ebselen (BioDeep_00000016481)
代谢物信息卡片
2-phenyl-1,2-benzisoselenazol-3(2H)-one
化学式: C13H9NOSe (274.9849314)
中文名称: 依布硒
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
InChI: InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:77543
- KEGG: C75847
- PubChem: 3194
- Metlin: METLIN43500
- DrugBank: DB12610
- ChEMBL: CHEMBL51085
- CAS: 60940-34-3
- MoNA: FiehnHILIC001906
- MoNA: FiehnHILIC000328
- PMhub: MS000008133
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Danuta Jantas, Piotr Warszyński, Władysław Lasoń. Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage.
Molecules (Basel, Switzerland).
2023 Dec; 29(1):. doi:
10.3390/molecules29010119. [PMID: 38202702] - Pawel Pabisz, Jerzy Bazak, Michal Sabat, Albert W Girotti, Witold Korytowski. Cholesterol Hydroperoxide Co-trafficking in Testosterone-generating Leydig Cells: GPx4 Inhibition of Cytotoxic and Anti-steroidogenic Effects.
Cell biochemistry and biophysics.
2023 Nov; ?(?):. doi:
10.1007/s12013-023-01194-5. [PMID: 37995086] - Ziqiao Sun, Kun Wu, Chenhan Feng, Xin Gen Lei. Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues.
Free radical biology & medicine.
2023 Sep; 208(?):708-717. doi:
10.1016/j.freeradbiomed.2023.09.010. [PMID: 37726091] - Ziqing Huang, Guanhui Chen, Hiokuan Wu, Xiaoqiong Huang, Ruogu Xu, Feilong Deng, Yiming Li. Ebselen restores peri-implantitis-induced osteogenic inhibition via suppressing BMSCs ferroptosis.
Experimental cell research.
2023 06; 427(2):113612. doi:
10.1016/j.yexcr.2023.113612. [PMID: 37116735] - Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Ruiqin Yao. Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
Behavioural brain research.
2023 Apr; 448(?):114444. doi:
10.1016/j.bbr.2023.114444. [PMID: 37098387] - Wenying Yu, Yucheng Zhao, Hui Ye, Nanping Wu, Yixian Liao, Nannan Chen, Zhiling Li, Ning Wan, Haiping Hao, Honggao Yan, Yibei Xiao, Maode Lai. Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2.
Journal of medicinal chemistry.
2022 12; 65(24):16252-16267. doi:
10.1021/acs.jmedchem.2c00954. [PMID: 36503248] - Hidehiko Yagasaki, Susumu Takekoshi, Kanae Kitatani, Chikara Kato, Hiroyuki Yamasaki, Kie Shioyama, Takaaki Tsuboi, Tomohiko Matsuzaki, Yutaka Inagaki, Ryota Masuda, Masayuki Iwazaki. Protective effect of ebselen on bleomycin-induced lung fibrosis: analysis of the molecular mechanism of lung fibrosis mediated by oxidized diacylglycerol.
Free radical research.
2022 Jul; 56(7-8):473-482. doi:
10.1080/10715762.2022.2092477. [PMID: 36562703] - Yikun Wu, Hua Shi, Yuangao Xu, Jun Pei, Shang Song, Wei Chen, Shuxiong Xu. Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats.
Molecular and cellular biochemistry.
2022 Jun; 477(6):1873-1885. doi:
10.1007/s11010-022-04413-4. [PMID: 35338455] - Qianqian Tian, Jinfang Jiang, Hanwei Yin, Jiao Ma, Guozhen Deng, Jialan Zhou, Dafang Zhong. Quantification of the major circulating metabolite of BS1801, an ebselen analog, in human plasma.
Journal of pharmaceutical and biomedical analysis.
2022 Apr; 212(?):114638. doi:
10.1016/j.jpba.2022.114638. [PMID: 35149420] - Hannah T Baddock, Sanja Brolih, Yuliana Yosaatmadja, Malitha Ratnaweera, Marcin Bielinski, Lonnie P Swift, Abimael Cruz-Migoni, Haitian Fan, Jeremy R Keown, Alexander P Walker, Garrett M Morris, Jonathan M Grimes, Ervin Fodor, Christopher J Schofield, Opher Gileadi, Peter J McHugh. Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
Nucleic acids research.
