NS-398 (BioDeep_00000016494)
代谢物信息卡片
N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
化学式: C13H18N2O5S (314.0936378)
中文名称: NS-398(COX-2抑制剂)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2
InChI: InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:73458
- KEGG: C71930
- PubChem: 4553
- Metlin: METLIN63036
- DrugBank: DB14060
- ChEMBL: CHEMBL7162
- CAS: 123653-11-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yeke Wu, Min Liu, Hongling Zhou, Xiang He, Wei Shi, Qianghua Yuan, Yuling Zuo, Bin Li, Qiongying Hu, Yunfei Xie. COX-2/PGE2/VEGF signaling promotes ERK-mediated BMSCs osteogenic differentiation under hypoxia by the paracrine action of ECs.
Cytokine.
2023 01; 161(?):156058. doi:
10.1016/j.cyto.2022.156058. [PMID: 36209650] - Julia Steinmetz-Späh, Samsul Arefin, Karin Larsson, Jabin Jahan, Neja Mudrovcic, Lars Wennberg, Peter Stenvinkel, Marina Korotkova, Karolina Kublickiene, Per-Johan Jakobsson. Effects of microsomal prostaglandin E synthase-1 inhibition on resistance artery tone in patients with end stage kidney disease.
British journal of pharmacology.
2022 04; 179(7):1433-1449. doi:
10.1111/bph.15729. [PMID: 34766335] - Sixiu Chen, Linxi Huang, Shoulian Zhou, Qingzhou Zhang, Mengna Ruan, Lili Fu, Bo Yang, Dechao Xu, Changlin Mei, Zhiguo Mao. NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models.
Journal of cellular and molecular medicine.
2021 10; 25(20):9597-9608. doi:
10.1111/jcmm.16903. [PMID: 34551202] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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Journal of ethnopharmacology.
2021 Apr; 270(?):113809. doi:
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European journal of medicinal chemistry.
2021 Mar; 213(?):113165. doi:
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Toxicology letters.
2020 Oct; 333(?):80-89. doi:
10.1016/j.toxlet.2020.07.027. [PMID: 32738273] - Shailendra Anoopkumar-Dukie, Tom Conere, Aileen Houston, Liam King, David Christie, Catherine McDermott, Ashley Allshire. The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2.
Prostaglandins & other lipid mediators.
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2013 Oct; 106(?):91-8. doi:
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Basic & clinical pharmacology & toxicology.
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American journal of nephrology.
2009; 30(4):346-53. doi:
10.1159/000229304. [PMID: 19609076] - Sung Ho Moon, Christopher M Jenkins, David J Mancuso, John Turk, Richard W Gross. Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium-independent phospholipase A2beta.
The Journal of biological chemistry.
2008 Dec; 283(49):33975-87. doi:
10.1074/jbc.m805817200. [PMID: 18927078] - Allison B Reiss, Steven E Carsons, Kamran Anwar, Soumya Rao, Sari D Edelman, Hongwei Zhang, Patricia Fernandez, Bruce N Cronstein, Edwin S L Chan. Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages.
Arthritis and rheumatism.
2008 Dec; 58(12):3675-83. doi:
10.1002/art.24040. [PMID: 19035488] - Maryam Ahmadi, David C Emery, David J Morgan. Prevention of both direct and cross-priming of antitumor CD8+ T-cell responses following overproduction of prostaglandin E2 by tumor cells in vivo.
Cancer research.
2008 Sep; 68(18):7520-9. doi:
10.1158/0008-5472.can-08-1060. [PMID: 18794140] - Lianyi Lu, Takahiro Shimizu, Kumiko Nakamura, Kunihiko Yokotani. Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats.
European journal of pharmacology.
2008 Aug; 590(1-3):177-84. doi:
10.1016/j.ejphar.2008.06.051. [PMID: 18598693] - Xing Yun Chai, Yue Lin Song, Zheng Ren Xu, Hai Ming Shi, Chang Cai Bai, Dan Bi, Jing Wen, Fei Fei Li, Peng Fei Tu. Itosides J-N from Itoa orientalis and structure - anti-COX-2 activity relationship of phenolic glycosides.
