bumetanide (BioDeep_00000016549)
natural product
代谢物信息卡片
Bumetanide aka 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
化学式: C17H20N2O5S (364.10928700000005)
中文名称: 布美他尼
谱图信息:
最多检出来源 Escherichia coli(natural_products) 50%
分子结构信息
SMILES: C1=C(C(=C(C=C1C(=O)O)NCCCC)OC2=CC=CC=C2)S(=O)(=O)N
InChI: InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
描述信息
D045283 - Natriuretic Agents > D004232 - Diuretics > D049994 - Sodium Potassium Chloride Symporter Inhibitors
C - Cardiovascular system > C03 - Diuretics > C03C - High-ceiling diuretics > C03CA - Sulfonamides, plain
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49184 - Loop Diuretic
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
KEIO_ID B093; [MS2] KO009094
KEIO_ID B093; [MS3] KO009095
KEIO_ID B093
同义名列表
数据库引用编号
39 个数据库交叉引用编号
- ChEBI: CHEBI:3213
- KEGG: C06859
- KEGGdrug: D00247
- PubChem: 2471
- Metlin: METLIN1393
- DrugBank: DB00887
- ChEMBL: CHEMBL1072
- MeSH: Bumetanide
- CAS: 28395-03-1
- CAS: 28395-03-1, 28434-74-4 (sodium salt)
- MoNA: CCMSLIB00000077072
- MoNA: WA001778
- MoNA: WA001777
- MoNA: WA001776
- MoNA: WA001775
- MoNA: WA001774
- MoNA: WA001773
- MoNA: CCMSLIB00000078087
- MoNA: CO000090
- MoNA: CO000089
- MoNA: CO000088
- MoNA: CO000087
- MoNA: CO000086
- MoNA: KO002515
- MoNA: KO000376
- MoNA: KO000377
- MoNA: KO009099
- MoNA: KO009094
- MoNA: KO002516
- MoNA: KO002514
- MoNA: KO009097
- MoNA: KO009095
- MoNA: KO000380
- MoNA: KO000378
- MoNA: KO000379
- MoNA: KO002513
- MoNA: KO002512
- MoNA: KO009098
- MoNA: KO009096
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Annalisa Savardi, Marco Borgogno, Marco De Vivo, Laura Cancedda. Pharmacological tools to target NKCC1 in brain disorders.
Trends in pharmacological sciences.
2021 12; 42(12):1009-1034. doi:
10.1016/j.tips.2021.09.005. [PMID: 34620512] - A Barany, C A Shaughnessy, R M Pelis, J Fuentes, J M Mancera, S D McCormick. Tissue and salinity specific Na+/Cl- cotransporter (NCC) orthologues involved in the adaptive osmoregulation of sea lamprey (Petromyzon marinus).
Scientific reports.
2021 11; 11(1):22698. doi:
10.1038/s41598-021-02125-1. [PMID: 34811419] - A M Beal. The effect of acetazolamide, amiloride, bumetanide and SITS on secretion of fluid and electrolytes by the parotid gland of common wombats, Vombatus ursinus.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2021 07; 191(4):777-791. doi:
10.1007/s00360-021-01367-9. [PMID: 33877412] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Philip Hampel, Kerstin Römermann, Björn Gailus, Marie Johne, Birthe Gericke, Edith Kaczmarek, Wolfgang Löscher. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Neuropharmacology.
2021 03; 185(?):108449. doi:
10.1016/j.neuropharm.2021.108449. [PMID: 33450274] - Wiebke Theilmann, Claudia Brandt, Bettina Bohnhorst, Anne-Mieke Winstroth, Anibh Martin Das, Martina Gramer, Andi Kipper, Markus Kalesse, Wolfgang Löscher. Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain-A new treatment strategy for neonatal seizures?.
Epilepsia.
2021 01; 62(1):269-278. doi:
10.1111/epi.16746. [PMID: 33140458] - Philip Hampel, Kerstin Römermann, Martina Gramer, Wolfgang Löscher. The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain.
Epilepsy & behavior : E&B.
2021 01; 114(Pt A):107616. doi:
10.1016/j.yebeh.2020.107616. [PMID: 33279441] - Panupong Hansrivijit, Chol Techorueangwiwat, Resha Khanal, Christina T Dimech, Charat Thongprayoon, Wisit Cheungpasitporn. Treatment outcomes of bumetanide continuous infusion: A systematic review and meta-analysis.
Nephrology (Carlton, Vic.).
