metolazone (BioDeep_00000016585)
natural product
代谢物信息卡片
Metolazone (Zaroxolyn)
化学式: C16H16ClN3O3S (365.0600856)
中文名称: 美托拉宗
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=C(C=C2C(=C1)NC(N(C2=O)C3=CC=CC=C3C)C)S(=O)(=O)N)Cl
InChI: InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
描述信息
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:64354
- KEGG: C07248
- KEGGdrug: D00431
- PubChem: 4170
- Metlin: METLIN1249
- DrugBank: DB00524
- ChEMBL: CHEMBL878
- MeSH: Metolazone
- CAS: 17560-51-9
- CAS: 56436-31-8
- CAS: 56436-32-9
- MoNA: CCMSLIB00000078199
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kristen M Ahlschwede, Edward Ofori, Terrick Andey, Anita Osei, John S Somberg. Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion.
Drug research.
2022 Jul; 72(6):299-305. doi:
10.1055/a-1813-9489. [PMID: 35537450] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Taylor D Steuber, Kristin M Janzen, Meredith L Howard. A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure.
Pharmacotherapy.
2020 09; 40(9):924-935. doi:
10.1002/phar.2440. [PMID: 32639593] - Zachary L Cox, Rebecca Hung, Daniel J Lenihan, Jeffrey M Testani. Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
JACC. Heart failure.
2020 03; 8(3):157-168. doi:
10.1016/j.jchf.2019.09.012. [PMID: 31838029] - Shaurya Srivastava, Tyler Kemnic, Kyle R Hildebrandt. BRASH syndrome.
BMJ case reports.
2020 Feb; 13(2):. doi:
10.1136/bcr-2019-233825. [PMID: 32094236] - Momin Salahudin, Hammad Shah, Muneeb Ullah Jan, Afrasyab Altaf. Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial.
JPMA. The Journal of the Pakistan Medical Association.
2019 Dec; 69(12):1794-1799. doi:
10.5455/jpma.3401. [PMID: 31853105] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Russell T Wise, Brady S Moffett, Ayse Akcan-Arikan, Marianne Galati, Natasha Afonso, Paul A Checchia. Enhancement of diuresis with metolazone in infant paediatric cardiac intensive care patients.
Cardiology in the young.
2018 Jan; 28(1):27-31. doi:
10.1017/s1047951117001330. [PMID: 28889825] - Xueqing Li, Rutao Wang, Yang Liu, Yun Liu, Heng Zheng, Yabo Feng, Na Zhao, Hongbin Geng, Wanzhi Zhang, Aidong Wen. Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population.
BMC pharmacology & toxicology.
2017 11; 18(1):73. doi:
10.1186/s40360-017-0178-x. [PMID: 29145890] - Jiezhao Zhou, Meiling Chen, Ying Li, Fanglin Yu, Xiaohui Cheng, Yang Yang, Yan Liu, Xiangyang Xie, Zhiping Li, Hui Zhang, Xingguo Mei. Simultaneous determination of metolazone and valsartan in plasma by on-line SPE coupled with liquid chromatography/tandem mass spectrometry.
European journal of mass spectrometry (Chichester, England).
2017 Oct; 23(5):305-312. doi:
10.1177/1469066717716726. [PMID: 29028382] - Soren Snitker, Rebecca M Doerfler, Elsayed Z Soliman, Rajat Deo, Wendy L St Peter, Susan Kramlik, Michael J Fischer, Sankar Navaneethan, Patrice Delafontaine, Bernard G Jaar, Akinlolu Ojo, Gail K Makos, Anne Slaven, Matthew R Weir, Min Zhan, Jeffrey C Fink. Association of QT-Prolonging Medication Use in CKD with Electrocardiographic Manifestations.
Clinical journal of the American Society of Nephrology : CJASN.
2017 09; 12(9):1409-1417. doi:
10.2215/cjn.12991216. [PMID: 28793999] - Christopher J Michaud, Kendall C Mintus. Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit.
The Annals of pharmacotherapy.
2017 Apr; 51(4):286-292. doi:
10.1177/1060028016683971. [PMID: 28228057] - Maria Cardinale, Jerry Altshuler, Jeffrey M Testani. Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone.
