Atosiban (BioDeep_00000016484)
代谢物信息卡片
(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt
化学式: C43H67N11O12S2 (993.4412)
中文名称: 阿托西班
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
InChI: InChI=1S/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C98292 - Oxytocin Antagonist
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
G - Genito urinary system and sex hormones
Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135899
- KEGG: C77085
- PubChem: 5311010
- DrugBank: DB09059
- ChEMBL: CHEMBL382301
- CAS: 90779-69-4
- medchemexpress: HY-17572
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Ivaldo Jesus Almeida Belém-Filho, Taíz Francine Silva Brasil, Eduardo Albino Trindade Fortaleza, José Antunes-Rodrigues, Fernando Morgan Aguiar Corrêa. A functional selective effect of oxytocin secreted under restraint stress in rats.
European journal of pharmacology.
2021 Aug; 904(?):174182. doi:
10.1016/j.ejphar.2021.174182. [PMID: 34004212] - S Santos, C Haslinger, M Mennet, U von Mandach, M Hamburger, A P Simões-Wüst. Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: an in vitro study.
BMC complementary and alternative medicine.
2019 Nov; 19(1):292. doi:
10.1186/s12906-019-2711-5. [PMID: 31685022] - L Herve, V Lollivier, H Quesnel, Marion Boutinaud. Oxytocin Induces Mammary Epithelium Disruption and Could Stimulate Epithelial Cell Exfoliation.
Journal of mammary gland biology and neoplasia.
2018 09; 23(3):139-147. doi:
10.1007/s10911-018-9400-8. [PMID: 29948751] - Peter Keov, Zita Liutkevičiūtė, Roland Hellinger, Richard J Clark, Christian W Gruber. Discovery of peptide probes to modulate oxytocin-type receptors of insects.
Scientific reports.
2018 07; 8(1):10020. doi:
10.1038/s41598-018-28380-3. [PMID: 29968789] - Ali Mohammad Alizadeh, Zahra Heydari, Mostafa Rahimi, Behzad Bazgir, Hossein Shirvani, Sadaf Alipour, Yassaman Heidarian, Solmaz Khalighfard, Amin Isanejad. Oxytocin mediates the beneficial effects of the exercise training on breast cancer.
Experimental physiology.
2018 02; 103(2):222-235. doi:
10.1113/ep086463. [PMID: 29143998] - Mariusz Grzesiak, Zuzanna Gaj, Rafał Kocyłowski, Joanna Suliburska, Przemysław Oszukowski, Wojciech Horzelski, Constantin von Kaisenberg, Maciej Banach. Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth.
Oxidative medicine and cellular longevity.
2018; 2018(?):3919106. doi:
10.1155/2018/3919106. [PMID: 30622667] - Umit M Kocyigit, Ahmet Şevki Taşkıran, Parham Taslimi, Ahmet Yokuş, Yusuf Temel, İlhami Gulçin. Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats.
Journal of biochemical and molecular toxicology.
2017 Nov; 31(11):. doi:
10.1002/jbt.21972. [PMID: 29116677] - Timothy A Katte, Tristan A Reekie, Eryn L Werry, William T Jorgensen, Rochelle Boyd, Erick C N Wong, Damien W Gulliver, Mark Connor, Michael Kassiou. Investigation of pyrazolo-sulfonamides as putative small molecule oxytocin receptor agonists.
European journal of medicinal chemistry.
2017 Aug; 136(?):330-333. doi:
10.1016/j.ejmech.2017.05.013. [PMID: 28505537] - Ye He, Huan Wu, Xiaojin He, Qiong Xing, Ping Zhou, Yunxia Cao, Zhaolian Wei. Administration of atosiban in patients with endometriosis undergoing frozen-thawed embryo transfer: a prospective, randomized study.
Fertility and sterility.
2016 Aug; 106(2):416-22. doi:
10.1016/j.fertnstert.2016.04.019. [PMID: 27143518] - Rafael Taeho Han, Hyunkyoung Lee, JaeHee Lee, Sat-Byol Lee, Hee Jin Kim, Seung Keun Back, Heung Sik Na. Brief Isolation Changes Nociceptive Behaviors and Compromises Drug Tests in Mice.
Pain practice : the official journal of World Institute of Pain.
2016 07; 16(6):749-57. doi:
10.1111/papr.12325. [PMID: 26212903] - J H Jiang, Z He, Y L Peng, W D Jin, J Mu, H X Xue, Z Wang, M Chang, R Wang. Effects of Phoenixin-14 on anxiolytic-like behavior in mice.
Behavioural brain research.
