Apatinib (BioDeep_00000015459)
Main id: BioDeep_00000176131
代谢物信息卡片
Apatinib
化学式: C24H23N5O (397.1902508)
中文名称: 阿帕替尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
InChI: InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGG: C76598
- KEGGdrug: D11288
- PubChem: 11315474
- DrugBank: DB14765
- ChEMBL: CHEMBL3186534
- CAS: 811803-05-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingtao Liu, Hui Li, Ranran Guo, Xia Yu, Yu Li. The inhibitory effect of apatinib on different small cell lung cancer cells and in lung cancer-bearing mice and patients.
The clinical respiratory journal.
2024 Feb; 18(2):e13738. doi:
10.1111/crj.13738. [PMID: 38403875] - Juan Ren, Jun Yan, Faisal Raza, Hajra Zafar, Haopeng Wan, Xue Chen, Qingrong Cui, Haiyang Li, Xiangqi Wang. A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury.
Recent patents on anti-cancer drug discovery.
2024; 19(2):199-208. doi:
10.2174/1574892818666230417093208. [PMID: 38214359] - Weixue Wang, Tongtong Wang, Yan Zhang, Ting Deng, Haiyang Zhang, Y I Ba. Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells.
Oncology research.
2024; 32(3):489-502. doi:
10.32604/or.2023.046676. [PMID: 38370339] - Yan Zhou, Mei Li, Bing Zhang, Cheng Yang, Yaling Wang, Shuier Zheng, Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li, Yonggang Wang, Aina He, Zan Shen, Jianjun Zhang, Xiaoshuang Li, Qingcheng Yang, Haiyan Hu, Yang Yao. A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas.
BMC medicine.
2023 Nov; 21(1):470. doi:
10.1186/s12916-023-03132-x. [PMID: 38031088] - Jin Li, Shukui Qin, Lu Wen, Junsheng Wang, Wenying Deng, Weijian Guo, Tongfu Jia, Da Jiang, Guifang Zhang, Yifu He, Yi Ba, Haijun Zhong, Lin Wang, Xiaoyan Lin, Jianwei Yang, Jun Zhao, Yuxian Bai, Xiangyuan Wu, Feng Gao, Guogui Sun, Yongjuan Wu, Feng Ye, Qiong Wang, Zhong Xie, Tienan Yi, Yong Huang, Guohua Yu, Lin Lu, Ying Yuan, Wei Li, Likun Liu, Yuping Sun, Ying Sun, Lifeng Yin, Zhiguo Hou. Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a prospective, single-arm, multicenter, phase IV study.
BMC medicine.
2023 05; 21(1):173. doi:
10.1186/s12916-023-02841-7. [PMID: 37147645] - Xu Liu, Ling Guo, Fang-Yun Xie, Wei-Han Hu, Ming-Yuan Chen, Qing-Mei He, Zhi-Min Xu, Chu-Qing Zhang, Ying-Lin Peng, Ling-Long Tang, Yan-Ping Mao, Rui Sun, Ji-Bin Li, Athanassios Argiris, Edwin P Hui, Ying Sun, Jun Ma. Adjuvant Apatinib in Nasopharyngeal Carcinoma With Residual Epstein-Barr Virus DNA After Radiation Therapy: A Biomarker-Driven, Phase 2 Trial.
International journal of radiation oncology, biology, physics.
2022 Aug; 113(5):1063-1071. doi:
10.1016/j.ijrobp.2022.04.049. [PMID: 35550406] - Pingfan Zhou, Wanwan Xiao, Xiaoshuang Wang, Yayun Wu, Ruizhi Zhao, Yan Wang. A Comparison Study on Polysaccharides Extracted from Atractylodes chinensis (DC.) Koidz. Using Different Methods: Structural Characterization and Anti-SGC-7901 Effect of Combination with Apatinib.
Molecules (Basel, Switzerland).