2020 Oct; 25(10):744-748. doi:
10.1111/nep.13739. [PMID: 32725702] - Robert S Jones, Donna Ruszaj, Mark D Parker, Marilyn E Morris. Contribution of Monocarboxylate Transporter 6 to the Pharmacokinetics and Pharmacodynamics of Bumetanide in Mice.
Drug metabolism and disposition: the biological fate of chemicals.
2020 09; 48(9):788-795. doi:
10.1124/dmd.120.000068. [PMID: 32587098] - Shaurya Srivastava, Tyler Kemnic, Kyle R Hildebrandt. BRASH syndrome.
BMJ case reports.
2020 Feb; 13(2):. doi:
10.1136/bcr-2019-233825. [PMID: 32094236] - Sibel Guzel, Charles L Cai, Taimur Ahmad, Michelle Quan, Gloria B Valencia, Jacob V Aranda, Kay D Beharry. Bumetanide Suppression of Angiogenesis in a Rat Model of Oxygen-Induced Retinopathy.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21030987. [PMID: 32024231] - Baoda Han, Yunhe Jiang, Guoxin Cui, Jianing Mi, M Rob G Roelfsema, Grégory Mouille, Julien Sechet, Salim Al-Babili, Manuel Aranda, Heribert Hirt. CATION-CHLORIDE CO-TRANSPORTER 1 (CCC1) Mediates Plant Resistance against Pseudomonas syringae.
Plant physiology.
2020 02; 182(2):1052-1065. doi:
10.1104/pp.19.01279. [PMID: 31806735] - Jun-Yan Feng, Hong-Hua Li, Bing Wang, Ling Shan, Fei-Yong Jia. Successive clinical application of vitamin D and bumetanide in children with autism spectrum disorder: A case report.
Medicine.
2020 Jan; 99(2):e18661. doi:
10.1097/md.0000000000018661. [PMID: 31914053] - Theresa Auer, Philipp Schreppel, Thomas Erker, Christoph Schwarzer. Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches.
Pharmacology & therapeutics.
2020 01; 205(?):107422. doi:
10.1016/j.pharmthera.2019.107422. [PMID: 31626872] - Ciaran A Shaughnessy, Stephen D McCormick. Functional characterization and osmoregulatory role of the Na+-K+-2Cl- cotransporter in the gill of sea lamprey (Petromyzon marinus), a basal vertebrate.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 01; 318(1):R17-R29. doi:
10.1152/ajpregu.00125.2019. [PMID: 31617750] - Frederik H Verbrugge, Pieter Martens, Koen Ameloot, Veerle Haemels, Joris Penders, Matthias Dupont, Wai Hong Wilson Tang, Walter Droogné, Wilfried Mullens. Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance.
European journal of heart failure.
2019 11; 21(11):1415-1422. doi:
10.1002/ejhf.1478. [PMID: 31074184] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Atsuyoshi Okada, Keiichiro Suzuki, Keisuke Hara, Moeko Kojina, Tetsuya Aiba. In Vivo Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure.
Biological & pharmaceutical bulletin.
2019; 42(3):501-506. doi:
10.1248/bpb.b18-00659. [PMID: 30828081] - Shivani C Kharod, Seok Kyu Kang, Shilpa D Kadam. Off-Label Use of Bumetanide for Brain Disorders: An Overview.
Frontiers in neuroscience.
2019; 13(?):310. doi:
10.3389/fnins.2019.00310. [PMID: 31068771] - H Murad, T Ghabrah, M Rafeeq, S Ali. Subdiuretic dose of furosemide enhances albuterol effects in asthmatic mice rather than bumetanide.
Allergologia et immunopathologia.
2018 Nov; 46(6):585-593. doi:
10.1016/j.aller.2018.05.001. [PMID: 30193887] - Chin-Mao Hung, Chung-Kan Peng, Chin-Pyng Wu, Kun-Lun Huang. Bumetanide attenuates acute lung injury by suppressing macrophage activation.
Biochemical pharmacology.
2018 10; 156(?):60-67. doi:
10.1016/j.bcp.2018.08.013. [PMID: 30102895] - Karen M Hallow, Gabriel Helmlinger, Peter J Greasley, John J V McMurray, David W Boulton. Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis.
Diabetes, obesity & metabolism.
2018 03; 20(3):479-487. doi:
10.1111/dom.13126. [PMID: 29024278] - Maria D Donovan, Khaled Abduljalil, John F Cryan, Geraldine B Boylan, Brendan T Griffin. Application of a physiologically-based pharmacokinetic model for the prediction of bumetanide plasma and brain concentrations in the neonate.