2015 Jun; 286(?):39-48. doi:
10.1016/j.bbr.2015.02.011. [PMID: 25687846] - S Babic, M Pokusa, V Danevova, S T Ding, D Jezova. Effects of atosiban on stress-related neuroendocrine factors.
The Journal of endocrinology.
2015 Apr; 225(1):9-17. doi:
10.1530/joe-14-0560. [PMID: 25609735] - Fariba Houshmand, Mahdieh Faghihi, Saleh Zahediasl. Role of atrial natriuretic Peptide in oxytocin induced cardioprotection.
Heart, lung & circulation.
2015 Jan; 24(1):86-93. doi:
10.1016/j.hlc.2014.05.023. [PMID: 25126708] - Ernest Hung Yu Ng, Raymond Hang Wun Li, Leining Chen, Vuong Thi Ngoc Lan, Ho Manh Tuong, Song Quan. A randomized double blind comparison of atosiban in patients undergoing IVF treatment.
Human reproduction (Oxford, England).
2014 Dec; 29(12):2687-94. doi:
10.1093/humrep/deu263. [PMID: 25336707] - Naguib Salleh, Vivi Noryati Ahmad. In-VITRo effect of Ficus deltoidea on the contraction of isolated rat's uteri is mediated via multiple receptors binding and is dependent on extracellular calcium.
BMC complementary and alternative medicine.
2013 Dec; 13(?):359. doi:
10.1186/1472-6882-13-359. [PMID: 24330515] - Seung Pil Yun, Su Shin Park, Jung Min Ryu, Jae Hong Park, Mi Ok Kim, Jang-Hern Lee, Ho Jae Han. Mechanism of PKA-dependent and lipid-raft independent stimulation of Connexin43 expression by oxytoxin in mouse embryonic stem cells.
Molecular endocrinology (Baltimore, Md.).
2012 Jul; 26(7):1144-57. doi:
10.1210/me.2011-1343. [PMID: 22564436] - Maryam Moghimian, Mahdieh Faghihi, Seyed Morteza Karimian, Alireza Imani. The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: role of oxytocin.
Stress (Amsterdam, Netherlands).
2012 Jul; 15(4):385-92. doi:
10.3109/10253890.2011.630436. [PMID: 22044052] - Yavuz Simsek, Onder Celik, Abdullah Karaer, Ercan Yılmaz, Mehmet Gul, Elif Ozerol, Sedat Bilgic, Nilufer Celik. Elevated cardiac oxidative stress in newborn rats from mothers treated with atosiban.
Archives of gynecology and obstetrics.
2012 Mar; 285(3):655-61. doi:
10.1007/s00404-011-2069-5. [PMID: 21866331] - Carine B Bourguet, Eugénie Goupil, Danaë Tassy, Xin Hou, Eryk Thouin, Felix Polyak, Terence E Hébert, Audrey Claing, Stéphane A Laporte, Sylvain Chemtob, William D Lubell. Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.
Journal of medicinal chemistry.
2011 Sep; 54(17):6085-97. doi:
10.1021/jm200608k. [PMID: 21774512] - Hiroaki Matsushita, Kazuhito Tomizawa, Naoki Okimoto, Tei-Ichi Nishiki, Iori Ohmori, Hideki Matsui. Oxytocin mediates the antidepressant effects of mating behavior in male mice.
Neuroscience research.
2010 Oct; 68(2):151-3. doi:
10.1016/j.neures.2010.06.007. [PMID: 20600375] - Ali Mohammad Alizadeh, Mahdieh Faghihi, Hamid Reza Sadeghipour, Fahimeh Mohammadghasemi, Alireza Imani, Fariba Houshmand, Vahid Khori. Oxytocin protects rat heart against ischemia-reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel.
Peptides.
2010 Jul; 31(7):1341-5. doi:
10.1016/j.peptides.2010.04.012. [PMID: 20417240] - Vivekanandan Kannan, Deepak Gadamsetty, Madhankumar Rose, Stella Maria, Imran Mustafa, Anand Khedkar, Nitesh Dave, Muruganandam Arumugam, Harish Iyer. Quantitative determination of oxytocin receptor antagonist atosiban in rat plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 May; 878(15-16):1069-76. doi:
10.1016/j.jchromb.2010.03.011. [PMID: 20356809] - Fariba Houshmand, Mahdieh Faghihi, Saleh Zahediasl. Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats.
Peptides.
2009 Dec; 30(12):2301-8. doi:
10.1016/j.peptides.2009.09.010. [PMID: 19761809] - Mei Feng, Junfang Qin, Chao Wang, Yanfang Ye, Shuanglian Wang, Dongping Xie, Paulus S Wang, Chuanyong Liu. Estradiol upregulates the expression of oxytocin receptor in colon in rats.
