Resmetirom (BioDeep_00000015484)
代谢物信息卡片
化学式: C17H12Cl2N6O4 (434.0297)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
InChI: InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)
数据库引用编号
6 个数据库交叉引用编号
- KEGG: C77150
- KEGGdrug: D11602
- PubChem: 15981237
- DrugBank: DB12914
- ChEMBL: CHEMBL3261331
- CAS: 920509-32-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xiaojing Wang, Liangjing Wang, Lin Geng, Naoki Tanaka, Bin Ye. Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065843. [PMID: 36982915] - Qiu Li, Benqiang Yao, Shiting Zhao, Zhou Lu, Yan Zhang, Qiuping Xiang, Xishan Wu, Haonan Yu, Cheng Zhang, Junhua Li, Xiaoxi Zhuang, Donghai Wu, Yong Li, Yong Xu. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist.
Journal of medicinal chemistry.
2022 05; 65(10):7193-7211. doi:
10.1021/acs.jmedchem.2c00144. [PMID: 35507418] - Andrea Caddeo, Marta Anna Kowalik, Marina Serra, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli, Amedeo Columbano, Andrea Perra. TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD.
International journal of molecular sciences.
2021 Dec; 22(23):. doi:
10.3390/ijms222313105. [PMID: 34884910] - Suzanna L Attia, Samir Softic, Marialena Mouzaki. Evolving Role for Pharmacotherapy in NAFLD/NASH.
Clinical and translational science.
2021 01; 14(1):11-19. doi:
10.1111/cts.12839. [PMID: 32583961] - Riccardo Zucchi. Thyroid Hormone Analogues: An Update.
Thyroid : official journal of the American Thyroid Association.
2020 08; 30(8):1099-1105. doi:
10.1089/thy.2020.0071. [PMID: 32098589] - Massimiliano Runfola, Simona Sestito, Lorenza Bellusci, Valeria La Pietra, Vincenzo Maria D'Amore, Marta Anna Kowalik, Grazia Chiellini, Sheraz Gul, Andrea Perra, Amedeo Columbano, Luciana Marinelli, Ettore Novellino, Simona Rapposelli. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis.
European journal of medicinal chemistry.
2020 Feb; 188(?):112006. doi:
10.1016/j.ejmech.2019.112006. [PMID: 31931337] - Martha J Kelly, Sherrie Pietranico-Cole, J Douglas Larigan, Nancy-Ellen Haynes, Charles H Reynolds, Nathan Scott, John Vermeulen, Mark Dvorozniak, Karin Conde-Knape, Kuo-Sen Huang, Sung-Sau So, Kshitij Thakkar, Yimin Qian, Bruce Banner, Frank Mennona, Sara Danzi, Irwin Klein, Rebecca Taub, Jefferson Tilley. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.
Journal of medicinal chemistry.
2014 May; 57(10):3912-23. doi:
10.1021/jm4019299. [PMID: 24712661] - Rebecca Taub, Edward Chiang, Malorie Chabot-Blanchet, Martha J Kelly, Richard A Reeves, Marie-Claude Guertin, Jean-Claude Tardif. Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist.
Atherosclerosis.
2013 Oct; 230(2):373-80. doi:
10.1016/j.atherosclerosis.2013.07.056. [PMID: 24075770]
