L-homoserine lactone (BioDeep_00000015679)

   


代谢物信息卡片


L-homoserine lactone

化学式: C4H7NO2 (101.0476762)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 42.86%

分子结构信息

SMILES: C1COC(=O)C1N
InChI: InChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2/t3-/m0/s1

描述信息

The L-enantiomer of homoserine lactone.

同义名列表

1 个代谢物同义名

L-homoserine lactone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Carla Dias, Marta Ribeiro, Ana Correia-Branco, Raul Domínguez-Perles, Fátima Martel, Maria José Saavedra, Manuel Simões. Virulence, attachment and invasion of Caco-2 cells by multidrug-resistant bacteria isolated from wild animals. Microbial pathogenesis. 2019 Mar; 128(?):230-235. doi: 10.1016/j.micpath.2019.01.011. [PMID: 30615997]
  • Merve Eylul Kiymaci, Nurten Altanlar, Mehmet Gumustas, Sibel A Ozkan, Ahmet Akin. Quorum sensing signals and related virulence inhibition of Pseudomonas aeruginosa by a potential probiotic strain's organic acid. Microbial pathogenesis. 2018 Aug; 121(?):190-197. doi: 10.1016/j.micpath.2018.05.042. [PMID: 29807134]
  • Allie Clinton Smith, Anne Rice, Bryan Sutton, Rebecca Gabrilska, Aimee K Wessel, Marvin Whiteley, Kendra P Rumbaugh. Albumin Inhibits Pseudomonas aeruginosa Quorum Sensing and Alters Polymicrobial Interactions. Infection and immunity. 2017 09; 85(9):. doi: 10.1128/iai.00116-17. [PMID: 28630071]
  • Ran Zhao, Hanmin Zhang, Xiang Zou, Fenglin Yang. Effects of Inhibiting Acylated Homoserine Lactones (AHLs) on Anammox Activity and Stability of Granules'. Current microbiology. 2016 Jul; 73(1):108-14. doi: 10.1007/s00284-016-1031-y. [PMID: 27061587]
  • Christian Schwarzer, Zhu Fu, Stacey Shuai, Salil Babbar, Guoping Zhao, Chi Li, Terry E Machen. Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak/Bax-independent release of mitochondrial cytochrome C in fibroblasts. Cellular microbiology. 2014 Jul; 16(7):1094-104. doi: 10.1111/cmi.12263. [PMID: 24438098]
  • Grzegorz Czerwonka, Michał Arabski, Sławomir Wąsik, Agnieszka Jabłońska-Wawrzycka, Patrycja Rogala, Wiesław Kaca. Morphological changes in Proteus mirabilis O18 biofilm under the influence of a urease inhibitor and a homoserine lactone derivative. Archives of microbiology. 2014 Mar; 196(3):169-77. doi: 10.1007/s00203-014-0952-8. [PMID: 24481535]
  • Soumya Palliyil, Christina Downham, Ian Broadbent, Keith Charlton, Andrew J Porter. High-sensitivity monoclonal antibodies specific for homoserine lactones protect mice from lethal Pseudomonas aeruginosa infections. Applied and environmental microbiology. 2014 Jan; 80(2):462-9. doi: 10.1128/aem.02912-13. [PMID: 24185854]
  • Hagit Bar-Rogovsky, Adrian Hugenmatter, Dan S Tawfik. The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases. The Journal of biological chemistry. 2013 Aug; 288(33):23914-27. doi: 10.1074/jbc.m112.427922. [PMID: 23788644]
  • Uta von Rad, Ilona Klein, Petre I Dobrev, Jana Kottova, Eva Zazimalova, Agnes Fekete, Anton Hartmann, Philippe Schmitt-Kopplin, Jörg Durner. Response of Arabidopsis thaliana to N-hexanoyl-DL-homoserine-lactone, a bacterial quorum sensing molecule produced in the rhizosphere. Planta. 2008 Dec; 229(1):73-85. doi: 10.1007/s00425-008-0811-4. [PMID: 18766372]
  • Shinichi Miyairi, Kazuhiro Tateda, Etsu T Fuse, Chihiro Ueda, Hiroaki Saito, Tohru Takabatake, Yoshikazu Ishii, Manabu Horikawa, Masaji Ishiguro, Theodore J Standiford, Keizo Yamaguchi. Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection. Journal of medical microbiology. 2006 Oct; 55(Pt 10):1381-1387. doi: 10.1099/jmm.0.46658-0. [PMID: 17005787]
  • Egon A Ozer, Alejandro Pezzulo, Diana M Shih, Carlene Chun, Clement Furlong, Aldons J Lusis, Everett P Greenberg, Joseph Zabner. Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS microbiology letters. 2005 Dec; 253(1):29-37. doi: 10.1016/j.femsle.2005.09.023. [PMID: 16260097]
  • Fan Yang, Lian-Hui Wang, Jing Wang, Yi-Hu Dong, Jiang Yong Hu, Lian-Hui Zhang. Quorum quenching enzyme activity is widely conserved in the sera of mammalian species. FEBS letters. 2005 Jul; 579(17):3713-7. doi: 10.1016/j.febslet.2005.05.060. [PMID: 15963993]
  • Mario Juhas, Lutz Wiehlmann, Birgit Huber, Doris Jordan, Joerg Lauber, Prabhakar Salunkhe, Anna Silke Limpert, Franz von Götz, Ivo Steinmetz, Leo Eberl, Burkhard Tümmler. Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa. Microbiology (Reading, England). 2004 Apr; 150(Pt 4):831-841. doi: 10.1099/mic.0.26906-0. [PMID: 15073293]
  • Christiane Buch, Jens Sigh, John Nielsen, Jens Laurits Larsen, Lone Gram. Production of acylated homoserine lactones by different serotypes of Vibrio anguillarum both in culture and during infection of rainbow trout. Systematic and applied microbiology. 2003 Sep; 26(3):338-49. doi: 10.1078/072320203322497365. [PMID: 14529176]
  • Feng Xu, Tony Byun, Heinz-Josef Deussen, Kyle R Duke, Heinz-Josef Dussen. Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase. Journal of biotechnology. 2003 Feb; 101(1):89-96. doi: 10.1016/s0168-1656(02)00305-x. [PMID: 12523973]