American journal of physiology. Endocrinology and metabolism.
2009 May; 296(5):E1059-66. doi:
10.1152/ajpendo.90609.2008. [PMID: 19258489] - Julia Borg, Olle Melander, Linda Johansson, Kerstin Uvnäs-Moberg, Jens F Rehfeld, Bodil Ohlsson. Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia.
BMC gastroenterology.
2009 Feb; 9(?):17. doi:
10.1186/1471-230x-9-17. [PMID: 19243587] - Chiu-Lung Wu, Ming-Luen Doong, Paulus S Wang. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats.
European journal of pharmacology.
2008 Feb; 580(3):407-15. doi:
10.1016/j.ejphar.2007.11.024. [PMID: 18078924] - N Vitoratos, A Kountouris, E Makrakis, K Papadias, G Creatsas. No effect of tocolytic therapy with atosiban on maternal serum interleukin-6 and tumor necrosis factor-alpha in threatened preterm labor.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2007 Oct; 20(10):725-8. doi:
10.1080/14767050701574542. [PMID: 17763273] - Piotr Pierzynski, Barbara Gajda, Zdzislaw Smorag, Allan Dahl Rasmussen, Waldemar Kuczynski. Effect of atosiban on rabbit embryo development and human sperm motility.
Fertility and sterility.
2007 May; 87(5):1147-52. doi:
10.1016/j.fertnstert.2006.08.089. [PMID: 17224148] - Jerry Chan, Dominique Cabrol, Ingemar Ingemarsson, Karel Marsal, Jean-Marie Moutquin, Nicholas M Fisk. Pragmatic comparison of beta2-agonist side effects within the Worldwide Atosiban versus Beta Agonists study.
European journal of obstetrics, gynecology, and reproductive biology.
2006 Sep; 128(1-2):135-41. doi:
10.1016/j.ejogrb.2006.01.030. [PMID: 16504369] - Mamadou M Bah, Tomas J Acosta, Wojciech Pilawski, Katarzyna Deptula, Kiyoshi Okuda, Dariusz J Skarzynski. Role of intraluteal prostaglandin F(2alpha), progesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum.
Prostaglandins & other lipid mediators.
2006 May; 79(3-4):218-29. doi:
10.1016/j.prostaglandins.2006.01.002. [PMID: 16647636] - Ragner Liedman, Lee Grant, Sarah Igidbashian, Ian James, Alison McLeod, Laurence Skillern, Mats Akerlund. Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea.
Acta obstetricia et gynecologica Scandinavica.
2006; 85(2):207-11. doi:
10.1080/00016340500495082. [PMID: 16532916] - Jacques Damas, Nancy Garbacki, Pierre J Lefèbvre. Does insulin release kinins in rats?.
European journal of pharmacology.
2005 Nov; 525(1-3):154-60. doi:
10.1016/j.ejphar.2005.10.001. [PMID: 16297383] - Birgitte Buur Rasmussen, Lotte Seiding Larsen, Thomas Senderovitz. Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers.
BJOG : an international journal of obstetrics and gynaecology.
2005 Nov; 112(11):1492-9. doi:
10.1111/j.1471-0528.2005.00735.x. [PMID: 16225568] - Alessandra Reversi, Valeria Rimoldi, Tiziana Marrocco, Paola Cassoni, Giovanni Bussolati, Marco Parenti, Bice Chini. The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism.
The Journal of biological chemistry.
2005 Apr; 280(16):16311-8. doi:
10.1074/jbc.m409945200. [PMID: 15705593] - Rocco Cirillo, Enrico Gillio Tos, Matthias K Schwarz, Anna Quattropani, Alexander Scheer, Marc Missotten, Jerome Dorbais, Anthony Nichols, Francesco Borrelli, Claudio Giachetti, Lucia Golzio, Paolo Marinelli, Russell J Thomas, Claude Chevillard, Florence Laurent, Karine Portet, Claude Barberis, Andre Chollet. Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor.
The Journal of pharmacology and experimental therapeutics.
2003 Jul; 306(1):253-61. doi:
10.1124/jpet.103.049395. [PMID: 12660315] - Chiu-Lung Wu, Chen-Road Hung, Full-Young Chang, K-Y Francis Pau, Paulus S Wang. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2003 Apr; 367(4):406-13. doi:
10.1007/s00210-003-0690-y. [PMID: 12690433] - Chiu-Lung Wu, Chen-Road Hung, Full-Young Chang, K-Y Francis Pau, Jui-Ling Wang, Paulus S Wang. Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats.
