atenolol (BioDeep_00000016580)
natural product
代谢物信息卡片
(±)-2-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
化学式: C14H22N2O3 (266.16303419999997)
中文名称: 阿替洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O
InChI: InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
描述信息
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
CONFIDENCE standard compound; INTERNAL_ID 4076
CONFIDENCE Reference Standard (Level 1)
CONFIDENCE standard compound; INTERNAL_ID 1106
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].
同义名列表
数据库引用编号
53 个数据库交叉引用编号
- ChEBI: CHEBI:2904
- KEGG: C06833
- KEGGdrug: D00235
- PubChem: 2249
- Metlin: METLIN1128
- DrugBank: DB00335
- ChEMBL: CHEMBL24
- MeSH: Atenolol
- CAS: 1309283-25-7
- CAS: 1309283-20-2
- CAS: 106020-65-9
- CAS: 29122-68-7
- CAS: 60966-51-0
- MoNA: CCMSLIB00000077060
- MoNA: MoNA038839
- MoNA: MoNA038837
- MoNA: MoNA038339
- MoNA: MoNA037594
- MoNA: MoNA036815
- MoNA: MoNA036814
- MoNA: MoNA036813
- MoNA: MoNA036812
- MoNA: MoNA036810
- MoNA: MoNA036809
- MoNA: MoNA035478
- MoNA: MoNA035476
- MoNA: MoNA035477
- MoNA: MoNA033319
- MoNA: MoNA033317
- MoNA: MoNA033316
- MoNA: WA001323
- MoNA: WA001322
- MoNA: WA001321
- MoNA: WA001320
- MoNA: WA001319
- MoNA: WA001318
- MoNA: HMDB0001924_ms_ms_1854
- MoNA: HMDB0001924_ms_ms_1853
- MoNA: HMDB0001924_ms_ms_1852
- MoNA: UF407604
- MoNA: UF407603
- MoNA: UF407602
- MoNA: UF407601
- MoNA: TUE00083
- MoNA: TUE00082
- MoNA: TUE00081
- MoNA: AU110605
- MoNA: AU110604
- MoNA: AU110603
- MoNA: AU110602
- MoNA: AU110601
- RefMet: Atenolol
- medchemexpress: HY-17498
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qi Yang, Lili Fan, Erwei Hao, Xiaotao Hou, Jiagang Deng, Zhongshang Xia, Zhengcai Du. Construction of An Oral Bioavailability Prediction Model Based on Machine Learning for Evaluating Molecular Modifications.
Journal of pharmaceutical sciences.
2024 May; 113(5):1155-1167. doi:
10.1016/j.xphs.2024.02.026. [PMID: 38430955] - Emma Ivantsova, Isaac Konig, Christopher L Souders, David McNabney, Denina D B Simmons, Christopher J Martyniuk. Lipidomic, metabolomic, and behavior responses of zebrafish (Danio rerio) exposed to environmental levels of the beta blocker atenolol.
The Science of the total environment.
2023 Mar; 866(?):161272. doi:
10.1016/j.scitotenv.2022.161272. [PMID: 36587689] - Ming Yi, Jinxiu Lou, Wanlu Zhu, Dan Li, Pingfeng Yu, Huijie Lu. Mechanism of β-blocker biodegradation by wastewater microorganisms.
Journal of hazardous materials.
2023 02; 444(Pt A):130338. doi:
10.1016/j.jhazmat.2022.130338. [PMID: 36417780] - Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Obaidullah, Mater H Mahnashi, Osama M Alshehri, Mohammed M Jalal, Khalid J Alzahrani, Ibrahim F Halawani. Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196199. [PMID: 36234730] - Pandeng Miao, Jie Gan, Jian Zhang, Mingxuan Ma, Xiaoqi Li, Yingxiang Du, Zijie Feng, Liu Zhang. Carboxymethyl-β-cyclodextrin and histidine-zeolitic imidazolate framework-8 used for enantioseparation of three basic drugs in open-tubular capillary electrochromatography.
Chirality.
2022 09; 34(9):1209-1218. doi:
10.1002/chir.23480. [PMID: 35678370] - Fatma Ilgaz, Selin Seda Timur, Cemil Can Eylem, Emirhan Nemutlu, Çiğdem Eroğlu Erdem, Hakan Eroğlu, Hülya Gökmen-Özel. Do Thickening Agents Used in Dysphagia Diet Affect Drug Bioavailability?.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Jul; 174(?):106197. doi:
10.1016/j.ejps.2022.106197. [PMID: 35489612] - Arzu Ulvi, Senar Aydın, Mehmet Emin Aydın. Fate of selected pharmaceuticals in hospital and municipal wastewater effluent: occurrence, removal, and environmental risk assessment.
