T0901317 (BioDeep_00000015480)
Volatile Flavor Compounds
代谢物信息卡片
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide
化学式: C17H12F9NO3S (481.0394150000001)
中文名称: T0901317
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O
InChI: InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
描述信息
T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα[1]. T0901317 activates FXR with an EC50 of 5 μM[2]. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively[3]. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice[4][5].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- KEGG: C74506
- PubChem: 447912
- DrugBank: DB07080
- ChEMBL: CHEMBL62136
- CAS: 293754-55-9
- medchemexpress: HY-10626
- KEGG: C15630
- PubChem: 17396620
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ye-Rang Yun, Ji-Eun Lee. Kimchi attenuates endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice.
Nutrition research (New York, N.Y.).
2024 Apr; 124(?):43-54. doi:
10.1016/j.nutres.2024.01.013. [PMID: 38367426] - Xueyun Liu, Man Hu, Chen Ye, Lihong Liao, Chang Ding, Lijuan Sun, Jichao Liang, Yong Chen. Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPARα pathway.
Chemico-biological interactions.
2022 Dec; 368(?):110250. doi:
10.1016/j.cbi.2022.110250. [PMID: 36347319] - Yingmao Luo, Xiaolin Tan, Xiong Zhang, Yuan Li, Jie Huang, Yu Deng. Effect of liver X receptor agonist TO901317 on cognitive function in APP/PS1 double transgenic mice with Alzheimer's disease and the underlying mechanism.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2022 Oct; 47(10):1324-1331. doi:
10.11817/j.issn.1672-7347.2022.210770. [PMID: 36411683] - Nao Namba, Tomomi Noguchi-Yachide, Yuichiro Matsumoto, Yuichi Hashimoto, Shinya Fujii. Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists.
Bioorganic & medicinal chemistry.
2022 07; 66(?):116792. doi:
10.1016/j.bmc.2022.116792. [PMID: 35576658] - Yang Na, Lin Ke, Zhang Jie, Wang Jinping, Meng Tao, Zhu Jie, Yang Liu, Zhou Yueqin. Amelioration of Cholesterol Rich diet-induced Impaired Cognition in AD Transgenic Mice by an LXR Agonist TO901317 Is Associated with the Activation of the LXR-β-RXR-α-ABCA1 Transmembrane Transport System and Improving the Composition of Lipid Raft.
Experimental aging research.
2022 Jul; ?(?):1-12. doi:
10.1080/0361073x.2022.2095605. [PMID: 35792710] - Meng-Ting Zhou, Zhen-Yu Li, Jun Fan, Pin-Dong Li, Ye Wang, Sheng Zhang, Xiao-Fang Dai. Liver X receptors agonist T0901317 exerts ferroptosis sensitization in cancer.
Neoplasma.
2022 Mar; 69(2):331-340. doi:
10.4149/neo_2021_210810n1132. [PMID: 35081722] - Hye Sun Shin, Yuri Lee, Mi Hee Shin, Soo Ick Cho, Christos C Zouboulis, Min Kyoung Kim, Dong Hun Lee, Jin Ho Chung. Histone Deacetylase 1 Reduces Lipogenesis by Suppressing SREBP1 Transcription in Human Sebocyte Cell Line SZ95.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094477. [PMID: 33922983] - Ryan G Snodgrass, Yvonne Benatzy, Tobias Schmid, Dmitry Namgaladze, Malwina Mainka, Nils Helge Schebb, Dieter Lütjohann, Bernhard Brüne. Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation.
Cell death and differentiation.
2021 04; 28(4):1301-1316. doi:
10.1038/s41418-020-00652-4. [PMID: 33177619] - Chuanrui Ma, Ke Feng, Xiaoxiao Yang, Zhimou Yang, Zhongyan Wang, Yuna Shang, Guanwei Fan, Lipei Liu, Shu Yang, Xiaoju Li, Jihong Han, Yajun Duan, Yuanli Chen. Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.
British journal of pharmacology.
2021 04; 178(7):1620-1638. doi:
10.1111/bph.15387. [PMID: 33506494] - Yoshio Shimizu, Takafumi Tamura, Akira Kemmochi, Yohei Owada, Yusuke Ozawa, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Noriyuki Nakano, Shingo Sakashita, Tatsuya Oda, Nobuhiro Ohkohchi. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model.
Journal of gastroenterology and hepatology.
2021 Mar; 36(3):800-810. doi:
10.1111/jgh.15239. [PMID: 32870526] - Jae Kwang Kim, Il Je Cho, Eun Ok Kim, Dae Geon Lee, Dae Hwa Jung, Sung Hwan Ki, Sae Kwang Ku, Sang Chan Kim. Hemistepsin A inhibits T0901317-induced lipogenesis in the liver.
BMB reports.
2021 Feb; 54(2):106-111. doi:
. [PMID: 32843130] - Maaike Blankestijn, Ivo P van de Peppel, Ales Dvorak, Nikola Capkova, Libor Vitek, Johan W Jonker, Henkjan J Verkade. Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats.
Pediatric research.