Pharmacotherapy.
2016 08; 36(8):843-51. doi:
10.1002/phar.1787. [PMID: 27321568] - Christine E Shulenberger, Anthony Jiang, Sandeep Devabhakthuni, Vijay Ivaturi, Tao Liu, Brent N Reed. Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance.
Pharmacotherapy.
2016 08; 36(8):852-60. doi:
10.1002/phar.1798. [PMID: 27393709] - Ramkumar Dubey, Manik Ghosh, Barij Nayan Sinha, Venkateswari Muthukrishnan. Simultaneous Determination and Pharmacokinetics of Metolazone, Losartan and Losartan Carboxylic Acid in Rat Plasma by HPLC-ESI-MS-MS.
Journal of chromatographic science.
2015 Oct; 53(9):1520-7. doi:
10.1093/chromsci/bmv047. [PMID: 25947361] - Michael P Moranville, Suji Choi, Jennifer Hogg, Allen S Anderson, Jonathan D Rich. Comparison of metolazone versus chlorothiazide in acute decompensated heart failure with diuretic resistance.
Cardiovascular therapeutics.
2015 Apr; 33(2):42-9. doi:
10.1111/1755-5922.12109. [PMID: 25712736] - Hon Wai Benjamin Cheng, Mau-Kwong Sham, Kwok-Ying Chan, Cho-Wing Li, Ho-Yan Au, Terence Yip. Combination therapy with low-dose metolazone and furosemide: a 'needleless' approach in managing refractory fluid overload in elderly renal failure patients under palliative care.
International urology and nephrology.
2014 Sep; 46(9):1809-13. doi:
10.1007/s11255-014-0724-z. [PMID: 24824145] - Mohammed I Walash, Nahed M El-Enany, Manal I Eid, Mona E Fathy. Simultaneous determination of metolazone and losartan potassium in their binary mixtures using high-performance liquid chromatography with fluorimetric detection: application to combined tablets and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2014 Aug; 29(5):462-70. doi:
10.1002/bio.2570. [PMID: 23996979] - Bijin Thajudeen, Mario F Rubin. Hemodynamic acute kidney injury in immunoglobulin A nephropathy: nephrosarca theory revisited.
The American journal of medicine.
2013 Dec; 126(12):e13-4. doi:
10.1016/j.amjmed.2013.07.033. [PMID: 24140146] - Tien M H Ng, Erica Konopka, Alifiya F Hyderi, Shenche Hshieh, Yuki Tsuji, Brian J Kim, Song Y Han, Duc H Phan, Aaron I Jeng, Mimi Lou, Uri Elkayam. Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure.
Journal of cardiovascular pharmacology and therapeutics.
2013 Jul; 18(4):345-53. doi:
10.1177/1074248413482755. [PMID: 23538300] - Yanyan Jia, Yan Zhang, Chao Wang, Zhirui Wang, Yu Liu, Jingwen Wang, Aidong Wen. An improved LC-MS/MS method for quantitative determination of metolazone in human plasma and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2011 Oct; 25(10):1138-43. doi:
10.1002/bmc.1583. [PMID: 21387350] - Z Khawaja, C S Wilcox. Role of the kidneys in resistant hypertension.
International journal of hypertension.
2011 Mar; 2011(?):143471. doi:
10.4061/2011/143471. [PMID: 21461391] - Mohammad Sarraf, Robert W Schrier. Cardiorenal syndrome in acute heart failure syndromes.
International journal of nephrology.
2011 Mar; 2011(?):293938. doi:
10.4061/2011/293938. [PMID: 21423563] - Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A Wagner. Proliferation of acid-secretory cells in the kidney during adaptive remodelling of the collecting duct.
PloS one.
2011; 6(10):e25240. doi:
10.1371/journal.pone.0025240. [PMID: 22039408] - Claudio Ronco, Peter McCullough, Stefan D Anker, Inder Anand, Nadia Aspromonte, Sean M Bagshaw, Rinaldo Bellomo, Tomas Berl, Ilona Bobek, Dinna N Cruz, Luciano Daliento, Andrew Davenport, Mikko Haapio, Hans Hillege, Andrew A House, Nevin Katz, Alan Maisel, Sunil Mankad, Pierluigi Zanco, Alexandre Mebazaa, Alberto Palazzuoli, Federico Ronco, Andrew Shaw, Geoff Sheinfeld, Sachin Soni, Giorgio Vescovo, Nereo Zamperetti, Piotr Ponikowski. Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative.