Environmental science and pollution research international.
2022 Jun; ?(?):. doi:
10.1007/s11356-022-21131-y. [PMID: 35655023] - Satoru Mitsuboshi, Takahiro Niimura, Fuka Aizawa, Mitsuhiro Goda, Yoshito Zamami, Keisuke Ishizawa. Atenolol and mortality events in patients with chronic kidney disease: Analysis of data from the Japanese Adverse Drug Event Report database.
Basic & clinical pharmacology & toxicology.
2022 04; 130(4):553-556. doi:
10.1111/bcpt.13717. [PMID: 35174631] - Nicole L LeBlanc, Katherine F Scollan, Sumeia Mohamed, J Mark Christensen. Investigation of the short-term effects of a transdermal formulation of atenolol in healthy cats.
American journal of veterinary research.
2021 Oct; 82(10):811-817. doi:
10.2460/ajvr.82.10.811. [PMID: 34554869] - Rasha M S M Mohamed, Shimaa M Elshazly, Ola E Nafea, Dalia M Abd El Motteleb. Comparative cardioprotective effects of carvedilol versus atenolol in a rat model of cardiorenal syndrome type 4.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 10; 394(10):2117-2128. doi:
10.1007/s00210-021-02130-1. [PMID: 34398250] - Abdul Majid, Amir Javed, Mazhar Hussain, Zeeshan Faisal, Asim Elahi, Lubna Akhtar. Effect of nebivolol beneficial on lipid profile and glycemic control in comparison with Atenolol in patients with type 2 DM with concomitant hypertension.
Pakistan journal of pharmaceutical sciences.
2021 Sep; 34(5(Supplementary)):1891-1895. doi:
". [PMID: 34836856] - Vishal Duggal, I-Chun Thomas, Maria E Montez-Rath, Glenn M Chertow, Manjula Kurella Tamura. National Estimates of CKD Prevalence and Potential Impact of Estimating Glomerular Filtration Rate Without Race.
Journal of the American Society of Nephrology : JASN.
2021 06; 32(6):1454-1463. doi:
10.1681/asn.2020121780. [PMID: 33958490] - Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 05; 77(5):704-712. doi:
10.1053/j.ajkd.2020.07.023. [PMID: 33010357] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Zhipeng Zhang, Jie Guo, Maojun Cheng, Weixin Zhou, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Jing Liu, Sai-Sai Xie. Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2021 Mar; 213(?):113154. doi:
10.1016/j.ejmech.2021.113154. [PMID: 33476932] - Risa Kimura, Daisuke Kondo, Shota Takemi, Miyuki Fujishiro, Shinji Tsukahara, Takafumi Sakai, Ichiro Sakata. The role of central corticotrophin-releasing factor receptor signalling in plasma glucose maintenance through ghrelin secretion in calorie-restricted mice.
Journal of neuroendocrinology.
2021 03; 33(3):e12961. doi:
10.1111/jne.12961. [PMID: 33675127] - Ali Zeraatkar Moghaddam, Maryam Goharjoo, Ebrahim Ghiamati, Kamal Khodaei, Hadi Tabani. Gel electro-membrane extraction of propranolol and atenolol from blood serum samples: Effect of graphene-based nanomaterials on extraction efficiency of gel membrane.
Talanta.
2021 Jan; 222(?):121557. doi:
10.1016/j.talanta.2020.121557. [PMID: 33167255] - Samer Asmar, Letitia Bible, Mohamad Chehab, Andrew Tang, Muhammad Khurrum, Lourdes Castanon, Michael Ditillo, Molly Douglas, Bellal Joseph. Traumatic brain injury induced temperature dysregulation: What is the role of β blockers?.
The journal of trauma and acute care surgery.
2021 01; 90(1):177-184. doi:
10.1097/ta.0000000000002975. [PMID: 33332783] - Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry.
Angewandte Chemie (International ed. in English).
