nabumetone (BioDeep_00000016589)

   

natural product


代谢物信息卡片


nabumetone

化学式: C15H16O2 (228.1150236)
中文名称: 萘丁美酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(=CC=C2C(=C1)C=CC(=C2)CCC(C)=O)OC
InChI: InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents

同义名列表

1 个代谢物同义名

nabumetone



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Dominika Kapuścińska, Magdalena Narajczyk, Ivan Liakh, Bartosz Wielgomas, Anna Aksmann. Nabumetone and flufenamic acid pose a serious risk to aquatic plants: A study with Chlamydomonas reinhardtii as a model organism. Chemosphere. 2024 Feb; 349(?):140853. doi: 10.1016/j.chemosphere.2023.140853. [PMID: 38052310]
  • Anik Banik, Sheikh Rashel Ahmed, Emran Hossain Sajib, Anamika Deb, Shiuly Sinha, Kazi Faizul Azim. Identification of potential inhibitory analogs of metastasis tumor antigens (MTAs) using bioactive compounds: revealing therapeutic option to prevent malignancy. Molecular diversity. 2022 Oct; 26(5):2473-2502. doi: 10.1007/s11030-021-10345-w. [PMID: 34743299]
  • Saba Qureshi, Sonam Chandra, Deepti Chopra, Divya Dubey, Veena Jain, Somendu Kumar Roy, Ratan Singh Ray. Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line. Toxicology and applied pharmacology. 2021 06; 420(?):115516. doi: 10.1016/j.taap.2021.115516. [PMID: 33798594]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Roya Afsharipour, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani, Elahe Kazemi. Design of a pseudo stir bar sorptive extraction using graphenized pencil lead as the base of the molecularly imprinted polymer for extraction of nabumetone. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Sep; 238(?):118427. doi: 10.1016/j.saa.2020.118427. [PMID: 32388234]
  • Raj Kumar, Ashutosh Singh, Kajal Sharma, Divya Dhasmana, Neha Garg, Prem Felix Siril. Preparation, characterization and in vitro cytotoxicity of Fenofibrate and Nabumetone loaded solid lipid nanoparticles. Materials science & engineering. C, Materials for biological applications. 2020 Jan; 106(?):110184. doi: 10.1016/j.msec.2019.110184. [PMID: 31753394]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Lenka Jourova, Pavel Anzenbacher, Zuzana Matuskova, Rostislav Vecera, Jan Strojil, Milan Kolar, Milan Nobilis, Petra Hermanova, Tomas Hudcovic, Hana Kozakova, Miloslav Kverka, Eva Anzenbacherova. Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Nov; 49(11):1296-1302. doi: 10.1080/00498254.2018.1558310. [PMID: 30794062]
  • Filippo Fiorentini, Elvira Romero, Marco W Fraaije, Kurt Faber, Mélanie Hall, Andrea Mattevi. Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism. ACS chemical biology. 2017 09; 12(9):2379-2387. doi: 10.1021/acschembio.7b00470. [PMID: 28783300]
  • Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik. Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats. Phytotherapy research : PTR. 2017 Jan; 31(1):75-80. doi: 10.1002/ptr.5731. [PMID: 27714886]
  • Mohammad Asadi, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia, Bijan Abbasi. Vortex-assisted surfactant-enhanced emulsification microextraction based on solidification of floating organic drop combined with high performance liquid chromatography for determination of naproxen and nabumetone. Journal of chromatography. A. 2015 Dec; 1425(?):17-24. doi: 10.1016/j.chroma.2015.11.005. [PMID: 26627589]
  • Sunna Þorsteinsdóttir, Marie Juul Velander, Anette Bygum. [Medicine-caused itch, wounds and bullous skin in three patients with pseudoporphyria]. Ugeskrift for laeger. 2015 Apr; 177(17):. doi: NULL. [PMID: 25922166]
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  • Lenka Česlová, Michal Holčapek, Milan Nobilis. Identification of combined conjugation of nabumetone phase I metabolites with glucuronic acid and glycine in minipig biotransformation using coupling high-performance liquid chromatography with electrospray ionization mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):221-4. doi: 10.1016/j.jpba.2013.08.053. [PMID: 24083957]