2022 02; 50(3):1484-1500. doi:
10.1093/nar/gkab1303. [PMID: 35037045] - Siegfried T D Thun-Hohenstein, Timothy F Suits, Tika R Malla, Anthony Tumber, Lennart Brewitz, Hani Choudhry, Eidarus Salah, Christopher J Schofield. Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease.
ChemMedChem.
2022 02; 17(4):e202100582. doi:
10.1002/cmdc.202100582. [PMID: 34850566] - Pawel Pabisz, Jerzy Bazak, Albert W Girotti, Witold Korytowski. Anti-steroidogenic effects of cholesterol hydroperoxide trafficking in MA-10 Leydig cells: Role of mitochondrial lipid peroxidation and inhibition thereof by selenoperoxidase GPx4.
Biochemical and biophysical research communications.
2022 02; 591(?):82-87. doi:
10.1016/j.bbrc.2021.12.117. [PMID: 34999258] - Zydrune Polianskyte-Prause, Tuomas A Tolvanen, Sonja Lindfors, Kanta Kon, Laura C Hautala, Hong Wang, Tsutomu Wada, Hiroshi Tsuneki, Toshiyasu Sasaoka, Sanna Lehtonen. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice.
International journal of biological sciences.
2022; 18(5):1852-1864. doi:
10.7150/ijbs.66314. [PMID: 35342343] - Zhen Qiao, Ningning Wei, Lin Jin, Hongyi Zhang, Jiajie Luo, Yanru Zhang, KeWei Wang. The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus.
Bioorganic chemistry.
2021 12; 117(?):105455. doi:
10.1016/j.bioorg.2021.105455. [PMID: 34740055] - Angela Parise, Isabella Romeo, Nino Russo, Tiziana Marino. The Se-S Bond Formation in the Covalent Inhibition Mechanism of SARS-CoV-2 Main Protease by Ebselen-like Inhibitors: A Computational Study.
International journal of molecular sciences.
2021 Sep; 22(18):. doi:
10.3390/ijms22189792. [PMID: 34575955] - Pablo Andrei Nogara, Folorunsho Bright Omage, Gustavo Roni Bolzan, Cássia Pereira Delgado, Michael Aschner, Laura Orian, João Batista Teixeira Rocha. In silico Studies on the Interaction between Mpro and PLpro From SARS-CoV-2 and Ebselen, its Metabolites and Derivatives.
Molecular informatics.
2021 08; 40(8):e2100028. doi:
10.1002/minf.202100028. [PMID: 34018687] - Jennifer C Milligan, Theresa U Zeisner, George Papageorgiou, Dhira Joshi, Christelle Soudy, Rachel Ulferts, Mary Wu, Chew Theng Lim, Kang Wei Tan, Florian Weissmann, Berta Canal, Ryo Fujisawa, Tom Deegan, Hema Nagaraj, Ganka Bineva-Todd, Clovis Basier, Joseph F Curran, Michael Howell, Rupert Beale, Karim Labib, Nicola O'Reilly, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
The Biochemical journal.
2021 07; 478(13):2499-2515. doi:
10.1042/bcj20210197. [PMID: 34198327] - Claudio Santi, Cecilia Scimmi, Luca Sancineto. Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144230. [PMID: 34299505] - Le-Yun Sun, Cheng Chen, Jianpeng Su, Jia-Qi Li, Zhihui Jiang, Han Gao, Jia-Zhu Chigan, Huan-Huan Ding, Le Zhai, Ke-Wu Yang. Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals.
Bioorganic chemistry.
2021 07; 112(?):104889. doi:
10.1016/j.bioorg.2021.104889. [PMID: 33915460] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ewelina Weglarz-Tomczak, Jakub M Tomczak, Michał Talma, Małgorzata Burda-Grabowska, Mirosław Giurg, Stanley Brul. Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2.
Scientific reports.
2021 02; 11(1):3640. doi:
10.1038/s41598-021-83229-6. [PMID: 33574416] - Daifullah Al Aboud, Roua S Baty, Khalaf F Alsharif, Khalid Ebrahim Hassan, Ahmed S Zhery, Ola A Habotta, Ehab K Elmahallawy, Hatim K Amin, Ahmed E Abdel Moneim, Rami B Kassab. Protective efficacy of thymoquinone or ebselen separately against arsenic-induced hepatotoxicity in rat.
Environmental science and pollution research international.