2020 12; 59(51):23162-23168. doi:
10.1002/anie.202006481. [PMID: 32869436] - Laxmikant S Deshpande, Robert E Blair, Matthew Halquist, Leon Kosmider, Robert J DeLorenzo. Intramuscular atenolol and levetiracetam reduce mortality in a rat model of paraoxon-induced status epilepticus.
Annals of the New York Academy of Sciences.
2020 11; 1480(1):219-232. doi:
10.1111/nyas.14500. [PMID: 32961584] - Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
European journal of medicinal chemistry.
2020 Sep; 202(?):112475. doi:
10.1016/j.ejmech.2020.112475. [PMID: 32652406] - Qiaorong Ji, Yu Zhang, Huan Zhang, Jie Liu, Chengzhu Cao, Zhouyang Yuan, Qianqian Ma, Wei Zhang. Effects of β-adrenoceptor activation on haemodynamics during hypoxic stress in rats.
Experimental physiology.
2020 09; 105(9):1660-1668. doi:
10.1113/ep088669. [PMID: 32706493] - Stephen P Juraschek, Lara M Simpson, Barry R Davis, Robert H Shmerling, Jennifer L Beach, Anthony Ishak, Kenneth J Mukamal. The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Journal of hypertension.
2020 05; 38(5):954-960. doi:
10.1097/hjh.0000000000002359. [PMID: 31977576] - Eulalia María Beltrán, María Victoria Pablos, Carlos Fernández Torija, Miguel Ángel Porcel, Miguel González-Doncel. Uptake of atenolol, carbamazepine and triclosan by crops irrigated with reclaimed water in a Mediterranean scenario.
Ecotoxicology and environmental safety.
2020 Mar; 191(?):110171. doi:
10.1016/j.ecoenv.2020.110171. [PMID: 31958626] - Camila A Fleury, Elizandra P M Almeida, Thiago J Dionisio, Adriana M Calvo, Gabriela M Oliveira, Sandra L Amaral, Carlos F Santos, Flávio A C Faria. Passive Cigarette Smoking Impact on Blood Pressure Response to Epinephrine and Felypressin in 1K1C Hypertensive Rats Treated or not with Atenolol.
Arquivos brasileiros de cardiologia.
2020 02; 114(2):295-303. doi:
10.36660/abc.20180433. [PMID: 32215501] - Ashutosh K Dash, Debaraj Mukherjee, Abhijeet Dhulap, Saqlain Haider, Deepak Kumar. Green chemistry appended synthesis, metabolic stability and pharmacokinetic assessment of medicinally important chromene dihydropyrimidinones.
Bioorganic & medicinal chemistry letters.
2019 12; 29(24):126750. doi:
10.1016/j.bmcl.2019.126750. [PMID: 31699608] - João Paulo Bizarro Lopes, Luana Silva, Marco Antonio Ceschi, Diogo Seibert Lüdtke, Aline Rigon Zimmer, Thais Carine Ruaro, Rafael Ferreira Dantas, Cristiane Martins Cardoso de Salles, Floriano Paes Silva-Jr, Mario Roberto Senger, Gisele Barbosa, Lídia Moreira Lima, Isabella Alvim Guedes, Laurent Emmanuel Dardenne. Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
MedChemComm.
2019 Dec; 10(12):2089-2101. doi:
10.1039/c9md00358d. [PMID: 32904099] - Amal S M Gad El-Hak, Ahmed A K Mohammed, Ahmed F Abdel Hakiem, Refaat M Mahfouz. Molecular conformation, vibrational spectroscopic and NBO analysis of atenolol and atenolol-hydrochlorothiazide cocrystals.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Nov; 222(?):117200. doi:
10.1016/j.saa.2019.117200. [PMID: 31176161] - Panagiotis I Georgianos, Rajiv Agarwal. Systolic and diastolic hypertension among patients on hemodialysis: Musings on volume overload, arterial stiffness, and erythropoietin.
Seminars in dialysis.
2019 11; 32(6):507-512. doi:
10.1111/sdi.12837. [PMID: 31463996] - Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
10.1016/j.jchromb.2019.121793. [PMID: 31629310] - Yeliz Demir. The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis.
The Journal of pharmacy and pharmacology.
2019 Oct; 71(10):1576-1583. doi:
10.1111/jphp.13144. [PMID: 31347707] - Stephen P Juraschek, Lara M Simpson, Barry R Davis, Jennifer L Beach, Anthony Ishak, Kenneth J Mukamal. Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults: The ALLHAT Trial.