Journal of natural products.
2008 May; 71(5):814-9. doi:
10.1021/np800014s. [PMID: 18412396] - Wei Li, Yan Liu, Muhammad Mahmood Mukhtar, Rui Gong, Ying Pan, Sahibzada T Rasool, Yecheng Gao, Lei Kang, Qian Hao, Guiqing Peng, Yanni Chen, Xin Chen, Jianguo Wu, Ying Zhu. Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection.
PloS one.
2008 Apr; 3(4):e1985. doi:
10.1371/journal.pone.0001985. [PMID: 18414668] - Vishakha S Bhave, Shashikiran Donthamsetty, John R Latendresse, Harihara M Mehendale. Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury.
Toxicology and applied pharmacology.
2008 Apr; 228(2):239-46. doi:
10.1016/j.taap.2007.12.025. [PMID: 18336855] - Hung-Yun Lin, Heng-Yuan Tang, Travis Keating, Yun-Hsuan Wu, Ai Shih, Douglas Hammond, Mingzeng Sun, Aleck Hercbergs, Faith B Davis, Paul J Davis. Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated.
Carcinogenesis.
2008 Jan; 29(1):62-9. doi:
10.1093/carcin/bgm239. [PMID: 17984113] - Yuqiang Ge, Kevin A Strait, Peter K Stricklett, Tianxin Yang, Donald E Kohan. Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.
American journal of physiology. Renal physiology.
2007 Dec; 293(6):F1805-10. doi:
10.1152/ajprenal.00307.2007. [PMID: 17913832] - Deepa Sankaran, Neda Bankovic-Calic, Malcolm R Ogborn, Gary Crow, Harold M Aukema. Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease.
American journal of physiology. Renal physiology.
2007 Sep; 293(3):F821-30. doi:
10.1152/ajprenal.00257.2006. [PMID: 17537981] - Yanmei Jin, Caiqiao Zhang, Weidong Zeng, Kazuyoshi Taya, Tu Quang Tan. Interactive actions of prostaglandin and epidermal growth factor to enhance proliferation of granulosa cells from chicken prehierarchical follicles.
Prostaglandins & other lipid mediators.
2007 Jun; 83(4):285-94. doi:
10.1016/j.prostaglandins.2007.02.002. [PMID: 17499748] - Y Honma, I Arai, N Futaki, Y Hashimoto, M Sugimoto, T Sakurai, S Nakaike. Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.
The British journal of dermatology.
2007 Jun; 156(6):1178-87. doi:
10.1111/j.1365-2133.2007.07882.x. [PMID: 17459048] - Nina Grosman. Comparison of the influence of NSAIDs with different COX-selectivity on histamine release from mast cells isolated from naïve and sensitized rats.
International immunopharmacology.
2007 Apr; 7(4):532-40. doi:
10.1016/j.intimp.2006.12.010. [PMID: 17321477] - Rheem A Totah, Kyle E Allen, Pamela Sheffels, Dale Whittington, Evan D Kharasch. Enantiomeric metabolic interactions and stereoselective human methadone metabolism.
The Journal of pharmacology and experimental therapeutics.
2007 Apr; 321(1):389-99. doi:
10.1124/jpet.106.117580. [PMID: 17259447] - Javier R Caso, Jesús M Pradillo, Olivia Hurtado, Pedro Lorenzo, María A Moro, Ignacio Lizasoain. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.
Circulation.
2007 Mar; 115(12):1599-608. doi:
10.1161/circulationaha.106.603431. [PMID: 17372179] - David A Tipton, Denise C Gay, Vaughn A DeCoster. Effect of a cyclooxygenase-2 inhibitor on interleukin-1beta-stimulated activation of the transcription factor nuclear factor-kappa B in human gingival fibroblasts.