2021 Feb; 28(5):6195-6206. doi:
10.1007/s11356-020-10955-1. [PMID: 32989703] - Camilla Servidio, Francesco Stellacci. Therapeutic approaches against coronaviruses acute respiratory syndrome.
Pharmacology research & perspectives.
2021 02; 9(1):e00691. doi:
10.1002/prp2.691. [PMID: 33378565] - Kenta Arai, Yuumi Sato, Ikumi Nakajima, Manami Saito, Moeka Sasaki, Akiko Kanamori, Michio Iwaoka. Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates.
Bioorganic & medicinal chemistry.
2021 01; 29(?):115866. doi:
10.1016/j.bmc.2020.115866. [PMID: 33203607] - Karina Mayumi Sakita, Isis Regina Grenier Capoci, Pollyanna Cristina Vincenzi Conrado, Franciele Abigail Vilugron Rodrigues-Vendramini, Daniella Renata Faria, Glaucia Sayuri Arita, Tânia Cristina Alexandrino Becker, Patricia de Souza Bonfim-Mendonça, Terezinha Inez Estivalet Svidzinski, Erika Seki Kioshima. Efficacy of Ebselen Against Invasive Aspergillosis in a Murine Model.
Frontiers in cellular and infection microbiology.
2021; 11(?):684525. doi:
10.3389/fcimb.2021.684525. [PMID: 34249777] - C V Haritha, Khan Sharun, Bosco Jose. Ebselen, a new candidate therapeutic against SARS-CoV-2.
International journal of surgery (London, England).
2020 12; 84(?):53-56. doi:
10.1016/j.ijsu.2020.10.018. [PMID: 33120196] - Julia Liang, Chris Karagiannis, Eleni Pitsillou, Kevion K Darmawan, Ken Ng, Andrew Hung, Tom C Karagiannis. Site mapping and small molecule blind docking reveal a possible target site on the SARS-CoV-2 main protease dimer interface.
Computational biology and chemistry.
2020 Dec; 89(?):107372. doi:
10.1016/j.compbiolchem.2020.107372. [PMID: 32911432] - Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs.
Bioorganic & medicinal chemistry.
2020 11; 28(22):115745. doi:
10.1016/j.bmc.2020.115745. [PMID: 33007557] - Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E Campillo, Ana Martinez. COVID-19: Drug Targets and Potential Treatments.
Journal of medicinal chemistry.
2020 11; 63(21):12359-12386. doi:
10.1021/acs.jmedchem.0c00606. [PMID: 32511912] - Lu Zheng, Lina Zhang, Jiamin Huang, Kutty Selva Nandakumar, Shuwen Liu, Kui Cheng. Potential treatment methods targeting 2019-nCoV infection.
European journal of medicinal chemistry.
2020 Nov; 205(?):112687. doi:
10.1016/j.ejmech.2020.112687. [PMID: 32771797] - Bruna C W Fulco, Juliano T K Jung, Lorenzo O B Brum, Vanessa A Zborowski, Tales A C Goulart, Cristina W Nogueira. Similar hepatoprotective effectiveness of Diphenyl diselenide and Ebselen against cisplatin-induced disruption of metabolic homeostasis and redox balance in juvenile rats.
Chemico-biological interactions.
2020 Oct; 330(?):109234. doi:
10.1016/j.cbi.2020.109234. [PMID: 32860823] - Jinsong Zhang, Ramy Saad, Ethan Will Taylor, Margaret P Rayman. Selenium and selenoproteins in viral infection with potential relevance to COVID-19.
Redox biology.
2020 10; 37(?):101715. doi:
10.1016/j.redox.2020.101715. [PMID: 32992282] - Kangsa Amporndanai, Michael Rogers, Seiji Watanabe, Koji Yamanaka, Paul M O'Neill, S Samar Hasnain. Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.
EBioMedicine.
2020 Sep; 59(?):102980. doi:
10.1016/j.ebiom.2020.102980. [PMID: 32862101] - Cintia A Menéndez, Fabian Byléhn, Gustavo R Perez-Lemus, Walter Alvarado, Juan J de Pablo. Molecular characterization of ebselen binding activity to SARS-CoV-2 main protease.
Science advances.
2020 09; 6(37):. doi:
10.1126/sciadv.abd0345. [PMID: 32917717] - Helmut Sies, Michael J Parnham. Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections.
Free radical biology & medicine.