European heart journal.
2010 Mar; 31(6):703-11. doi:
10.1093/eurheartj/ehp507. [PMID: 20037146] - Elizabeth M Volz, G Michael Felker. How to use diuretics in heart failure.
Current treatment options in cardiovascular medicine.
2009 Dec; 11(6):426-32. doi:
10.1007/s11936-009-0045-1. [PMID: 19930980] - Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
10.1016/j.ejmech.2009.06.004. [PMID: 19586686] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Zhiying Zhang Rasmussen, Toke Barfod, Jakob Klit. [Renal effect of treatment for heart failure].
Ugeskrift for laeger.
2009 Feb; 171(9):718. doi:
NULL. [PMID: 19257999] - Arshdeep Tindni, Kumar Gaurav, Mukta Panda. Non-healing painful ulcers in a patient with chronic kidney disease and role of sodium thiosulfate: a case report.
Cases journal.
2008 Sep; 1(1):178. doi:
10.1186/1757-1626-1-178. [PMID: 18811973] - Brigitte Kaissling, Michel Le Hir. The renal cortical interstitium: morphological and functional aspects.
Histochemistry and cell biology.
2008 Aug; 130(2):247-62. doi:
10.1007/s00418-008-0452-5. [PMID: 18575881] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Shradha Rathi, William Kern, Kai Lau. Vitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure: a case report.
Journal of medical case reports.
2007 Nov; 1(?):155. doi:
10.1186/1752-1947-1-155. [PMID: 18042297] - Ivana Cvetanovic, Vasant Ranade, Janos Molnar, Andrew Whelton, John Somberg. The evaluation of the diuretic action of parenteral formulations of metolazone.
American journal of therapeutics.
2007 Jan; 14(1):25-9. doi:
10.1097/01.mjt.0000212710.65787.9c. [PMID: 17303972] - Gabriella Pridjian, Candice Pridjian, Svitlana Danchuk, Monica Ianosi-Irimie, Hop V Vu, Jules B Puschett. Beneficial effects of metolazone in a rat model of preeclampsia.
The Journal of pharmacology and experimental therapeutics.
2006 Sep; 318(3):1027-32. doi:
10.1124/jpet.106.104901. [PMID: 16717105] - Erika Moreno, Pedro San Cristóbal, Manuel Rivera, Norma Vázquez, Norma A Bobadilla, Gerardo Gamba. Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding.
The Journal of biological chemistry.
2006 Jun; 281(25):17266-17275. doi:
10.1074/jbc.m602614200. [PMID: 16624820] - G Splendiani, S Condò. [Diuretic therapy in heart failure].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2006 Jan; 23 Suppl 34(?):S74-6. doi:
. [PMID: 16634001] - Raymond A Lorenz, Rowland J Elwell. Pre-dosing metolazone with loop diuretic combination regimens.
Nephrology nursing journal : journal of the American Nephrology Nurses' Association.
2006 Jan; 33(1):78-9. doi:
NULL. [PMID: 16538931] - Jochen Beyer, Anabelle Bierl, Frank T Peters, Hans H Maurer. Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.
Therapeutic drug monitoring.
2005 Aug; 27(4):509-20. doi:
10.1097/01.ftd.0000160719.96445.91. [PMID: 16044110] - Jens Rosenberg, Finn Gustafsson, Søren Galatius, Per Rossen Hildebrandt. Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.
Cardiovascular drugs and therapy.
2005 Aug; 19(4):301-6. doi:
10.1007/s10557-005-3350-2. [PMID: 16189620] - Ernesto Sabath, Patricia Meade, Jennifer Berkman, Paola de los Heros, Erika Moreno, Norma A Bobadilla, Norma Vázquez, David H Ellison, Gerardo Gamba. Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease.
American journal of physiology. Renal physiology.
