Mannosamine (BioDeep_00000015557)
Secondary id: BioDeep_00000399961
BioNovoGene_Lab2019
代谢物信息卡片
(2S,3R,4S,5R)-2-AMINO-3,4,5,6-TETRAHYDROXYHEXANAL
化学式: C6H13NO5 (179.0794)
中文名称: D-甘露糖胺
谱图信息:
最多检出来源 Mus musculus(natural_products) 2.76%
分子结构信息
SMILES: C(C1C(C(C(C(O1)O)N)O)O)O
InChI: InChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3+,4-,5-,6?/m1/s1
描述信息
KEIO_ID M081
同义名列表
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:62324
- ChEBI: CHEBI:62325
- KEGG: C03570
- PubChem: 440049
- ChEMBL: CHEMBL4551840
- CAS: 14307-02-9
- MoNA: MoNA038588
- MoNA: MoNA037195
- MoNA: MoNA036114
- MoNA: MoNA036115
- MoNA: MoNA036113
- MoNA: MoNA032187
- MoNA: MoNA032186
- MoNA: MoNA032182
- MoNA: KO003485
- MoNA: KO003484
- MoNA: KO003483
- MoNA: KO003482
- MoNA: KO003486
- PubChem: 6362
- PDB-CCD: 95Z
- 3DMET: B04903
- NIKKAJI: J133.219H
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-275
- KNApSAcK: 62324
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Tae Sup Lee, Young Kim, Weiqi Zhang, In Ho Song, Ching-Hsuan Tung. Facile metabolic glycan labeling strategy for exosome tracking.
Biochimica et biophysica acta. General subjects.
2018 May; 1862(5):1091-1100. doi:
10.1016/j.bbagen.2018.02.001. [PMID: 29410228] - Izabella Z A Pawluczyk, Maryam G Najafabadi, Jeremy R Brown, Alan Bevington, Peter S Topham. Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats.
Laboratory investigation; a journal of technical methods and pathology.
2015 Sep; 95(9):1019-28. doi:
10.1038/labinvest.2015.78. [PMID: 26121320] - Mohit P Mathew, Elaine Tan, Shivam Shah, Rahul Bhattacharya, M Adam Meledeo, Jun Huang, Freddy A Espinoza, Kevin J Yarema. Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: implications for metabolic glycoengineering and drug delivery.
Bioorganic & medicinal chemistry letters.
2012 Nov; 22(22):6929-33. doi:
10.1016/j.bmcl.2012.09.017. [PMID: 23041156] - Raquel Da Costa Martins, Carlos Gamazo, María Sánchez-Martínez, Montserrat Barberán, Iván Peñuelas, Juan M Irache. Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Sep; 162(3):553-60. doi:
10.1016/j.jconrel.2012.07.030. [PMID: 22846987] - Monica De Caroli, Marcello S Lenucci, Gian-Pietro Di Sansebastiano, Giuseppe Dalessandro, Giulia De Lorenzo, Gabriella Piro. Protein trafficking to the cell wall occurs through mechanisms distinguishable from default sorting in tobacco.
The Plant journal : for cell and molecular biology.
2011 Jan; 65(2):295-308. doi:
10.1111/j.1365-313x.2010.04421.x. [PMID: 21223393] - Juan M Irache, Hesham H Salman, Sara Gomez, Socorro Espuelas, Carlos Gamazo. Poly(anhydride) nanoparticles as adjuvants for mucosal vaccination.
Frontiers in bioscience (Scholar edition).
2010 06; 2(3):876-90. doi:
10.2741/s108. [PMID: 20515831] - Anabel Elisa Rodríguez, Alicia Couto, Ignacio Echaide, Leonhard Schnittger, Monica Florin-Christensen. Babesia bovis contains an abundant parasite-specific protein-free glycerophosphatidylinositol and the genes predicted for its assembly.
Veterinary parasitology.
2010 Feb; 167(2-4):227-35. doi:
10.1016/j.vetpar.2009.09.024. [PMID: 19833438] - Alyaa Ibrahim, Fakhreddin Jamali. Improved sensitive high performance liquid chromatography assay for glucosamine in human and rat biological samples with fluorescence detection.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2010; 13(2):128-35. doi:
10.18433/j3t01s. [PMID: 20816000] - J R Farley, P Magnusson. Effects of tunicamycin, mannosamine, and other inhibitors of glycoprotein processing on skeletal alkaline phosphatase in human osteoblast-like cells.
Calcified tissue international.
2005 Jan; 76(1):63-74. doi:
10.1007/s00223-004-0023-2. [PMID: 15478002] - David M Mello, Brian D Nielsen, Tonia L Peters, John P Caron, Michael W Orth. Comparison of inhibitory effects of glucosamine and mannosamine on bovine articular cartilage degradation in vitro.
American journal of veterinary research.
2004 Oct; 65(10):1440-5. doi:
10.2460/ajvr.2004.65.1440. [PMID: 15524333] - Yeongjin Hong, Pamela Stanley. Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of mutations in the epimerase domain of the Gne gene.
