chlorpropamide (BioDeep_00000016595)

   


代谢物信息卡片


chlorpropamide

化学式: C10H13ClN2O3S (276.03353780000003)
中文名称: 1-(4-氯苯磺酰基)-3-丙脲
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCNC(=O)NS(=O)(=O)c(c1)ccc(Cl)c1
InChI: InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007004 - Hypoglycemic Agents
CONFIDENCE standard compound; INTERNAL_ID 420; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4086; ORIGINAL_PRECURSOR_SCAN_NO 4084
CONFIDENCE standard compound; INTERNAL_ID 420; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4103; ORIGINAL_PRECURSOR_SCAN_NO 4100
CONFIDENCE standard compound; INTERNAL_ID 420; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4094; ORIGINAL_PRECURSOR_SCAN_NO 4092
CONFIDENCE standard compound; INTERNAL_ID 420; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4084; ORIGINAL_PRECURSOR_SCAN_NO 4083
CONFIDENCE standard compound; INTERNAL_ID 420; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4194; ORIGINAL_PRECURSOR_SCAN_NO 4191
CONFIDENCE standard compound; INTERNAL_ID 420; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4083; ORIGINAL_PRECURSOR_SCAN_NO 4082

同义名列表

1 个代谢物同义名

chlorpropamide



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • N M Mkolo, O O Olaokun, P H King, I Janse van Rensburg, J N Eloff, V Naidoo. Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-Leprdb mice. BMC complementary medicine and therapies. 2022 Jun; 22(1):163. doi: 10.1186/s12906-022-03640-y. [PMID: 35725532]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Hana Nevídalová, Lenka Michalcová, Zdeněk Glatz. Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on l-tryptophan and lidocaine binding to human serum albumin. Journal of separation science. 2020 Nov; 43(22):4225-4233. doi: 10.1002/jssc.202000594. [PMID: 32966669]
  • Imocha Rajkumar Singh, Sivaprasad Mitra. Modulated Protein Binding Ability of Anti-Diabetic Drugs in Presence of Monodispersed Gold Nanoparticles and its Inhibitory Potential towards Advanced Glycated End (AGE) Product Formation. Journal of fluorescence. 2020 Jan; 30(1):193-204. doi: 10.1007/s10895-019-02485-y. [PMID: 31925653]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Imocha Rajkumar Singh, Sivaprasad Mitra. Interaction of chlorpropamide with serum albumin: Effect on advanced glycated end (AGE) product fluorescence. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Jan; 206(?):569-577. doi: 10.1016/j.saa.2018.08.055. [PMID: 30189383]
  • Pingyang Tao, Zhao Li, Ryan Matsuda, David S Hage. Chromatographic studies of chlorpropamide interactions with normal and glycated human serum albumin based on affinity microcolumns. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Oct; 1097-1098(?):64-73. doi: 10.1016/j.jchromb.2018.09.001. [PMID: 30205233]
  • Jee Sun Min, Jiseon Kim, Jung Ho Kim, Doyun Kim, Yu Fen Zheng, Ji Eun Park, Wooin Lee, Soo Kyung Bae. Quantitative determination of carfilzomib in mouse plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2017 Nov; 146(?):341-346. doi: 10.1016/j.jpba.2017.08.048. [PMID: 28918323]
  • Jing Li, Michael Fettiplace, Sy-Jou Chen, Benjamin Steinhorn, Zuohui Shao, Xiangdong Zhu, Changqing Li, Shaun Harty, Guy Weinberg, Terry L Vanden Hoek. Lipid emulsion rapidly restores contractility in stunned mouse cardiomyocytes: a comparison with therapeutic hypothermia. Critical care medicine. 2014 Dec; 42(12):e734-40. doi: 10.1097/ccm.0000000000000656. [PMID: 25402294]
  • Iara Maíra de Oliveira Viana, Paula de Paula Rosa Lima, Cristina Duarte Vianna Soares, Christian Fernandes. Simultaneous determination of oral antidiabetic drugs in human plasma using microextraction by packed sorbent and high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 96(?):241-8. doi: 10.1016/j.jpba.2014.03.042. [PMID: 24780925]
  • André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry. 2014 Apr; 57(7):3005-10. doi: 10.1021/jm401963n. [PMID: 24601604]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Kelly Koral, Elif Erkan. PKB/Akt partners with Dab2 in albumin endocytosis. American journal of physiology. Renal physiology. 2012 Apr; 302(8):F1013-24. doi: 10.1152/ajprenal.00289.2011. [PMID: 22218591]