2004 Aug; 287(2):F195-203. doi:
10.1152/ajprenal.00044.2004. [PMID: 15068971] - Yunje Kim, Sungil Kim, Myungsoo Kim, Won Lee. Determination of a Metolazone metabolite in human urine by high-performance liquid chromatography/diode-array detection, high-performance liquid chromatography/electrospray ionization mass spectrometry and gas chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2004; 18(8):917-22. doi:
10.1002/rcm.1398. [PMID: 15095363] - Joke C De Jong, Walter A Van Der Vliet, Lambertus P W J Van Den Heuvel, Peter H G M Willems, Nine V A M Knoers, René J M Bindels. Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome.
Journal of the American Society of Nephrology : JASN.
2002 Jun; 13(6):1442-8. doi:
10.1097/01.asn.0000017904.77985.03. [PMID: 12039972] - Fatemeh Akhlaghi, Christopher H Jackson, Jayan Parameshwar, Linda D Sharples, Andrew K Trull. Risk factors for the development and progression of dyslipidemia after heart transplantation.
Transplantation.
2002 Apr; 73(8):1258-64. doi:
10.1097/00007890-200204270-00012. [PMID: 11981418] - L P Brion, R A Primhak, I Ambrosio-Perez. Diuretics acting on the distal renal tubule for preterm infants with (or developing) chronic lung disease.
The Cochrane database of systematic reviews.
2002; ?(1):CD001817. doi:
NULL. [PMID: 11869608] - C Pauli-Magnus, T Mettang, U Kuhlmann. [Severe nephrotic syndrome with reversible acute kidney failure in lupus-associated membranous nephropathy].
Deutsche medizinische Wochenschrift (1946).
1999 Jun; 124(25-26):788-92. doi:
10.1055/s-2007-1024421. [PMID: 10414228] - H Kihara, H Terai, Y Kihara, T Kihara, H Takahashi, A Kosuda, M Shimomoto, M Fukunishi, T Tanaka. [Pheochromocytoma of the left retroperitoneal paraganglion associated with torsade de pointes: a case report].
Journal of cardiology.
1997 Jul; 30(1):37-44. doi:
NULL. [PMID: 9253694] - J L Segar, S Chemtob, E F Bell. Changes in body water compartments with diuretic therapy in infants with chronic lung disease.
Early human development.
1997 Apr; 48(1-2):99-107. doi:
10.1016/s0378-3782(96)01841-5. [PMID: 9131311] - P Blakely, D A Vaughn, D D Fanestil. Effects of calcium-modulating hormones on thiazide receptor density.
Journal of the American Society of Nephrology : JASN.
1996 Jul; 7(7):1052-7. doi:
10.1681/asn.v771052. [PMID: 8829121] - H Velázquez, A Bartiss, P Bernstein, D H Ellison. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules.
The American journal of physiology.
1996 Jan; 270(1 Pt 2):F211-9. doi:
10.1152/ajprenal.1996.270.1.f211. [PMID: 8769842] - Z Chen, D A Vaughn, P Blakely, D D Fanestil. Adrenocortical steroids increase renal thiazide diuretic receptor density and response.
Journal of the American Society of Nephrology : JASN.
1994 Dec; 5(6):1361-8. doi:
10.1681/asn.v561361. [PMID: 7894003] - Z Chen, D A Vaughn, D D Fanestil. Influence of gender on renal thiazide diuretic receptor density and response.
Journal of the American Society of Nephrology : JASN.
1994 Oct; 5(4):1112-9. doi:
10.1681/asn.v541112. [PMID: 7849251] - D Farthing, D A Sica, I Fakhry, T W Gehr. Novel high-performance liquid chromatographic method using solid-phase on-line elution for determination of metolazone in plasma and whole blood.
Journal of chromatography. B, Biomedical applications.
1994 Mar; 653(2):171-6. doi:
10.1016/0378-4347(93)e0427-r. [PMID: 8205244] - K S Channer, K A McLean, P Lawson-Matthew, M Richardson. Combination diuretic treatment in severe heart failure: a randomised controlled trial.
British heart journal.
1994 Feb; 71(2):146-50. doi:
10.1136/hrt.71.2.146. [PMID: 8130022] - D J Quan, S R Kayser. Ketorolac induced acute renal failure following a single dose.
