Benidipine hydrochloride (BioDeep_00000015461)

   


代谢物信息卡片


Benidipine hydrochloride

化学式: C28H32ClN3O6 (541.1979522)
中文名称: (-)-α-盐酸贝尼地平, 贝尼地平盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
InChI: /m1./s1

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C93038 - Cation Channel Blocker

同义名列表

2 个代谢物同义名

Benidipine hydrochloride; (-)-α-Benidipine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Y Kato, H Tanaka, T Saijyo, O Hattori, K Suzuki, T Hara, T Deguchi. Effect of the new calcium antagonist (+/-)-(R*)-3-[(R*)-1-benzyl-3- piperidyl] methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5- pyridinedicarboxylate hydrochloride (KW-3049) on cardiac hypertrophy in spontaneously hypertensive rats. The Journal of toxicological sciences. 1993 Aug; 18 Suppl 3(?):21-31. doi: 10.2131/jts.18.supplementiii_21. [PMID: 7505033]
  • K Higo, A Karasawa, K Kubo. Protective effects of benidipine hydrochloride (KW-3049), a calcium antagonist, against experimental arterial calcinosis and endothelial dysfunction in rats. Journal of pharmacobio-dynamics. 1992 Mar; 15(3):113-20. doi: 10.1248/bpb1978.15.113. [PMID: 1625168]
  • M Yamamoto, Y Gotoh, Y Imaizumi, M Watanabe. Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells. British journal of pharmacology. 1990 Aug; 100(4):669-76. doi: 10.1111/j.1476-5381.1990.tb14074.x. [PMID: 2169935]
  • A Karasawa, K Kubo. Protection by benidipine hydrochloride (KW-3049), a calcium antagonist, of ischemic kidney in rats via inhibitions of Ca-overload, ATP-decline and lipid peroxidation. Japanese journal of pharmacology. 1990 Apr; 52(4):553-62. doi: 10.1254/jjp.52.553. [PMID: 2342226]
  • S Akinaga, H Kobayashi, S Kobayashi, A Inoue, N Nakamizo, T Oka. Determination of the calcium antagonist benidipine hydrochloride in plasma by sensitive radioimmunoassay. Arzneimittel-Forschung. 1988 Nov; 38(11A):1738-41. doi: NULL. [PMID: 3219151]
  • A Ishii, K Nishida, T Oka, N Nakamizo. Sensitive radioreceptor assay of the calcium antagonist benidipine hydrochloride in plasma and urine. Arzneimittel-Forschung. 1988 Nov; 38(11A):1733-7. doi: NULL. [PMID: 3219150]
  • H Kobayashi, S Kobayashi, A Inoue, T Oka, N Nakamizo. Gas chromatographic method for the quantification of the new calcium antagonist benidipine hydrochloride in plasma using electron capture detection. Arzneimittel-Forschung. 1988 Nov; 38(11A):1730-3. doi: NULL. [PMID: 3219149]
  • H Kobayashi, T Ohishi, H Nishiie, S Kobayashi, A Inoue, T Oka, N Nakamizo. Absorption, distribution and excretion after oral administration of 14C-benidipine hydrochloride in rats and dogs. Arzneimittel-Forschung. 1988 Nov; 38(11A):1742-6. doi: NULL. [PMID: 3219152]
  • H Kobayashi, S Kobayashi, A Inoue, T Oka, N Nakamizo. Pharmacokinetic study of benidipine hydrochloride in rats and dogs. Arzneimittel-Forschung. 1988 Nov; 38(11A):1750-3. doi: NULL. [PMID: 3219154]
  • H Kobayashi, T Ohishi, H Nishiie, S Kobayashi, A Inoue, T Oka, N Nakamizo. Absorption, distribution and excretion of 14C-benidipine hydrochloride after repeated administration to rats. Arzneimittel-Forschung. 1988 Nov; 38(11A):1747-9. doi: NULL. [PMID: 3219153]
  • Y Fuji, H Suzuki, H Katsumata, S Nakajima, T Saruta. Hormonal and renal responses to oral once-daily calcium entry blocker in normotensive and hypertensive persons. Journal of cardiovascular pharmacology. 1988 Apr; 11(4):438-43. doi: 10.1097/00005344-198804000-00009. [PMID: 2453747]