  • Holger Rehmann. Epac2: a sulfonylurea receptor?. Biochemical Society transactions. 2012 Feb; 40(1):6-10. doi: 10.1042/bst20110640. [PMID: 22260657]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Minoru Ito, Michiaki Nagasawa, Naoki Omae, Tomohiro Ide, Yunike Akasaka, Koji Murakami. Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes. Journal of lipid research. 2011 Aug; 52(8):1450-60. doi: 10.1194/jlr.m012427. [PMID: 21636835]
  • Valentina L Kouznetsova, Igor F Tsigelny, Megha A Nagle, Sanjay K Nigam. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorganic & medicinal chemistry. 2011 Jun; 19(11):3320-40. doi: 10.1016/j.bmc.2011.04.045. [PMID: 21571536]
  • A A Oyagbemi, A A Odetola, O I Azeez. Antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius on alloxan induced diabetes mellitus in rats. African journal of medicine and medical sciences. 2010 Dec; 39 Suppl(?):171-8. doi: NULL. [PMID: 22416660]
  • David Buttar, Nicola Colclough, Stefan Gerhardt, Philip A MacFaul, Scott D Phillips, Alleyn Plowright, Paul Whittamore, Kin Tam, Klaus Maskos, Stefan Steinbacher, Holger Steuber. A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic & medicinal chemistry. 2010 Nov; 18(21):7486-96. doi: 10.1016/j.bmc.2010.08.052. [PMID: 20869876]
  • O I Azeez, A A Oyagbemi, M O Oyeyemi, A A Odetola. Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats. African health sciences. 2010 Sep; 10(3):283-91. doi: ". [PMID: 21327141]
  • Harry G Preuss, Bobby Echard, Debasis Bagchi, Nicholas V Perricone. Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats. International journal of medical sciences. 2010 Jun; 7(4):169-80. doi: 10.7150/ijms.7.169. [PMID: 20567593]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • M T Bakare-Odunola, I Enemali, M Garba, O O Obodozie, K B Mustapha. The influence of lamivudine, stavudine and nevirapine on the pharmacokinetics of chlorpropamide in human subjects. European journal of drug metabolism and pharmacokinetics. 2008 Jul; 33(3):165-71. doi: 10.1007/bf03191114. [PMID: 19007042]
  • H A Lawal, M K Atiku, D G Khelpai, N N Wannang. Hypoglycaemic and hypolipidaemic effect of aqueous leaf extract of Murraya koenigii in normal and alloxan-diabetic rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2008 Jun; 23(1-2):37-40. doi: 10.4314/njps.v23i1-2.54919. [PMID: 19434212]
  • M T Bakare-Odunola, A Mustapha, I Abdu Aguye. Effect of Nigerian meals on the pharmacokinetics of chlorpropamide in type II diabetic patients. European journal of drug metabolism and pharmacokinetics. 2008 Jan; 33(1):31-5. doi: 10.1007/bf03191016. [PMID: 18543582]
  • Harry G Preuss, Bobby Echard, Debasis Bagchi, Sidney Stohs. Inhibition by natural dietary substances of gastrointestinal absorption of starch and sucrose in rats 2. Subchronic studies. International journal of medical sciences. 2007 Aug; 4(4):209-15. doi: 10.7150/ijms.4.209. [PMID: 17713601]
  • Harry G Preuss, Bobby Echard, Debasis Bagchi, Sidney Stohs. Inhibition by natural dietary substances of gastrointestinal absorption of starch and sucrose in rats and pigs: 1. Acute studies. International journal of medical sciences. 2007 Aug; 4(4):196-202. doi: 10.7150/ijms.4.196. [PMID: 17713600]
  • Marcia Aparecida da Silva, Fabiana D Mendes, Rogério Antonio de Oliveira, Tausif Monif, Anil Patni, Simrit Reyar, Gustavo D Mendes, Gilberto De Nucci. Comparative bioavailability study with two chlorpropamide tablet formulations in healthy volunteers. Arzneimittel-Forschung. 2007; 57(9):591-8. doi: 10.1055/s-0031-1296654. [PMID: 17966758]
  • John A O Ojewole, Stephen O Adewole, Gbola Olayiwola. Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. 2006 Sep; 17(5):227-32. doi: ". [PMID: 17117226]
  • J A O Ojewole. Hypoglycaemic and hypotensive effects of Harpephyllum caffrum Bernh ex CF Krauss (Anacardiaceae) stem-bark aqueous extract in rats. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. 2006 Mar; 17(2):67-72. doi: ". [PMID: 16733599]