Journal of toxicology. Clinical toxicology.
1994; 32(3):305-9. doi:
10.3109/15563659409017963. [PMID: 8007038] - E B Ripley, T W Gehr, H Wallace, J Wade, C Kish, D A Sica. The effect of nonsteroidal agents (NSAIDs) on the pharmacokinetics and pharmacodynamics of metolazone.
International journal of clinical pharmacology and therapeutics.
1994 Jan; 32(1):12-8. doi:
NULL. [PMID: 8199745] - J L Segar, J E Robillard, K J Johnson, E F Bell, S Chemtob. Addition of metolazone to overcome tolerance to furosemide in infants with bronchopulmonary dysplasia.
The Journal of pediatrics.
1992 Jun; 120(6):966-73. doi:
10.1016/s0022-3476(05)81972-9. [PMID: 1593359] - D H Ellison, J Morrisey, G V Desir. Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex.
Biochimica et biophysica acta.
1991 Nov; 1069(2):241-9. doi:
10.1016/0005-2736(91)90131-q. [PMID: 1932064] - P Morsing, H Velázquez, F S Wright, D H Ellison. Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion.
The American journal of physiology.
1991 Jul; 261(1 Pt 2):F137-43. doi:
10.1152/ajprenal.1991.261.1.f137. [PMID: 1858894] - N Kröger, J Szuba, H Frenzel. [Metolazone in the treatment of advanced therapy-resistant dilated cardiomyopathy].
Medizinische Klinik (Munich, Germany : 1983).
1991 Jun; 86(6):305-8, 332. doi:
NULL. [PMID: 1886511] - H Luo, D D Fanestil. Inhibition of binding of [3H]metolazone to rat kidney membrane by stilbene disulfonates.
Biochemical pharmacology.
1991 Jun; 41(11):1745-50. doi:
10.1016/0006-2952(91)90179-9. [PMID: 2043163] - T W Gehr, D A Sica, D C Brater, H J Wallace, J Davis, I Fakhry. Metolazone pharmacokinetics and pharmacodynamics in renal transplantation.
International journal of clinical pharmacology, therapy, and toxicology.
1991 Mar; 29(3):116-23. doi:
NULL. [PMID: 2071258] - D Farthing, I Fakhry, T W Gehr, D A Sica. Quantitation of metolazone in urine by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography.
1990 Dec; 534(?):228-32. doi:
10.1016/s0378-4347(00)82167-2. [PMID: 2094710] - Z F Chen, D A Vaughn, K Beaumont, D D Fanestil. Effects of diuretic treatment and of dietary sodium on renal binding of 3H-metolazone.
Journal of the American Society of Nephrology : JASN.
1990 Jul; 1(1):91-8. doi:
10.1681/asn.v1191. [PMID: 1966553] - H Luo, K Beaumont, D A Vaughn, D D Fanestil. Solubilization of thiazide diuretic receptors from rat kidney membranes.
Biochimica et biophysica acta.
1990 Apr; 1052(1):119-22. doi:
10.1016/0167-4889(90)90065-l. [PMID: 2322588] - J M Tran, M A Farrell, D D Fanestil. Effect of ions on binding of the thiazide-type diuretic metolazone to kidney membrane.
The American journal of physiology.
1990 Apr; 258(4 Pt 2):F908-15. doi:
10.1152/ajprenal.1990.258.4.f908. [PMID: 2330985] - K Beaumont, D A Vaughn, R Casto, M P Printz, D D Fanestil. Thiazide diuretic receptors in spontaneously hypertensive rats and 2-kidney 1-clip hypertensive rats.
Clinical and experimental hypertension. Part A, Theory and practice.
1990; 12(2):215-26. doi:
10.3109/10641969009074730. [PMID: 2347095] - Kirancumar, P A Loureiro, J M Correia. [Metolazone in the treatment of refractory heart insufficiency. Experience of 10 cases].
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.
1989 Nov; 8(11):775-8. doi:
NULL. [PMID: 2631826] - G P Reams, J H Bauer. The effect of triple drug therapy on renal function in patients with essential hypertension.