Biopharmaceutics & drug disposition.
2018 Mar; 39(3):125-134. doi:
10.1002/bdd.2119. [PMID: 29319897] - Christopher S Wilcox, Wen Shen, David W Boulton, Bruce R Leslie, Steven C Griffen. Interaction Between the Sodium-Glucose-Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal Human Subjects.
Journal of the American Heart Association.
2018 02; 7(4):. doi:
10.1161/jaha.117.007046. [PMID: 29440005] - Xiao-Fang Lu, Meng-Di Jia, Sheng-Sheng Zhang, Lu-Qing Zhao. Effects of Hemp seed soft capsule on colonic ion transport in rats.
World journal of gastroenterology.
2017 Nov; 23(42):7563-7571. doi:
10.3748/wjg.v23.i42.7563. [PMID: 29204056] - Robert S Jones, Mark D Parker, Marilyn E Morris. Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6.
Molecular pharmaceutics.
2017 09; 14(9):2930-2936. doi:
10.1021/acs.molpharmaceut.7b00264. [PMID: 28513167] - Jozine M Ter Maaten, Veena S Rao, Jennifer S Hanberg, F Perry Wilson, Lavanya Bellumkonda, Mahlet Assefa, J Sam Broughton, Julie D'Ambrosi, W H Wilson Tang, Kevin Damman, Adriaan A Voors, David H Ellison, Jeffrey M Testani. Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure.
European journal of heart failure.
2017 08; 19(8):1014-1022. doi:
10.1002/ejhf.757. [PMID: 28105769] - Ling-Sha Ju, Jiao-Jiao Yang, Nikolaus Gravenstein, Christoph N Seubert, Timothy E Morey, Colin Sumners, Terrie Vasilopoulos, Jian-Jun Yang, Anatoly E Martynyuk. Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology.
2017 Jul; 81(?):96-104. doi:
10.1016/j.psyneuen.2017.04.001. [PMID: 28433802] - Kerstin Römermann, Maren Fedrowitz, Philip Hampel, Edith Kaczmarek, Kathrin Töllner, Thomas Erker, Douglas H Sweet, Wolfgang Löscher. Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain.
Neuropharmacology.
2017 05; 117(?):182-194. doi:
10.1016/j.neuropharm.2017.02.006. [PMID: 28192112] - Fushun Wang, Xiaowei Wang, Lee A Shapiro, Maria L Cotrina, Weimin Liu, Ernest W Wang, Simeng Gu, Wei Wang, Xiaosheng He, Maiken Nedergaard, Jason H Huang. NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.
Brain structure & function.
2017 04; 222(3):1543-1556. doi:
10.1007/s00429-016-1292-z. [PMID: 27586142] - E Lemonnier, N Villeneuve, S Sonie, S Serret, A Rosier, M Roue, P Brosset, M Viellard, D Bernoux, S Rondeau, S Thummler, D Ravel, Y Ben-Ari. Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders.
Translational psychiatry.
2017 03; 7(3):e1056. doi:
10.1038/tp.2017.10. [PMID: 28291262] - Yonggang Gao, Jing-Jing Zhou, Yun Zhu, Therese Kosten, De-Pei Li. Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation.
Neuroendocrinology.
2017; 104(2):194-208. doi:
10.1159/000446114. [PMID: 27077366] - Mei Hong Zhu, Tae Sik Sung, Masaaki Kurahashi, Lauren E O'Kane, Kate O'Driscoll, Sang Don Koh, Kenton M Sanders. Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal.
American journal of physiology. Gastrointestinal and liver physiology.
2016 12; 311(6):G1037-G1046. doi:
10.1152/ajpgi.00277.2016. [PMID: 27742704] - Andrew J Esbaugh, Brett Cutler. Intestinal Na+, K+, 2Cl- cotransporter 2 plays a crucial role in hyperosmotic transitions of a euryhaline teleost.
Physiological reports.
2016 11; 4(22):. doi:
10.14814/phy2.13028. [PMID: 27881573] - Sujay V Kharade, Daniel Flores, Craig W Lindsley, Lisa M Satlin, Jerod S Denton. ROMK inhibitor actions in the nephron probed with diuretics.
American journal of physiology. Renal physiology.
2016 04; 310(8):F732-F737. doi:
10.1152/ajprenal.00423.2015. [PMID: 26661652] - Sergio Montes, Armando Castro-Chávez, Circe Florian-Soto, Yessica Heras-Romero, Camilo Ríos, Susana Rivera-Mancía. Bumetanide increases manganese accumulation in the brain of rats with liver damage.
