β-D-Galp-(1→3)-D-GalpNAc (BioDeep_00000015691)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C14H25NO11 (383.14275399999997)
中文名称: 半乳-N-二糖
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)CO)O)O)O
InChI: InChI=1S/C14H25NO11/c1-4(18)15-7-12(9(20)6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9+,10+,11-,12-,13?,14+/m1/s1
描述信息
An amino disaccharide consisting of D-galactopyranose at the non-reducing end joined by a (1->3) glycosidic linkage to N-acetyl-beta-D-galactopyranose.
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:546807
- KEGG: C07278
- PubChem: 441248
- ChEMBL: CHEMBL443119
- MeSH: Antigens, Viral, Tumor
- CAS: 20972-29-6
- MetaboLights: MTBLC546807
- PubChem: 9487
- PDB-CCD: TF0
- NIKKAJI: J552.827E
- NIKKAJI: J750.838G
- KNApSAcK: 546807
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Wen-Yu Peng, Bizunesh Abere, Haibin Shi, Sabrina Toland, Thomas E Smithgall, Patrick S Moore, Yuan Chang. Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases.
Proceedings of the National Academy of Sciences of the United States of America.
2023 Dec; 120(51):e2316467120. doi:
10.1073/pnas.2316467120
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Oncogene.
2022 04; 41(15):2139-2151. doi:
10.1038/s41388-022-02235-8
. [PMID: 35194151] - Kashif Rasheed, Ugo Moens, Benedetta Policastro, John Inge Johnsen, Virve Koljonen, Harri Sihto, Weng-Onn Lui, Baldur Sveinbjørnsson. The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073702
. [PMID: 35409061] - Cyril Jacquot, Philippe P Pary, Varshini Babu, Ezana Belay, Yunchuan D Mo, Jennifer L Webb, Naomi L C Luban, Meghan Delaney. Erythrocyte T-antigen activation in children: Patient characteristics and the hemolytic risk of transfusion.
Pediatric blood & cancer.
2021 08; 68(8):e29082. doi:
10.1002/pbc.29082
. [PMID: 33900685] - Zongsong Wu, Fabrice E Graf, Hans H Hirsch. Acitretin and Retinoic Acid Derivatives Inhibit BK Polyomavirus Replication in Primary Human Proximal Renal Tubular Epithelial and Urothelial Cells.
Journal of virology.
2021 07; 95(15):e0012721. doi:
10.1128/jvi.00127-21
. [PMID: 34011542] - Rui-Fang Li, Guo-Xin Nan, Dan Wang, Chang Gao, Juan Yang, Zhong-Lin Zhang. BMP9 Can Induce Schwann Cells Expressing Simian Virus 40 T Antigen to Differentiate into Fat and Bone In Vivo and In Vitro.
Cellular reprogramming.
2021 04; 23(2):108-116. doi:
10.1089/cell.2020.0069
. [PMID: 33861637] - Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Domenico Caputo, Mario Clerici. JCPyV miR-J1-5p in Urine of Natalizumab-Treated Multiple Sclerosis Patients.
Viruses.
2021 03; 13(3):. doi:
10.3390/v13030468
. [PMID: 33809082] - Cinzia Borgogna, Silvia Albertini, Licia Martuscelli, Filippo Poletti, Alessandro Volpe, Guido Merlotti, Vicenzo Cantaluppi, Renzo Boldorini, Marisa Gariglio. Evidence of BK Polyomavirus Infection in Urothelial but not Renal Tumors from a Single Center Cohort of Kidney Transplant Recipients.
Viruses.
2021 Jan; 13(1):. doi:
10.3390/v13010056
. [PMID: 33401589] - Yu Jin, Yi Zhou, Wenfeng Deng, Yuchen Wang, Richard J Lee, Yanna Liu, Nahel Elias, Yangcheng Hu, Min-Hua Luo, Rumin Liu, Bowen Guan, Jian Geng, Jian Xu, Junfeng Ma, Jiapeng Zhou, Na Liu, Michael L Blute, Robert B Colvin, Chin-Lee Wu, Yun Miao. Genome-wide profiling of BK polyomavirus integration in bladder cancer of kidney transplant recipients reveals mechanisms of the integration at the nucleotide level.
Oncogene.
2021 01; 40(1):46-54. doi:
10.1038/s41388-020-01502-w
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In vitro cellular & developmental biology. Animal.
2021 Jan; 57(1):76-85. doi:
10.1007/s11626-020-00520-y
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Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2020 07; 33(7):1433-1442. doi:
10.1038/s41379-020-0489-0
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Nephron.
