journal of gastroenterology.
2005 Feb; 11(6):863-6. doi:
10.3748/wjg.v11.i6.863. [PMID: 15682482] - Lingwei Wang, Göran Olivecrona, Matthias Götberg, Martin L Olsson, Maria Sörhede Winzell, David Erlinge. ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells.
Circulation research.
2005 Feb; 96(2):189-96. doi:
10.1161/01.res.0000153670.07559.e4. [PMID: 15604418] - Georg Pongratz, Peter Härle, Georg Schnellinger, David Janele, Jürgen Schölmerich, Rainer H Straub. Norepinephrine in mice inhibits secretion of splenic IL-6 during the dark period but stimulates its secretion in the light period--possible role of the corticosterone tone.
Journal of neuroimmunology.
2005 Jan; 158(1-2):120-7. doi:
10.1016/j.jneuroim.2004.08.017. [PMID: 15589045] - Dana P Damron, Ira M Bernstein, Robert E Shapiro, Adrienne Schonberg. Uterine blood flow response to alpha-adrenergic blockade in nulligravid women of reproductive age.
Journal of the Society for Gynecologic Investigation.
2004 Sep; 11(6):388-92. doi:
10.1016/j.jsgi.2004.02.009. [PMID: 15350252] - Frederique M Poulet, Mark R Berardi, William Halliwell, Barbara Hartman, Carol Auletta, Henry Bolte. Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study.
Toxicologic pathology.
2004 Sep; 32(5):558-66. doi:
10.1080/01926230490505086. [PMID: 15603540] - Taka-Aki Koshimizu, Gozoh Tsujimoto, Akira Hirasawa, Yoko Kitagawa, Akito Tanoue. Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors.
Cardiovascular research.
2004 Sep; 63(4):662-72. doi:
10.1016/j.cardiores.2004.05.014. [PMID: 15306222] - Dian Zhang, Bingxiang Yuan, Xiuling Deng, Guangde Yang, Langchong He, Youyi Zhang, Qide Han. Chromatography studies on bio-affinity of nine ligands of alpha1-adrenoceptor to alpha1D subtypes overexpressed in cell membrane.
Science in China. Series C, Life sciences.
2004 Aug; 47(4):376-81. doi:
10.1360/03yc0109. [PMID: 15493479] - Raffaele Capasso, Francesca Borrelli, Francesco Capasso, Nicola Mascolo, Angelo A Izzo. Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Urology.
2004 Jul; 64(1):168-72. doi:
10.1016/j.urology.2004.02.021. [PMID: 15245964] - S Marra, L Hoffman-Goetz. Beta-adrenergic receptor blockade during exercise decreases intestinal lymphocyte apoptosis but not cell loss in mice.
Canadian journal of physiology and pharmacology.
2004 Jul; 82(7):465-73. doi:
10.1139/y04-072. [PMID: 15389293] - Srinath Setty, Wei Sun, Rodolfo Martinez, H Fred Downey, Johnathan D Tune. Alpha-adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in experimental diabetes mellitus.
Journal of applied physiology (Bethesda, Md. : 1985).
2004 Jul; 97(1):431-8. doi:
10.1152/japplphysiol.01122.2003. [PMID: 14978008] - Veronika Gresz, Tae-Hwan Kwon, Hong Gong, Peter Agre, Martin C Steward, Landon S King, Søren Nielsen. Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo.
American journal of physiology. Gastrointestinal and liver physiology.
2004 Jul; 287(1):G151-61. doi:
10.1152/ajpgi.00480.2003. [PMID: 14988067] - Cedric Moro, Francois Crampes, Coralie Sengenes, Isabelle De Glisezinski, Jean Galitzky, Claire Thalamas, Max Lafontan, Michel Berlan. Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 May; 18(7):908-10. doi:
10.1096/fj.03-1086fje. [PMID: 15033935] - Yutaka Oda, Tomoharu Funao, Katsuaki Tanaka, Akira Asada. Vasodilation increases the threshold for bupivacaine-induced convulsions in rats.
Anesthesia and analgesia.
2004 Mar; 98(3):677-82, table of contents. doi:
10.1213/01.ane.0000101984.50597.e9. [PMID: 14980918] - Duane J Myklejord. Undiagnosed pheochromocytoma: the anesthesiologist nightmare.
Clinical medicine & research.