European journal of pharmacology.
2016 Mar; 774(?):127-34. doi:
10.1016/j.ejphar.2016.02.012. [PMID: 26851372] - Vincent Jullien, Ronit M Pressler, Geraldine Boylan, Mats Blennow, Neil Marlow, Catherine Chiron, Gerard Pons. Pilot evaluation of the population pharmacokinetics of bumetanide in term newborn infants with seizures.
Journal of clinical pharmacology.
2016 Mar; 56(3):284-90. doi:
10.1002/jcph.596. [PMID: 26189501] - Maria D Donovan, Harriët Schellekens, Geraldine B Boylan, John F Cryan, Brendan T Griffin. In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide.
European journal of pharmacology.
2016 Jan; 770(?):117-25. doi:
10.1016/j.ejphar.2015.12.001. [PMID: 26673740] - Jeffrey M Testani, Jennifer S Hanberg, Susan Cheng, Veena Rao, Chukwuma Onyebeke, Olga Laur, Alexander Kula, Michael Chen, F Perry Wilson, Andrew Darlington, Lavanya Bellumkonda, Daniel Jacoby, W H Wilson Tang, Chirag R Parikh. Rapid and Highly Accurate Prediction of Poor Loop Diuretic Natriuretic Response in Patients With Heart Failure.
Circulation. Heart failure.
2016 Jan; 9(1):e002370. doi:
10.1161/circheartfailure.115.002370. [PMID: 26721915] - Jiaqiang Zhang, Changqing Xu, Dyanet L Puentes, Christoph N Seubert, Nikolaus Gravenstein, Anatoly E Martynyuk. Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats.
Neuroendocrinology.
2016; 103(5):440-51. doi:
10.1159/000437267. [PMID: 26159049] - Saeed Alshahrani, Mohammed Mashari Almutairi, Shams Kursan, Eduardo Dias-Junior, Mohamed Mahmoud Almiahuob, Lydia Aguilar-Bryan, Mauricio Di Fulvio. Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice.
The Journal of endocrinology.
2015 Dec; 227(3):153-65. doi:
10.1530/joe-15-0327. [PMID: 26400961] - Anthony S Malamas, Erlei Jin, Qi Zhang, John Haaga, Zheng-Rong Lu. Anti-angiogenic Effects of Bumetanide Revealed by DCE-MRI with a Biodegradable Macromolecular Contrast Agent in a Colon Cancer Model.
Pharmaceutical research.
2015 Sep; 32(9):3029-43. doi:
10.1007/s11095-015-1684-4. [PMID: 25840948] - Peicai Fu, Ronghua Tang, Zhiyuan Yu, Shanshan Huang, Minjie Xie, Xiang Luo, Wei Wang. Bumetanide-induced NKCC1 inhibition attenuates oxygen-glucose deprivation-induced decrease in proliferative activity and cell cycle progression arrest in cultured OPCs via p-38 MAPKs.
Brain research.
2015 Jul; 1613(?):110-9. doi:
10.1016/j.brainres.2015.04.006. [PMID: 25881895] - Frederik H Verbrugge, Matthias Dupont, Philippe B Bertrand, Petra Nijst, Joris Penders, Joseph Dens, David Verhaert, Pieter Vandervoort, W H Wilson Tang, Wilfried Mullens. Determinants and impact of the natriuretic response to diuretic therapy in heart failure with reduced ejection fraction and volume overload.
Acta cardiologica.
2015 Jun; 70(3):265-73. doi:
10.1080/ac.70.3.3080630. [PMID: 26226699] - Maria D Donovan, Fionn E O'Brien, Geraldine B Boylan, John F Cryan, Brendan T Griffin. The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat.
The Journal of pharmacy and pharmacology.
2015 Apr; 67(4):501-10. doi:
10.1111/jphp.12341. [PMID: 25490899] - Agnieszka Konopacka, Jing Qiu, Song T Yao, Michael P Greenwood, Mingkwan Greenwood, Thomas Lancaster, Wataru Inoue, Andre de Souza Mecawi, Fernanda M V Vechiato, Juliana B M de Lima, Ricardo Coletti, See Ziau Hoe, Andrew Martin, Justina Lee, Marina Joseph, Charles Hindmarch, Julian Paton, Jose Antunes-Rodrigues, Jaideep Bains, David Murphy. Osmoregulation requires brain expression of the renal Na-K-2Cl cotransporter NKCC2.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Apr; 35(13):5144-55. doi:
10.1523/jneurosci.4121-14.2015. [PMID: 25834041] - Katie M McCallister, Rebecca F Chhim, Mario Briceno-Medina, Chasity M Shelton, Mayte Figueroa, Mark Rayburn. Bumetanide continuous infusions in critically ill pediatric patients.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2015 Feb; 16(2):e19-22. doi:
10.1097/pcc.0000000000000303. [PMID: 25560424] - Kathrin Töllner, Claudia Brandt, Kerstin Römermann, Wolfgang Löscher. The organic anion transport inhibitor probenecid increases brain concentrations of the NKCC1 inhibitor bumetanide.