Journal of clinical pharmacology.
1989 Sep; 29(9):803-8. doi:
10.1002/j.1552-4604.1989.tb03423.x. [PMID: 2572610] - K Beaumont, D A Vaughn, D P Healy. Thiazide diuretic receptors: autoradiographic localization in rat kidney with [3H]metolazone.
The Journal of pharmacology and experimental therapeutics.
1989 Jul; 250(1):414-9. doi:
. [PMID: 2746509] - L W Stevenson, K A Dracup, J H Tillisch. Efficacy of medical therapy tailored for severe congestive heart failure in patients transferred for urgent cardiac transplantation.
The American journal of cardiology.
1989 Feb; 63(7):461-4. doi:
10.1016/0002-9149(89)90320-2. [PMID: 2644800] - K Beaumont, D A Vaughn, A R Maciejewski, D D Fanestil. Reversible downregulation of thiazide diuretic receptors by acute renal ischemia.
The American journal of physiology.
1989 Feb; 256(2 Pt 2):F329-34. doi:
10.1152/ajprenal.1989.256.2.f329. [PMID: 2916665] - K Beaumont, D A Vaughn, D D Fanestil. Thiazide diuretic drug receptors in rat kidney: identification with [3H]metolazone.
Proceedings of the National Academy of Sciences of the United States of America.
1988 Apr; 85(7):2311-4. doi:
10.1073/pnas.85.7.2311. [PMID: 3353380] - K Beaumont, D A Vaughn. Renal thiazide diuretic receptors: site heterogeneity.
Proceedings of the Western Pharmacology Society.
1988; 31(?):259-61. doi:
NULL. [PMID: 3211912] - E H Garin. A comparison of combinations of diuretics in nephrotic edema.
American journal of diseases of children (1960).
1987 Jul; 141(7):769-71. doi:
10.1001/archpedi.1987.04460070071028. [PMID: 3296741] - D S Lukeman, D D Fanestil. Interactions of diuretics with the peripheral-type benzodiazepine receptor in rat kidney.
The Journal of pharmacology and experimental therapeutics.
1987 Jun; 241(3):950-5. doi:
. [PMID: 3037074] - A Greenberg. What's new in diuretic therapy.
American family physician.
1986 May; 33(5):200-12. doi:
NULL. [PMID: 3706097] - K J Hogg, W S Hillis. Captopril/metolazone induced renal failure.
Lancet (London, England).
1986 Mar; 1(8479):501-2. doi:
10.1016/s0140-6736(86)92959-4. [PMID: 2869237] - C L Curry, S M Janda, R Harris, J H MacKay, C A Nugent, J Ryan, H Schnaper, J Schoenberger. Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension.
Clinical therapeutics.
1986; 9(1):47-62. doi:
NULL. [PMID: 3545477] - M Moser. Low-dose diuretic therapy for hypertension.
Clinical therapeutics.
1986; 8(5):554-62. doi:
NULL. [PMID: 3768929] - J Egel, J Pfanstiel, J B Puschett. Diuretic effects on renal brush border membrane transport and metabolism.
Life sciences.
1985 Nov; 37(18):1675-81. doi:
10.1016/0024-3205(85)90294-2. [PMID: 4058246] - C Marone, F Muggli, W Lahn, F J Frey. Pharmacokinetic and pharmacodynamic interaction between furosemide and metolazone in man.
European journal of clinical investigation.
1985 Oct; 15(5):253-7. doi:
10.1111/j.1365-2362.1985.tb00179.x. [PMID: 3935455] - A Greenberg, R Wallia, J B Puschett. Combined effect of bumetanide and metolazone in normal volunteers.
Journal of clinical pharmacology.
1985 Jul; 25(5):369-73. doi:
10.1002/j.1552-4604.1985.tb02857.x. [PMID: 4031114] - D C Brater, R H Pressley, S A Anderson. Mechanisms of the synergistic combination of metolazone and bumetanide.
The Journal of pharmacology and experimental therapeutics.
1985 Apr; 233(1):70-4. doi:
NULL. [PMID: 3981464] - H Groth, H Vetter, R Achermann, U Kuhlmann, W Siegenthaler, W Vetter. [Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of metolazone and furosemide].