2022 Jul; 27(15):. doi:
10.3390/molecules27154727. [PMID: 35897903] - Yongxiang Xia, Weiwei Tang, Xiaofeng Qian, Xiangcheng Li, Feng Cheng, Ke Wang, Feng Zhang, Chuanyong Zhang, Donghua Li, Jinhua Song, Hui Zhang, Jie Zhao, Aihua Yao, Xiaofeng Wu, Chen Wu, Guwei Ji, Xisheng Liu, Feipeng Zhu, Lang Qin, Xuan Xiao, Zhenhua Deng, Xiangyi Kong, Si Li, Yangyang Yu, Wenjing Xi, Wanglong Deng, Chuang Qi, Hanyuan Liu, Liyong Pu, Ping Wang, Xuehao Wang. Efficacy and safety of camrelizumab plus apatinib during the perioperative period in resectable hepatocellular carcinoma: a single-arm, open label, phase II clinical trial.
Journal for immunotherapy of cancer.
2022 04; 10(4):. doi:
10.1136/jitc-2022-004656. [PMID: 35379737] - Nazila Fathi Maroufi, Mohsen Rashidi, Vahid Vahedian, Raheleh Jahanbazi, Sahar Mostafaei, Maryam Akbarzadeh, Hamid Kazemzadeh, Hamid-Reza Nejabati, Alireza Isazadeh, Mohammad-Reza Rashidi, Mohammad Nouri. Effect of Apatinib plus melatonin on vasculogenic mimicry formation by cancer stem cells from breast cancer cell line.
Breast cancer (Tokyo, Japan).
2022 Mar; 29(2):260-273. doi:
10.1007/s12282-021-01310-4. [PMID: 34725795] - Ming Li, Ou Cai, Yuanjie Yu, Shiyun Tan. Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Feb; 96(?):153903. doi:
10.1016/j.phymed.2021.153903. [PMID: 35026514] - Fanjie Qu, Shuang Wu, Jie Zhang. Tislelizumab combined with apatinib in the treatment of advanced renal clear cell carcinoma: a case report.
Anti-cancer drugs.
2022 01; 33(1):e834-e839. doi:
10.1097/cad.0000000000001241. [PMID: 34459463] - Dawei Ren, Mi Feng, Shengmin Zhang, Yun Zhang, Ji Li. Effect of Apatinib Combined with Seggio on the Expression of Serum AFP and CA724 and Long-Term Survival Rate in Patients with Advanced Gastric Cancer Undergoing Comfortable Nursing Intervention.
Journal of healthcare engineering.
2022; 2022(?):2004973. doi:
10.1155/2022/2004973. [PMID: 35432838] - YanWei Li, Feng He, Yu Zhang, ZhanYu Pan. Apatinib and Ginsenoside-Rb1 Synergetically Control the Growth of Hypopharyngeal Carcinoma Cells.
Disease markers.
2022; 2022(?):3833489. doi:
10.1155/2022/3833489. [PMID: 35069931] - Fengli Zhang, Yanfen Yin, Wenwen Xu, Zhou Zhou, Xin Sun, Ping Li. Apatinib combined with Keytruda treatment induces apoptosis of gastric carcinoma cells through CES4/miR-616-5p/DUSP2 axis.
Basic & clinical pharmacology & toxicology.
2021 Nov; 129(5):345-356. doi:
10.1111/bcpt.13641. [PMID: 34365722] - Hongyan Cheng, Liju Zong, Yujia Kong, Xiaoyu Wang, Yu Gu, Wei Cang, Jun Zhao, Xirun Wan, Junjun Yang, Yang Xiang. Camrelizumab plus apatinib in patients with high-risk chemorefractory or relapsed gestational trophoblastic neoplasia (CAP 01): a single-arm, open-label, phase 2 trial.
The Lancet. Oncology.
2021 11; 22(11):1609-1617. doi:
10.1016/s1470-2045(21)00460-5. [PMID: 34624252] - Congcong Ren, Jing Zhao, Lin Kang, Yan Di, Gang Qiu, Qingxue Wang. Successful treatment of radiotherapy and apatinib in patient with mediastinal mixed non-seminomatous germ cell tumor: A case report.
Medicine.
2021 Oct; 100(43):e27617. doi:
10.1097/md.0000000000027617. [PMID: 34713845] - Hao Chen, Tao Jiang, Fangyu Lin, Hongdan Guan, Jianwei Zheng, Qing Liu, Bing Du, Yeyuan Huang, Xiaoyan Lin. PD-1 inhibitor combined with apatinib modulate the tumor microenvironment and potentiate anti-tumor effect in mice bearing gastric cancer.