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  • Nao Setoguchi, Norito Takamura, Ken-ichi Fujita, Kenji Ogata, Jin Tokunaga, Toyotaka Nishio, Etsuo Chosa, Kazuhiko Arimori, Keiichi Kawai, Ryuichi Yamamoto. A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis. Biopharmaceutics & drug disposition. 2013 Mar; 34(2):125-36. doi: 10.1002/bdd.1829. [PMID: 23225308]
  • José Antonio Murillo Pulgarín, Aurelia Alañón Molina, Fernando Martínez Ferreras. Simultaneous determination of nabumetone and its principal metabolite in medicines and human urine by time-resolved fluorescence. The Analyst. 2012 Nov; 137(21):5144-52. doi: 10.1039/c2an35412h. [PMID: 22977877]
  • Robert L Jackson, Barbara Hunt, Patricia A MacDonald. The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age. BMC geriatrics. 2012 Mar; 12(?):11. doi: 10.1186/1471-2318-12-11. [PMID: 22436129]
  • Jean-Pascal Fournier, Maryse Lapeyre-Mestre, Agnès Sommet, Julie Dupouy, Jean-Christophe Poutrain, Jean-Louis Montastruc. Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study. PloS one. 2012; 7(3):e34187. doi: 10.1371/journal.pone.0034187. [PMID: 22479557]
  • Takako Hirata, Shuh Narumiya. Prostanoids as regulators of innate and adaptive immunity. Advances in immunology. 2012; 116(?):143-74. doi: 10.1016/b978-0-12-394300-2.00005-3. [PMID: 23063076]
  • Kang Nyeong Lee, Oh Young Lee, Myung-Gyu Choi, Seok Reyol Choi, Dong Ho Lee, Yong Chan Lee, Tae Nyeun Kim, Suck Chei Choi, Jong Sun Rew, Sang-Yong Seol. Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. Journal of Korean medical science. 2011 Aug; 26(8):1074-80. doi: 10.3346/jkms.2011.26.8.1074. [PMID: 21860559]
  • Sandeep Rahar, Gaurav Swami, Navneet Nagpal, Manisha A Nagpal, Gagan Shah Singh. Preparation, characterization, and biological properties of β-glucans. Journal of advanced pharmaceutical technology & research. 2011 Apr; 2(2):94-103. doi: 10.4103/2231-4040.82953. [PMID: 22171300]
  • Lenka Nespesná, Martin Stícha, Olga Matousková, Frantisek Perlík, Ondrej Slanar. [Determination of nabumetone and 6-methoxy-2-naphthylacetic acid in plasma using HPLC with UV and MS detection]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 2011 Feb; 60(1):17-24. doi: NULL. [PMID: 21650014]
  • Rahila Ahmad Pathan, Bhulan Kumar Singh, K K Pillai, Kiran Dubey. Naproxen aggravates doxorubicin-induced cardiomyopathy in rats. Indian journal of pharmacology. 2010 Feb; 42(1):44-9. doi: 10.4103/0253-7613.62411. [PMID: 20606837]
  • Sunday Olakunle Idowu, Morenikeji Ambali Adeyemo, Udochi Ihechiluru Ogbonna. Engineering and validation of a novel lipid thin film for biomembrane modeling in lipophilicity determination of drugs and xenobiotics. Journal of biological engineering. 2009 Sep; 3(?):14. doi: 10.1186/1754-1611-3-14. [PMID: 19735551]
  • Keiichi Kawai, Ryuichi Nishii, Naoto Shikano, Nobuo Makino, Noriyuki Kuga, Mitsuyoshi Yoshimoto, Seishi Jinnouchi, Shigeki Nagamachi, Shozo Tamura, Norito Takamura. Serum protein binding displacement: theoretical analysis using a hypothetical radiopharmaceutical and experimental analysis with 123I-N-isopropyl-p-iodoamphetamine. Nuclear medicine and biology. 2009 Jan; 36(1):99-106. doi: 10.1016/j.nucmedbio.2008.10.005. [PMID: 19181274]
  • Bhavin N Patel, Naveen Sharma, Mallika Sanyal, Arpana Prasad, Pranav S Shrivastav. High-throughput LC-MS/MS assay for 6-methoxy-2-naphthylacetic acid, an active metabolite of nabumetone in human plasma and its application to bioequivalence study. Biomedical chromatography : BMC. 2008 Nov; 22(11):1213-24. doi: 10.1002/bmc.1047. [PMID: 18651608]
  • Klefah A K Musa, Leif A Eriksson. Theoretical study of the phototoxicity of naproxen and the active form of nabumetone. The journal of physical chemistry. A. 2008 Oct; 112(43):10921-30. doi: 10.1021/jp805614y. [PMID: 18834087]