2021 02; 89(3):510-517. doi:
10.1038/s41390-020-0926-2. [PMID: 32357361] - Ke Feng, Chuanrui Ma, Yuxin Liu, Xiaoxiao Yang, Zhimou Yang, Yaoxia Chen, Tengyan Xu, Chengbiao Yang, Shuang Zhang, Qi Li, Zhuo Wei, Dan Zhao, Peng Zeng, Jihong Han, Jie Gao, Yuanli Chen, Yajun Duan. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis.
Theranostics.
2021; 11(6):2634-2654. doi:
10.7150/thno.53139. [PMID: 33456564] - Jing Zeng, Daitze Wu, Hui Hu, John A T Young, Zhipeng Yan, Lu Gao. Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes.
Hepatology (Baltimore, Md.).
2020 12; 72(6):1935-1948. doi:
10.1002/hep.31217. [PMID: 32145089] - Yong Huang, Ke Ning, Wen-Wen Li, Ge Lin, Cui-Lan Hou, Ming-Jie Wang, Yi-Chun Zhu. Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells.
American journal of physiology. Cell physiology.
2020 12; 319(6):C1082-C1096. doi:
10.1152/ajpcell.00244.2019. [PMID: 32938225] - Junyou Li, Mengqi Liu, Yazhou Li, Dan-Dan Sun, Zhihao Shu, Qian Tan, Shimeng Guo, Rongrong Xie, Lixin Gao, Hongbo Ru, Yi Zang, Hong Liu, Jia Li, Yu Zhou. Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis.
Journal of medicinal chemistry.
2020 11; 63(21):12748-12772. doi:
10.1021/acs.jmedchem.0c01065. [PMID: 32991173] - Yanfei Hao, Xinlin Wang, Fenglan Zhang, Meiling Wang, Yanfang Wang, Hao Wang, Yuan Du, Tian Wang, Fenghua Fu, Zhuye Gao, Leiming Zhang. Inhibition of notch enhances the anti-atherosclerotic effects of LXR agonists while reducing fatty liver development in ApoE-deficient mice.
Toxicology and applied pharmacology.
2020 11; 406(?):115211. doi:
10.1016/j.taap.2020.115211. [PMID: 32853627] - Rai Ajit K Srivastava, Angelo B Cefalu, Nishtha S Srivastava, Maurizio Averna. NPC1L1 and ABCG5/8 induction explain synergistic fecal cholesterol excretion in ob/ob mice co-treated with PPAR-α and LXR agonists.
Molecular and cellular biochemistry.
2020 Oct; 473(1-2):247-262. doi:
10.1007/s11010-020-03826-3. [PMID: 32661772] - Xinyue Yu, Huimin Guo, Hua He, Xiaoying Deng, Xia Yuan, Zhaodi Han, Yuan Tian, Zunjian Zhang, Yin Huang. Pharmacokinetics of T0901317 in mouse serum and tissues using a validated UFLC-IT-TOF/MS method.
Journal of pharmaceutical and biomedical analysis.
2020 Sep; 189(?):113420. doi:
10.1016/j.jpba.2020.113420. [PMID: 32593849] - Ting Li, Jiayu Yin, Yubin Ji, Ping Lin, Yanjie Li, Zixun Yang, Shumei Hu, Jin Wang, Baihui Zhang, Saloni Koshti, Junfeng Wang, Chenfeng Ji, Shoudong Guo. Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXRα/ABCA1 pathway.
Archives of pharmacal research.
2020 Aug; 43(8):788-797. doi:
10.1007/s12272-020-01255-w. [PMID: 32779151] - Xin Zhang, Yuyin Xu, Qianming Bai, Xiaobo Li, Jing Han, Yingyong Hou, Yuan Ji, Zhigang Zhang. Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease.
American journal of physiology. Gastrointestinal and liver physiology.
2020 07; 319(1):G87-G96. doi:
10.1152/ajpgi.00380.2019. [PMID: 32475129] - Katsuaki Ito, Noora Sjöstedt, Melina M Malinen, Cen Guo, Kim L R Brouwer. Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk.
The Journal of pharmacology and experimental therapeutics.
2020 05; 373(2):261-268. doi:
10.1124/jpet.119.263459. [PMID: 32127372] - Eva Hansmann, Elvira Mennillo, Emiko Yoda, Mélanie Verreault, Olivier Barbier, Shujuan Chen, Robert H Tukey. Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice.
Drug metabolism and disposition: the biological fate of chemicals.
2020 04; 48(4):255-263. doi:
10.1124/dmd.119.090068. [PMID: 31980500] - Hannah C Lifsey, Rupinder Kaur, Bradley H Thompson, Lisa Bennett, Ryan E Temel, Gregory A Graf. Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine.
The Journal of nutritional biochemistry.