International immunopharmacology.
2021 Oct; 99(?):107929. doi:
10.1016/j.intimp.2021.107929. [PMID: 34343940] - Zhenjie Ye, Lingjie Wu, Xiaoying Zhang, Yingying Hu, Ling Zheng. Quantification of sorafenib, lenvatinib, and apatinib in human plasma for therapeutic drug monitoring by UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2021 Aug; 202(?):114161. doi:
10.1016/j.jpba.2021.114161. [PMID: 34052550] - Song-Bo Kou, Zhen-Yi Lin, Bao-Li Wang, Jie-Hua Shi, Ying-Xin Liu. Evaluation of the interaction of novel tyrosine kinase inhibitor apatinib mesylate with bovine serum albumin using spectroscopies and theoretical calculation approaches.
Journal of biomolecular structure & dynamics.
2021 Aug; 39(13):4795-4806. doi:
10.1080/07391102.2020.1782767. [PMID: 32568635] - Shukui Qin, Qiu Li, Shanzhi Gu, Xiaoming Chen, Lizhu Lin, Zishu Wang, Aibing Xu, Xi Chen, Cuncai Zhou, Zhenggang Ren, Lin Yang, Li Xu, Yuxian Bai, Lei Chen, Jun Li, Hongming Pan, Bangwei Cao, Weijia Fang, Wei Wu, Ge Wang, Ying Cheng, Zhuang Yu, Xu Zhu, Da Jiang, Yinying Lu, Huaming Wang, Jianming Xu, Li Bai, Yunpeng Liu, Hailan Lin, Changping Wu, Yang Zhang, Ping Yan, Chunlei Jin, Jianjun Zou. Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
The lancet. Gastroenterology & hepatology.
2021 07; 6(7):559-568. doi:
10.1016/s2468-1253(21)00109-6. [PMID: 33971141] - Hui Chen, Liangjun Xue, Lihong Liu, Pengfei Li. Efficacy of apatinib combined with tegafur gimeracil and oteracil potassium in the second-line treatment of advanced gastric cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 May; 26(3):917-923. doi:
. [PMID: 34268954] - Liying Zhao, Yanmei Peng, Sixiao He, Ru Li, Ziqing Wang, Junhao Huang, Xuetao Lei, Guoxin Li, Qiang Ma. Apatinib induced ferroptosis by lipid peroxidation in gastric cancer.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2021 May; 24(3):642-654. doi:
10.1007/s10120-021-01159-8. [PMID: 33544270] - Jieqiong Liu, Ying Li, Qian Li, Dandan Liang, Quanren Wang, Qiang Liu. Biomarkers of response to camrelizumab combined with apatinib: an analysis from a phase II trial in advanced triple-negative breast cancer patients.
Breast cancer research and treatment.
2021 Apr; 186(3):687-697. doi:
10.1007/s10549-021-06128-4. [PMID: 33634417] - Madhav Sachar, Cheol Hee Park, Luana Pesco-Koplowitz, Barry Koplowitz, Arlo McGinn. Absence of ethnic difference on single-dose pharmacokinetics of rivoceranib between healthy male Caucasian, Japanese, and Chinese subjects.
Fundamental & clinical pharmacology.
2021 Apr; 35(2):485-495. doi:
10.1111/fcp.12619. [PMID: 33098705] - Xiufeng Cong, Jun Chen, Wei Zheng. The combination of camrelizumab and apatinib obtained ongoing partial remission for a patient with osimertinib-resistant non-small cell lung cancer: case report.
Annals of palliative medicine.
2021 Mar; 10(3):3469-3474. doi:
10.21037/apm-19-462. [PMID: 33040541] - Zhaonan Li, Quanjing Chen, Wenguang Zhang, Guangyan Si, Jing Li, Dechao Jiao, Xinwei Han. Efficacy and Safety of the Arsenic Trioxide/Lipiodol Emulsion in the Transcatheter Arterial Chemoembolization Combined with Apatinib in the Treatment of Advanced Hepatocellular Carcinoma.
Canadian journal of gastroenterology & hepatology.