  • J A O Ojewole. Antiinflammatory, analgesic and hypoglycemic effects of Mangifera indica Linn. (Anacardiaceae) stem-bark aqueous extract. Methods and findings in experimental and clinical pharmacology. 2005 Oct; 27(8):547-54. doi: 10.1358/mf.2005.27.8.928308. [PMID: 16273134]
  • Nelson L Fuentes, Hernan Sagua, Glauco Morales, Jorge Borquez, Aurelio San Martin, Julia Soto, Luis A Loyola. Experimental antihyperglycemic effect of diterpenoids of llareta Azorella compacta (Umbelliferae) Phil in rats. Phytotherapy research : PTR. 2005 Aug; 19(8):713-6. doi: 10.1002/ptr.1740. [PMID: 16177976]
  • Ji-Hong Shon, Young-Ran Yoon, Min-Jung Kim, Kyoung-Ah Kim, Young-Chae Lim, Kwang-Hyeon Liu, Dong-Hoon Shin, Chung Han Lee, In-June Cha, Jae-Gook Shin. Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism. British journal of clinical pharmacology. 2005 May; 59(5):552-63. doi: 10.1111/j.1365-2125.2005.02364.x. [PMID: 15842554]
  • Loretta Aureli, Gabriele Cruciani, Maria Candida Cesta, Roberto Anacardio, Lucio De Simone, Alessio Moriconi. Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry. 2005 Apr; 48(7):2469-79. doi: 10.1021/jm049227l. [PMID: 15801837]
  • D M Wood, S Athwal, A Panahloo. The advantages and disadvantages of a 'herbal' medicine in a patient with diabetes mellitus: a case report. Diabetic medicine : a journal of the British Diabetic Association. 2004 Jun; 21(6):625-7. doi: 10.1111/j.1464-5491.2004.01202.x. [PMID: 15154951]
  • J A O Ojewole. Hypoglycemic effect of Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark aqueous extract in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2003 Nov; 10(8):675-81. doi: 10.1078/0944-7113-00295. [PMID: 14692729]
  • S Amos, L Binda, M Adamu, H O Vongtau, J Abbah, E K I Omogbai, P A Akah, B B Bukar, C Wambebe, K Gamaniel. Effect of the aqueous extract of Chrysanthellum indicum on calcium mobilization and activation of rat portal vein. Journal of ethnopharmacology. 2003 Sep; 88(1):57-62. doi: 10.1016/s0378-8741(03)00155-7. [PMID: 12902051]
  • G Colmenarejo, A Alvarez-Pedraglio, J L Lavandera. Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry. 2001 Dec; 44(25):4370-8. doi: 10.1021/jm010960b. [PMID: 11728183]
  • B N Nguyen, S A Yablon, C Y Chen. Hypodipsic hypernatremia and diabetes insipidus following anterior communicating artery aneurysm clipping: diagnostic and therapeutic challenges in the amnestic rehabilitation patient. Brain injury. 2001 Nov; 15(11):975-80. doi: 10.1080/02699050110063459. [PMID: 11689095]
  • E L Knight, J Avorn. Quality indicators for appropriate medication use in vulnerable elders. Annals of internal medicine. 2001 Oct; 135(8 Pt 2):703-10. doi: 10.7326/0003-4819-135-8_part_2-200110161-00009. [PMID: 11601953]
  • L Gribaldo, I Malerba, A Collotta, S Casati, A Pessina. Inhibition of CFU-E/BFU-E by 3'-azido-3'-deoxythymidine, chlorpropamide, and protoporphirin IX zinc (II): a comparison between direct exposure of progenitor cells and long-term exposure of bone marrow cultures. Toxicological sciences : an official journal of the Society of Toxicology. 2000 Nov; 58(1):96-101. doi: 10.1093/toxsci/58.1.96. [PMID: 11053545]
  • F Magni, L Marazzini, S Pereira, L Monti, M Galli Kienle. Identification of sulfonylureas in serum by electrospray mass spectrometry. Analytical biochemistry. 2000 Jun; 282(1):136-41. doi: 10.1006/abio.2000.4597. [PMID: 10860510]
  • C F Agboola-Abu, A E Ohwovoriole, K S Akinlade. The effect of oral hypoglycaemic agents on dyslipidaemia in Nigerian patients with newly diagnosed non-insulin dependent diabetes mellitus--a prospective study. West African journal of medicine. 2000 Apr; 19(2):126-31. doi: NULL. [PMID: 11070748]
  • T Tetiker, M Sert, M Koçak. Efficacy of indapamide in central diabetes insipidus. Archives of internal medicine. 1999 Sep; 159(17):2085-7. doi: 10.1001/archinte.159.17.2085. [PMID: 10510995]
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