Journal of periodontology.
2007 Mar; 78(3):542-9. doi:
10.1902/jop.2007.060250. [PMID: 17335379] - Jin Cheng Yao, Wei Gang Duan, Yu Yun, De Quan Liu, Ming Yan, Zhen Zhou Jiang, Lu Yong Zhang. Screening method for nonsteroidal antiinflammatory drugs based on the cyclooxygenase 2 pathway activated by serum-free stimulation in A549 cells.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2007 Mar; 127(3):527-32. doi:
10.1248/yakushi.127.527. [PMID: 17329938] - Naoko Miura, Masato Fukutake, Masahiro Yamamoto, Nobuhiro Ohtake, Seiichi Iizuka, Sachiko Imamura, Naoko Tsuchiya, Makoto Ishimatsu, Yuichi Nakamura, Atsushi Ishige, Kenji Watanabe, Yoshio Kase, Shuichi Takeda. An herbal medicine orengedokuto prevents indomethacin-induced enteropathy.
Biological & pharmaceutical bulletin.
2007 Mar; 30(3):495-501. doi:
10.1248/bpb.30.495. [PMID: 17329845] - Vaqar Mustafa Adhami, Arshi Malik, Najia Zaman, Sami Sarfaraz, Imtiaz Ahmad Siddiqui, Deeba Nadeem Syed, Farrukh Afaq, Farrukh Sierre Pasha, Mohammad Saleem, Hasan Mukhtar. Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Mar; 13(5):1611-9. doi:
10.1158/1078-0432.ccr-06-2269. [PMID: 17332308] - Edwin S L Chan, Hongwei Zhang, Patricia Fernandez, Sari D Edelman, Michael H Pillinger, Louis Ragolia, Thomas Palaia, Steven Carsons, Allison B Reiss. Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk.
Arthritis research & therapy.
2007; 9(1):R4. doi:
10.1186/ar2109. [PMID: 17244362] - Christian Doutremepuich, Omar Aguejouf, Francisco X Eizayaga, Vanessa Desplat. Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition?.
Pathophysiology of haemostasis and thrombosis.
2007; 36(1):40-4. doi:
10.1159/000112638. [PMID: 18332613] - Haeil Park, Young Hoon Kim, Hyeun Wook Chang, Hyun Pyo Kim. Anti-inflammatory activity of the synthetic C-C biflavonoids.
The Journal of pharmacy and pharmacology.
2006 Dec; 58(12):1661-7. doi:
10.1211/jpp.58.12.0014. [PMID: 17331331] - S Pérez Martínez, M Hermoso, M Farina, M L Ribeiro, M Rapanelli, M Espinosa, M Villalón, A Franchi. 17-beta-Estradiol upregulates COX-2 in the rat oviduct.
Prostaglandins & other lipid mediators.
2006 Sep; 80(3-4):155-64. doi:
10.1016/j.prostaglandins.2006.06.002. [PMID: 16939880] - Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi, Tsuyoshi Sasaki, Lianyi Lu, Kunihiko Yokotani. Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.
European journal of pharmacology.
2006 Jul; 541(3):152-7. doi:
10.1016/j.ejphar.2006.05.013. [PMID: 16765344] - Frank Helle, Øyvind B Vågnes, Bjarne M Iversen. Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension.
American journal of physiology. Renal physiology.
2006 Jul; 291(1):F140-7. doi:
10.1152/ajprenal.00279.2005. [PMID: 16467128] - Naoaki Harada, Kenji Okajima, Mitsuhiro Uchiba. Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Critical care medicine.
2006 Jul; 34(7):1883-91. doi:
10.1097/01.ccm.0000220764.10155.03. [PMID: 16641616] - Lamine Aoudjit, Anna Potapov, Tomoko Takano. Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor.
American journal of physiology. Renal physiology.