Schweizerische medizinische Wochenschrift.
1985 Jan; 115(2):41-5. doi:
. [PMID: 3969541] - W C Arnold. Efficacy of metolazone and furosemide in children with furosemide-resistant edema.
Pediatrics.
1984 Nov; 74(5):872-5. doi:
NULL. [PMID: 6493882] - G T McInnes, I R Harrison, J R Shelton, R M Perkins, J M Clarke. Relative potency of prorenoate potassium and spironolactone in attenuating diuretic induced hypokalaemia.
British journal of clinical pharmacology.
1984 Aug; 18(2):169-74. doi:
10.1111/j.1365-2125.1984.tb02449.x. [PMID: 6487456] - J W Cronin, S F Kroop, J Diamond, A R Rolla. Alkalemia in diabetic ketoacidosis.
The American journal of medicine.
1984 Jul; 77(1):192-4. doi:
10.1016/0002-9343(84)90461-3. [PMID: 6430081] - H Groth, H Vetter, U Kuhlmann, R Burger, W Siegenthaler, W Vetter. [Antihypertensive therapy in chronic kidney failure. Comparison of pharmacologic effect of metolazone and furosemide].
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.
1983 Nov; 72(45):1423-7. doi:
NULL. [PMID: 6361725] - G T McInnes, J R Shelton, R M Perkins, I R Harrison, J M Clarke. Use of a bioassay in healthy men to evaluate diuretic-spironolactone combinations.
British journal of clinical pharmacology.
1983 May; 15(5):564-6. doi:
10.1111/j.1365-2125.1983.tb02092.x. [PMID: 6860532] - S A Kempson, J C Kowalski, J B Puschett. Direct effect of metolazone on sodium-dependent transport across the renal brush border membrane.
The Journal of laboratory and clinical medicine.
1983 Feb; 101(2):308-16. doi:
NULL. [PMID: 6822765] - G T McInnes, J M Clarke, J R Shelton. Dose-response relationships for spironolactone in combination with a potassium-wasting diuretic.
Clinical pharmacology and therapeutics.
1983 Jan; 33(1):35-43. doi:
10.1038/clpt.1983.5. [PMID: 6848297] - E Cunningham, F H Oliveros, L Nascimento. Metolazone therapy of active calcium nephrolithiasis.
Clinical pharmacology and therapeutics.
1982 Nov; 32(5):642-5. doi:
10.1038/clpt.1982.215. [PMID: 7128005] - R R Brodie, L F Chasseaud, L M Walmsley. Determination of the diuretic agent metolazone in plasma by high-performance liquid chromatography.
Journal of chromatography.
1981 Dec; 226(2):526-32. doi:
10.1016/s0378-4347(00)86093-4. [PMID: 7320183] - J Winaver, P Teredesai, C Anast, J B Puschett. Investigations into the mechanism of the phosphaturia induced by chlorothiazide.
The Journal of pharmacology and experimental therapeutics.
1981 Jul; 218(1):46-54. doi:
NULL. [PMID: 7241388] - R R Ghose, S K Gupta. Synergistic action of metolazone with 'loop' diuretics.
British medical journal (Clinical research ed.).
1981 May; 282(6274):1432-3. doi:
10.1136/bmj.282.6274.1432. [PMID: 6784852] - C W Vose, D C Muirhead, G L Evans, P M Stevens, S R Burford. Quantitation of metolazone in plasma and urine by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography.
1981 Feb; 222(2):311-5. doi:
10.1016/s0378-4347(00)81067-1. [PMID: 7251748] - J Furrer, O M Hess, U Kuhlmann, N Satz, W Siegenthaler. [Furosemide and metolazone: a highly effective diuretic combination].
Schweizerische medizinische Wochenschrift.
1980 Nov; 110(48):1825-9. doi:
NULL. [PMID: 7280609] - J F Winchester, R J Kellett, K Boddy, P Boyle, H J Dargie, M E Mahaffey, D M Ward, A C Kennedy. Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations.
Clinical pharmacology and therapeutics.
1980 Nov; 28(5):611-8. doi:
10.1038/clpt.1980.211. [PMID: 7438679]