European journal of pharmacology.
2015 Jan; 746(?):167-73. doi:
10.1016/j.ejphar.2014.11.019. [PMID: 25449033] - Nawar Dalila, Jürgen Brockmöller, Mladen Vassilev Tzvetkov, Markus Schirmer, Martin Haubrock, Stefan Viktor Vormfelde. Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs.
Pharmacogenomics.
2015 Jan; 16(2):115-27. doi:
10.2217/pgs.14.163. [PMID: 25616098] - Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Joris Penders, W H Wilson Tang, Wilfried Mullens. Urinary composition during decongestive treatment in heart failure with reduced ejection fraction.
Circulation. Heart failure.
2014 Sep; 7(5):766-72. doi:
10.1161/circheartfailure.114.001377. [PMID: 25037309] - Steven Jacobs, Walter Droogne, Valerie Waelbers, Klaartje Van den Bossche, Hilde Bollen, Jef Geens, Filip Rega, Daniel Burkhoff, Bart Meyns. Evolution of renal function after partial and full mechanical support for chronic heart failure.
The International journal of artificial organs.
2014 May; 37(5):364-70. doi:
10.5301/ijao.5000326. [PMID: 24811310] - Kathrin Töllner, Claudia Brandt, Manuel Töpfer, Gerda Brunhofer, Thomas Erker, Mario Gabriel, Peter W Feit, Jenna Lindfors, Kai Kaila, Wolfgang Löscher. A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
Annals of neurology.
2014 Apr; 75(4):550-62. doi:
10.1002/ana.24124. [PMID: 24615913] - Manuel Töpfer, Kathrin Töllner, Claudia Brandt, Friederike Twele, Sonja Bröer, Wolfgang Löscher. Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy.
The European journal of neuroscience.
2014 Feb; 39(4):673-87. doi:
10.1111/ejn.12424. [PMID: 24251546] - Tien M H Ng, Erica Konopka, Alifiya F Hyderi, Shenche Hshieh, Yuki Tsuji, Brian J Kim, Song Y Han, Duc H Phan, Aaron I Jeng, Mimi Lou, Uri Elkayam. Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure.
Journal of cardiovascular pharmacology and therapeutics.
2013 Jul; 18(4):345-53. doi:
10.1177/1074248413482755. [PMID: 23538300] - Barry E Bleske, Megan M Clark, Audrey H Wu, Michael P Dorsch. The effect of continuous infusion loop diuretics in patients with acute decompensated heart failure with hypoalbuminemia.
Journal of cardiovascular pharmacology and therapeutics.
2013 Jul; 18(4):334-7. doi:
10.1177/1074248412474347. [PMID: 23424098] - Tian Wang, Yu-Qin Yang, Takatoshi Karasawa, Qi Wang, Amanda Phillips, Bing-Cai Guan, Ke-Tao Ma, Meiyan Jiang, Ding-Hua Xie, Peter S Steyger, Zhi-Gen Jiang. Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels.
Cell biochemistry and biophysics.
2013 Apr; 65(3):381-98. doi:
10.1007/s12013-012-9442-2. [PMID: 23109177] - Jeffrey H Barsuk, Robert A Gordon, Elaine R Cohen, William G Cotts, David Malkenson, Clyde W Yancy, Mark V Williams. A diuretic protocol increases volume removal and reduces readmissions among hospitalized patients with acute decompensated heart failure.
Congestive heart failure (Greenwich, Conn.).
2013 Mar; 19(2):53-60. doi:
10.1111/chf.12020. [PMID: 23336425] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Saeed Alshahrani, Mauricio Di Fulvio. Enhanced insulin secretion and improved glucose tolerance in mice with homozygous inactivation of the Na(+)K(+)2Cl(-) co-transporter 1.
The Journal of endocrinology.
