lorazepam (BioDeep_00000016578)

   


代谢物信息卡片


lorazepam

化学式: C15H10Cl2N2O2 (320.01193)
中文名称: 劳拉西泮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
InChI: InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; INTERNAL_ID 1512
CONFIDENCE standard compound; INTERNAL_ID 8600
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3138

同义名列表

1 个代谢物同义名

lorazepam



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Colleen Elizabeth Howing, Farzad Razi, Wael Hakmeh. Resolution of status epilepticus after ketamine administration. The American journal of emergency medicine. 2022 Apr; 54(?):328.e1-328.e2. doi: 10.1016/j.ajem.2021.10.052. [PMID: 34763960]
  • Kimberly N Shudofsky, Paddy K C Janssen, Norbert Foudraine, Jos L M L le Noble. Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome. Journal of clinical pharmacology. 2022 04; 62(4):568-570. doi: 10.1002/jcph.2005. [PMID: 34793610]
  • Samuel Reinfeld, Adeeb Yacoub. A Case of Delirious Mania Induced by COVID-19 Treated With Electroconvulsive Therapy. The journal of ECT. 2021 12; 37(4):e38-e39. doi: 10.1097/yct.0000000000000789. [PMID: 34294651]
  • Camila De Avila, Luis F Rauseo Lopez, Yamini Mandelia. Acute COVID-19 Infection Associated With Necrotizing Disseminated Acute Leukoencephalopathy and Brain Microhemorrhages in a Pediatric Patient. The Pediatric infectious disease journal. 2021 12; 40(12):e493-e496. doi: 10.1097/inf.0000000000003302. [PMID: 34533490]
  • Martijn de Neeling, Wim van Paesschen. Stupor in a catatonic patient due to an interaction between high-dose lorazepam and valproic acid: a case report. Acta neurologica Belgica. 2021 Aug; 121(4):1077-1078. doi: 10.1007/s13760-021-01728-9. [PMID: 34296394]
  • Kyriaki Marouda, Leonidas Mantonakis, Konstantinos Kollias. Brief psychotic disorder with delusion content related to the COVID-19 outbreak. Psychiatrike = Psychiatriki. 2021 Apr; 32(1):79-82. doi: 10.22365/jpsych.2021.004. [PMID: 33759811]
  • Erich Seifritz, Hans-Jürgen Möller, Hans-Peter Volz, Walter E Müller, Talar Hopyan, Anna Wacker, Sandra Schläfke, Siegfried Kasper. No Abuse Potential of Silexan in Healthy Recreational Drug Users: A Randomized Controlled Trial. The international journal of neuropsychopharmacology. 2021 03; 24(3):171-180. doi: 10.1093/ijnp/pyaa064. [PMID: 33300578]
  • Mahsa Sheikh, Mohammad Reza Hadjmohammadi, Mohammad Hossein Fatemi. Simultaneous extraction and analysis of clozapine and lorazepam from human plasma using dual solvent-stir bar microextraction with different acceptor phases followed by high-performance liquid chromatography ultra-violet detection. Analytical methods : advancing methods and applications. 2021 01; 13(1):110-116. doi: 10.1039/d0ay01431a. [PMID: 33315030]
  • Jamelleh Amouri, Patricia S Andrews, Stephan Heckers, E Wesley Ely, Jo Ellen Wilson. A Case of Concurrent Delirium and Catatonia in a Woman With Coronavirus Disease 2019. Journal of the Academy of Consultation-Liaison Psychiatry. 2021 Jan; 62(1):109-114. doi: 10.1016/j.psym.2020.09.002. [PMID: 33069380]
  • Daniel Brunnhoelzl, Alexander N Hanania, Alfredo Echeverria, Jan Sunde, Connie Tran, Michelle Ludwig. Paracervical blocks facilitate timely brachytherapy amidst COVID-19. Brachytherapy. 2021 Jan; 20(1):284-289. doi: 10.1016/j.brachy.2020.08.002. [PMID: 32891569]
  • Peter M Haddad, Majid Al Abdulla, Javed Latoo, Yousaf Iqbal. Brief psychotic disorder associated with quarantine and mild COVID-19. BMJ case reports. 2020 Dec; 13(12):. doi: 10.1136/bcr-2020-240088. [PMID: 33328211]