2020 02; 76(?):108263. doi:
10.1016/j.jnutbio.2019.108263. [PMID: 31759199] - Richard W J Helder, Walter A Boiten, Rianne van Dijk, Gerrit S Gooris, Abdoelwaheb El Ghalbzouri, Joke A Bouwstra. The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 02; 1865(2):158546. doi:
10.1016/j.bbalip.2019.158546. [PMID: 31678517] - Sunggun Kim, Yeo Yeong Yoon, Ye Won Park, Wan-Kyunn Whang, So-Young Park, Kwang Woo Hwang. Cynandione A from Cynanchum wilfordii inhibits hepatic de novo lipogenesis by activating the LKB1/AMPK pathway in HepG2 cells.
Journal of natural medicines.
2020 Jan; 74(1):142-152. doi:
10.1007/s11418-019-01356-x. [PMID: 31463669] - Zizhen Zhang, Hao Chen, Ziyang Chen, Peng Ding, Yingchen Ju, Qiong Gu, Jun Xu, Huihao Zhou. Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay.
European journal of medicinal chemistry.
2019 Sep; 178(?):458-467. doi:
10.1016/j.ejmech.2019.06.011. [PMID: 31202993] - Daniela Passeri, Andrea Carotti, Jose M Ramos Pittol, Gianmario Ciaccioli, Roberto Pellicciari, Saskia W C van Mil, Antimo Gioiello. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.
MedChemComm.
2019 Aug; 10(8):1412-1419. doi:
10.1039/c9md00264b. [PMID: 31673308] - Rui Lou, Haixia Cao, Shuchen Dong, Chen Shi, Xiaoyue Xu, Rong Ma, Jianzhong Wu, Jifeng Feng. Liver X receptor agonist T0901317 inhibits the migration and invasion of non-small-cell lung cancer cells in vivo and in vitro.
Anti-cancer drugs.
2019 06; 30(5):495-500. doi:
10.1097/cad.0000000000000758. [PMID: 30724772] - H F Xu, J Luo, X Y Zhang, J Li, M Bionaz. Activation of liver X receptor promotes fatty acid synthesis in goat mammary epithelial cells via modulation of SREBP1 expression.
Journal of dairy science.
2019 Apr; 102(4):3544-3555. doi:
10.3168/jds.2018-15538. [PMID: 30738675] - Celio Ferreira, Ramona Meyer, Henriette E Meyer Zu Schwabedissen. The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1.
Biochimica et biophysica acta. Gene regulatory mechanisms.
2019 04; 1862(4):447-456. doi:
10.1016/j.bbagrm.2019.02.007. [PMID: 30831268] - Éric Jubinville, Joanie Routhier, Michaël Maranda-Robitaille, Marie Pineault, Nadia Milad, Maude Talbot, Marie-Josée Beaulieu, Sophie Aubin, Marie-Ève Paré, Mathieu Laplante, Mathieu C Morissette. Pharmacological activation of liver X receptor during cigarette smoke exposure adversely affects alveolar macrophages and pulmonary surfactant homeostasis.
American journal of physiology. Lung cellular and molecular physiology.
2019 04; 316(4):L669-L678. doi:
10.1152/ajplung.00482.2018. [PMID: 30702343] - Wei Wang, Ken-Ichi Nakashima, Takao Hirai, Makoto Inoue. Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers.
Journal of natural medicines.
2019 Mar; 73(2):419-430. doi:
10.1007/s11418-018-01277-1. [PMID: 30656541] - Mikio Takanashi, Takeshi Kimura, Chengcheng Li, Masaki Tanaka, Ako Matsuhashi, Hiroki Yoshida, Akari Noda, Pengfei Xu, Satoru Takase, Sachiko Okazaki, Yoko Iizuka, Hidetoshi Kumagai, Yuichi Ikeda, Takanari Gotoda, Manabu Takahashi, Hiroaki Yagyu, Shun Ishibashi, Toshimasa Yamauchi, Takashi Kadowaki, Guosheng Liang, Hiroaki Okazaki. Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.
Arteriosclerosis, thrombosis, and vascular biology.
2019 03; 39(3):373-386. doi:
10.1161/atvbaha.118.311931. [PMID: 30700132] - Nan Xu, Jun Li, Yujie Gao, Nuoya Zhou, Qiuying Ma, Min Wu, Yamin Zhang, Xiaoyan Sun, Jun Xie, Guanxin Shen, Ming Yang, Qiming Tu, Xiaowei Xu, Jintao Zhu, Juan Tao. Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus.
Biomaterials.
2019 03; 197(?):380-392. doi:
10.1016/j.biomaterials.2019.01.034. [PMID: 30703743] - Qiang Wang, Fan Feng, Jiayou Wang, Meijia Ren, Zhonggang Shi, Xiang Mao, Heng Zhang, Xiaoli Ju. Liver X receptor activation reduces gastric cancer cell proliferation by suppressing Wnt signalling via LXRβ relocalization.
Journal of cellular and molecular medicine.
2019 02; 23(2):789-797. doi:
10.1111/jcmm.13974. [PMID: 30338932] - Guang-Hui Chen, Zhi Luo, Christer Hogstrand, Kun Wu, Shi-Cheng Ling. SREBP1, PPARG and AMPK pathways mediated the Cu-induced change in intestinal lipogenesis and lipid transport of yellow catfish Pelteobagrus fulvidraco.