2020; 144 Suppl 1(?):28-36. doi:
10.1159/000510967
. [PMID: 33221810] - Jia Liu, Eline N Kuipers, Hetty C M Sips, Jennifa C Dorleijn, Andrea D van Dam, Constantinos Christodoulides, Fredrik Karpe, Guangqian Zhou, Mariëtte R Boon, Patrick C N Rensen, Antoine A F de Vries, Sander Kooijman. Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 12; 1864(12):158511. doi:
10.1016/j.bbalip.2019.08.007
. [PMID: 31465889] - Karoline Leuzinger, Klaudia Naegele, Stefan Schaub, Hans H Hirsch. Quantification of plasma BK polyomavirus loads is affected by sequence variability, amplicon length, and non-encapsidated viral DNA genome fragments.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2019 12; 121(?):104210. doi:
10.1016/j.jcv.2019.104210
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Biosensors & bioelectronics.
2019 Sep; 141(?):111401. doi:
10.1016/j.bios.2019.111401
. [PMID: 31195202] - Elisa Mazzoni, Francesca Frontini, John Charles Rotondo, Nunzia Zanotta, Arianna Fioravanti, Francesca Minelli, Elena Torreggiani, Giuseppina Campisciano, Annalisa Marcuzzi, Giovanni Guerra, Alberto Tommasini, Antoine Touzé, Fernanda Martini, Mauro Tognon, Manola Comar. Antibodies reacting to mimotopes of Simian virus 40 large T antigen, the viral oncoprotein, in sera from children.
Journal of cellular physiology.
2019 04; 234(4):3170-3179. doi:
10.1002/jcp.27490
. [PMID: 30362540] - Miriam Becker, Melissa Dominguez, Lilo Greune, Laura Soria-Martinez, Moritz M Pfleiderer, Rachel Schowalter, Christopher B Buck, Bärbel S Blaum, M Alexander Schmidt, Mario Schelhaas. Infectious Entry of Merkel Cell Polyomavirus.
Journal of virology.
2019 03; 93(6):. doi:
10.1128/jvi.02004-18
. [PMID: 30626687] - Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Koushi Hidaka, Tsutomu Takegami. Establishment of COS-JC cells persistently producing archetype JC polyomavirus.
Microbiology and immunology.
2018 Aug; 62(8):524-530. doi:
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. [PMID: 29932215] - Iwona Bil-Lula, Mieczysław Woźniak. Co-infection with human polyomavirus BK enhances gene expression and replication of human adenovirus.
Archives of virology.
2018 Jul; 163(7):1841-1849. doi:
10.1007/s00705-018-3810-1
. [PMID: 29582163] - Elvis T Ajuh, Zongsong Wu, Emma Kraus, Fabian H Weissbach, Tobias Bethge, Rainer Gosert, Nicole Fischer, Hans H Hirsch. Novel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements.
Journal of virology.
2018 04; 92(7):. doi:
10.1128/jvi.02231-17
. [PMID: 29343574] - Elisa Mazzoni, Silvia Pietrobon, Miriam Bilancia, Fabrizio Vinante, Antonella Rigo, Isacco Ferrarini, Antonio D'Agostino, Maria Vittoria Casali, Fernanda Martini, Mauro Tognon. High prevalence of antibodies reacting to mimotopes of Simian virus 40 large T antigen, the oncoprotein, in serum samples of patients affected by non-Hodgkin lymphoma.
Cancer immunology, immunotherapy : CII.
2017 Sep; 66(9):1189-1198. doi:
10.1007/s00262-017-2008-9
. [PMID: 28455653] - John Charles Rotondo, Ilaria Bononi, Andrea Puozzo, Marcello Govoni, Valentina Foschi, Giovanni Lanza, Roberta Gafà, Pauline Gaboriaud, Françoise Antoine Touzé, Rita Selvatici, Fernanda Martini, Mauro Tognon. Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2017 Jul; 23(14):3929-3934. doi:
10.1158/1078-0432.ccr-16-2899
. [PMID: 28174236] - D J Kenan, P A Mieczkowski, E Latulippe, I Côté, H K Singh, V Nickeleit. BK Polyomavirus Genomic Integration and Large T Antigen Expression: Evolving Paradigms in Human Oncogenesis.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2017 Jun; 17(6):1674-1680. doi:
10.1111/ajt.14191
. [PMID: 28039910] - Arvind Varsani, Greg Frankfurter, Daisy Stainton, Maketalena F Male, Simona Kraberger, Jennifer M Burns. Identification of a polyomavirus in Weddell seal (Leptonychotes weddellii) from the Ross Sea (Antarctica).
Archives of virology.
2017 May; 162(5):1403-1407. doi:
10.1007/s00705-017-3239-y
. [PMID: 28124141] - Cheng Xu, Lu Cao, Jianhua Liu, Zhongrun Qian, Yu Peng, Wenjing Zhu, Yongming Qiu, Yingying Lin. Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
Oncology research.