2012 Oct; 215(1):59-70. doi:
10.1530/joe-12-0244. [PMID: 22872759] - Louise C Evans, Dawn E Livingstone, Christopher J Kenyon, Maurits A Jansen, James W Dear, John J Mullins, Matthew A Bailey. A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.
American journal of physiology. Renal physiology.
2012 Aug; 303(4):F494-502. doi:
10.1152/ajprenal.00165.2012. [PMID: 22622456] - Geoffrey M Coast. Intracellular Na+, K+ and Cl- activities in Acheta domesticus Malpighian tubules and the response to a diuretic kinin neuropeptide.
The Journal of experimental biology.
2012 Aug; 215(Pt 16):2774-85. doi:
10.1242/jeb.072223. [PMID: 22837449] - Gian Maria Pacifici. Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants.
Paediatric drugs.
2012 Aug; 14(4):233-46. doi:
10.2165/11596620-000000000-00000. [PMID: 22702741] - Dinesh S Patel, Naveen Sharma, Mukesh C Patel, Bhavin N Patel, Pranav S Shrivastav, Mallika Sanyal. Application of a rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of bumetanide in human plasma for a bioequivalence study.
Journal of pharmaceutical and biomedical analysis.
2012 Jul; 66(?):365-70. doi:
10.1016/j.jpba.2012.03.018. [PMID: 22475517] - Vladimir Pech, Monika Thumova, Young Hee Kim, Diana Agazatian, Edith Hummler, Bernard C Rossier, Alan M Weinstein, Masayoshi Nanami, Susan M Wall. ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.
American journal of physiology. Renal physiology.
2012 Jul; 303(1):F45-55. doi:
10.1152/ajprenal.00030.2012. [PMID: 22496413] - E S G den Deurwaarder, E J Steenbergen, E K Hoogeveen, J F M Wetzels. Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy?.
Clinical nephrology.
2012 Jun; 77(6):501-4. doi:
10.5414/cn106969. [PMID: 22595394] - Thomas Zeuthen, Nanna Macaulay. Cotransport of water by Na⁺-K⁺-2Cl⁻ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2.
The Journal of physiology.
2012 Mar; 590(5):1139-54. doi:
10.1113/jphysiol.2011.226316. [PMID: 22250214] - Masanori Tachikawa, Saori Ikeda, Jun Fujinawa, Shirou Hirose, Shin-ichi Akanuma, Ken-ichi Hosoya. γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.
PloS one.
2012; 7(2):e32557. doi:
10.1371/journal.pone.0032557. [PMID: 22384273] - Spencer D Watts, Katherine L Suchland, Susan G Amara, Susan L Ingram. A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes.
PloS one.
2012; 7(4):e35373. doi:
10.1371/journal.pone.0035373. [PMID: 22506078] - Gary Laverty, Ashley Anttila, Jenava Carty, Varudhini Reddy, Jamie Yum, Sighvatur S Arnason. CFTR mediated chloride secretion in the avian renal proximal tubule.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2012 Jan; 161(1):53-60. doi:
10.1016/j.cbpa.2011.09.005. [PMID: 21964154] - Vin-Cent Wu, Chun-Fu Lai, Chih-Chung Shiao, Yu-Feng Lin, Pei-Chen Wu, Chia-Ter Chao, Fu-Chang Hu, Tao-Min Huang, Yu-Chang Yeh, I-Jung Tsai, Tze-Wah Kao, Yin-Yi Han, Wen-Chung Wu, Chun-Cheng Hou, Guang-Huar Young, Wen-Je Ko, Tun-Jun Tsai, Kwan-Dun Wu. Effect of diuretic use on 30-day postdialysis mortality in critically ill patients receiving acute dialysis.
PloS one.
2012; 7(3):e30836. doi:
10.1371/journal.pone.0030836. [PMID: 22431960] - Yoshiteru Noutoshi, Mika Ikeda, Ken Shirasu. Diuretics prime plant immunity in Arabidopsis thaliana.
PloS one.
2012; 7(10):e48443. doi:
10.1371/journal.pone.0048443. [PMID: 23144763] - Wen Liu, Carlos Schreck, Richard A Coleman, James B Wade, Yubelka Hernandez, Beth Zavilowitz, Richard Warth, Thomas R Kleyman, Lisa M Satlin. Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD.
American journal of physiology. Renal physiology.
2011 Nov; 301(5):F1088-97. doi:
10.1152/ajprenal.00347.2011. [PMID: 21816753] - Klaus Höcherl, Melanie Gerl, Frank Schweda. Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release.
Hypertension (Dallas, Tex. : 1979).
