Sacubitrilat (BioDeep_00000016532)
代谢物信息卡片
化学式: C22H25NO5 (383.173264)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O)C(=O)O
InChI: InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Toshio Kawanami, Rajeshri G Karki, Emma Cody, Qian Liu, Guiqing Liang, Gary M Ksander, Dean F Rigel, Nikolaus Schiering, Yongjin Gong, Gary M Coppola, Yuki Iwaki, Robert Sun, Alan Neubert, Li Fan, Sara Ingles, Allan D'Arcy, Frederic Villard, Paul Ramage, Arco Y Jeng, Jennifer Leung-Chu, Jing Liu, Michael Beil, Fumin Fu, Wei Chen, Frederic Cumin, Christian Wiesmann, Muneto Mogi. Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS medicinal chemistry letters.
2020 Feb; 11(2):188-194. doi:
10.1021/acsmedchemlett.9b00578. [PMID: 32071687] - Guoxing Wang, Qian Zhang, Wei Yuan, Junyuan Wu, Chunsheng Li. Enalapril protects against myocardial ischemia/reperfusion injury in a swine model of cardiac arrest and resuscitation.
International journal of molecular medicine.
2016 Nov; 38(5):1463-1473. doi:
10.3892/ijmm.2016.2737. [PMID: 27633002] - Oliver Domenig, Arndt Manzel, Nadja Grobe, Eva Königshausen, Christopher C Kaltenecker, Johannes J Kovarik, Johannes Stegbauer, Susan B Gurley, Dunja van Oyen, Marlies Antlanger, Michael Bader, Daisy Motta-Santos, Robson A Santos, Khalid M Elased, Marcus D Säemann, Ralf A Linker, Marko Poglitsch. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney.
Scientific reports.
2016 09; 6(?):33678. doi:
10.1038/srep33678. [PMID: 27649628] - Scott A Hubers, Nancy J Brown. Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Circulation.
2016 Mar; 133(11):1115-24. doi:
10.1161/circulationaha.115.018622. [PMID: 26976916] - Jessie Gu, Adele Noe, Priya Chandra, Suliman Al-Fayoumi, Monica Ligueros-Saylan, Ramesh Sarangapani, Suzanne Maahs, Gary Ksander, Dean F Rigel, Arco Y Jeng, Tsu-Han Lin, Weiyi Zheng, William P Dole. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).
Journal of clinical pharmacology.
2010 Apr; 50(4):401-14. doi:
10.1177/0091270009343932. [PMID: 19934029] - G M Ksander, R D Ghai, R deJesus, C G Diefenbacher, A Yuan, C Berry, Y Sakane, A Trapani. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.
Journal of medicinal chemistry.
1995 May; 38(10):1689-700. doi:
10.1021/jm00010a014. [PMID: 7752193]