Food chemistry.
2018 Dec; 269(?):595-602. doi:
10.1016/j.foodchem.2018.07.048. [PMID: 30100477] - Ping Jin, Yitong Bian, Kai Wang, Guangzhi Cong, Ru Yan, Yong Sha, Xueping Ma, Juan Zhou, Zuyi Yuan, Shaobin Jia. Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.
Life sciences.
2018 Dec; 214(?):41-50. doi:
10.1016/j.lfs.2018.10.060. [PMID: 30393020] - Yen-Ning Lin, Charles C N Wang, Hsiao-Yun Chang, Fang-Yi Chu, Yu-An Hsu, Wai-Kok Cheng, Wei-Chih Ma, Chao-Jung Chen, Lei Wan, Yun-Ping Lim. Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis.
Journal of agricultural and food chemistry.
2018 Nov; 66(44):11647-11662. doi:
10.1021/acs.jafc.8b04116. [PMID: 30359008] - Yen-Ning Lin, Hsiao-Yun Chang, Charles C N Wang, Fang-Yi Chu, Hsin-Yi Shen, Chao-Jung Chen, Yun-Ping Lim. Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis.
Journal of agricultural and food chemistry.
2018 Oct; 66(42):10964-10976. doi:
10.1021/acs.jafc.8b03372. [PMID: 30351048] - Kwang-Youn Kim, Kwang-Il Park, Seul Gi Lee, Su Youn Baek, Eun Hye Lee, Sang Chan Kim, Sang-Hun Kim, Sul-Gi Park, Sun-Nyoung Yu, Tae Woo Oh, Joung-Hee Kim, Keuk-Jun Kim, Soon-Cheol Ahn, Young Woo Kim. Deoxypodophyllotoxin in Anthriscus sylvestris alleviates fat accumulation in the liver via AMP-activated protein kinase, impeding SREBP-1c signal.
Chemico-biological interactions.
2018 Oct; 294(?):151-157. doi:
10.1016/j.cbi.2018.08.025. [PMID: 30148990] - Yi-Wen Li, Chung-Hsing Wang, Chao-Jung Chen, Charles C N Wang, Cheng-Li Lin, Wai-Kok Cheng, Hsin-Yi Shen, Yun-Ping Lim. Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies.
Archives of toxicology.
2018 09; 92(9):2829-2844. doi:
10.1007/s00204-018-2263-3. [PMID: 30003287] - Ju-Hee Lee, Su Youn Baek, Eun Jeong Jang, Sae Kwang Ku, Kyu Min Kim, Sung Hwan Ki, Chang-Eop Kim, Kwang Il Park, Sang Chan Kim, Young Woo Kim. Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Chemico-biological interactions.
2018 Jun; 289(?):68-74. doi:
10.1016/j.cbi.2018.04.023. [PMID: 29702089] - Ryokichi Koyama, Yasunori Fukuda, Yusuke Kamada, Hideyuki Nakagawa, Darbi Witmer, Geza Ambrus-Aikelin, Bi-Ching Sang, Masaharu Nakayama, Hidehisa Iwata. Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening.
Assay and drug development technologies.
2018 May; 16(4):194-204. doi:
10.1089/adt.2018.852. [PMID: 29874096] - Jingjing Wang, Chong Xiao, Zhengkai Wei, Yanan Wang, Xu Zhang, Yunhe Fu. Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells.
Veterinary immunology and immunopathology.
2018 Mar; 197(?):87-92. doi:
10.1016/j.vetimm.2018.02.002. [PMID: 29475512] - Sayaka Nomura, Kaori Endo-Umeda, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa. Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility.
Bioorganic & medicinal chemistry letters.
2018 02; 28(4):796-801. doi:
10.1016/j.bmcl.2017.12.024. [PMID: 29398545] - Mehdi Hichor, Venkat Krishnan Sundaram, Stéphanie A Eid, Ronza Abdel-Rassoul, Patrice X Petit, Didier Borderie, Jean Bastin, Assaad A Eid, Marin Manuel, Julien Grenier, Charbel Massaad. Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.
Scientific reports.
2018 02; 8(1):2524. doi:
10.1038/s41598-018-20980-3. [PMID: 29410501] - Pattira Chonlaket, Teerasak Wongwan, Sunhapas Soodvilai. Liver X receptor activation inhibits SGLT2-mediated glucose transport in human renal proximal tubular cells.
Experimental physiology.
2018 02; 103(2):250-260. doi:
10.1113/ep086478. [PMID: 29127736] - Silu Cheng, Shufang Liang, Qun Liu, Zhengting Deng, Yuanhui Zhang, Juan Du, Ya'ni Zhang, Shu Li, Binbin Cheng, Changquan Ling. Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways.
International journal of molecular medicine.
2018 Feb; 41(2):1089-1095. doi:
10.3892/ijmm.2017.3291. [PMID: 29207101] - Yanhong Guo, Wenmin Yuan, Bilian Yu, Rui Kuai, Wenting Hu, Emily E Morin, Minerva T Garcia-Barrio, Jifeng Zhang, James J Moon, Anna Schwendeman, Y Eugene Chen. Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression.