Hypertension (Dallas, Tex. : 1979).
2019 10; 74(4):1033-1040. doi:
10.1161/hypertensionaha.119.13445. [PMID: 31476905] - Anum Butt, Nazish Waris, Kulsoom Baqa, Urooj Nazim, Afshan Naz, Sumera Rais Abbasi, Sumreen Begum. Comparative effect of Beta blocker-Atenolol and Murraya koenigii (L.) spreng (Curry leaves) on cardiac enzyme (CK-MB) level in male albino rats.
Pakistan journal of pharmaceutical sciences.
2019 Jul; 32(4):1643-1648. doi:
". [PMID: 31608885] - Deepali Gupta, Jen-Chieh Chuang, Bharath K Mani, Kripa Shankar, Juan A Rodriguez, Sherri Osborne-Lawrence, Nathan P Metzger, Jeffrey M Zigman. β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019 06; 44(7):1319-1327. doi:
10.1038/s41386-019-0334-7. [PMID: 30758330] - Asmita Magotra, Abhishek Gour, Deepak K Sharma, Ashutosh K Dash, Gurdarshan Singh, Debaraj Mukherjee, Utpal Nandi. Pharmacokinetic evaluation of medicinally important synthetic N,N' diindolylmethane glucoside: Improved synthesis and metabolic stability.
Bioorganic & medicinal chemistry letters.
2019 04; 29(8):1007-1011. doi:
10.1016/j.bmcl.2019.02.010. [PMID: 30777609] - Radka Kodešová, Aleš Klement, Oksana Golovko, Miroslav Fér, Antonín Nikodem, Martin Kočárek, Roman Grabic. Root uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three soils and four plants.
Environmental science and pollution research international.
2019 Apr; 26(10):9876-9891. doi:
10.1007/s11356-019-04333-9. [PMID: 30734257] - Mohamed H Solayman, Taimour Y Langaee, Yan Gong, Mohamed H Shahin, Stephen T Turner, Arlene B Chapman, John G Gums, Eric Boerwinkle, Amber L Beitelshees, Manal El-Hamamsy, Lamia El-Wakeel, Rhonda M Cooper-DeHoff, Osama A Badary, Julie A Johnson. Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Apr; 131(?):93-98. doi:
10.1016/j.ejps.2019.02.013. [PMID: 30753892] - Michele Bombelli, Mario Macchiarulo, Rita Facchetti, Davide Maggiolini, Cesare Cuspidi, Gianfranco Parati, Giuseppe Mancia, Guido Grassi. Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis.
Journal of hypertension.
2019 04; 37(4):844-850. doi:
10.1097/hjh.0000000000001951. [PMID: 30817467] - Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto, Katsuhisa Inoue. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats.
Drug metabolism and disposition: the biological fate of chemicals.
2019 04; 47(4):386-391. doi:
10.1124/dmd.118.084483. [PMID: 30622163] - Isaac A Adedara, Sanmi E Alake, Laide O Olajide, Mercy O Adeyemo, Temitayo O Ajibade, Ebenezer O Farombi. Taurine Ameliorates Thyroid Hypofunction and Renal Injury in L-NAME-Induced Hypertensive Rats.
Drug research.
2019 Feb; 69(2):83-92. doi:
10.1055/a-0643-4604. [PMID: 29996172] - Karine Panico, Mariana V Abrahão, Mayra Trentin-Sonoda, Humberto Muzi-Filho, Adalberto Vieyra, Marcela S Carneiro-Ramos. Cardiac Inflammation after Ischemia-Reperfusion of the Kidney: Role of the Sympathetic Nervous System and the Renin-Angiotensin System.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 53(4):587-605. doi:
10.33594/000000159. [PMID: 31535830] - Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, Michel Mansur Machado. Cytotoxic and genotoxic effects of antihypertensives distributed in Brazil by social programs: Are they safe?.
Environmental toxicology and pharmacology.
2018 Oct; 63(?):1-5. doi:
10.1016/j.etap.2018.08.005. [PMID: 30107356] - Yan Wang, Mengzhen Niu, Sha Yin, Fei Zhang, Ruizan Shi. Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.
Pharmacological reports : PR.
2018 Oct; 70(5):917-929. doi:
10.1016/j.pharep.2018.04.004. [PMID: 30099298] - Ajay Gupta, Judith Mackay, Andrew Whitehouse, Thomas Godec, Tim Collier, Stuart Pocock, Neil Poulter, Peter Sever. Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial.
