Gamithromycin (BioDeep_00000016492)
代谢物信息卡片
Gamithromycin
化学式: C40H76N2O12 (776.5397976)
中文名称: 加米霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1CC(C(C(C(OC(=O)C(C(C(C(C(CC1C)(C)O)OC2C(C(CC(O2)C)N(C)C)O)C)OC3CC(C(C(O3)C)O)(C)OC)C)CC)(C)O)O)C
InChI: InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:195437
- KEGG: C72760
- PubChem: 59364992
- DrugBank: DB11416
- ChEMBL: CHEMBL2107342
- CAS: 145435-72-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emma Gordon, Christopher K Cebra, Bernadette V Stang, John Mark Christensen, Sultan M Alshahrani, Thanh Duong, Rose Huang, Bruce Nosky. Plasma pharmacokinetics, pulmonary disposition, and safety of subcutaneous gamithromycin in alpacas.
Journal of veterinary pharmacology and therapeutics.
2022 May; 45(3):283-290. doi:
10.1111/jvp.13045. [PMID: 35170771] - Yonghuan Yan, Haichao Zhang, Lianfeng Ai, Weijun Kang, Kaoqi Lian, Jing Wang. Determination of gamithromycin residues in eggs, milk and edible tissue of food-producing animals by solid phase extraction combined with ultrahigh-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 May; 1171(?):122637. doi:
10.1016/j.jchromb.2021.122637. [PMID: 33735805] - Dietmar Hamel, Alexandra Richard-Mazet, Florian Voisin, Inge Böhne, Florence Fraisse, Renate Rauh, Rose Huang, Michael Kellermann, Laura Letendre, Pascal Dumont, Steffen Rehbein. Gamithromycin in swine: Pharmacokinetics and clinical evaluation against swine respiratory disease.
Veterinary medicine and science.
2021 03; 7(2):455-464. doi:
10.1002/vms3.375. [PMID: 33058489] - Yu-Feng Zhou, Ming-Xiao Bu, Ping Liu, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao. Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets.
BMC veterinary research.
2020 Mar; 16(1):81. doi:
10.1186/s12917-020-02300-y. [PMID: 32138735] - S Berlin, S Wallstabe, E Scheuch, S Oswald, M Hasan, D Wegner, M Grube, M Venner, A Ullrich, W Siegmund. Intestinal and hepatic contributions to the pharmacokinetic interaction between gamithromycin and rifampicin after single-dose and multiple-dose administration in healthy foals.
Equine veterinary journal.
2018 Jul; 50(4):525-531. doi:
10.1111/evj.12796. [PMID: 29239016] - S Berlin, T Randow, E Scheuch, M Grube, M Venner, W Siegmund. Pharmacokinetics and pulmonary distribution of gamithromycin after intravenous administration in foals.
Journal of veterinary pharmacology and therapeutics.
2017 Aug; 40(4):406-410. doi:
10.1111/jvp.12402. [PMID: 28317153] - K D DeDonder, M D Apley, M Li, R Gehring, D M Harhay, B V Lubbers, B J White, S F Capik, B KuKanich, J E Riviere, R K Tessman. Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multisource commingled feedlot cattle.
Journal of veterinary pharmacology and therapeutics.
2016 Apr; 39(2):157-66. doi:
10.1111/jvp.12267. [PMID: 26441021] - Elke Plessers, Heidi Wyns, Anneleen Watteyn, Bart Pardon, Siegrid De Baere, Stanislas U Sys, Patrick De Backer, Siska Croubels. Immunomodulatory properties of gamithromycin and ketoprofen in lipopolysaccharide-challenged calves with emphasis on the acute-phase response.
Veterinary immunology and immunopathology.
2016 Mar; 171(?):28-37. doi:
10.1016/j.vetimm.2016.01.007. [PMID: 26964715] - Heidi Wyns, Evelyne Meyer, Elke Plessers, Anneleen Watteyn, Thomas van Bergen, Stijn Schauvliege, Siegrid De Baere, Mathias Devreese, Patrick De Backer, Siska Croubels. Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation.