2020 08; 156(?):107-112. doi:
10.1016/j.freeradbiomed.2020.06.032. [PMID: 32598985] - Lucia A Seale, Daniel J Torres, Marla J Berry, Matthew W Pitts. A role for selenium-dependent GPX1 in SARS-CoV-2 virulence.
The American journal of clinical nutrition.
2020 08; 112(2):447-448. doi:
10.1093/ajcn/nqaa177. [PMID: 32592394] - Bruna Cruz Weber Fulco, Juliano Ten Kathen Jung, Pietro Maria Chagas, Suzan Gonçalves Rosa, Vinicius Costa Prado, Cristina Wayne Nogueira. Diphenyl diselenide is as effective as Ebselen in a juvenile rat model of cisplatin-induced nephrotoxicity.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2020 Jul; 60(?):126482. doi:
10.1016/j.jtemb.2020.126482. [PMID: 32135444] - Megan Scudellari. The sprint to solve coronavirus protein structures - and disarm them with drugs.
Nature.
2020 05; 581(7808):252-255. doi:
10.1038/d41586-020-01444-z. [PMID: 32415276] - Andrielli Leitemberger, Mariana S Sonego, Fábio D Garcia, Alana C F Dos Santos, Bruna C Piccoli, Fernanda D da Silva, Cláudia S Oliveira, Fabiana K Seixas, Luciano Dornelles, João B T Rocha, Pablo A Nogara, Kyle M Schachtschneider, Tiago Collares, Oscar E D Rodrigues. Synthesis and biological evaluation of new antioxidant and antiproliferative chalcogenobiotin derivatives for bladder carcinoma treatment.
Bioorganic & medicinal chemistry.
2020 05; 28(9):115423. doi:
10.1016/j.bmc.2020.115423. [PMID: 32205047] - Isabella Pregardier Klann, Franciele Martini, Suzan Gonçalves Rosa, Cristina Wayne Nogueira. Ebselen reversed peripheral oxidative stress induced by a mouse model of sporadic Alzheimer's disease.
Molecular biology reports.
2020 Mar; 47(3):2205-2215. doi:
10.1007/s11033-020-05326-5. [PMID: 32095983] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Saad Shaaban, Abeer M Ashmawy, Amr Negm, Ludger A Wessjohann. Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma.
European journal of medicinal chemistry.
2019 Oct; 179(?):515-526. doi:
10.1016/j.ejmech.2019.06.075. [PMID: 31276896] - A Y Al-Brakati, R B Kassab, M S Lokman, E K Elmahallawy, H K Amin, A E Abdel Moneim. Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity in female rats.
Human & experimental toxicology.
2019 Apr; 38(4):482-493. doi:
10.1177/0960327118818246. [PMID: 30558456] - Hager Tarek H Ismail. Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats.
Biological trace element research.
2019 Feb; 187(2):452-463. doi:
10.1007/s12011-018-1395-x. [PMID: 29858966] - Walaa M El-Hady, Azza A A Galal. Neurotoxic Outcomes of Subchronic Manganese Chloride Exposure via Contaminated Water in Adult Male Rats and the Potential Benefits of Ebselen.
Biological trace element research.
2018 Nov; 186(1):208-217. doi:
10.1007/s12011-018-1291-4. [PMID: 29516356] - Amany Tharwat Mohammed, Lamiaa L M Ebraheim, Mohamed M M Metwally. Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese Toxicity: Structural and Bioanalytical Approach in a Rat Model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jun; 102(?):739-748. doi:
10.1016/j.biopha.2018.03.086. [PMID: 29604593] - Zeynep Soyman, Hafize Uzun, Nihan Bayindir, Mukaddes Esrefoglu, Birtan Boran. Can ebselen prevent cisplatin-induced ovarian damage?.
Archives of gynecology and obstetrics.
2018 Jun; 297(6):1549-1555. doi:
10.1007/s00404-018-4750-4. [PMID: 29600321] - Anna Jaromin, Robert Zarnowski, Magdalena Piętka-Ottlik, David R Andes, Jerzy Gubernator. Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity.
Nanomedicine (London, England).
2018 05; 13(10):1139-1155. doi:
10.2217/nnm-2017-0337. [PMID: 29873597] - Yan Yu, Yanhong Jin, Jie Zhou, Haoqiang Ruan, Han Zhao, Shiying Lu, Yue Zhang, Di Li, Xiaoyun Ji, Benfang Helen Ruan. Ebselen: Mechanisms of Glutamate Dehydrogenase and Glutaminase Enzyme Inhibition.