Lancet (London, England).
2018 09; 392(10153):1127-1137. doi:
10.1016/s0140-6736(18)31776-8. [PMID: 30158072] - Moayad Mustafa Hejazi, Ala Osman Bacha, Mohammed Kaleemuddin, Fahad A Al-Abassi, Abdulbasit I Al-Alsieni, Imran Kazmi, Firoz Anwar. Alteration of serum immunoglobins, C-reactive protein, vitamin D, and electrolyte by atenolol and amlodipine in stress-induced hypertensive rats.
Molecular and cellular biochemistry.
2018 Aug; 445(1-2):99-103. doi:
10.1007/s11010-017-3255-y. [PMID: 29248973] - Navid Niaei, Mohammad Hasanzadeh, Nasrin Shadjou. Molecular interaction of some cardiovascular drugs with human serum albumin at physiological-like conditions: A new approach.
Journal of molecular recognition : JMR.
2018 08; 31(8):e2715. doi:
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American journal of physiology. Endocrinology and metabolism.
2018 08; 315(2):E240-E249. doi:
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Cardiovascular therapeutics.
2018 Aug; 36(4):e12434. doi:
10.1111/1755-5922.12434. [PMID: 29752864] - Ei Mon Phyo Lwin, Cobus Gerber, Catherine Leggett, Yunmei Song, Usha Ritchie, Sean Turner, William Hague, Richard Upton, Sanjay Garg. Estimation of Atenolol Transfer Into Milk and Infant Exposure During Its Use in Lactating Women.
Journal of human lactation : official journal of International Lactation Consultant Association.
2018 08; 34(3):592-599. doi:
10.1177/0890334418771308. [PMID: 29870669] - Madiha Maboos, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Iqbal Nasiri, Tazeen Hussain, Hafiza Fouzia Ahmed, Wajiha Iffat. Effect of lipid and cellulose based matrix former on the release of highly soluble drug from extruded/spheronized, sintered and compacted pellets.
Lipids in health and disease.
2018 Jun; 17(1):136. doi:
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Clinical journal of the American Society of Nephrology : CJASN.
2018 04; 13(4):604-611. doi:
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Journal of biomolecular structure & dynamics.
2018 Apr; 36(5):1095-1107. doi:
10.1080/07391102.2017.1311805. [PMID: 28345378] - Caitrin W McDonough, Oyunbileg Magvanjav, Ana C C Sá, Nihal M El Rouby, Chintan Dave, Amelia N Deitchman, Marina Kawaguchi-Suzuki, Wenbin Mei, Yong Shen, Ravi Shankar Prasad Singh, Mohamed Solayman, Kent R Bailey, Eric Boerwinkle, Arlene B Chapman, John G Gums, Amy Webb, Steven E Scherer, Wolfgang Sadee, Stephen T Turner, Rhonda M Cooper-DeHoff, Yan Gong, Julie A Johnson. Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
Circulation. Genomic and precision medicine.
2018 04; 11(4):e001854. doi:
10.1161/circgen.117.001854. [PMID: 29650764] - Shucheng Sun, Yujia Wang, Xin Liu, Rao Fu, Li Yang. Rapid and sensitive tapered-capillary microextraction combined to on-line sample stacking-capillary electrophoresis for extraction and quantification of two beta-blockers in human urine.
Talanta.
2018 Apr; 180(?):90-97. doi:
10.1016/j.talanta.2017.12.035. [PMID: 29332838] - San Kim, Sang Hoo Park, Dong Yoon Kim, Seok Joong Yun, Ok Jun Lee, Heon Seok Han. Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy.
Journal of Korean medical science.
2018 Feb; 33(8):e54. doi:
10.3346/jkms.2018.33.e54. [PMID: 29441752] - Mun Hee Choi, Jin Soo Lee, Sung Eun Lee, Seong-Joon Lee, Dukyong Yoon, Rae Woong Park, Ji Man Hong. Central and cerebral haemodynamic changes after antihypertensive therapy in ischaemic stroke patients: A double-blind randomised trial.
Scientific reports.
2018 01; 8(1):1556. doi:
10.1038/s41598-018-19998-4. [PMID: 29367614] - Yagoup Gorbani, Hüma Yılmaz, Hasan Basan. Spectrofluorimetric determination of atenolol from human urine using high-affinity molecularly imprinted solid-phase extraction sorbent.
