2-Hydroxyflavanone (BioDeep_00000016098)
Secondary id: BioDeep_00000173309
代谢物信息卡片
5-(Trifluoromethyl)-2-furaldehyde
化学式: C15H12O3 (240.0786402)
中文名称: 2-羟基黄烷酮
谱图信息:
最多检出来源 Viridiplantae(plant) 39.33%
分子结构信息
SMILES: C1C(=O)C2=CC=CC=C2OC1(C3=CC=CC=C3)O
InChI: InChI=1S/C15H12O3/c16-13-10-15(17,11-6-2-1-3-7-11)18-14-9-5-4-8-12(13)14/h1-9,17H,10H2
数据库引用编号
33 个数据库交叉引用编号
- KEGG: C22005
- PubChem: 176925
- PubChem: 15817242
- ChEMBL: CHEMBL75897
- KNApSAcK: C00055624
- CAS: 17348-76-4
- MoNA: PR310483
- MoNA: PR308790
- MoNA: RIKENPlaSMA006982
- MoNA: RIKENPlaSMA006977
- MoNA: RIKENPlaSMA006972
- MoNA: RIKENPlaSMA006967
- MoNA: RIKENPlaSMA006962
- MoNA: RIKENPlaSMA006957
- MoNA: RIKENPlaSMA006952
- MoNA: RIKENPlaSMA006947
- MoNA: RIKENPlaSMA006942
- MoNA: RIKENPlaSMA006937
- MoNA: RIKENPlaSMA006932
- MoNA: RIKENPlaSMA006928
- MoNA: RIKENPlaSMA003259
- MoNA: RIKENPlaSMA003254
- MoNA: RIKENPlaSMA003245
- MoNA: RIKENPlaSMA003240
- MoNA: RIKENPlaSMA003235
- MoNA: RIKENPlaSMA003230
- MoNA: RIKENPlaSMA003225
- MoNA: RIKENPlaSMA003220
- MoNA: RIKENPlaSMA003215
- MoNA: RIKENPlaSMA003210
- MoNA: RIKENPlaSMA003205
- PMhub: MS000014093
- PubChem: 384585065
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Himangshu Sonowal, Kota V Ramana. 2'-Hydroxyflavanone prevents LPS-induced inflammatory response and cytotoxicity in murine macrophages.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Dec; 69(?):104966. doi:
10.1016/j.tiv.2020.104966. [PMID: 32800949] - Katherina Garcia Vanegas, Arésu Bondrup Larsen, Michael Eichenberger, David Fischer, Uffe Hasbro Mortensen, Michael Naesby. Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae.
Microbial cell factories.
2018 Jul; 17(1):107. doi:
10.1186/s12934-018-0952-5. [PMID: 29986709] - Takamitsu Ito, Shunsuke Fujimoto, Fumiaki Suito, Makoto Shimosaka, Goro Taguchi. C-Glycosyltransferases catalyzing the formation of di-C-glucosyl flavonoids in citrus plants.
The Plant journal : for cell and molecular biology.
2017 Jul; 91(2):187-198. doi:
10.1111/tpj.13555. [PMID: 28370711] - Lucie Zemanova, Jakub Hofman, Eva Novotna, Kamil Musilek, Tereza Lundova, Jana Havrankova, Anna Hostalkova, Jakub Chlebek, Lucie Cahlikova, Vladimír Wsol. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.
Journal of natural products.
2015 Nov; 78(11):2666-74. doi:
10.1021/acs.jnatprod.5b00616. [PMID: 26529431] - Sharad S Singhal, Jyotsana Singhal, James L Figarola, Arthur Riggs, David Horne, Sanjay Awasthi. 2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.
Biochemical pharmacology.
2015 Aug; 96(3):151-8. doi:
10.1016/j.bcp.2015.04.022. [PMID: 25957660] - Neeraj K Patel, Khemraj Bairwa, Rahul Gangwal, Gaurav Jaiswal, Sanjay M Jachak, Abhay T Sangamwar, Kamlesh K Bhutani. 2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies.
Bioorganic & medicinal chemistry letters.
2015 May; 25(9):1952-5. doi:
10.1016/j.bmcl.2015.03.025. [PMID: 25824662] - Alon Mantel, Amanda B Carpenter-Mendini, Joanne B Vanbuskirk, Anna De Benedetto, Lisa A Beck, Alice P Pentland. Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis.
The Journal of investigative dermatology.
2012 Apr; 132(4):1103-10. doi:
10.1038/jid.2011.412. [PMID: 22170488] - Maria Graça Miguel, Maria Dulce Antunes. Is propolis safe as an alternative medicine?.
Journal of pharmacy & bioallied sciences.
2011 Oct; 3(4):479-95. doi:
10.4103/0975-7406.90101. [PMID: 22219581] - Lokesh Dalasanur Nagaprashantha, Rit Vatsyayan, Jyotsana Singhal, Poorna Lelsani, Laszlo Prokai, Sanjay Awasthi, Sharad S Singhal. 2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.