Pflugers Archiv : European journal of physiology.
2002 Nov; 445(2):187-93. doi:
10.1007/s00424-002-0925-7. [PMID: 12457239] - Genowefa Kotwica, Anita Franczak, Stanisław Okrasa, Marek Koziorowski, Beata Kurowicka. Effects of mating stimuli and oxytocin on plasma cortisol concentration in gilts.
Reproductive biology.
2002 Mar; 2(1):25-37. doi:
NULL. [PMID: 14666160] - Mats Akerlund. Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea.
Progress in brain research.
2002; 139(?):359-65. doi:
10.1016/s0079-6123(02)39030-7. [PMID: 12436949] - J E Scott, P L Grigsby, J J Hirst, G Jenkin. Inhibition of prostaglandin synthesis and its effect on uterine activity during established premature labor in sheep.
Journal of the Society for Gynecologic Investigation.
2001 Sep; 8(5):266-76. doi:
10.1016/s1071-5576(01)00124-1. [PMID: 11677146] - G Gimpl, F Fahrenholz. The oxytocin receptor system: structure, function, and regulation.
Physiological reviews.
2001 Apr; 81(2):629-83. doi:
10.1152/physrev.2001.81.2.629. [PMID: 11274341] - W Huang, M Sjöquist, O Skott, E M Stricker, A F Sved. Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Mar; 280(3):R760-5. doi:
10.1152/ajpregu.2001.280.3.r760. [PMID: 11171655] - P L Grigsby, K R Poore, J J Hirst, G Jenkin. Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist.
American journal of obstetrics and gynecology.
2000 Sep; 183(3):649-57. doi:
10.1067/mob.2000.106584. [PMID: 10992188] - D C Braga, E Mori, K T Higa, M Morris, L C Michelini. Central oxytocin modulates exercise-induced tachycardia.
American journal of physiology. Regulatory, integrative and comparative physiology.
2000 Jun; 278(6):R1474-82. doi:
10.1152/ajpregu.2000.278.6.r1474. [PMID: 10848513] - L Valentin, P Sladkevicius, H Kindahl, A Broeders, K Marsal, P Melin. Effects of a vasopressin antagonist in women with dysmenorrhea.
Gynecologic and obstetric investigation.
2000; 50(3):170-7. doi:
10.1159/000010319. [PMID: 11014949] - O Wellnitz, R M Bruckmaier, C Albrecht, J W Blum. Atosiban, an oxytocin receptor blocking agent: pharmacokinetics and inhibition of milk ejection in dairy cows.
The Journal of dairy research.
1999 Feb; 66(1):1-8. doi:
10.1017/s0022029998003227. [PMID: 10191468] - G Kotwica, A Franczak, S Okrasa, J Kotwica. Effect of an oxytocin antagonist on prostaglandin F2 alpha secretion and the course of luteolysis in sows.
Acta veterinaria Hungarica.
1999; 47(2):249-62. doi:
10.1556/004.47.1999.2.10. [PMID: 10344085] - A Fjellestad-Paulsen, S Lundin. Metabolism of vasopressin, oxytocin and their analogues [Mpa1, D-Arg8]-vasopressin (dDAVP) and [Mpa1, D-Tyr(Et)2, Thr4, Orn8]-oxytocin (antocin) in human kidney and liver homogenates.
Regulatory peptides.
1996 Nov; 67(1):27-32. doi:
10.1016/s0167-0115(96)00103-6. [PMID: 8952002] - M B Renfree, L J Parry, G Shaw. Infusion with an oxytocin receptor antagonist delays parturition in a marsupial.
Journal of reproduction and fertility.
1996 Sep; 108(1):131-7. doi:
10.1530/jrf.0.1080131. [PMID: 8958839] - E Björkstrand, S Ahlénius, U Smedh, K Uvnäs-Moberg. The oxytocin receptor antagonist 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin inhibits effects of the 5-HT1A receptor agonist 8-OH-DPAT on plasma levels of insulin, cholecystokinin and somatostatin.
Regulatory peptides.
1996 May; 63(1):47-52. doi:
10.1016/0167-0115(96)00034-1. [PMID: 8795088] - S Lundin, P Svedman, P Höglund, K Jönsson, A Broeders, P Melin. Absorption of an oxytocin antagonist (antocin) and a vasopressin analogue (dDAVP) through a standardized skin erosion in volunteers.
Pharmaceutical research.
1995 Dec; 12(12):2024-9. doi:
10.1023/a:1016272729556. [PMID: 8786983] - T M Goodwin, L Millar, L North, L S Abrams, R C Weglein, M L Holland. The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions.