Luminescence : the journal of biological and chemical luminescence.
2017 Dec; 32(8):1391-1397. doi:
10.1002/bio.3335. [PMID: 28569404] - Daniel A Duprez, Natalia Florea, Sue Duval, Catherine Koukol, Jay N Cohn. Effect of nebivolol or atenolol vs. placebo on cardiovascular health in subjects with borderline blood pressure: the EVIDENCE study.
Journal of human hypertension.
2017 12; 32(1):20-25. doi:
10.1038/s41371-017-0019-9. [PMID: 29184167] - Mieko Okada, Luiz Fernando Reis Falcão, David Ferez, José Luiz Martins, Paolo Ruggero Errante, Francisco Sandro Menezes Rodrigues, Afonso Caricati-Neto, Márcia Marinho, Guilherme Fenelon, Itamar Souza Oliveira-Júnior. Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion.
Acta cirurgica brasileira.
2017 11; 32(11):964-972. doi:
10.1590/s0102-865020170110000008. [PMID: 29236801] - Xiaomei Chen, Tim Slättengren, Elizabeth C M de Lange, David E Smith, Margareta Hammarlund-Udenaes. Revisiting atenolol as a low passive permeability marker.
Fluids and barriers of the CNS.
2017 Oct; 14(1):30. doi:
10.1186/s12987-017-0078-x. [PMID: 29089037] - Murali Mohan Reddy Devalapalli, Hanumanth Srikanth Cheruvu, Thejaswi Yertha, Vijaya Bhaskar Veeravalli, Sunitha Sampathi, Savithri Shivakumar. Hansen solubility parameters for assay method optimization of simvastatin, ramipril, atenolol, hydrochlorothiazide and aspirin in human plasma using liquid chromatography with tandem mass spectrometry.
Journal of separation science.
2017 Sep; 40(18):3662-3674. doi:
10.1002/jssc.201700565. [PMID: 28722356] - Yoshihisa Mimura, Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki Yuasa. Functional Identification of Plasma Membrane Monoamine Transporter (PMAT/SLC29A4) as an Atenolol Transporter Sensitive to Flavonoids Contained in Apple Juice.
Journal of pharmaceutical sciences.
2017 09; 106(9):2592-2598. doi:
10.1016/j.xphs.2017.01.009. [PMID: 28089688] - Anushka C Galasiti Kankanamalage, Yunjeong Kim, Athri D Rathnayake, Kevin R Alliston, Michelle M Butler, Steven C Cardinale, Terry L Bowlin, William C Groutas, Kyeong-Ok Chang. Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease.
Journal of medicinal chemistry.
2017 07; 60(14):6239-6248. doi:
10.1021/acs.jmedchem.7b00497. [PMID: 28671827] - Qian Wan, Yanhui Liu, Chunli Yang, Lihong Liu. On-line double focusing of atenolol and metoprolol in human urine using capillary electrophoresis with the aid of β-cyclodextrin.
Analytica chimica acta.
2017 Jul; 978(?):61-67. doi:
10.1016/j.aca.2017.04.052. [PMID: 28595728] - Bharath K Mani, Aki Uchida, Young Lee, Sherri Osborne-Lawrence, Maureen J Charron, Roger H Unger, Eric D Berglund, Jeffrey M Zigman. Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.
Diabetes.
2017 07; 66(7):1847-1857. doi:
10.2337/db16-1303. [PMID: 28487437] - Tolga Aksu, Tümer Erdem Güler, Kazım Serhan Özcan, Serdar Bozyel, Kıvanç Yalın. Renal sympathetic denervation assisted treatment of electrical storm due to polymorphic ventricular tachycardia in a patient with cathecolaminergic polymorphic ventricular tachycardia.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.
2017 Jul; 45(5):441-449. doi:
10.5543/tkda.2017.72773. [PMID: 28694398] - Fengzhi Yang, Fangzhou Xie, Ying Zhang, Yu Xia, Wenlu Liu, Faqin Jiang, Celine Lam, Yixue Qiao, Dongsheng Xie, Jianqi Li, Lei Fu. Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.
Bioorganic & medicinal chemistry letters.