2017 Mar; 25(3):407-415. doi:
10.3727/096504016x14743350548249
. [PMID: 27660925] - Takaaki Kinoshita, Chikara Sato, Takashi J Fuwa, Shoko Nishihara. Short stop mediates axonal compartmentalization of mucin-type core 1 glycans.
Scientific reports.
2017 02; 7(?):41455. doi:
10.1038/srep41455
. [PMID: 28150729] - Kenta Takahashi, Tsuyoshi Sekizuka, Hitomi Fukumoto, Kazuo Nakamichi, Tadaki Suzuki, Yuko Sato, Hideki Hasegawa, Makoto Kuroda, Harutaka Katano. Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.
Journal of virology.
2017 Jan; 91(1):. doi:
10.1128/jvi.01335-16
. [PMID: 27795410] - Priya Yadav, Ganesh Shahane, Sureshkumar Ramasamy, Durba Sengupta, Sushama Gaikwad. Structural-functional insights and studies on saccharide binding of Sophora japonica seed lectin.
International journal of biological macromolecules.
2016 Oct; 91(?):75-84. doi:
10.1016/j.ijbiomac.2016.05.047
. [PMID: 27185070] - Mohammad R Hasan, Rusung Tan, Ghada Al-Rawahi, Eva Thomas, Peter Tilley. Comparative evaluation of laboratory developed real-time PCR assays and RealStar(®) BKV PCR Kit for quantitative detection of BK polyomavirus.
Journal of virological methods.
2016 08; 234(?):80-6. doi:
10.1016/j.jviromet.2016.04.009
. [PMID: 27091098] - N Papa, N Zanotta, A Knowles, E Orzan, M Comar. Detection of Malawi polyomavirus sequences in secondary lymphoid tissues from Italian healthy children: a transient site of infection.
Virology journal.
2016 Jun; 13(?):97. doi:
10.1186/s12985-016-0553-z
. [PMID: 27287743] - M Samimi, L Molet, M Fleury, H Laude, A Carlotti, C Gardair, M Baudin, L Gouguet, E Maubec, M Avenel-Audran, E Esteve, E Wierzbicka-Hainaut, N Beneton, F Aubin, F Rozenberg, N Dupin, M F Avril, G Lorette, S Guyetant, P Coursaget, A Touzé. Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with Merkel cell carcinoma.
The British journal of dermatology.
2016 Apr; 174(4):813-22. doi:
10.1111/bjd.14313
. [PMID: 26600395] - Marcus Hoffmann, Kristina Marx, Udo Reichl, Manfred Wuhrer, Erdmann Rapp. Site-specific O-Glycosylation Analysis of Human Blood Plasma Proteins.
Molecular & cellular proteomics : MCP.
2016 Feb; 15(2):624-41. doi:
10.1074/mcp.m115.053546
. [PMID: 26598643] - Ling Yan, Mohamed E Salama, Christian Lanciault, Linh Matsumura, Megan L Troxell. Polyomavirus large T antigen is prevalent in urothelial carcinoma post-kidney transplant.
Human pathology.
2016 Feb; 48(?):122-31. doi:
10.1016/j.humpath.2015.09.021
. [PMID: 26615524] - Mauro Tognon, Alfredo Corallini, Marco Manfrini, Angelo Taronna, Janet S Butel, Silvia Pietrobon, Lorenzo Trevisiol, Ilaria Bononi, Emanuela Vaccher, Giuseppe Barbanti-Brodano, Fernanda Martini, Elisa Mazzoni. Specific Antibodies Reacting with SV40 Large T Antigen Mimotopes in Serum Samples of Healthy Subjects.
PloS one.
2016; 11(1):e0145720. doi:
10.1371/journal.pone.0145720
. [PMID: 26731525] - Daniel J Kenan, Piotr A Mieczkowski, Raquel Burger-Calderon, Harsharan K Singh, Volker Nickeleit. The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome.
The Journal of pathology.
2015 Nov; 237(3):379-89. doi:
10.1002/path.4584
. [PMID: 26172456] - Khan Behlol Ayaz Ahmed, Ansari Sulthan Mohammed, Anbazhagan Veerappan. Interaction of sugar stabilized silver nanoparticles with the T-antigen specific lectin, jacalin from Artocarpus integrifolia.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Jun; 145(?):110-116. doi:
10.1016/j.saa.2015.01.133
. [PMID: 25770933] - Liesl K Jeffers-Francis, Raquel Burger-Calderon, Jennifer Webster-Cyriaque. Effect of Leflunomide, Cidofovir and Ciprofloxacin on replication of BKPyV in a salivary gland in vitro culture system.
Antiviral research.
2015 Jun; 118(?):46-55. doi:
10.1016/j.antiviral.2015.02.002
. [PMID: 25790744] - Tomomi Ichimiya, Megumi Maeda, Shou Sakamura, Masato Kanazawa, Shoko Nishihara, Yoshinobu Kimura. Identification of β1,3-galactosyltransferases responsible for biosynthesis of insect complex-type N-glycans containing a T-antigen unit in the honeybee.