2021; 2021(?):5565793. doi:
10.1155/2021/5565793. [PMID: 34458205] - Yongjuan Wu, Guangyuan Cheng, Hui Chen, Jingzhong Wang, Jiangtao Wang, Wanbi Wang. IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma.
Clinical hemorheology and microcirculation.
2021; 77(1):37-47. doi:
10.3233/ch-200857. [PMID: 32651310] - Salma El-Sayed Radwan, Amal El-Kamel, Eiman I Zaki, Susi Burgalassi, Erica Zucchetti, Riham M El-Moslemany. Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy.
International journal of nanomedicine.
2021; 16(?):4481-4494. doi:
10.2147/ijn.s316564. [PMID: 34239300] - Dengke Hong, Jiajia Yang, Jingjing Guo, Yu Zhang, Zhikui Chen. Ultrasound-Targeted Microbubble Destruction Enhances Inhibitory Effect of Apatinib on Angiogenesis in Triple Negative Breast Carcinoma Xenografts.
Analytical cellular pathology (Amsterdam).
2021; 2021(?):8837950. doi:
10.1155/2021/8837950. [PMID: 33959473] - Qin Shi, Yongning Lu, Songjiang Huang, Chen Zhou, Chongtu Yang, Jiacheng Liu, Jinqiang Ma, Bin Xiong. Apatinib-loaded CalliSpheres Beads for embolization in a rabbit VX2 liver tumor: characterization in vitro, pharmacokinetics and tumor response in vivo.
Drug delivery.
2020 Dec; 27(1):1301-1307. doi:
10.1080/10717544.2020.1818881. [PMID: 32924634] - Yan Cui, Yuxuan Cao, Muyang Cao, Xueting Chen, Guobin Liu, Hui Chen. Efficacy and safety of apatinib monotherapy in metastatic renal cell carcinoma (mRCC) patients: A single-arm observational study.
Urologic oncology.
2020 12; 38(12):936.e1-936.e6. doi:
10.1016/j.urolonc.2020.07.023. [PMID: 32839081] - Jinglin Gao, Huan Ren, Zhangying Feng, Shanshan Chen, Yu Liang, Wanqiu Liu, Qian Zhou, Mingxia Wang. Effects of multidose simvastatin co-administration on pharmacokinetic profile of apatinib in rats by UPLC-MS/MS.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Sep; 50(9):1115-1120. doi:
10.1080/00498254.2020.1740952. [PMID: 32150479] - Yunchao Zhang, Shiqiang Yin, Yingjie Jia, Lei Qin. Safety and efficacy of apatinib combined with iodine-125 in chemotherapy-refractory advanced lung cancer: A case report.
Medicine.
2020 Aug; 99(33):e21600. doi:
10.1097/md.0000000000021600. [PMID: 32872014] - Fengli Zhang, Yanfen Yin, Tiantian Ni, Mei Zhang, Zhou Zhou, Xin Sun, Wanghao Kuang, Ping Li. Treatment effect of apatinib combined chemotherapy as second-line or above therapy in patients with advanced gastric cancer or adenocarcinoma of the gastroesophageal junction.
Die Pharmazie.
2020 08; 75(8):389-394. doi:
10.1691/ph.2020.0403. [PMID: 32758339] - Sheng-Quan Fang, Jian Huang, Feng Zhang, Hong-Mei Ni, Qi-Long Chen, Jun-Ran Zhu, Zhi-Chao Fu, Liang Zhu, Wei-Wei Hao, Guang-Bo Ge. Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo.
The Journal of pharmacy and pharmacology.
2020 Jul; 72(7):979-989. doi:
10.1111/jphp.13268. [PMID: 32285478] - Yingying Du, Qisheng Cao, Congqiao Jiang, Hui Liang, Zhongliang Ning, Chushu Ji, Jinguo Wang, Chaoping Zhou, Zonghui Jiang, Changjun Yu, Lei Li, Yong Zhao, Yuemei Xu, Tengyun Xu, Wenjun Hu, Daoqin Wang, Huaidong Cheng, Guihe Wang, Jinhua Zhou, Song Wang, Yanshun Zhang, Zhiqiang Hu, Xinzhong Li, Donghui Lu, Jun Zhang, Hua Xie, Guoping Sun. Effectiveness and safety of low-dose apatinib in advanced gastric cancer: A real-world study.
