5-Iodotubercidin (BioDeep_00000016531)
代谢物信息卡片
化学式: C11H13IN4O4 (391.9981528)
中文名称: 5-碘胸苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)I
InChI: InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1
描述信息
D004791 - Enzyme Inhibitors
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:40167
- KEGG: C74253
- PubChem: 97297
- Metlin: METLIN45255
- DrugBank: DB04604
- ChEMBL: CHEMBL99203
- CAS: 24386-93-4
- medchemexpress: HY-15424
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianyuan Zhao, Qian Liu, Dongrong Yi, Quanjie Li, SaiSai Guo, Ling Ma, Yongxin Zhang, Dongxin Dong, Fei Guo, Zhenlong Liu, Tao Wei, Xiaoyu Li, Shan Cen. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis.
Antiviral research.
2022 02; 198(?):105254. doi:
10.1016/j.antiviral.2022.105254. [PMID: 35101534] - Elena Kozgunova, Tetsuya Higashiyama, Daisuke Kurihara. Cytokinesis defect in BY-2 cells caused by ATP-competitive kinase inhibitors.
Plant signaling & behavior.
2016 10; 11(10):e1238547. doi:
10.1080/15592324.2016.1238547. [PMID: 27662076] - Kiran S Toti, Danielle Osborne, Antonella Ciancetta, Detlev Boison, Kenneth A Jacobson. South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
Journal of medicinal chemistry.
2016 07; 59(14):6860-77. doi:
10.1021/acs.jmedchem.6b00689. [PMID: 27410258] - Ercument Dirice, Deepika Walpita, Amedeo Vetere, Bennett C Meier, Sevim Kahraman, Jiang Hu, Vlado Dančík, Sean M Burns, Tamara J Gilbert, David E Olson, Paul A Clemons, Rohit N Kulkarni, Bridget K Wagner. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.
Diabetes.
2016 06; 65(6):1660-71. doi:
10.2337/db15-1127. [PMID: 26953159] - Elena Kozgunova, Takamasa Suzuki, Masaki Ito, Tetsuya Higashiyama, Daisuke Kurihara. Haspin has Multiple Functions in the Plant Cell Division Regulatory Network.
Plant & cell physiology.
2016 Apr; 57(4):848-61. doi:
10.1093/pcp/pcw030. [PMID: 26872832] - Justin L Anglin, Yongcheng Song. A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.
Journal of medicinal chemistry.
2013 Nov; 56(22):8972-83. doi:
10.1021/jm4007752. [PMID: 23879463] - Edward P Acosta, Kay L Limoli, Lan Trinh, Neil T Parkin, Jennifer R King, Jodi M Weidler, Ighovwerha Ofotokun, Christos J Petropoulos. Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data.
Antimicrobial agents and chemotherapy.
2012 Nov; 56(11):5938-45. doi:
10.1128/aac.00691-12. [PMID: 22964257] - A Peairs, A Radjavi, S Davis, L Li, A Ahmed, S Giri, C M Reilly. Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells.
Clinical and experimental immunology.
2009 Jun; 156(3):542-51. doi:
10.1111/j.1365-2249.2009.03924.x. [PMID: 19438609] - Shailendra Giri, Ramandeep Rattan, Ehtishamul Haq, Mushfiquddin Khan, Rifat Yasmin, Je-song Won, Lyndon Key, Avtar K Singh, Inderjit Singh. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model.
Nutrition & metabolism.
2006 Aug; 3(?):31. doi:
10.1186/1743-7075-3-31. [PMID: 16901342] - William F Waas, Kevin N Dalby. Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2.
Biochemistry.
2003 Mar; 42(10):2960-70. doi:
10.1021/bi027171w. [PMID: 12627962] - Javier García-Villafranca, José Castro. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase.
Biochemical pharmacology.
2002 Jun; 63(11):1997-2000. doi:
10.1016/s0006-2952(02)01013-4. [PMID: 12093476] - A Deussen, M Stappert, S Schäfer, M Kelm. Quantification of extracellular and intracellular adenosine production: understanding the transmembranous concentration gradient.
Circulation.
1999 Apr; 99(15):2041-7. doi:
10.1161/01.cir.99.15.2041. [PMID: 10209010] - R K Dubey, D G Gillespie, Z Mi, E K Jackson. Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors.
Circulation.
1997 Oct; 96(8):2656-66. doi:
10.1161/01.cir.96.8.2656. [PMID: 9355907] - S Glombitza, S Dragon, M Berghammer, M Pannermayr, R Baumann. Adenosine causes cAMP-dependent activation of chick embryo red cell carbonic anhydrase and 2,3-DPG synthesis.
The American journal of physiology.
1996 Oct; 271(4 Pt 2):R973-81. doi:
10.1152/ajpregu.1996.271.4.r973. [PMID: 8897990] - K Kroll, D W Stepp. Adenosine kinetics in canine coronary circulation.
The American journal of physiology.
1996 Apr; 270(4 Pt 2):H1469-83. doi:
10.1152/ajpheart.1996.270.4.h1469. [PMID: 8967391] - J Sayos, J J Centelles, J Mallol, E I Canela, C Lluis, R Franco. Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM).
Biochemical Society transactions.
1991 Aug; 19(3):323S. doi:
10.1042/bst019323s. [PMID: 1783158] - D E Bergstrom, A J Brattesani, M K Ogawa, P A Reddy, M J Schweickert, J Balzarini, E De Clercq. Antiviral activity of C-5 substituted tubercidin analogues.
Journal of medicinal chemistry.
1984 Mar; 27(3):285-92. doi:
10.1021/jm00369a010. [PMID: 6699874]