2011 Oct; 58(4):611-8. doi:
10.1161/hypertensionaha.111.173229. [PMID: 21859963] - Jeong Sook Kim, Woong Bin Kim, Young-Beom Kim, Yeon Lee, Yoon Sik Kim, Feng-Yan Shen, Seung Won Lee, Dawon Park, Hee-Joo Choi, Jinyoung Hur, Joong Jean Park, Hee Chul Han, Christopher S Colwell, Young-Wuk Cho, Yang In Kim. Chronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Sep; 31(37):13312-22. doi:
10.1523/jneurosci.1440-11.2011. [PMID: 21917814] - James A McCormick, Kerim Mutig, Joshua H Nelson, Turgay Saritas, Ewout J Hoorn, Chao-Ling Yang, Shaunessy Rogers, Joshua Curry, Eric Delpire, Sebastian Bachmann, David H Ellison. A SPAK isoform switch modulates renal salt transport and blood pressure.
Cell metabolism.
2011 Sep; 14(3):352-64. doi:
10.1016/j.cmet.2011.07.009. [PMID: 21907141] - D Liu, H He, G L Li, J Chen, D Yin, Z P Liao, L Tang, Q R Huang, Z F Lai, M He. Mechanisms of chloride in cardiomyocyte anoxia-reoxygenation injury: the involvement of oxidative stress and NF-kappaB activation.
Molecular and cellular biochemistry.
2011 Sep; 355(1-2):201-9. doi:
10.1007/s11010-011-0855-9. [PMID: 21553261] - Jin-Xia Zhu, Hong Xue, Tuo Ji, Ying Xing. Cellular localization of NKCC2 and its possible role in the Cl- absorption in the rat and human distal colonic epithelia.
Translational research : the journal of laboratory and clinical medicine.
2011 Sep; 158(3):146-54. doi:
10.1016/j.trsl.2011.04.003. [PMID: 21867980] - Jesse Rinehart, Norma Vázquez, Kristopher T Kahle, Caleb A Hodson, Aaron M Ring, Erol E Gulcicek, Angeliki Louvi, Norma A Bobadilla, Gerardo Gamba, Richard P Lifton. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.
The Journal of biological chemistry.
2011 Aug; 286(34):30171-80. doi:
10.1074/jbc.m111.222893. [PMID: 21733846] - Kevin Watt, Jennifer S Li, Daniel K Benjamin, Michael Cohen-Wolkowiez. Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation.
Journal of cardiovascular pharmacology.
2011 Aug; 58(2):126-32. doi:
10.1097/fjc.0b013e318213aac2. [PMID: 21346597] - Se Jin Park, Jae Il Shin. Complications of nephrotic syndrome.
Korean journal of pediatrics.
2011 Aug; 54(8):322-8. doi:
10.3345/kjp.2011.54.8.322. [PMID: 22087198] - C Cefaratti, A Romani. Modulation of Na+/Mg²+ exchanger stoichiometry ratio by Cl⁻ ions in basolateral rat liver plasma membrane vesicles.
Molecular and cellular biochemistry.
2011 May; 351(1-2):133-42. doi:
10.1007/s11010-011-0720-x. [PMID: 21234652] - Yijun Li, Ryan Cleary, Mark Kellogg, Janet S Soul, Gerard T Berry, Frances E Jensen. Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Apr; 879(13-14):998-1002. doi:
10.1016/j.jchromb.2011.02.018. [PMID: 21414852] - Shoujin Hao, Hong Zhao, Zbigniew Darzynkiewicz, Sailaja Battula, Nicholas R Ferreri. Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.
American journal of physiology. Renal physiology.
2011 Apr; 300(4):F966-75. doi:
10.1152/ajprenal.00408.2010. [PMID: 21228109] - Anke Hannemann, Peter W Flatman. Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells.
PloS one.
2011 Mar; 6(3):e17992. doi:
10.1371/journal.pone.0017992. [PMID: 21464992] - Z Khawaja, C S Wilcox. Role of the kidneys in resistant hypertension.
International journal of hypertension.
2011 Mar; 2011(?):143471. doi:
10.4061/2011/143471. [PMID: 21461391] - Kakulavarapu V Rama Rao, Pichili V B Reddy, Kevin M Curtis, Michael D Norenberg. Aquaporin-4 expression in cultured astrocytes after fluid percussion injury.
Journal of neurotrauma.