EBioMedicine.
2018 Feb; 28(?):225-233. doi:
10.1016/j.ebiom.2017.12.021. [PMID: 29361501] - Saeromi Kang, Jin Huang, Bo-Kyung Lee, Young-Suk Jung, Eunok Im, Jung-Min Koh, Dong-Soon Im. Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2018 Feb; 1863(2):105-116. doi:
10.1016/j.bbalip.2017.11.002. [PMID: 29126901] - Ryohei Kaseda, Yohei Tsuchida, Hai-Chun Yang, Patricia G Yancey, Jianyong Zhong, Huan Tao, Aihua Bian, Agnes B Fogo, Mac Rae F Linton, Sergio Fazio, Talat Alp Ikizler, Valentina Kon. Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism.
BMC nephrology.
2018 01; 19(1):17. doi:
10.1186/s12882-018-0814-8. [PMID: 29374468] - María Sol Kruse, Lucas Gabriel Suarez, Héctor Coirini. LXR activation increases the expression of GnRH AND αMSH in the rat hypothalamus in vivo.
Neuroscience letters.
2018 01; 664(?):20-27. doi:
10.1016/j.neulet.2017.11.011. [PMID: 29128625] - Yohei Owada, Takafumi Tamura, Tomohito Tanoi, Yusuke Ozawa, Yoshio Shimizu, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Noriyuki Nakano, Shingo Sakashita, Toshiya Matsukawa, Hiroko Isoda, Nobuhiro Ohkohchi. Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features.
Pathology international.
2018 Jan; 68(1):12-22. doi:
10.1111/pin.12612. [PMID: 29154469] - Erica Dresselhaus, James M Duerr, Fabien Vincent, Emily K Sylvain, Mercedes Beyna, Lorraine F Lanyon, Erik LaChapelle, Martin Pettersson, Kelly R Bales, Gayathri Ramaswamy. Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.
PloS one.
2018; 13(3):e0194661. doi:
10.1371/journal.pone.0194661. [PMID: 29579087] - Mabel Toribio, Min Hi Park, Markella V Zanni, Gregory K Robbins, Tricia H Burdo, Kenneth C Williams, Meghan N Feldpausch, Lauren Stone, Kathleen Melbourne, Steven K Grinspoon, Michael L Fitzgerald. HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Antiretroviral Therapy.
The Journal of clinical endocrinology and metabolism.
2017 11; 102(11):4250-4259. doi:
10.1210/jc.2017-01334. [PMID: 28945911] - Jin Huang, Saeromi Kang, Soo-Jin Park, Dong-Soon Im. Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes.
Cellular signalling.
2017 11; 39(?):84-94. doi:
10.1016/j.cellsig.2017.08.003. [PMID: 28821440] - Teerasak Wongwan, Suticha Kittayaruksakul, Nithi Asavapanumas, Varanuj Chatsudthipong, Sunhapas Soodvilai. Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells.
Pflugers Archiv : European journal of physiology.
2017 11; 469(11):1471-1481. doi:
10.1007/s00424-017-2033-8. [PMID: 28741179] - Vanya Nikolova, Georgia Papacleovoulou, Elena Bellafante, Luiza Borges Manna, Eugene Jansen, Silvère Baron, Shadi Abu-Hayyeh, Malcolm Parker, Catherine Williamson. Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis.
American journal of physiology. Endocrinology and metabolism.
2017 10; 313(4):E463-E472. doi:
10.1152/ajpendo.00449.2016. [PMID: 28420650] - Kaori Endo-Umeda, Atsushi Aoyama, Masato Shimizu, Minoru Ishikawa, Yuichi Hashimoto, Sachiko Yamada, Makoto Makishima. 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators.
The Journal of steroid biochemistry and molecular biology.
2017 09; 172(?):136-148. doi:
10.1016/j.jsbmb.2017.07.014. [PMID: 28736297] - Michelle M Angrish, Charlene A McQueen, Elaine Cohen-Hubal, Maribel Bruno, Yue Ge, Brian N Chorley. Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 09; 159(1):159-169. doi:
10.1093/toxsci/kfx121. [PMID: 28903485] - Delphine Carbonnelle, Trang H Luu, Chloe Chaillou, Jean-Michel Huvelin, Jean-Marie Bard, Hassan Nazih. LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells.
Anticancer research.
2017 08; 37(8):4067-4073. doi:
10.21873/anticanres.11792. [PMID: 28739689] - Alistair C Leitch, Philip M E Probert, James A Shayman, Stephanie K Meyer, George E N Kass, Matthew C Wright. B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.
Toxicology.
2017 07; 386(?):120-132. doi:
10.1016/j.tox.2017.05.014. [PMID: 28552552] - Wen Su, Jun Peng, Sha Li, Yu-Bing Dai, Chun-Jiong Wang, Hu Xu, Min Gao, Xiong-Zhong Ruan, Jan-Åke Gustafsson, You-Fei Guan, Xiao-Yan Zhang. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c.
American journal of physiology. Endocrinology and metabolism.