  • Mojca Brunskole, Bogdan Stefane, Karmen Zorko, Marko Anderluh, Jure Stojan, Tea Lanisnik Rizner, Stanislav Gobec. Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening. Bioorganic & medicinal chemistry. 2008 Jun; 16(11):5881-9. doi: 10.1016/j.bmc.2008.04.066. [PMID: 18482840]
  • Idris bin Long, Harbindar Jeet Singh, Gurubelli Janardhana Rao. Comparative effects of indomethacin and nabumetone on urine and electrolyte output in conscious rats. Journal of pharmacological sciences. 2005 Nov; 99(3):272-6. doi: 10.1254/jphs.fpj05008x. [PMID: 16293937]
  • N Canudas, D Zamora, J E Villamizar, J Fuentes, C Castelli, A Taddei. Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone. Die Pharmazie. 2005 Aug; 60(8):604-8. doi: ". [PMID: 16124404]
  • R Nageswara Rao, S Meena, D Nagaraju, A Raghu Ram Rao. Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids. Biomedical chromatography : BMC. 2005 Jun; 19(5):362-8. doi: 10.1002/bmc.458. [PMID: 15627281]
  • J A Murillo Pulgarín, A Alañón Molina, M T Alañón Pardo. Simplex optimization of the variables affecting the micelle-stabilized room temperature phosphorescence of 6-methoxy-2-naphthylacetic acid and its kinetic determination in human urine. Analytical biochemistry. 2005 Apr; 339(1):157-64. doi: 10.1016/j.ab.2005.01.012. [PMID: 15766723]
  • J F Sheen, G R Her. Application of pentafluorophenyl hydrazine derivatives to the analysis of nabumetone and testosterone in human plasma by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2004 Dec; 380(7-8):891-7. doi: 10.1007/s00216-004-2877-6. [PMID: 15700167]
  • M Nobilis, M Holcapek, L Kolárová, J Kopecký, M Kunes, Z Svoboda, J Kvetina. Identification and determination of phase II nabumetone metabolites by high-performance liquid chromatography with photodiode array and mass spectrometric detection. Journal of chromatography. A. 2004 Mar; 1031(1-2):229-36. doi: 10.1016/j.chroma.2004.01.031. [PMID: 15058587]
  • Thomas Hedner, Ola Samulesson, Peter Währborg, Hans Wadenvik, Kjell-Arne Ung, Anders Ekbom. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. Drugs. 2004; 64(20):2315-43; discussion 2344. doi: 10.2165/00003495-200464200-00004. [PMID: 15456329]
  • M Nobilis, J Kopecký, J Kvetina, Z Svoboda, M Pour, J Kunes, M Holcapek, L Kolárová. Comparative biotransformation and disposition studies of nabumetone in humans and minipigs using high-performance liquid chromatography with ultraviolet, fluorescence and mass spectrometric detection. Journal of pharmaceutical and biomedical analysis. 2003 Aug; 32(4-5):641-56. doi: 10.1016/s0731-7085(03)00171-7. [PMID: 12899954]
  • H T Sørensen, S Friis, B Nørgård, L Mellemkjaer, W J Blot, J K McLaughlin, A Ekbom, J A Baron. Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study. British journal of cancer. 2003 Jun; 88(11):1687-92. doi: 10.1038/sj.bjc.6600945. [PMID: 12771981]
  • Kamila Kobylińska, Małgorzata Barlińska, Maria Kobylińska. Analysis of nabumetone in human plasma by HPLC. Application to single dose pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2003 Jun; 32(2):323-8. doi: 10.1016/s0731-7085(03)00078-5. [PMID: 12763542]
  • Jeffrey R LaDuca, Peter H Bouman, Anthony A Gaspari. Nonsteroidal antiinflammatory drug-induced pseudoporphyria: a case series. Journal of cutaneous medicine and surgery. 2002 Jul; 6(4):320-6. doi: 10.1007/s10227-001-0051-8. [PMID: 12118363]
  • D J W van Kraaij, A H I Hovestad-Witterland, M de Metz, E J Vollaard. A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers. British journal of clinical pharmacology. 2002 Jun; 53(6):644-7. doi: 10.1046/j.1365-2125.2002.01605.x. [PMID: 12047490]
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  • E Mikami, T Goto, T Ohno, H Matsumoto, M Nishida. Simultaneous analysis of naproxen, nabumetone and its major metabolite 6-methoxy-2-naphthylacetic acid in pharmaceuticals and human urine by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2000 Oct; 23(5):917-25. doi: 10.1016/s0731-7085(00)00365-4. [PMID: 11022916]
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