2011 Mar; 28(3):371-81. doi:
10.1089/neu.2010.1705. [PMID: 21204635] - Milette Oliveros, Jennifer T Pham, Eunice John, Ashraf Resheidat, Rama Bhat. The use of bumetanide for oliguric acute renal failure in preterm infants.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2011 Mar; 12(2):210-4. doi:
10.1097/pcc.0b013e3181e912a7. [PMID: 20625335] - Timothy E Bunchman. Acute kidney injury treatment and the optimization of diuretics in newborns.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2011 Mar; 12(2):234-5. doi:
10.1097/pcc.0b013e3181e8b718. [PMID: 21646954] - Roman Tyzio, Camille Allene, Romain Nardou, Michel A Picardo, Sumii Yamamoto, Sudhir Sivakumaran, Maddalena D Caiati, Sylvain Rheims, Marat Minlebaev, Mathieu Milh, Pascal Ferré, Rustem Khazipov, Jean-Louis Romette, Jean Lorquin, Rosa Cossart, Ilgam Khalilov, Astrid Nehlig, Enrico Cherubini, Yehezkel Ben-Ari. Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Jan; 31(1):34-45. doi:
10.1523/jneurosci.3314-10.2011. [PMID: 21209187] - Promsuk Jutabha, Naohiko Anzai, Toru Kimura, Atsuo Taniguchi, Wako Urano, Hisashi Yamanaka, Hitoshi Endou, Hiroyuki Sakurai. Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms.
Journal of pharmacological sciences.
2011; 115(2):249-53. doi:
NULL. [PMID: 21282933] - S Mousavi, B Levcovich, M Mojtahedzadeh. A systematic review on pharmacokinetic changes in critically ill patients: role of extracorporeal membrane oxygenation.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2011; 19(5):312-21. doi:
NULL. [PMID: 22615675] - Kiran S Panickar, Richard A Anderson. Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia.
International journal of molecular sciences.
2011; 12(11):8181-207. doi:
10.3390/ijms12118181. [PMID: 22174658] - Promsuk Jutabha, Naohiko Anzai, Kenichiro Kitamura, Atsuo Taniguchi, Shuji Kaneko, Kunimasa Yan, Hideomi Yamada, Hidetaka Shimada, Toru Kimura, Tomohisa Katada, Toshiyuki Fukutomi, Kimio Tomita, Wako Urano, Hisashi Yamanaka, George Seki, Toshiro Fujita, Yoshinori Moriyama, Akira Yamada, Shunya Uchida, Michael F Wempe, Hitoshi Endou, Hiroyuki Sakurai. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.
The Journal of biological chemistry.
2010 Nov; 285(45):35123-32. doi:
10.1074/jbc.m110.121301. [PMID: 20810651] - Teddy M Musselman, Zheng Zhang, Shyama M E Masilamani. Differential regulation of the bumetanide-sensitive cotransporter (NKCC2) by ovarian hormones.
Steroids.
2010 Nov; 75(11):760-5. doi:
10.1016/j.steroids.2010.05.014. [PMID: 20580730] - Atsuko Ishikawa, Kentaro Kono, Rie Sakae, Tetsuya Aiba, Hiromu Kawasaki, Yuji Kurosaki. Altered electrolyte handling of the choroid plexus in rats with glycerol-induced acute renal failure.
Biopharmaceutics & drug disposition.
2010 Nov; 31(8-9):455-63. doi:
10.1002/bdd.726. [PMID: 20848389] - S Reddy, A Bahl, K K Talwar. Congestive heart failure in Indians: how do we improve diagnosis & management?.
The Indian journal of medical research.
2010 Nov; 132(?):549-60. doi:
NULL. [PMID: 21150007] - Sung-Sen Yang, Yi-Fen Lo, Chin-Chen Wu, Shu-Wha Lin, Chien-Ju Yeh, Pauling Chu, Huey-Kang Sytwu, Shinichi Uchida, Sei Sasaki, Shih-Hua Lin. SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.
Journal of the American Society of Nephrology : JASN.
2010 Nov; 21(11):1868-77. doi:
10.1681/asn.2009121295. [PMID: 20813865] - Soojung Lee, Hye Jeong Lee, Han Soo Yang, Ian M Thornell, Mark O Bevensee, Inyeong Choi. Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport.
Experimental physiology.
2010 Sep; 95(9):926-37. doi:
10.1113/expphysiol.2010.053967. [PMID: 20591978] - Vijay Lapsia, Amir Kazory. Loop diuretics for heart failure-associated hyponatremia.
The American journal of medicine.
2010 Aug; 123(8):e5-6. doi:
10.1016/j.amjmed.2009.12.035. [PMID: 20670712]