Cancer medicine.
2020 07; 9(14):5008-5014. doi:
10.1002/cam4.3105. [PMID: 32441892] - Fen Wang, Xia Yuan, Jun Jia, Xiaoxia Bi, Zeqiang Zhou, Qiming Zhou, Xia Li, Changguo Luo, Minghui Deng, Liangjie Yi, Yong Li, Jianxin Lu, Wenzhi Su, Hanbin Chen, Yu Zhu, Shubin Wang. Apatinib Monotherapy for Chemotherapy-Refractory Metastatic Colorectal Cancer: A Multi-centre, Single-Arm, Prospective Study.
Scientific reports.
2020 04; 10(1):6058. doi:
10.1038/s41598-020-62961-5. [PMID: 32269247] - Xin Li, Minghui Liu, Hongbing Zhang, Hongyu Liu, Jun Chen. Clinical study of apatinib combined with EGFR-TKI in the treatment of chronic progression after EGFR-TKI treatment in non-small cell lung cancer (ChiCTR1800019185).
Thoracic cancer.
2020 03; 11(3):819-826. doi:
10.1111/1759-7714.13303. [PMID: 31918452] - X R Chen, Z Chang, H Q Wang. [Hypothyroidism caused by apatinib in patient with lung metastasis from rectal adenocarcinoma: a case report].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2019 12; 41(12):959-960. doi:
10.3760/cma.j.issn.0253-3766.2019.12.014. [PMID: 31874556] - Jieshan Guan, Zhijie Luo, Zhiwei Xiao, Yubin Xie, Lizhu Lin. Treatment of consistent BRAF/HRAS gene mutation and MYC amplification radiation-induced abdominal wall angiosarcoma with low-dose apatinib: a case report.
BMC cancer.
2019 Dec; 19(1):1188. doi:
10.1186/s12885-019-6351-4. [PMID: 31805975] - Sumei Chen, Ke Zhang, Xianqin Wan, Yuanyuan Chen, Shenglin Ma, Qinghua Deng. The use of apatinib in treating primary pleural synovial sarcoma: A case report.
Medicine.
2019 Dec; 98(51):e18382. doi:
10.1097/md.0000000000018382. [PMID: 31861000] - Xian Wu, Shucheng Huang. HER2-specific chimeric antigen receptor-engineered natural killer cells combined with apatinib for the treatment of gastric cancer.
Bulletin du cancer.
2019 Nov; 106(11):946-958. doi:
10.1016/j.bulcan.2019.03.012. [PMID: 31711572] - Y F Li, H Y Jiang, Q Li, M Zhu, J Lyu, H Y Zhao. [Clinical study of apatinib combined with chemotherapy for advanced non-small cell lung cancer with negative driving genes].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2019 Oct; 41(10):775-781. doi:
10.3760/cma.j.issn.0253-3766.2019.10.010. [PMID: 31648501] - Siqi Feng, Huan Wang, Ying Wang, Runbin Sun, Yuan Xie, Zhu Zhou, Hong Wang, Jiye Aa, Fang Zhou, Guangji Wang. Apatinib induces 3-hydroxybutyric acid production in the liver of mice by peroxisome proliferator-activated receptor α activation to aid its antitumor effect.
Cancer science.
2019 Oct; 110(10):3328-3339. doi:
10.1111/cas.14168. [PMID: 31429167] - Mingtao Liu, Xiuxiu Wang, Hui Li, Lisheng Xu, Lijun Jing, Peng Jiang, Baoyi Liu, Yu Li. The effect of apatinib combined with chemotherapy or targeted therapy on non-small cell lung cancer in vitro and vivo.
Thoracic cancer.
2019 10; 10(10):1868-1878. doi:
10.1111/1759-7714.13162. [PMID: 31486270] - Ping Fang, Liqin Zhang, Xianru Zhang, Jiawen Yu, Jun Sun, Qi-An Jiang, Mingbao Zha, Anastasia P Nesterova, Hongbao Cao. Apatinib Mesylate in the treatment of advanced progressed lung adenocarcinoma patients with EGFR-TKI resistance -A Multicenter Randomized Trial.
Scientific reports.