2017 04; 312(4):E357-E367. doi:
10.1152/ajpendo.00310.2016. [PMID: 28270440] - Ni Li, Xiao Wang, Yanni Xu, Yuan Lin, Ningyu Zhu, Peng Liu, Duo Lu, Shuyi Si. Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics.
Molecular pharmacology.
2017 04; 91(4):264-276. doi:
10.1124/mol.116.105213. [PMID: 28087808] - Pascal Heitel, Janosch Achenbach, Daniel Moser, Ewgenij Proschak, Daniel Merk. DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Bioorganic & medicinal chemistry letters.
2017 03; 27(5):1193-1198. doi:
10.1016/j.bmcl.2017.01.066. [PMID: 28169169] - Shimpi Bedi, Genesis Victoria Hines, Valery V Lozada-Fernandez, Camila de Jesus Piva, Alagammai Kaliappan, S Dean Rider, Heather A Hostetler. Fatty acid binding profile of the liver X receptor α.
Journal of lipid research.
2017 02; 58(2):393-402. doi:
10.1194/jlr.m072447. [PMID: 28011707] - Vladimir S Shavva, Alexandra M Bogomolova, Artemy A Nikitin, Ella B Dizhe, Dmitry A Tanyanskiy, Alexander M Efremov, Galina N Oleinikova, Andrej P Perevozchikov, Sergey V Orlov. Insulin-Mediated Downregulation of Apolipoprotein A-I Gene in Human Hepatoma Cell Line HepG2: The Role of Interaction Between FOXO1 and LXRβ Transcription Factors.
Journal of cellular biochemistry.
2017 02; 118(2):382-396. doi:
10.1002/jcb.25651. [PMID: 27404023] - Ye-Rang Yun, Ji-Hyun Kim, Ji Ha Kim, Myeong Ho Jung. Protective effects of gomisin N against hepatic steatosis through AMPK activation.
Biochemical and biophysical research communications.
2017 Jan; 482(4):1095-1101. doi:
10.1016/j.bbrc.2016.11.164. [PMID: 27914812] - Emma C L Cook, Jessica K Nelson, Vincenzo Sorrentino, Duco Koenis, Martina Moeton, Saskia Scheij, Roelof Ottenhoff, Boris Bleijlevens, Anke Loregger, Noam Zelcer. Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.
PloS one.
2017; 12(2):e0172721. doi:
10.1371/journal.pone.0172721. [PMID: 28231341] - Rebekka Pohl, Elisabeth M Haberl, Lisa Rein-Fischboeck, Sebastian Zimny, Maximilian Neumann, Charalampos Aslanidis, Doris Schacherer, Sabrina Krautbauer, Kristina Eisinger, Thomas S Weiss, Christa Buechler. Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis.
European journal of clinical investigation.
2017 Jan; 47(1):7-18. doi:
10.1111/eci.12695. [PMID: 27797398] - Irene Paterniti, Michela Campolo, Rosalba Siracusa, Marika Cordaro, Rosanna Di Paola, Vittorio Calabrese, Michele Navarra, Salvatore Cuzzocrea, Emanuela Esposito. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease.
PloS one.
2017; 12(4):e0174470. doi:
10.1371/journal.pone.0174470. [PMID: 28369131] - Yoriko Sakane, Naotetsu Kanamoto, Ichiro Yamauchi, Tetsuya Tagami, Yusuke Morita, Masako Miura, Masakatsu Sone, Akihiro Yasoda, Takeshi Kimura, Kazuwa Nakao, Nobuya Inagaki. Regulation of type 1 iodothyronine deiodinase by LXRα.
PloS one.
2017; 12(6):e0179213. doi:
10.1371/journal.pone.0179213. [PMID: 28617824] - Xiao Hu, Haitao Shen, Yu Wang, Min Zhao. Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-κB and JNK/p38 MAPK Signal Pathways.
BioMed research international.
2017; 2017(?):4652695. doi:
10.1155/2017/4652695. [PMID: 28480221] - Ellen K Kick, Brett B Busch, Richard Martin, William C Stevens, Venkataiah Bollu, Yinong Xie, Brant C Boren, Michael C Nyman, Max H Nanao, Lam Nguyen, Artur Plonowski, Ira G Schulman, Grace Yan, Huiping Zhang, Xiaoping Hou, Meriah N Valente, Rangaraj Narayanan, Kamelia Behnia, A David Rodrigues, Barry Brock, James Smalley, Glenn H Cantor, John Lupisella, Paul Sleph, Denise Grimm, Jacek Ostrowski, Ruth R Wexler, Todd Kirchgessner, Raju Mohan. Discovery of Highly Potent Liver X Receptor β Agonists.
ACS medicinal chemistry letters.
2016 Dec; 7(12):1207-1212. doi:
10.1021/acsmedchemlett.6b00234. [PMID: 27994765] - Adam M Speen, Hye-Young H Kim, Rebecca N Bauer, Megan Meyer, Kymberly M Gowdy, Michael B Fessler, Kelly E Duncan, Wei Liu, Ned A Porter, Ilona Jaspers. Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.