ACS chemical biology.
2017 12; 12(12):3003-3011. doi:
10.1021/acschembio.7b00728. [PMID: 29072450] - Yongli Xie, Yibin Tan, Youbiao Zheng, Xiubo Du, Qiong Liu. Ebselen ameliorates β-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic Alzheimer's disease mice.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2017 Aug; 22(6):851-865. doi:
10.1007/s00775-017-1463-2. [PMID: 28502066] - Natalie N Orie, Andrew R Warren, Jovana Basaric, Cesar Lau-Cam, Magdalena Piętka-Ottlik, Jacek Młochowski, Blase Billack. In vitro assessment of the growth and plasma membrane H+ -ATPase inhibitory activity of ebselen and structurally related selenium- and sulfur-containing compounds in Candida albicans.
Journal of biochemical and molecular toxicology.
2017 Jun; 31(6):. doi:
10.1002/jbt.21892. [PMID: 28151580] - Raquel Mello da Rosa, Bruna Candia Piccoli, Fernanda D'Avila da Silva, Luciano Dornelles, João B T Rocha, Mariana Souza Sonego, Karine Rech Begnini, Tiago Collares, Fabiana K Seixas, Oscar E D Rodrigues. Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.
MedChemComm.
2017 Feb; 8(2):408-414. doi:
10.1039/c6md00640j. [PMID: 30108758] - Joshua A Beckman, Allison B Goldfine, Jane A Leopold, Mark A Creager. Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial.
American journal of physiology. Heart and circulatory physiology.
2016 12; 311(6):H1431-H1436. doi:
10.1152/ajpheart.00504.2016. [PMID: 27765750] - Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki. Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs.
Bioorganic & medicinal chemistry letters.
2016 11; 26(22):5411-5417. doi:
10.1016/j.bmcl.2016.10.033. [PMID: 27777006] - Flavio A R Barbosa, Rômulo F S Canto, Sumbal Saba, Jamal Rafique, Antonio L Braga. Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2016 11; 24(22):5762-5770. doi:
10.1016/j.bmc.2016.09.031. [PMID: 27681239] - Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone, Cecilia Giulivi. Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Molecular medicine (Cambridge, Mass.).
2016 Oct; 22(?):548-559. doi:
10.2119/molmed.2016.00122. [PMID: 27385396] - Holger Steinbrenner, Esra Bilgic, Antonio Pinto, Melanie Engels, Lena Wollschläger, Laura Döhrn, Kristine Kellermann, Udo Boeken, Payam Akhyari, Artur Lichtenberg. Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.
Inflammation.
2016 Aug; 39(4):1363-76. doi:
10.1007/s10753-016-0368-5. [PMID: 27192987] - Noriko Noguchi. Ebselen, a useful tool for understanding cellular redox biology and a promising drug candidate for use in human diseases.
Archives of biochemistry and biophysics.
2016 Apr; 595(?):109-12. doi:
10.1016/j.abb.2015.10.024. [PMID: 27095225] - Alvaro Mordente, Andrea Silvestrini, Giuseppe Ettore Martorana, Daniela Tavian, Elisabetta Meucci. Inhibition of Anthracycline Alcohol Metabolite Formation in Human Heart Cytosol: A Potential Role for Several Promising Drugs.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Nov; 43(11):1691-701. doi:
10.1124/dmd.115.065110. [PMID: 26265744] - Paul D Hanavan, Chad R Borges, Benjamin A Katchman, Douglas O Faigel, Thai H Ho, Chen-Ting Ma, Eduard A Sergienko, Nathalie Meurice, Joachim L Petit, Douglas F Lake. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Oncotarget.
2015 Jul; 6(21):18418-28. doi:
10.18632/oncotarget.4099. [PMID: 26158899] - Mikkel Allingstrup, Arash Afshari. Selenium supplementation for critically ill adults.
The Cochrane database of systematic reviews.
2015 Jul; ?(7):CD003703. doi:
10.1002/14651858.cd003703.pub3. [PMID: 26214143] - Elyse Di Marco, Jay C Jha, Arpeeta Sharma, Jennifer L Wilkinson-Berka, Karin A Jandeleit-Dahm, Judy B de Haan. Are reactive oxygen species still the basis for diabetic complications?.