  • Erica B Baller, Charlotte S Hogan, Mark A Fusunyan, Ana Ivkovic, James W Luccarelli, Elizabeth Madva, Mladen Nisavic, Nathan Praschan, Nadia V Quijije, Scott R Beach, Felicia A Smith. Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19. Psychosomatics. 2020 Nov; 61(6):585-596. doi: 10.1016/j.psym.2020.05.013. [PMID: 32828569]
  • Luca Docci, Kenichi Umehara, Stephan Krähenbühl, Stephen Fowler, Neil Parrott. Construction and Verification of Physiologically Based Pharmacokinetic Models for Four Drugs Majorly Cleared by Glucuronidation: Lorazepam, Oxazepam, Naloxone, and Zidovudine. The AAPS journal. 2020 10; 22(6):128. doi: 10.1208/s12248-020-00513-5. [PMID: 33033903]
  • Sol Jaworowski, Mark Weiser, Cornelius Gropp, Moria Malka. Three Cases of COVID-19-related First Onset Brief Reactive Psychosis. The Israel Medical Association journal : IMAJ. 2020 10; 22(10):612. doi: NULL. [PMID: 33070483]
  • Brittany M Gouse, William E Spears, Ashley Nieves Archibald, Cristina Montalvo. Catatonia in a hospitalized patient with COVID-19 and proposed immune-mediated mechanism. Brain, behavior, and immunity. 2020 10; 89(?):529-530. doi: 10.1016/j.bbi.2020.08.007. [PMID: 32791211]
  • Marissa P Caan, Christopher T Lim, Mark Howard. A Case of Catatonia in a Man With COVID-19. Psychosomatics. 2020 Sep; 61(5):556-560. doi: 10.1016/j.psym.2020.05.021. [PMID: 32605766]
  • Bárbara Antunes, Ben Bowers, Isaac Winterburn, Michael P Kelly, Robert Brodrick, Kristian Pollock, Megha Majumder, Anna Spathis, Iain Lawrie, Rob George, Richella Ryan, Stephen Barclay. Anticipatory prescribing in community end-of-life care in the UK and Ireland during the COVID-19 pandemic: online survey. BMJ supportive & palliative care. 2020 Sep; 10(3):343-349. doi: 10.1136/bmjspcare-2020-002394. [PMID: 32546559]
  • Ke Wang, Zhiguo Zhang, Muqing Yu, Yu Tao, Min Xie. 15-day mortality and associated risk factors for hospitalized patients with COVID-19 in Wuhan, China: an ambispective observational cohort study. Intensive care medicine. 2020 07; 46(7):1472-1474. doi: 10.1007/s00134-020-06047-w. [PMID: 32328724]
  • N A Uvais. Psychological Impact of the COVID-19 Pandemic Among the Elderly: A Case Series From India. The primary care companion for CNS disorders. 2020 06; 22(4):. doi: 10.4088/pcc.20com02675. [PMID: 32589829]
  • Somayeh Taymouri, Mohsen Minaiyan, Farnaz Ebrahimi, Naser Tavakoli. In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus. IET nanobiotechnology. 2020 Apr; 14(2):148-154. doi: 10.1049/iet-nbt.2019.0156. [PMID: 32433032]
  • Chenyi Chen, Róger M Martínez, Tsai-Tsen Liao, Chin-Yau Chen, Chih-Yung Yang, Yawei Cheng. An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices. Communications biology. 2020 03; 3(1):113. doi: 10.1038/s42003-020-0850-3. [PMID: 32157156]
  • John M Cunningham, Katherine V Sachs, Rebecca Allyn. Cefepime-Induced Neurotoxicity Presenting with Nonconvulsive Status Epilepticus Admitted as a Stroke Alert. The American journal of case reports. 2020 Mar; 21(?):e921643. doi: 10.12659/ajcr.921643. [PMID: 32147665]
  • Amit Dahal, Rabin Neupane, Sai Hs Boddu, Jwala Renukuntla, Rahul Khupse, Richard Dudley. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. International journal of pharmaceutical compounding. 2020 Mar; 24(2):168-175. doi: NULL. [PMID: 32196480]
