RO4929097 (BioDeep_00000016500)
代谢物信息卡片
化学式: C22H20F5N3O3 (469.142475)
中文名称: N1-[(7S)-6,7-二氢-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]-2,2-二甲基-N3-(2,2,3,3,3-五氟丙基)丙二酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChI: InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D000091062 - Gamma Secretase Inhibitors and Modulators
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:86474
- KEGG: C76705
- PubChem: 49867930
- DrugBank: DB11870
- ChEMBL: CHEMBL4297422
- CAS: 847925-91-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mrinal M Gounder, Evan Rosenbaum, Nian Wu, Mark A Dickson, Tahir N Sheikh, Sandra P D'Angelo, Ping Chi, Mary Lou Keohan, Joseph P Erinjeri, Cristina R Antonescu, Narasimhan Agaram, Meera R Hameed, Moriah Martindale, Robert A Lefkowitz, Aimee M Crago, Sam Singer, William D Tap, Naoko Takebe, Li-Xuan Qin, Gary K Schwartz. A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2022 04; 28(8):1586-1594. doi:
10.1158/1078-0432.ccr-21-3874. [PMID: 35110418] - Chun-Wu Tung, Yung-Chien Hsu, Chang-Jhih Cai, Ya-Hsueh Shih, Ching-Jen Wang, Pey-Jium Chang, Chun-Liang Lin. Trichostatin A ameliorates renal tubulointerstitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway.
Scientific reports.
2017 11; 7(1):14495. doi:
10.1038/s41598-017-15162-6. [PMID: 29101337] - Ran Xu, Fumiko Shimizu, Koos Hovinga, Kathryn Beal, Sasan Karimi, Leif Droms, Kyung K Peck, Philip Gutin, J Bryan Iorgulescu, Thomas Kaley, Lisa DeAngelis, Elena Pentsova, Craig Nolan, Christian Grommes, Timothy Chan, Dylan Bobrow, Adilia Hormigo, Justin R Cross, Nian Wu, Naoko Takebe, Katherine Panageas, Percy Ivy, Jeffrey G Supko, Viviane Tabar, Antonio Omuro. Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016 Oct; 22(19):4786-4796. doi:
10.1158/1078-0432.ccr-16-0048. [PMID: 27154916] - Alexandra Pisklakova, Eileen Grigson, Maria Ozerova, Feng Chen, Daniel M Sullivan, Yulia Nefedova. Anti-myeloma effect of pharmacological inhibition of Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment.
Cancer biology & therapy.
2016 05; 17(5):477-85. doi:
10.1080/15384047.2016.1156261. [PMID: 26934342] - Noelle K LoConte, Albiruni R A Razak, Percy Ivy, Amye Tevaarwerk, Rachael Leverence, Jill Kolesar, Lillian Siu, Sam J Lubner, Daniel L Mulkerin, William R Schelman, Dustin A Deming, Kyle D Holen, Lakeesha Carmichael, Jens Eickhoff, Glenn Liu. A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors.
Investigational new drugs.
2015 Feb; 33(1):169-76. doi:
10.1007/s10637-014-0166-6. [PMID: 25318436] - Suzanne Richter, Philippe L Bedard, Eric Xueyu Chen, Blaise A Clarke, Ben Tran, Sebastien J Hotte, Anastasios Stathis, Hal W Hirte, Albiruni R A Razak, Michael Reedijk, Zhuo Chen, Brenda Cohen, Wen-Jiang Zhang, Lisa Wang, S Percy Ivy, Malcolm J Moore, Amit M Oza, Lillian L Siu, Elaine McWhirter. A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).
Investigational new drugs.
2014 Apr; 32(2):243-9. doi:
10.1007/s10637-013-9965-4. [PMID: 23645447] - S Sahebjam, P L Bedard, V Castonguay, Z Chen, M Reedijk, G Liu, B Cohen, W-J Zhang, B Clarke, T Zhang, S Kamel-Reid, H Chen, S P Ivy, A R A Razak, A M Oza, E X Chen, H W Hirte, A McGarrity, L Wang, L L Siu, S J Hotte. A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503).
British journal of cancer.
2013 Aug; 109(4):943-9. doi:
10.1038/bjc.2013.380. [PMID: 23868004] - Jianmei Wu, Patricia M Lorusso, Larry H Matherly, Jing Li. Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the γ-secretase inhibitor RO4929097.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Apr; 18(7):2066-79. doi:
10.1158/1078-0432.ccr-11-2684. [PMID: 22351688] - Jianmei Wu, Richard Wiegand, Patricia LoRusso, Jing Li. Validation and implementation of a liquid chromatography/tandem mass spectrometry assay for quantitation of the total and unbound RO4929097, a γ-secretase inhibitor targeting Notch signaling, in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jun; 879(19):1537-43. doi:
10.1016/j.jchromb.2011.03.045. [PMID: 21497565] - Wei He, Leopoldo Luistro, Daisy Carvajal, Melissa Smith, Tom Nevins, Xuefeng Yin, James Cai, Brian Higgins, Kenneth Kolinsky, Christine Rizzo, Kathryn Packman, David Heimbrook, John F Boylan. High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097.
Molecular oncology.
2011 Jun; 5(3):292-301. doi:
10.1016/j.molonc.2011.01.001. [PMID: 21315665]