Clinical science (London, England : 1979).
2015 Jul; 129(2):199-216. doi:
10.1042/cs20150093. [PMID: 25927680] - Saad Shaaban, Amr Negm, Mohamed A Sobh, Ludger A Wessjohann. Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation.
European journal of medicinal chemistry.
2015 Jun; 97(?):190-201. doi:
10.1016/j.ejmech.2015.05.002. [PMID: 25969171] - S M Tan, A Sharma, N Stefanovic, J B de Haan. Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy.
Free radical research.
2015 Mar; 49(3):219-27. doi:
10.3109/10715762.2014.993628. [PMID: 25465090] - Vanessa Nascimento, Natasha L Ferreira, Rômulo F S Canto, Karen L Schott, Emily P Waczuk, Luca Sancineto, Claudio Santi, João B T Rocha, Antonio L Braga. Synthesis and biological evaluation of new nitrogen-containing diselenides.
European journal of medicinal chemistry.
2014 Nov; 87(?):131-9. doi:
10.1016/j.ejmech.2014.09.022. [PMID: 25244678] - Vijay P Singh, Jia-Fei Poon, Ray J Butcher, Lars Engman. Pyridoxine-derived organoselenium compounds with glutathione peroxidase-like and chain-breaking antioxidant activity.
Chemistry (Weinheim an der Bergstrasse, Germany).
2014 Sep; 20(39):12563-71. doi:
10.1002/chem.201403229. [PMID: 25123932] - Andréa E M Stinghen, Jean-Marc Chillon, Ziad A Massy, Agnès Boullier. Differential effects of indoxyl sulfate and inorganic phosphate in a murine cerebral endothelial cell line (bEnd.3).
Toxins.
2014 Jun; 6(6):1742-60. doi:
10.3390/toxins6061742. [PMID: 24902077] - Maria A Pino, Magdalena Pietka-Ottlik, Blase Billack. Selected ebselen analogs reduce mechlorethamine toxicity in vitro.
Cutaneous and ocular toxicology.
2014 Mar; 33(1):32-41. doi:
10.3109/15569527.2013.794818. [PMID: 23734969] - Michael J Parnham, Helmut Sies. The early research and development of ebselen.
Biochemical pharmacology.
2013 Nov; 86(9):1248-53. doi:
10.1016/j.bcp.2013.08.028. [PMID: 24012716] - I J Kade, B D Balogun, J B T Rocha. In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology.
Chemico-biological interactions.
2013 Oct; 206(1):27-36. doi:
10.1016/j.cbi.2013.07.014. [PMID: 23933410] - Xin Li, Lin Zhang, Ya-Wei Xu, Cheng Wang, Yang Zhao, Ping Yu, Shao-Wu Lv, Gang-Lin Yan, Jun-Qiu Liu, Gui-Min Luo. The protective effects of 6-CySeCD with GPx activity against UVB-induced injury in HaCaT cells.
The Australasian journal of dermatology.
2013 May; 54(2):120-5. doi:
10.1111/j.1440-0960.2012.00962.x. [PMID: 23094659] - Robson L Puntel, Daniel H Roos, Rodrigo Lopes Seeger, João B T Rocha. Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.
Toxicology in vitro : an international journal published in association with BIBRA.
2013 Feb; 27(1):59-70. doi:
10.1016/j.tiv.2012.10.011. [PMID: 23103426] - Sih Min Tan, Arpeeta Sharma, Derek Y C Yuen, Nada Stefanovic, Guy Krippner, Govindasamy Mugesh, Zhonglin Chai, Judy B de Haan. The modified selenenyl amide, M-hydroxy ebselen, attenuates diabetic nephropathy and diabetes-associated atherosclerosis in ApoE/GPx1 double knockout mice.
PloS one.
2013; 8(7):e69193. doi:
10.1371/journal.pone.0069193. [PMID: 23874911] - Yongliang Liang, James R Roede, Sergey Dikalov, Nana Gletsu Miller, Samuel C Dudley, Arshed Quyyumi, Dean P Jones. Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation.
Clinica chimica acta; international journal of clinical chemistry.
2012 Dec; 414(?):1-6. doi:
10.1016/j.cca.2012.06.003. [PMID: 22687643] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Sirinart Kumfu, Siriporn Chattipakorn, Kroekkiat Chinda, Suthat Fucharoen, Nipon Chattipakorn. T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.