The Journal of biological chemistry.
2016 Nov; 291(48):25192-25206. doi:
10.1074/jbc.m116.732362. [PMID: 27703007] - María E Reyes-Quiroz, Gonzalo Alba, Javier Sáenz, Isabel Geniz, Juan Jiménez, José Martín-Nieto, Consuelo Santa-María, Francisco Sobrino. Platelet-activating factor and hydrogen peroxide exert a dual modulatory effect on the transcription of LXRα and its target genes in human neutrophils.
International immunopharmacology.
2016 Sep; 38(?):357-66. doi:
10.1016/j.intimp.2016.05.001. [PMID: 27351826] - Helen H Wang, Xiaodan Li, Shailendra B Patel, David Q-H Wang. Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice.
Hepatology (Baltimore, Md.).
2016 09; 64(3):853-64. doi:
10.1002/hep.28570. [PMID: 27014967] - Yating Li, Changwen Jing, Xinyi Tang, Yuanyuan Chen, Xiao Han, Yunxia Zhu. LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells.
Endocrine.
2016 Sep; 53(3):689-700. doi:
10.1007/s12020-016-0915-8. [PMID: 27071658] - Minoru Koura, Yuki Yamaguchi, Sayaka Kurobuchi, Hisashi Sumida, Yuichiro Watanabe, Takashi Enomoto, Takayuki Matsuda, Ayumu Okuda, Tomoaki Koshizawa, Yuki Matsumoto, Kimiyuki Shibuya. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist.
Bioorganic & medicinal chemistry.
2016 08; 24(16):3436-46. doi:
10.1016/j.bmc.2016.05.048. [PMID: 27283790] - Shan Yu, Sijia Li, Adam Henke, Evan D Muse, Bo Cheng, Gustav Welzel, Arnab K Chatterjee, Danling Wang, Jason Roland, Christopher K Glass, Matthew Tremblay. Dissociated sterol-based liver X receptor agonists as therapeutics for chronic inflammatory diseases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2016 07; 30(7):2570-9. doi:
10.1096/fj.201600244r. [PMID: 27025962] - Amr Alaarg, Kang He Zheng, Fleur M van der Valk, Acarilia Eduardo da Silva, Miranda Versloot, Linda C Quarles van Ufford, Dominik M Schulte, Gert Storm, Josbert M Metselaar, Erik S G Stroes, Anouk A J Hamers. Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.
Vascular pharmacology.
2016 07; 82(?):51-9. doi:
10.1016/j.vph.2016.04.006. [PMID: 27189780] - James P Hamilton, Lahari Koganti, Abigael Muchenditsi, Venkata S Pendyala, David Huso, Joseph Hankin, Robert C Murphy, Dominik Huster, Uta Merle, Christopher Mangels, Nan Yang, James J Potter, Esteban Mezey, Svetlana Lutsenko. Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B(-/-) (Wilson disease) mice.
Hepatology (Baltimore, Md.).
2016 06; 63(6):1828-41. doi:
10.1002/hep.28406. [PMID: 26679751] - Hanlu Ding, Yi Li, Yunlin Feng, Jin Chen, Xiang Zhong, Nan Wang, Wei Wang, Ping Zhang, Li Wang. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor‑κB.
Molecular medicine reports.
2016 Jun; 13(6):4888-96. doi:
10.3892/mmr.2016.5138. [PMID: 27082844] - Chun-Mu Miao, Kun He, Pei-Zhi Li, Zuo-Jin Liu, Xi-Wen Zhu, Zhi-Bing Ou, Xiong-Zhong Ruan, Jian-Ping Gong, Chang-An Liu. LXRα represses LPS-induced inflammatory responses by competing with IRF3 for GRIP1 in Kupffer cells.
International immunopharmacology.
2016 Jun; 35(?):272-279. doi:
10.1016/j.intimp.2016.04.009. [PMID: 27085678] - Elina Shrestha, Maryem A Hussein, Jeffery N Savas, Mireille Ouimet, Tessa J Barrett, Sarah Leone, John R Yates, Kathryn J Moore, Edward A Fisher, Michael J Garabedian. Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
The Journal of biological chemistry.
2016 May; 291(21):11172-84. doi:
10.1074/jbc.m116.726729. [PMID: 27026705] - Shawn J Stachel, Celina Zerbinatti, Michael T Rudd, Mali Cosden, Sokreine Suon, Kausik K Nanda, Keith Wessner, Jillian DiMuzio, Jill Maxwell, Zhenhua Wu, Jason M Uslaner, Maria S Michener, Peter Szczerba, Edward Brnardic, Vanessa Rada, Yuntae Kim, Robert Meissner, Peter Wuelfing, Yang Yuan, Jeanine Ballard, Marie Holahan, Daniel J Klein, Jun Lu, Xavier Fradera, Gopal Parthasarathy, Victor N Uebele, Zhongguo Chen, Yingjie Li, Jian Li, Andrew J Cooke, D Jonathan Bennett, Mark T Bilodeau, John Renger. Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
Journal of medicinal chemistry.