The Journal of biological chemistry.
2003 Dec; 278(52):53045-54. doi:
10.1074/jbc.m309967200. [PMID: 14561743] - Marisa A Gallicchio, Christoph Kaun, Johann Wojta, Bernd Binder, Leon A Bach. Urokinase type plasminogen activator receptor is involved in insulin-like growth factor-induced migration of rhabdomyosarcoma cells in vitro.
Journal of cellular physiology.
2003 Oct; 197(1):131-8. doi:
10.1002/jcp.10352. [PMID: 12942549] - L R Quinlan, M T Kane. Nature of glycosylphosphatidylinositols produced by mouse embryonic stem cells.
Reproduction (Cambridge, England).
2001 Nov; 122(5):785-91. doi:
10.1530/rep.0.1220785. [PMID: 11690539] - K Schmidt, M Schrader, H F Kern, R Kleene. Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains.
The Journal of biological chemistry.
2001 Apr; 276(17):14315-23. doi:
10.1074/jbc.m006221200. [PMID: 11152672] - M Donaldson, H A Wood, P C Kulakosky, M L Shuler. Use of mannosamine for inducing the addition of outer arm N-acetylglucosamine onto N-linked oligosaccharides of recombinant proteins in insect cells.
Biotechnology progress.
1999 Mar; 15(2):168-73. doi:
10.1021/bp9900211. [PMID: 10194391] - C Lupu, C A Goodwin, A D Westmuckett, J J Emeis, M F Scully, V V Kakkar, F Lupu. Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae. Regulatory mechanism(s) of the anticoagulant properties of the endothelium.
Arteriosclerosis, thrombosis, and vascular biology.
1997 Nov; 17(11):2964-74. doi:
10.1161/01.atv.17.11.2964. [PMID: 9409283] - N Malagolini, D Cavallone, F Serafini-Cessi. Intracellular transport, cell-surface exposure and release of recombinant Tamm-Horsfall glycoprotein.
Kidney international.
1997 Nov; 52(5):1340-50. doi:
10.1038/ki.1997.459. [PMID: 9350657] - M P Marzolo, P Bull, A González. Apical sorting of hepatitis B surface antigen (HBsAg) is independent of N-glycosylation and glycosylphosphatidylinositol-anchored protein segregation.
Proceedings of the National Academy of Sciences of the United States of America.
1997 Mar; 94(5):1834-9. doi:
10.1073/pnas.94.5.1834. [PMID: 9050865] - X Yang, P E Ryals. Cytodifferentiation in Tetrahymena vorax is linked to glycosyl-phosphatidylinositol-anchored protein assembly.
The Biochemical journal.
1994 Mar; 298 Pt 3(?):697-703. doi:
10.1042/bj2980697. [PMID: 8141785] - M S Sandrin, H A Vaughan, P L Dabkowski, I F McKenzie. Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.
Proceedings of the National Academy of Sciences of the United States of America.
1993 Dec; 90(23):11391-5. doi:
10.1073/pnas.90.23.11391. [PMID: 7504304] - Y T Pan, T Kamitani, C Bhuvaneswaran, Y Hallaq, C D Warren, E T Yeh, A D Elbein. Inhibition of glycosylphosphatidylinositol anchor formation by mannosamine.
The Journal of biological chemistry.
1992 Oct; 267(29):21250-5. doi:
NULL. [PMID: 1400435] - Y T Pan, R De Gespari, C D Warren, A D Elbein. Formation of unusual mannosamine-containing lipid-linked oligosaccharides in Madin-Darby canine kidney cell cultures.
The Journal of biological chemistry.
1992 May; 267(13):8991-9. doi:
NULL. [PMID: 1577737] - M P Lisanti, E Rodríguez-Boulan. Polarized sorting of GPI-linked proteins in epithelia and membrane microdomains.
Cell biology international reports.
1991 Nov; 15(11):1023-49. doi:
10.1016/0309-1651(91)90054-m. [PMID: 1782665] - M P Lisanti, M C Field, I W Caras, A K Menon, E Rodriguez-Boulan. Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.
The EMBO journal.
1991 Aug; 10(8):1969-77. doi:
10.1002/j.1460-2075.1991.tb07726.x. [PMID: 1829673] - Y T Pan, A D Elbein. The effect of mannosamine on the formation of lipid-linked oligosaccharides and glycoproteins in canine kidney cells.
Archives of biochemistry and biophysics.
1985 Nov; 242(2):447-56. doi:
10.1016/0003-9861(85)90229-2. [PMID: 4062291] - T Onoda, S Morikawa, T Harada, K Morikawa. Antitumor activity of D-mannosamine in vitro: cytotoxic effect produced by mannosamine in combination with free fatty acids on human leukemia T-cell lines.
Japanese journal of clinical oncology.
1985 Sep; 15(3):545-52. doi:
10.1093/oxfordjournals.jjco.a039081. [PMID: 3877190]