European journal of haematology.
2012 Jun; 88(6):535-48. doi:
10.1111/j.1600-0609.2012.01779.x. [PMID: 22404220] - Michael D Costa, Bibiana M Gai, Carmine I Acker, Ana Cristina G Souza, Ricardo Brandão, Cristina W Nogueira. Ebselen reduces hyperglycemia temporarily-induced by diazinon: a compound with insulin-mimetic properties.
Chemico-biological interactions.
2012 May; 197(2-3):80-6. doi:
10.1016/j.cbi.2012.03.008. [PMID: 22484362] - Ann R Holmes, Mikhail V Keniya, Irena Ivnitski-Steele, Brian C Monk, Erwin Lamping, Larry A Sklar, Richard D Cannon. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
Antimicrobial agents and chemotherapy.
2012 Mar; 56(3):1508-15. doi:
10.1128/aac.05706-11. [PMID: 22203607] - A P Marreilha Dos Santos, Rui L Lucas, Vanda Andrade, M Luísa Mateus, Dejan Milatovic, Michael Aschner, M Camila Batoreu. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.
Toxicology and applied pharmacology.
2012 Feb; 258(3):394-402. doi:
10.1016/j.taap.2011.12.003. [PMID: 22178737] - Tumay Ozgur, Murat Tutanc, Ismail Zararsiz, Sedat Motor, Oktay Hasan Ozturk, Mehmet Yaldiz, Ozgur Yildirim Kurtgoz. The protective effect of ebselen on radiocontrast-induced nephrotoxicity.
Renal failure.
2012; 34(8):991-7. doi:
10.3109/0886022x.2012.706880. [PMID: 22880804] - Atsuyoshi Nishina, Hirokazu Kimura, Kunihisa Kozawa, Geoffroy Sommen, Takao Nakamura, Heinz Heimgartner, Mamoru Koketsu, Shoei Furukawa. A superoxide anion-scavenger, 1,3-selenazolidin-4-one suppresses serum deprivation-induced apoptosis in PC12 cells by activating MAP kinase.
Toxicology and applied pharmacology.
2011 Dec; 257(3):388-95. doi:
10.1016/j.taap.2011.09.022. [PMID: 22001386] - Ejaife O Agbani, Paul Coats, Roger M Wadsworth. Acute hypoxia stimulates intracellular peroxynitrite formation associated with pulmonary artery smooth muscle cell proliferation.
Journal of cardiovascular pharmacology.
2011 May; 57(5):584-8. doi:
10.1097/fjc.0b013e3182135e1b. [PMID: 21326106] - Murat Kizilgun, Yavuz Poyrazoglu, Yesim Oztas, Halil Yaman, Erdinc Cakir, Tuncer Cayci, Ozgur Emin Akgul, Yasemin Gulcan Kurt, Hakan Yaren, Zeki Ilker Kunak, Enis Macit, Esin Ozkan, Mine Yavuz Taslipinar, Turker Turker, Ayhan Ozcan. Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury.
Renal failure.
2011; 33(5):512-7. doi:
10.3109/0886022x.2011.574767. [PMID: 21545313] - Phyllis Chew, Derek Y C Yuen, Nada Stefanovic, Josefa Pete, Melinda T Coughlan, Karin A Jandeleit-Dahm, Merlin C Thomas, Franklin Rosenfeldt, Mark E Cooper, Judy B de Haan. Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.
Diabetes.
2010 Dec; 59(12):3198-207. doi:
10.2337/db10-0195. [PMID: 20823099] - Chi Duong, Huei Jiunn Seow, Steven Bozinovski, Peter J Crack, Gary P Anderson, Ross Vlahos. Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.
American journal of physiology. Lung cellular and molecular physiology.
2010 Sep; 299(3):L425-33. doi:
10.1152/ajplung.00038.2010. [PMID: 20511341] - Silvana Cassano, Savina Agnese, Valentina D'Amato, Massimo Papale, Corrado Garbi, Patrizio Castagnola, Maria Rosaria Ruocco, Immacolata Castellano, Emmanuele De Vendittis, Mariarosaria Santillo, Stefano Amente, Antonio Porcellini, Enrico Vittorio Avvedimento. Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.
The Journal of biological chemistry.
