bisacodyl (BioDeep_00000016588)
natural product
代谢物信息卡片
bisacodyl
化学式: C22H19NO4 (361.1314014000001)
中文名称: 比沙可啶
谱图信息:
最多检出来源 Viridiplantae(plant) 90.91%
分子结构信息
SMILES: C1(=CC=C(C=C1)OC(=O)C)C(C2=CC=CC=N2)C3=CC=C(C=C3)OC(=O)C
InChI: InChI=1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3
描述信息
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AB - Contact laxatives
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AG - Enemas
C78276 - Agent Affecting Digestive System or Metabolism > C29697 - Laxative
D005765 - Gastrointestinal Agents > D002400 - Cathartics
D005765 - Gastrointestinal Agents > D054368 - Laxatives
Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect[1].
同义名列表
1 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:3125
- KEGG: C06851
- KEGGdrug: D00245
- KEGGdrug: D81813
- PubChem: 2391
- Metlin: METLIN1347
- DrugBank: DB09020
- ChEMBL: CHEMBL942
- MeSH: Bisacodyl
- CAS: 603-50-9
- MoNA: CCMSLIB00000078638
- PMhub: MS000001428
- medchemexpress: HY-B0557
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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