2004 Feb; 2(1):59-62. doi:
10.3121/cmr.2.1.59. [PMID: 15931336] - Eun Jung Kim, Yun Jung Lee, Jang Hern Lee, Ho Jae Han. Effect of epinephrine on alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2004; 14(4-6):395-406. doi:
10.1159/000080349. [PMID: 15319543] - L F G Silva, M O Moraes, G S M Santana, F A Frota Bezerra, G De Nucci, M E A Moraes. Phentolamine bioequivalence study.
International journal of clinical pharmacology and therapeutics.
2004 Jan; 42(1):43-9. doi:
NULL. [PMID: 14756387] - Steven L Bealer, Francis W Flynn. Central neurokinin 3 receptors increase systemic oxytocin release: interaction with norepinephrine.
Experimental neurology.
2003 Dec; 184(2):1027-33. doi:
10.1016/j.expneurol.2003.08.012. [PMID: 14769397] - Aaron M Fields, Alan D Kaye, Todd A Richards, Ikhlass N Ibrahim, James E Heavner, Bracken J Dewitt, Erin Z Bayer. Pulmonary vascular responses to ma huang extract.
Journal of alternative and complementary medicine (New York, N.Y.).
2003 Oct; 9(5):727-33. doi:
10.1089/107555303322524571. [PMID: 14629850] - Frederick Jia-Pei Miao, Paul Green, Neal Benowitz, Jon D Levine. Vagal modulation of spinal nicotine-induced inhibition of the inflammatory response mediated by descending antinociceptive controls.
Neuropharmacology.
2003 Oct; 45(5):605-11. doi:
10.1016/s0028-3908(03)00224-7. [PMID: 12941374] - Raghvendra K Dubey, Lefteris C Zacharia, Delbert G Gillespie, Bruno Imthurn, Edwin K Jackson. Catecholamines block the antimitogenic effect of estradiol on human glomerular mesangial cells.
Hypertension (Dallas, Tex. : 1979).
2003 Sep; 42(3):349-55. doi:
10.1161/01.hyp.0000088320.81260.26. [PMID: 12913061] - E Pagani, S Glina, P Puech-Leão, C M Strunz, S Chao, C Timo-Iaria. Anxiety and high plasma catecholamines do not impair pharmaco-induced erection of psychogenic erectile dysfunctional patients.
International journal of impotence research.
2003 Aug; 15(4):282-6. doi:
10.1038/sj.ijir.3901002. [PMID: 12934057] - Tadayoshi Miyamoto, Toru Kawada, Hiroshi Takaki, Masashi Inagaki, Yusuke Yanagiya, Yintie Jin, Masaru Sugimachi, Kenji Sunagawa. High plasma norepinephrine attenuates the dynamic heart rate response to vagal stimulation.
American journal of physiology. Heart and circulatory physiology.
2003 Jun; 284(6):H2412-8. doi:
10.1152/ajpheart.00660.2002. [PMID: 12598233] - Raymond D Harbison, Todd Stedeford, Carlos Muro-Cacho, Diana I Mosquera, Marek Banasik. Activation of alpha(1)-adrenergic receptors potentiates the nephrotoxicity of ethylene dibromide.
Toxicology.
2003 Apr; 186(3):181-9. doi:
10.1016/s0300-483x(02)00747-3. [PMID: 12628311] - Steven L Bealer, William R Crowley. Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation.
Regulatory peptides.
2003 Mar; 111(1-3):41-6. doi:
10.1016/s0167-0115(02)00222-7. [PMID: 12609747] - Dirk Gründemann, Ann-Cathrin Koschker, Christine Haag, Cornelius Honold, Tim Zimmermann, Edgar Schömig. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
British journal of pharmacology.
2002 Nov; 137(6):910-8. doi:
10.1038/sj.bjp.0704926. [PMID: 12411423] - Wei Wang, Sandor A Falk, Suparoek Jittikanont, Patricia E Gengaro, Charles L Edelstein, Robert W Schrier. Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice.
American journal of physiology. Renal physiology.
2002 Sep; 283(3):F583-7. doi:
10.1152/ajprenal.00270.2001. [PMID: 12167611] - Bruno Balsiger, Andreas Rickenbacher, Penelope Jane Boden, Erwin Biecker, Janice Tsui, Michael Dashwood, Jürg Reichen, Sidney George Shaw. Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function.
Clinical science (London, England : 1979).
2002 Aug; 103 Suppl 48(?):430S-433S. doi:
10.1042/cs103s430s. [PMID: 12193138]