2017 05; 27(10):2166-2170. doi:
10.1016/j.bmcl.2017.03.060. [PMID: 28372909] - Abbas Yousefpour, Hamid Modarress, Fatemeh Goharpey, Sepideh Amjad-Iranagh. Combination of anti-hypertensive drugs: a molecular dynamics simulation study.
Journal of molecular modeling.
2017 May; 23(5):158. doi:
10.1007/s00894-017-3333-9. [PMID: 28397088] - Ei Mon Phyo Lwin, Cobus Gerber, Yunmei Song, Catherine Leggett, Usha Ritchie, Sean Turner, Sanjay Garg. A new LC-MS/MS bioanalytical method for atenolol in human plasma and milk.
Bioanalysis.
2017 Apr; 9(7):517-530. doi:
10.4155/bio-2016-0304. [PMID: 28300420] - Surya Narayan Ratha Adhikari, Satyabrata Panda. Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage.
Polimery w medycynie.
2017 Jan; 47(1):5-11. doi:
10.17219/pim/70498. [PMID: 29160624] - Yan Wang, Fei Zhang, Yu Liu, Sha Yin, Xuefen Pang, Zhidong Li, Zehui Wei. Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2017; 39(7):628-639. doi:
10.1080/10641963.2017.1306539. [PMID: 28640644] - Antonin Azaïs, Julie Mendret, Eddy Petit, Stephan Brosillon. Influence of volumetric reduction factor during ozonation of nanofiltration concentrates for wastewater reuse.
Chemosphere.
2016 Dec; 165(?):497-506. doi:
10.1016/j.chemosphere.2016.09.071. [PMID: 27681105] - Jia Yin, Haichuan Duan, Joanne Wang. Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.
The Journal of pharmacology and experimental therapeutics.
2016 Dec; 359(3):401-410. doi:
10.1124/jpet.116.236158. [PMID: 27758931] - Mikhail Krasavin, Alexey Lukin, Daria Bagnyukova, Nikolay Zhurilo, Ihor Zahanich, Sergey Zozulya, Jouni Ihalainen, Markus M Forsberg, Marko Lehtonen, Jarkko Rautio, Daniel Moore, Irina G Tikhonova. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.
Bioorganic & medicinal chemistry.
2016 11; 24(21):5481-5494. doi:
10.1016/j.bmc.2016.09.004. [PMID: 27647366] - Peter M Okin, Sverre E Kjeldsen, Richard B Devereux. Impact of achieved systolic blood pressure on renal function in hypertensive patients.
European heart journal. Quality of care & clinical outcomes.
2016 10; 2(4):271-276. doi:
10.1093/ehjqcco/qcw017. [PMID: 29474712] - Kamel A Gharaibeh, Stephen T Turner, Abdurrahman M Hamadah, Arlene B Chapman, Rhonda M Cooper-Dehoff, Julie A Johnson, John G Gums, Kent R Bailey, Gary L Schwartz. Comparison of Blood Pressure Control Rates Among Recommended Drug Selection Strategies for Initial Therapy of Hypertension.
American journal of hypertension.
2016 10; 29(10):1186-94. doi:
10.1093/ajh/hpw067. [PMID: 27365079] - David Dahlgren, Carl Roos, Pernilla Johansson, Anders Lundqvist, Christer Tannergren, Bertil Abrahamsson, Erik Sjögren, Hans Lennernäs. Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms.
Molecular pharmaceutics.
2016 09; 13(9):3022-33. doi:
10.1021/acs.molpharmaceut.6b00515. [PMID: 27500599] - Bharath K Mani, Sherri Osborne-Lawrence, Prasanna Vijayaraghavan, Chelsea Hepler, Jeffrey M Zigman. β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.
The Journal of clinical investigation.
2016 09; 126(9):3467-78. doi:
10.1172/jci86270. [PMID: 27548523] - Mohsen Zeeb, Hadi Farahani, Mohammad Kazem Papan. Determination of atenolol in human plasma using ionic-liquid-based ultrasound-assisted in situ solvent formation microextraction followed by high-performance liquid chromatography.
Journal of separation science.