2006 Jun; 290(6):F1534-42. doi:
10.1152/ajprenal.00267.2005. [PMID: 16396944] - Alexandra Wibberley, Gerald P McCafferty, Christopher Evans, Richard M Edwards, J Paul Hieble. Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.
British journal of pharmacology.
2006 May; 148(2):154-61. doi:
10.1038/sj.bjp.0706715. [PMID: 16547526] - P Harding, L Balasubramanian, J Swegan, A Stevens, W F Glass. Transforming growth factor beta regulates cyclooxygenase-2 in glomerular mesangial cells.
Kidney international.
2006 May; 69(9):1578-85. doi:
10.1038/sj.ki.5000323. [PMID: 16572115] - Goutarou Katsuno, Hideo Kohka Takahashi, Hiromi Iwagaki, Kenji Mizuno, Takahito Yagi, Shuji Mori, Shinya Saito, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka. The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.
Clinical immunology (Orlando, Fla.).
2006 Apr; 119(1):110-9. doi:
10.1016/j.clim.2005.12.004. [PMID: 16458073] - Wenling Ye, Hui Zhang, Elaine Hillas, Donald E Kohan, R Lance Miller, Raoul D Nelson, Matthew Honeggar, Tianxin Yang. Expression and function of COX isoforms in renal medulla: evidence for regulation of salt sensitivity and blood pressure.
American journal of physiology. Renal physiology.
2006 Feb; 290(2):F542-9. doi:
10.1152/ajprenal.00232.2005. [PMID: 16189289] - Wei-hao Sun, Han Su, Li-jiu Zhang, Yun Shao, Hai-chen Xu, Tao Zhang, Yi-ping Xue, Guo-xian Ding, Yun-lin Cheng. [Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and apoptosis of gastric cancer cell].
Zhonghua yi xue za zhi.
2006 Jan; 86(4):250-4. doi:
NULL. [PMID: 16677505] - Véronique Blais, Nicolas P Turrin, Serge Rivest. Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
Journal of neurochemistry.
2005 Dec; 95(6):1563-74. doi:
10.1111/j.1471-4159.2005.03480.x. [PMID: 16277613] - Ikue Furuhashi, Susumu Iwata, Shoji Shibata, Toshitsugu Sato, Hideo Inoue. Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.
The Journal of pharmacy and pharmacology.
2005 Dec; 57(12):1661-6. doi:
10.1211/jpp.57.12.0017. [PMID: 16354411] - Zhenheng Guo, Wen Su, Shannon Allen, Huan Pang, Alan Daugherty, Eric Smart, Ming C Gong. COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice.
Cardiovascular research.
2005 Sep; 67(4):723-35. doi:
10.1016/j.cardiores.2005.04.008. [PMID: 15885672] - Seon Hwa Lee, Michelle V Williams, Raymond N Dubois, Ian A Blair. Cyclooxygenase-2-mediated DNA damage.
The Journal of biological chemistry.
2005 Aug; 280(31):28337-46. doi:
10.1074/jbc.m504178200. [PMID: 15964853] - Borja García-Bueno, José L M Madrigal, Ignacio Lizasoain, María A Moro, Pedro Lorenzo, Juan C Leza. The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats.
Psychopharmacology.
2005 Jul; 180(3):513-22. doi:
10.1007/s00213-005-2195-5. [PMID: 15719215] - Toshihiro Sakurai, Kazuhiro Tamura, Hiroshi Kogo. Stimulatory effects of eicosanoids on ovarian angiogenesis in early luteal phase in cyclooxygenase-2 inhibitor-treated rats.
European journal of pharmacology.
2005 Jun; 516(2):158-64. doi:
10.1016/j.ejphar.2005.03.003. [PMID: 15921676] - Yvonne Denkins, Doty Kempf, Melissa Ferniz, Shilpa Nileshwar, Dario Marchetti. Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma.
Journal of lipid research.
2005 Jun; 46(6):1278-84. doi:
10.1194/jlr.m400474-jlr200. [PMID: 15772428]