  • Yan Li, Jun Ma, Yinghui Jin, Nan Li, Rui Zheng, Wei Mu, Jiaying Wang, Jin Hua Si, Jing Chen, Hong Cai Shang. Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit. The Cochrane database of systematic reviews. 2020 02; 2(?):CD012670. doi: 10.1002/14651858.cd012670.pub2. [PMID: 32108325]
  • R A Kalekin, O V Saltykova, G M Rodionova, V I Gegechkori, A M Orlova. [On the issue of the detection of pregabalin and lorazepam in the cases of their joint presence for the purpose of chemical toxicological studies]. Sudebno-meditsinskaia ekspertiza. 2020; 63(1):36-41. doi: 10.17116/sudmed20206301136. [PMID: 32040086]
  • Rowan Saloner, David J Grelotti, Griffin Tyree, Erin E Sundermann, Qing Ma, Scott Letendre, Robert K Heaton, Mariana Cherner. Benzodiazepine Use Is Associated With an Increased Risk of Neurocognitive Impairment in People Living With HIV. Journal of acquired immune deficiency syndromes (1999). 2019 12; 82(5):475-482. doi: 10.1097/qai.0000000000002183. [PMID: 31714426]
  • Wuan Shuen Yap, Anton V Dolzhenko, Zahraa Jalal, Muhammad Abdul Hadi, Tahir Mehmood Khan. Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis. Scientific reports. 2019 12; 9(1):18042. doi: 10.1038/s41598-019-54529-9. [PMID: 31792285]
  • Piotr Adamowicz, Ewa Meissner, Marta Maślanka. Fatal intoxication with new synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA. Clinical toxicology (Philadelphia, Pa.). 2019 Nov; 57(11):1103-1108. doi: 10.1080/15563650.2019.1580371. [PMID: 30806094]
  • Daniel Sikavi, Jennifer McMahon, John A Fromson. Catatonia Due to Tacrolimus Toxicity 16 Years After Renal Transplantation: Case Report and Literature Review. Journal of psychiatric practice. 2019 Nov; 25(6):481-484. doi: 10.1097/pra.0000000000000425. [PMID: 31821227]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Sabrina Lehmann, Alissa Sczyslo, Judith Froch-Cortis, Markus Alexander Rothschild, Mario Thevis, Hilke Andresen-Streichert, Katja Mercer-Chalmers-Bender. Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. Forensic science international. 2019 Oct; 303(?):109959. doi: 10.1016/j.forsciint.2019.109959. [PMID: 31546164]
  • Panagiotis Theodosis-Nobelos, Georgios Papagiouvannis, Panos N Kourounakis, Eleni A Rekka. Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183277. [PMID: 31505754]
  • Xia Wen, Francesca Di Paola, Nitin Chopra. Psychotropics in Your Medicine Cabinet: A Case Study of Dimenhydrinate Use. Journal of addiction medicine. 2019 Sep; 13(5):412-414. doi: 10.1097/adm.0000000000000511. [PMID: 30844875]
  • Ana Velosa, António Neves, J Bernardo Barahona-Corrêa, Albino J Oliveira-Maia. Neuroleptic malignant syndrome: a concealed diagnosis with multitreatment approach. BMJ case reports. 2019 Jun; 12(6):. doi: 10.1136/bcr-2018-225840. [PMID: 31213433]
  • Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka, Kenji Tabata. Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. Biopharmaceutics & drug disposition. 2019 May; 40(5-6):176-187. doi: 10.1002/bdd.2181. [PMID: 30985942]
  • Ajay P Nayak, Tonio Pera, Deepak A Deshpande, James V Michael, Jennifer R Liberato, Shi Pan, Eric Tompkins, Henry P Morelli, Roslyn Yi, Nadan Wang, Raymond B Penn. Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling. American journal of physiology. Lung cellular and molecular physiology. 2019 05; 316(5):L894-L902. doi: 10.1152/ajplung.00426.2018. [PMID: 30724097]
