N-Acetylgalactosamine 6-sulfate (BioDeep_00000015682)

 

Secondary id: BioDeep_00001869911


代谢物信息卡片


N-Acetyl-D-galactosamine 6-sulfate

化学式: C8H15NO9S (301.04675000000003)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 45.45%

分子结构信息

SMILES: CC(=O)NC(C(O)1)C(O)C(O)C(O1)COS(O)(=O)=O
InChI: InChI=1S/C8H15NO9S/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H,15,16,17)/t5-,6+,7+,8-/m0/s1

描述信息

KEIO_ID A184

同义名列表

2 个代谢物同义名

N-Acetylgalactosamine 6-sulfate; N-Acetyl-D-galactosamine 6-sulfate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Laurence Perrin, Odile Fenneteau, Brice Ilharreborde, Yline Capri, Marion Gérard, Emmanuel Bui Quoc, Sandrine Passemard, Jamal Ghoumid, Catherine Caillaud, Roseline Froissart, Anne-Claude Tabet, Sophie Lebon, Vincent El Ghouzzi, Keyvan Mazda, Alain Verloes. A new lysosomal storage disorder resembling Morquio syndrome in sibs. European journal of medical genetics. 2012 Mar; 55(3):157-62. doi: 10.1016/j.ejmg.2012.01.001. [PMID: 22330346]
  • Maria Francisca Coutinho, Lúcia Lacerda, Sandra Alves. Glycosaminoglycan storage disorders: a review. Biochemistry research international. 2012; 2012(?):471325. doi: 10.1155/2012/471325. [PMID: 22013531]
  • Lisa Martell, Kelly Lau, Miranda Mei, Vicki Burnett, Celeste Decker, Erik D Foehr. Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers. Orphanet journal of rare diseases. 2011 Dec; 6(?):84. doi: 10.1186/1750-1172-6-84. [PMID: 22176730]
  • Jonathan P Hintze, Shunji Tomatsu, Tadashi Fujii, Adriana M Montaño, Seiji Yamaguchi, Yasuyuki Suzuki, Masaru Fukushi, Takeshi Ishimaru, Tadao Orii. Comparison of liquid chromatography-tandem mass spectrometry and sandwich ELISA for determination of keratan sulfate in plasma and urine. Biomarker insights. 2011; 6(?):69-78. doi: 10.4137/bmi.s7451. [PMID: 21792275]
  • Shunji Tomatsu, Adriana M Montaño, Monica Gutierrez, Jeffrey H Grubb, Hirotaka Oikawa, Vu Chi Dung, Amiko Ohashi, Tatsuo Nishioka, Masamichi Yamada, Mana Yamada, Yasuhiro Tosaka, Georgeta G Trandafirescu, Tadao Orii. Characterization and pharmacokinetic study of recombinant human N-acetylgalactosamine-6-sulfate sulfatase. Molecular genetics and metabolism. 2007 May; 91(1):69-78. doi: 10.1016/j.ymgme.2007.01.004. [PMID: 17336563]
  • H Bouzidi, S Khedhiri, S Laradi, S Ferchichi, M Daudon, A Miled. [Mucopolysaccharidosis IVA (Morquio A syndrome): clinical, biological and therapeutic aspects]. Annales de biologie clinique. 2007 Jan; 65(1):5-11. doi: NULL. [PMID: 17264033]
  • Shunji Tomatsu, Mirella Filocamo, Koji O Orii, William S Sly, Monica A Gutierrez, Tatsuo Nishioka, Olga Peña Serrato, Paola Di Natale, Adriana Maria Montaño, Seiji Yamaguchi, Naomi Kondo, Tadao Orii, Akihiko Noguchi. Mucopolysaccharidosis IVA (Morquio A): identification of novel common mutations in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene in Italian patients. Human mutation. 2004 Aug; 24(2):187-8. doi: 10.1002/humu.9265. [PMID: 15241807]
  • Shunji Tomatsu, Tatiana Dieter, Ida V Schwartz, Piedad Sarmient, Roberto Giugliani, Luis A Barrera, Norberto Guelbert, Raquel Kremer, Gabriela M Repetto, Monica A Gutierrez, Tatsuo Nishioka, Olga Peña Serrato, Adriana Maria Montaño, Seiji Yamaguchi, Akihiko Noguchi. Identification of a common mutation in mucopolysaccharidosis IVA: correlation among genotype, phenotype, and keratan sulfate. Journal of human genetics. 2004; 49(9):490-494. doi: 10.1007/s10038-004-0178-8. [PMID: 15309681]
  • Shunji Tomatsu, Koji O Orii, Carole Vogler, Jun Nakayama, Beth Levy, Jeffrey H Grubb, Monica A Gutierrez, Soomin Shim, Seiji Yamaguchi, Tatsuo Nishioka, Adriana Maria Montano, Akihiko Noguchi, Tadao Orii, Naomi Kondo, William S Sly. Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease. Human molecular genetics. 2003 Dec; 12(24):3349-58. doi: 10.1093/hmg/ddg366. [PMID: 14583446]
  • C Leteux, W Chai, R W Loveless, C T Yuen, L Uhlin-Hansen, Y Combarnous, M Jankovic, S C Maric, Z Misulovin, M C Nussenzweig, T Feizi. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. The Journal of experimental medicine. 2000 Apr; 191(7):1117-26. doi: 10.1084/jem.191.7.1117. [PMID: 10748230]
  • J E Christner. Biosynthesis of chondroitin sulfate proteoglycan by P388D1 macrophage-like cell line. Arteriosclerosis (Dallas, Tex.). 1988 Sep; 8(5):535-43. doi: 10.1161/01.atv.8.5.535. [PMID: 3142452]
  • J J Hopwood, H Elliott. Urinary excretion of sulphated N-acetylhexosamines in patients with various mucopolysaccharidoses. The Biochemical journal. 1985 Aug; 229(3):579-86. doi: 10.1042/bj2290579. [PMID: 3931626]
  • . . . . doi: . [PMID: 16287098]