2016 Apr; 59(7):3489-98. doi:
10.1021/acs.jmedchem.6b00176. [PMID: 27011007] - Benjamin Lemaire, Akira Kubota, Conor M O'Meara, David C Lamb, Robert L Tanguay, Jared V Goldstone, John J Stegeman. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.
Toxicology and applied pharmacology.
2016 Apr; 296(?):73-84. doi:
10.1016/j.taap.2016.02.001. [PMID: 26853319] - Xiaohan Lu, Fei Wang, Chuanming Xu, Sunny Soodvilai, Kexin Peng, Jiahui Su, Long Zhao, Kevin T Yang, Yumei Feng, Shu-Feng Zhou, Jan-Åke Gustafsson, Tianxin Yang. Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor.
Proceedings of the National Academy of Sciences of the United States of America.
2016 Mar; 113(13):E1898-906. doi:
10.1073/pnas.1602397113. [PMID: 26984496] - Akihiro Shimada, Hideki Kimura, Koji Oida, Hideo Kanehara, Yukihiro Bando, Shinobu Sakamoto, Takanobu Wakasugi, Takashi Saga, Yasuki Ito, Kazuko Kamiyama, Daisuke Mikami, Masayuki Iwano, Tsutomu Hirano, Haruyoshi Yoshida. Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association.
Lipids in health and disease.
2016 Mar; 15(?):57. doi:
10.1186/s12944-016-0223-6. [PMID: 26984517] - Olivier Briand, Véronique Touche, Sophie Colin, Gemma Brufau, Alberto Davalos, Marleen Schonewille, Fabiola Bovenga, Véronique Carrière, Jan Freark de Boer, Camille Dugardin, Béatrice Riveau, Véronique Clavey, Anne Tailleux, Antonio Moschetta, Miguel A Lasunción, Albert K Groen, Bart Staels, Sophie Lestavel. Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1.
Gastroenterology.
2016 Mar; 150(3):650-8. doi:
10.1053/j.gastro.2015.11.015. [PMID: 26602218] - Caroline Lucia Pinto, Sharanya Maanasi Kalasekar, Catherine W McCollum, Anne Riu, Philip Jonsson, Justin Lopez, Eric C Swindell, Abdel Bouhlatouf, Patrick Balaguer, Maria Bondesson, Jan-Åke Gustafsson. Lxr regulates lipid metabolic and visual perception pathways during zebrafish development.
Molecular and cellular endocrinology.
2016 Jan; 419(?):29-43. doi:
10.1016/j.mce.2015.09.030. [PMID: 26427652] - Dorota Harasiuk, Marcin Baranowski, Piotr Zabielski, Adrian Chabowski, Jan Górski. Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(1):350-9. doi:
10.1159/000445629. [PMID: 27352290] - Hidehiro Furumoto, Tharnath Nanthirudjanar, Takashi Hirata, Tatsuya Sugawara. Dietary Effects of Oxidized Eicosapentaenoic Acid (EPA) and Intact EPA on Hepatic Steatosis Induced by a High-sucrose Diet and Liver-X-receptor α Agonist in Mice.
Journal of oleo science.
2016; 65(3):233-40. doi:
10.5650/jos.ess15227. [PMID: 26876675] - Meng Yang, Rong Wang, Jing Sun, Kezhou Yu, Bing Chen, Liang Xu, Bing Zhao, Haiping Wang. The liver X receptor agonist TO901317 protects mice against cisplatin-induced kidney injury.
Experimental biology and medicine (Maywood, N.J.).
2015 Dec; 240(12):1717-27. doi:
10.1177/1535370215589906. [PMID: 26062799] - Norimasa Tamehiro, Min Hi Park, Victoria Hawxhurst, Kamalpreet Nagpal, Marv E Adams, Vassilis I Zannis, Douglas T Golenbock, Michael L Fitzgerald. LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.
Biochemistry.
2015 Nov; 54(46):6931-41. doi:
10.1021/acs.biochem.5b00894. [PMID: 26506427] - Tharnath Nanthirudjanar, Hidehiro Furumoto, Jiawen Zheng, Young-Il Kim, Tsuyoshi Goto, Nobuyuki Takahashi, Teruo Kawada, Si-Bum Park, Akiko Hirata, Nahoko Kitamura, Shigenobu Kishino, Jun Ogawa, Takashi Hirata, Tatsuya Sugawara. Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes.
Lipids.
2015 Nov; 50(11):1093-102. doi:
10.1007/s11745-015-4067-z. [PMID: 26399511] - Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee. AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells.
Molecular and cellular endocrinology.
2015 Oct; 414(?):148-55. doi:
10.1016/j.mce.2015.07.031. [PMID: 26254015] - Kun He, Zhuo-Ya Dai, Pei-Zhi Li, Xi-Wen Zhu, Jian-Ping Gong. Association between liver X receptor-α and neuron-derived orphan nuclear receptor-1 in Kupffer cells of C57BL/6 mice during inflammation.
Molecular medicine reports.
2015 Oct; 12(4):6098-104. doi:
10.3892/mmr.2015.4155. [PMID: 26239564]