Glycoconjugate journal.
2015 May; 32(3-4):141-51. doi:
10.1007/s10719-015-9585-7
. [PMID: 25931033] - Arvind Varsani, Elizabeth L Porzig, Scott Jennings, Simona Kraberger, Kata Farkas, Laurel Julian, Melanie Massaro, Grant Ballard, David G Ainley. Identification of an avian polyomavirus associated with Adélie penguins (Pygoscelis adeliae).
The Journal of general virology.
2015 Apr; 96(Pt 4):851-857. doi:
10.1099/vir.0.000038
. [PMID: 25537375] - Shalaka S Hampras, Raphael P Viscidi, Kathy J Helzlsouer, Ji-Hyun Lee, William J Fulp, Anna R Giuliano, Elizabeth A Platz, Dana E Rollison. Prospective study of seroreactivity to JC virus T-antigen and risk of colorectal cancers and adenomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2014 Nov; 23(11):2591-6. doi:
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Biochemical and biophysical research communications.
2014 May; 447(3):543-9. doi:
10.1016/j.bbrc.2014.04.030
. [PMID: 24735545] - Sophie Borchert, Manja Czech-Sioli, Friederike Neumann, Claudia Schmidt, Peter Wimmer, Thomas Dobner, Adam Grundhoff, Nicole Fischer. High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.
Journal of virology.
2014 Mar; 88(6):3144-60. doi:
10.1128/jvi.02916-13
. [PMID: 24371076] - Corinna Schmitt, Lubna Raggub, Silvia Linnenweber-Held, Ortwin Adams, Anke Schwarz, Albert Heim. Donor origin of BKV replication after kidney transplantation.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2014 Feb; 59(2):120-5. doi:
10.1016/j.jcv.2013.11.009
. [PMID: 24361208] - Alexander Link, Francesc Balaguer, Takeshi Nagasaka, C Richard Boland, Ajay Goel. MicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract.
PloS one.
2014; 9(6):e100036. doi:
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Journal of virology.
2013 Dec; 87(24):13179-92. doi:
10.1128/jvi.02224-13
. [PMID: 24067972] - Borislav A Alexiev, Parmjeet Randhawa, Eduardo Vazquez Martul, Gang Zeng, Chunqing Luo, Emilio Ramos, Cinthia B Drachenberg, John C Papadimitriou. BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.
Human pathology.
2013 May; 44(5):908-17. doi:
10.1016/j.humpath.2012.09.019
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Annales de biologie clinique.
2013 Mar; 71(2):215-8. doi:
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Virology.
2013 Feb; 436(2):295-303. doi:
10.1016/j.virol.2012.12.005
. [PMID: 23276405] - Gemma Llaverias, Joan Carles Escolà-Gil, Enrique Lerma, Josep Julve, Cristina Pons, Anna Cabré, Montserrat Cofán, Emilio Ros, José Luis Sánchez-Quesada, Francisco Blanco-Vaca. Phytosterols inhibit the tumor growth and lipoprotein oxidizability induced by a high-fat diet in mice with inherited breast cancer.
The Journal of nutritional biochemistry.
2013 Jan; 24(1):39-48. doi:
10.1016/j.jnutbio.2012.01.007
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The Journal of veterinary medical science.
2013; 75(9):1223-5. doi:
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Comparative medicine.
2012 Oct; 62(5):400-8. doi:
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Journal of virology.
2012 Oct; 86(19):10321-6. doi:
10.1128/jvi.01210-12
. [PMID: 22740408] - Girgis Obaid, Isabelle Chambrier, Michael J Cook, David A Russell. Targeting the oncofetal Thomsen-Friedenreich disaccharide using jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy.
Angewandte Chemie (International ed. in English).
2012 Jun; 51(25):6158-62. doi:
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. [PMID: 22573473] - Bo Liang, Irina Tikhanovich, Heinz Peter Nasheuer, William R Folk. Stimulation of BK virus DNA replication by NFI family transcription factors.
Journal of virology.
2012 Mar; 86(6):3264-75. doi:
10.1128/jvi.06369-11
. [PMID: 22205750] - Qi Li, Ying Zhang, Yue Sheng, Rong Huo, Bo Sun, Xue Teng, Na Li, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Dong. Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II.
The Biochemical journal.
2012 Feb; 441(3):859-67. doi:
10.1042/bj20111604
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Virology.
2012 Jan; 422(2):235-41. doi:
10.1016/j.virol.2011.10.026
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Carcinogenesis.
2012 Jan; 33(1):140-8. doi:
10.1093/carcin/bgr238
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Digestive diseases and sciences.
2012 Jan; 57(1):79-84. doi:
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