American journal of obstetrics and gynecology.
1995 Sep; 173(3 Pt 1):913-7. doi:
10.1016/0002-9378(95)90365-8. [PMID: 7573268] - W Huang, Q Z Zhai, M Sjöquist. Intrathecal injection of an oxytocin-receptor antagonist attenuated postnephrectomy natriuresis in the male rat.
Neuroscience letters.
1995 Jul; 195(1):33-6. doi:
10.1016/0304-3940(95)11773-p. [PMID: 7478248] - G D Lutterodt. Interaction between oxytocin and 'sidaverin' on the gravid and non-gravid rat uterus.
Pharmacological research.
1995 Jul; 32(1-2):89-94. doi:
10.1016/s1043-6618(95)80014-x. [PMID: 8668653] - W Huang, S L Lee, M Sjöquist. Natriuretic role of endogenous oxytocin in male rats infused with hypertonic NaCl.
The American journal of physiology.
1995 Mar; 268(3 Pt 2):R634-40. doi:
10.1152/ajpregu.1995.268.3.r634. [PMID: 7900905] - M Akerlund, P Melin, M Maggi. Potential use of oxytocin and vasopressin V1a antagonists in the treatment of preterm labour and primary dysmenorrhoea.
Advances in experimental medicine and biology.
1995; 395(?):595-600. doi:
. [PMID: 8714023] - J R Jasper, C M Harrell, J A O'Brien, D J Pettibone. Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.
Life sciences.
1995; 57(24):2253-61. doi:
10.1016/0024-3205(95)02218-8. [PMID: 7475979] - M Sjöquist, W Huang, E Jacobsson, S L Lee, H R Ulfendahl. Natriuretic role of oxytocin in sodium homeostasis in rats.
Advances in experimental medicine and biology.
1995; 395(?):353-4. doi:
NULL. [PMID: 8713990] - T Bossmar, M Akerlund, G Fantoni, J Szamatowicz, P Melin, M Maggi. Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban.
American journal of obstetrics and gynecology.
1994 Dec; 171(6):1634-42. doi:
10.1016/0002-9378(94)90415-4. [PMID: 7802081] - G Jenkin, D Buttress, R Harding. Oxytocin receptor blockade and prostaglandin release in late pregnant sheep.
European journal of obstetrics, gynecology, and reproductive biology.
1994 Jan; 53(1):1-6. doi:
10.1016/0028-2243(94)90128-7. [PMID: 8187913] - P C Greig, G A Massmann, K T Demarest, R C Weglein, M L Holland, J P Figueroa. Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep.
American journal of obstetrics and gynecology.
1993 Oct; 169(4):897-902. doi:
10.1016/0002-9378(93)90023-c. [PMID: 8238146] - S Lundin, A Broeders, P Melin. Pharmacokinetic properties of the tocolytic agent [Mpa1, D-Tyr(Et)2, Thr4, Orn8]-oxytocin (antocin) in healthy volunteers.
Clinical endocrinology.
1993 Sep; 39(3):369-74. doi:
10.1111/j.1365-2265.1993.tb02379.x. [PMID: 8222299] - E Björkstrand, M Eriksson, K Uvnäs-Moberg. Plasma levels of oxytocin after food deprivation and hypoglycaemia, and effects of 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin on blood glucose in rats.
Acta physiologica Scandinavica.
1992 Mar; 144(3):355-9. doi:
10.1111/j.1748-1716.1992.tb09305.x. [PMID: 1585819] - T Engstrøm, A Atke, H Vilhardt. Oxytocin receptors and contractile response of the myometrium after long term infusion of prostaglandin F2 alpha, indomethacin, oxytocin and an oxytocin antagonist in rats.
Regulatory peptides.
1988 Jan; 20(1):65-72. doi:
10.1016/0167-0115(88)90058-4. [PMID: 2832879] - S Lundin, M Akerlund, P O Fagerström, A Hauksson, P Melin. Pharmacokinetics in the human of a new synthetic vasopressin and oxytocin uterine antagonist.
Acta endocrinologica.
1986 Aug; 112(4):465-72. doi:
10.1530/acta.0.1120465. [PMID: 3751461] - M Akerlund, A Hauksson, S Lundin, P Melin, J Trojnar. Vasotocin analogues which competitively inhibit vasopressin stimulated uterine activity in healthy women.
British journal of obstetrics and gynaecology.
1986 Jan; 93(1):22-7. doi:
10.1111/j.1471-0528.1986.tb07807.x. [PMID: 3942702]