  • Stephan von Düring, Corinne Challet, Laurent Christin. Endoscopic removal of a gastric pharmacobezoar induced by clomipramine, lorazepam, and domperidone overdose: a case report. Journal of medical case reports. 2019 Feb; 13(1):45. doi: 10.1186/s13256-019-1984-0. [PMID: 30808405]
  • Siddharth Iyengar, Charles Bornmann, Farid Abdelmalak, Tulisa LaRocca. Catatonia due to alprazolam withdrawal. BMJ case reports. 2018 Dec; 11(1):. doi: 10.1136/bcr-2018-227175. [PMID: 30567266]
  • Claudia V Turco, Jenin El-Sayes, Mitchell B Locke, Robert Chen, Steven Baker, Aimee J Nelson. Effects of lorazepam and baclofen on short- and long-latency afferent inhibition. The Journal of physiology. 2018 11; 596(21):5267-5280. doi: 10.1113/jp276710. [PMID: 30192388]
  • Sante E I Carone, Danilo L Menaldo, Marco A Sartim, Carolina P Bernardes, Renato C Caetano, Ronivaldo R da Silva, Hamilton Cabral, Benedito Barraviera, Rui S Ferreira Junior, Suely V Sampaio. BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots. Toxicology and applied pharmacology. 2018 10; 357(?):50-61. doi: 10.1016/j.taap.2018.08.018. [PMID: 30145175]
  • Ashley Jahn, Charlie Bodreau, Kate Farthing, Fawzy Elbarbry. Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model. European journal of drug metabolism and pharmacokinetics. 2018 Aug; 43(4):423-430. doi: 10.1007/s13318-018-0462-1. [PMID: 29392569]
  • Maximilian Gericke, Dirk Hartmann. [A Lot of Hot Steam: the Cannabinoid Hyperemesis Syndrome]. Deutsche medizinische Wochenschrift (1946). 2018 Aug; 143(16):1182-1185. doi: 10.1055/a-0599-9317. [PMID: 30086564]
  • Joanna L Stollings, Jennifer L Thompson, Benjamin A Ferrell, Mika Scheinin, Grant R Wilkinson, Christopher G Hughes, Ayumi K Shintani, E Wesley Ely, Timothy D Girard, Pratik P Pandharipande, Mayur B Patel. Sedative Plasma Concentrations and Delirium Risk in Critical Illness. The Annals of pharmacotherapy. 2018 06; 52(6):513-521. doi: 10.1177/1060028017753480. [PMID: 29363356]
  • Victoria López-Corominas, Nuria Gilabert Iriondo, Isabel Gomila Muñiz, Bernardino Barceló Martín. Double false result in a drug screen after accidental pediatric poisoning. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2018 02; 30(1):64-65. doi: NULL. [PMID: 29437315]
  • Souleiman El Balkhi, Maxime Chaslot, Nicolas Picard, Sylvain Dulaurent, Martine Delage, Olivier Mathieu, Franck Saint-Marcoux. Characterization and identification of eight designer benzodiazepine metabolites by incubation with human liver microsomes and analysis by a triple quadrupole mass spectrometer. International journal of legal medicine. 2017 Jul; 131(4):979-988. doi: 10.1007/s00414-017-1541-6. [PMID: 28160051]
  • Matteo Caloro, Giuseppa Calabrò, Georgios D Kotzalidis, Ilaria Cuomo, John M Corkery, Alessandro Emiliano Vento, Luana Lionetto, Sergio De Filippis, Valentina Ranieri, Davide Lonati, Carlo Alessandro Locatelli, Eleonora de Pisa, Antonio Di Tommaso, Paolo Girardi, Fabrizio Schifano. Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. Addictive behaviors. 2016 09; 60(?):53-7. doi: 10.1016/j.addbeh.2016.03.032. [PMID: 27088514]
  • Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh. Anxiolytic, antidepressant, and antistress activities of the aqueous extract of Cinnamomum tamala Nees and Eberm in rats. Indian journal of pharmacology. 2016 Sep; 48(5):555-561. doi: 10.4103/0253-7613.190752. [PMID: 27721543]
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