Carcinogenesis.
2011 Apr; 32(4):568-75. doi:
10.1093/carcin/bgr021. [PMID: 21304051] - Rong Tsao. Chemistry and biochemistry of dietary polyphenols.
Nutrients.
2010 12; 2(12):1231-46. doi:
10.3390/nu2121231. [PMID: 22254006] - Sheng Yin, Melissa L Sykes, Rohan A Davis, Todd Shelper, Vicky M Avery, David Camp, Ronald J Quinn. New galloylated flavanonols from the Australian plant Glochidion sumatranum.
Planta medica.
2010 Nov; 76(16):1877-81. doi:
10.1055/s-0030-1250071. [PMID: 20597044] - Diana S Antal, Stefan Schwaiger, Ernst P Ellmerer-Müller, Hermann Stuppner. Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents.
Planta medica.
2010 Oct; 76(15):1765-72. doi:
10.1055/s-0030-1249878. [PMID: 20446241] - Rosa-Maria Valls, Aranzazu Soler, Josefa Girona, Mercedes Heras, Maria-Paz Romero, Maria-Isabel Covas, Rosa Solà, Lluis Masana, Maria-Jose Motilva. Effect of the long-term regular intake of virgin olive oil on the phenolic metabolites in human fasting plasma.
Journal of pharmaceutical and biomedical analysis.
2010 Sep; 53(1):68-74. doi:
10.1016/j.jpba.2010.03.006. [PMID: 20359841] - Yegang Du, Hung Chu, Mingfu Wang, Ivan K Chu, Clive Lo. Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum.
Journal of experimental botany.
2010 Feb; 61(4):983-94. doi:
10.1093/jxb/erp364. [PMID: 20007684] - Rita de Cássia da Silveira e Sá, Leandra Eugênia Gomes de Oliveira, Franklin Ferreira de Farias Nóbrega, Jnanabrata Bhattacharyya, Reinaldo Nóbrega de Almeida. Antinociceptive and toxicological effects of Dioclea grandiflora seed pod in mice.
Journal of biomedicine & biotechnology.
2010; 2010(?):606748. doi:
10.1155/2010/606748. [PMID: 20368784] - Masaaki Nomura, Tatsuo Takahashi, Naoto Nagata, Kikue Tsutsumi, Shinjiro Kobayashi, Tetsuo Akiba, Koichi Yokogawa, Shuzo Moritani, Ken-ichi Miyamoto. Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.
Biological & pharmaceutical bulletin.
2008 Jul; 31(7):1403-9. doi:
10.1248/bpb.31.1403. [PMID: 18591783] - Songlin Li, Quanbin Han, Chunfeng Qiao, Jingzheng Song, Chuen Lung Cheng, Hongxi Xu. Chemical markers for the quality control of herbal medicines: an overview.
Chinese medicine.
2008 Jun; 3(?):7. doi:
10.1186/1749-8546-3-7. [PMID: 18588699] - Lei Zhang, Liang Xu, Shan-Shan Xiao, Qiong-Feng Liao, Qing Li, Jian Liang, Xiao-Hui Chen, Kai-Shun Bi. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry.
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2007 Sep; 44(5):1019-28. doi:
10.1016/j.jpba.2007.04.019. [PMID: 17658714] - Xiang Hua Han, Seong Su Hong, Ji Sang Hwang, Myung Koo Lee, Bang Yeon Hwang, Jai Seup Ro. Monoamine oxidase inhibitory components from Cayratia japonica.
Archives of pharmacal research.
2007 Jan; 30(1):13-7. doi:
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Prikladnaia biokhimiia i mikrobiologiia.
2005 Jan; 41(1):107-12. doi:
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Planta medica.
2004 Jul; 70(7):646-51. doi:
10.1055/s-2004-827189. [PMID: 15303256] - Roberto A S Schweizer, Marcel Zürcher, Zoltan Balazs, Bernhard Dick, Alex Odermatt. Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.
The Journal of biological chemistry.
2004 Apr; 279(18):18415-24. doi:
10.1074/jbc.m313615200. [PMID: 14973125] - Hiroshi Ueda, Chikako Yamazaki, Masatoshi Yamazaki. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production.
Bioscience, biotechnology, and biochemistry.
2004 Jan; 68(1):119-25. doi:
10.1271/bbb.68.119. [PMID: 14745173] - Roberto A S Schweizer, Atanas G Atanasov, Brigitte M Frey, Alex Odermatt. A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity.
Molecular and cellular endocrinology.
2003 Dec; 212(1-2):41-9. doi:
10.1016/j.mce.2003.09.027. [PMID: 14654249] - S Moro, A M van Rhee, L H Sanders, K A Jacobson. Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.
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