2016 Jun; 39(11):2138-45. doi:
10.1002/jssc.201501365. [PMID: 27061492] - Pyung Chun Oh, Woong Chol Kang, Jeonggeun Moon, Yae Min Park, Sihun Kim, Myeong Gun Kim, Kyounghoon Lee, Taehoon Ahn, Eak Kyun Shin. Anti-Anginal and Metabolic Effects of Carvedilol and Atenolol in Patients with Stable Angina Pectoris: A Prospective, Randomized, Parallel, Open-Label Study.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2016 Jun; 16(3):221-8. doi:
10.1007/s40256-016-0168-1. [PMID: 27021556] - S W Chang, Y Gong, C W McDonough, T Y Langaee, N Nasiri Kenari, A L Beitelshees, J G Gums, A B Chapman, S T Turner, J A Johnson, R M Cooper-DeHoff. Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation?.
Clinical and translational science.
2016 Apr; 9(2):114-22. doi:
10.1111/cts.12389. [PMID: 26946962] - Jaivik V Shah, Daxesh P Patel, Priyanka A Shah, Mallika Sanyal, Pranav S Shrivastav. Simultaneous quantification of atenolol and chlorthalidone in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2016 Feb; 30(2):208-16. doi:
10.1002/bmc.3537. [PMID: 26096961] - Rajiv Agarwal. Treating hypertension in hemodialysis improves symptoms seemingly unrelated to volume excess.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2016 Jan; 31(1):142-9. doi:
10.1093/ndt/gfv371. [PMID: 26546591] - Julie K K Vishram, Björn Dahlöf, Richard B Devereux, Hans Ibsen, Sverre E Kjeldsen, Lars H Lindholm, Giuseppe Mancia, Peter M Okin, Peter M Rothwell, Kristian Wachtell, Michael H Olsen. Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage: a LIFE substudy.
Journal of hypertension.
2015 Dec; 33(12):2422-30. doi:
10.1097/hjh.0000000000000739. [PMID: 26378687] - Jia Yin, Haichuan Duan, Yoshiyuki Shirasaka, Bhagwat Prasad, Joanne Wang. Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Dec; 43(12):1872-81. doi:
10.1124/dmd.115.066175. [PMID: 26374172] - Shuai Wu, Wei Xu, Fu-Rong Wang, Xiu-Wei Yang. Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer.
Molecules (Basel, Switzerland).
2015 Oct; 20(10):18704-16. doi:
10.3390/molecules201018704. [PMID: 26501241] - Jiangxia Ren, Yan Zhou, Guoqiang Zhang, Liting Zhou, Jing Zhao, Yuhui Wei, Xin'an Wu. Role of age-related decrease of renal organic cation transporter 2 in the effect of atenolol on renal excretion of metformin in rats.
European journal of drug metabolism and pharmacokinetics.
2015 Sep; 40(3):349-54. doi:
10.1007/s13318-014-0214-9. [PMID: 24981592] - Abbas Yousefpour, Hamid Modarress, Fatemeh Goharpey, Sepideh Amjad-Iranagh. Interaction of PEGylated anti-hypertensive drugs, amlodipine, atenolol and lisinopril with lipid bilayer membrane: A molecular dynamics simulation study.
Biochimica et biophysica acta.
2015 Aug; 1848(8):1687-98. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2015 Aug; 66(2):305-12. doi:
10.1053/j.ajkd.2015.01.018. [PMID: 25818679] - Cheuk-Chun Szeto, Philip Kam-Tao Li. Cardiovascular disease: Questioning the effect of β-blockers on vascular stiffness.
Nature reviews. Nephrology.
2015 Aug; 11(8):447-8. doi:
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Journal of chromatographic science.
2015 Aug; 53(7):1123-30. doi:
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European journal of pain (London, England).
2015 Jul; 19(6):772-80. doi:
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Analytical chemistry.
2015 Jun; 87(12):6212-9. doi:
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Clinical journal of the American Society of Nephrology : CJASN.
2015 Apr; 10(4):547-50. doi:
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Clinical journal of the American Society of Nephrology : CJASN.
2015 Apr; 10(4):639-45. doi:
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Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.
2015 Apr; 119(2):585-91. doi:
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Environmental science and pollution research international.
2015 Mar; 22(6):4383-95. doi:
10.1007/s11356-014-3646-5. [PMID: 25300180] - Yan-rong Ma, Jing Huang, Yun-yun Shao, Kang Ma, Guo-qiang Zhang, Yan Zhou, Rao Zhi, Hong-yan Qin, Xin-an Wu. Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating multidrug and toxin extrusion protein 1 (rMate1) expression in the kidney of rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Feb; 68(?):18-26. doi:
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Journal of anesthesia.
2015 Feb; 29(1):56-64. doi:
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