2010 Jul; 285(31):24141-53. doi:
10.1074/jbc.m109.098525. [PMID: 20495008] - Waseem Hassan, Mohammad Ibrahim, Joao Batista Teixeira Rocha. Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver preparations.
Pathology, research and practice.
2010 Jun; 206(6):357-60. doi:
10.1016/j.prp.2009.12.009. [PMID: 20188485] - Blase Billack, Magdalena Pietka-Ottlik, Michelle Santoro, Stacia Nicholson, Jacek Młochowski, Cesar Lau-Cam. Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs in S. cerevisiae cultures.
Journal of enzyme inhibition and medicinal chemistry.
2010 Jun; 25(3):312-7. doi:
10.3109/14756360903179419. [PMID: 20210698] - Frank J Raucci, Dayanjan S Wijesinghe, Charles E Chalfant, Clive M Baumgarten. Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Cardiovascular research.
2010 Apr; 86(1):55-62. doi:
10.1093/cvr/cvp399. [PMID: 20008476] - Emna El Golli Bennour, Chayma Bouaziz, Moncef Ladjimi, Flore Renaud, Hassen Bacha. Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: is oxidative stress a common process?.
Environmental toxicology.
2009 Dec; 24(6):538-48. doi:
10.1002/tox.20449. [PMID: 19051279] - Waseem Hassan, Mohammad Ibrahim, Joao Batista Teixeira Rocha. Towards the mechanism and comparative effect of diphenyl diselenide, diphenyl ditelluride and ebselen under various pathophysiological conditions in rat's kidney preparation.
Chemico-biological interactions.
2009 Nov; 182(1):52-8. doi:
10.1016/j.cbi.2009.06.023. [PMID: 19589335] - Turan Tunc, Bulent Uysal, Cuneyt Atabek, Vural Kesik, Bahadir Caliskan, Emin Oztas, Nail Ersoz, Sukru Oter, Ahmet Guven. Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.
The Journal of surgical research.
2009 Aug; 155(2):210-6. doi:
10.1016/j.jss.2008.06.017. [PMID: 19505699] - Yoshihiro Suzuki, Tetsuro Yoshimaru, Toshio Inoue, Chisei Ra. Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity.
Molecular immunology.
2009 Jul; 46(11-12):2200-9. doi:
10.1016/j.molimm.2009.04.013. [PMID: 19467708] - Blase Billack, Michelle Santoro, Cesar Lau-Cam. Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.
Microbial drug resistance (Larchmont, N.Y.).
2009 Jun; 15(2):77-83. doi:
10.1089/mdr.2009.0872. [PMID: 19432523] - Se-Jin Kim, Channy Park, A Lum Han, Myung-Ja Youn, Jeong-Han Lee, Yunha Kim, Eun-Sook Kim, Hyung-Jin Kim, Jin-Kyung Kim, Ho-Kyun Lee, Sang-Young Chung, Hongseob So, Raekil Park. Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells.
Hearing research.
2009 May; 251(1-2):70-82. doi:
10.1016/j.heares.2009.03.003. [PMID: 19286452] - Waseem Hassan, Mohammad Ibrahim, Cristina W Nogueira, Antonio Luis Braga, Imdad Ullah Mohammadzai, Paulo Sergio Taube, Joao Batista Teixeira Rocha. Enhancement of iron-catalyzed lipid peroxidation by acidosis in brain homogenate: comparative effect of diphenyl diselenide and ebselen.
Brain research.
2009 Mar; 1258(?):71-7. doi:
10.1016/j.brainres.2008.12.046. [PMID: 19135432] - Gabriele Ghisleni, Lisiane O Porciúncula, Sabrina Mioranzza, Carina R Boeck, João B T Rocha, Diogo O Souza. Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.
Brain research.
2008 Jul; 1221(?):134-40. doi:
10.1016/j.brainres.2008.04.033. [PMID: 18554575] - Richard Harkewicz, Karsten Hartvigsen, Felicidad Almazan, Edward A Dennis, Joseph L Witztum, Yury I Miller. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein.
The Journal of biological chemistry.
2008 Apr; 283(16):10241-51. doi:
10.1074/jbc.m709006200. [PMID: 18263582] - Ana P Ardais, Francielli W Santos, Cristina W Nogueira. Ebselen attenuates cadmium-induced testicular damage in mice.
Journal of applied toxicology : JAT.
2008 Apr; 28(3):322-8. doi:
10.1002/jat.1282. [PMID: 17624921]