Veterinary immunology and immunopathology.
2015 Dec; 168(3-4):211-22. doi:
10.1016/j.vetimm.2015.09.014. [PMID: 26547885] - E Plessers, A Watteyn, H Wyns, B Pardon, P De Backer, S Croubels. Study of the immunomodulatory properties of gamithromycin and dexamethasone in a lipopolysaccharide inflammation model in calves.
Research in veterinary science.
2015 Dec; 103(?):218-23. doi:
10.1016/j.rvsc.2015.10.014. [PMID: 26679821] - Anneleen Watteyn, Mathias Devreese, Siegrid De Baere, Heidi Wyns, Elke Plessers, Filip Boyen, Freddy Haesebrouck, Patrick De Backer, Siska Croubels. Pharmacokinetic and pharmacodynamic properties of gamithromycin in turkey poults with respect to Ornithobacterium rhinotracheale.
Poultry science.
2015 Sep; 94(9):2066-74. doi:
10.3382/ps/pev217. [PMID: 26195808] - Siegrid De Baere, Mathias Devreese, Anneleen Watteyn, Heidi Wyns, Elke Plessers, Patrick De Backer, Siska Croubels. Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitative determination of gamithromycin in animal plasma, lung tissue and pulmonary epithelial lining fluid.
Journal of chromatography. A.
2015 Jun; 1398(?):73-82. doi:
10.1016/j.chroma.2015.04.022. [PMID: 25937131] - Meredyth L Jones, Kevin E Washburn, Virginia R Fajt, Somchai Rice, Johann F Coetzee. Synovial fluid pharmacokinetics of tulathromycin, gamithromycin and florfenicol after a single subcutaneous dose in cattle.
BMC veterinary research.
2015 Feb; 11(?):26. doi:
10.1186/s12917-015-0346-4. [PMID: 25886555] - Michael Kellermann, Rose A Huang, Andrew B Forbes, Steffen Rehbein. Gamithromycin plasma and skin pharmacokinetics in sheep.
Research in veterinary science.
2014 Oct; 97(2):199-203. doi:
10.1016/j.rvsc.2014.08.008. [PMID: 25241389] - H Wyns, E Meyer, E Plessers, A Watteyn, S De Baere, P De Backer, S Croubels. Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in pigs.
Research in veterinary science.
2014 Feb; 96(1):160-3. doi:
10.1016/j.rvsc.2013.11.012. [PMID: 24331716] - John D Mitchell, Shan Goh, Quintin A McKellar, Declan J McKeever. In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony.
Veterinary journal (London, England : 1997).
2013 Sep; 197(3):806-11. doi:
10.1016/j.tvjl.2013.05.025. [PMID: 23810743] - A Watteyn, E Plessers, H Wyns, S De Baere, P De Backer, S Croubels. Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens.
Poultry science.
2013 Jun; 92(6):1516-22. doi:
10.3382/ps.2012-02932. [PMID: 23687147] - L J Berghaus, S Giguère, T L Sturgill, D Bade, T J Malinski, R Huang. Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals.
Journal of veterinary pharmacology and therapeutics.
2012 Feb; 35(1):59-66. doi:
10.1111/j.1365-2885.2011.01292.x. [PMID: 21443748] - Steeve Giguère, Rose Huang, Thomas J Malinski, Paul M Dorr, Ronald K Tessman, Bruce A Somerville. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells, and lung tissue in cattle.
American journal of veterinary research.
2011 Mar; 72(3):326-30. doi:
10.2460/ajvr.72.3.326. [PMID: 21355734] - R A Huang, L T Letendre, N Banav, J Fischer, B Somerville. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity.
Journal of veterinary pharmacology and therapeutics.
2010 Jun; 33(3):227-37. doi:
10.1111/j.1365-2885.2009.01125.x. [PMID: 20557439]