2019 Sep; 9(1):14013. doi:
10.1038/s41598-019-50350-6. [PMID: 31570733] - Yue Yu, Jing Shi, Feng Wang, Xiao-Hui Tang, Yu-Guo Liu. Quantification of the Plasma Concentration of Apatinib by 2-Dimensional Liquid Chromatography.
Therapeutic drug monitoring.
2019 08; 41(4):489-496. doi:
10.1097/ftd.0000000000000609. [PMID: 31083044] - Qian Liang, Lingxin Kong, Yang Du, Xu Zhu, Jie Tian. Antitumorigenic and antiangiogenic efficacy of apatinib in liver cancer evaluated by multimodality molecular imaging.
Experimental & molecular medicine.
2019 07; 51(7):1-11. doi:
10.1038/s12276-019-0274-7. [PMID: 31285418] - Jingjing Wang, Songqing Fan, Yeqian Feng, Haixia Zhang, Wen Zou, Chunhong Hu. Antiangiogenic therapy for Wilms tumor in an adult and literature review.
Anti-cancer drugs.
2019 07; 30(6):640-645. doi:
10.1097/cad.0000000000000792. [PMID: 30985306] - Kai Zhou, Jing-Wei Zhang, Qi-Zhi Wang, Wen-Yue Liu, Jia-Li Liu, Lan Yao, Ming-Min Cai, Sui-Ying Ni, Qing-Yun Cai, Guang-Ji Wang, Fang Zhou. Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice.
Acta pharmacologica Sinica.
2019 Apr; 40(4):556-562. doi:
10.1038/s41401-018-0058-y. [PMID: 29977004] - Dan Lou, Xiao Cui, Su-Su Bao, Wei Sun, Wen-He Pan, Meng-Chun Chen, Yao-Yao Dong, Guo-Xin Hu, Rui-Jie Chen, Zhe Wang. Effects of ketoconazole, voriconazole, and itraconazole on the pharmacokinetics of apatinib in rats.
Drug development and industrial pharmacy.
2019 Apr; 45(4):689-693. doi:
10.1080/03639045.2019.1569042. [PMID: 30632818] - Ying Zhang, Chen Chen, Meng Ren, Xiaofeng Cong, Zhi Li, Lei Yang. Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy: A case report.
Medicine.
2019 Mar; 98(13):e15050. doi:
10.1097/md.0000000000015050. [PMID: 30921232] - Jun Jin, Jiahao Du, Yanwei Wu. Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report.
Medicine.
2019 Jan; 98(1):e13491. doi:
10.1097/md.0000000000013491. [PMID: 30608382] - Ruixuan Geng, Li Song, Jin Li, Lin Zhao. The safety of apatinib for the treatment of gastric cancer.
Expert opinion on drug safety.
2018 Nov; 17(11):1145-1150. doi:
10.1080/14740338.2018.1535592. [PMID: 30324820] - Si-Qi Feng, Guang-Ji Wang, Jing-Wei Zhang, Yuan Xie, Run-Bin Sun, Fei Fei, Jing-Qiu Huang, Ying Wang, Ji-Ye Aa, Fang Zhou. Combined treatment with apatinib and docetaxel in A549 xenograft mice and its cellular pharmacokinetic basis.
Acta pharmacologica Sinica.
2018 Oct; 39(10):1670-1680. doi:
10.1038/aps.2018.16. [PMID: 29770798] - Chaoxu Yang, Shukui Qin. Apatinib targets both tumor and endothelial cells in hepatocellular carcinoma.
Cancer medicine.
2018 09; 7(9):4570-4583. doi:
10.1002/cam4.1664. [PMID: 30109780] - Fei Teng, Zhiyuan Xu, Jiahui Chen, Guowei Zheng, Guodian Zheng, Hang Lv, Yiping Wang, Lijing Wang, Xiangdong Cheng. DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer.
Oncology reports.
2018 Sep; 40(3):1203-1222. doi:
10.3892/or.2018.6520. [PMID: 29956792] - Yang Zhao, Ye Chen, Ke Cheng, Zhi-Ping Li, Hao Zeng, Ji-Yan Liu. Renal Ewing sarcoma treated with apatinib.
Anti-cancer drugs.
2018 08; 29(7):702-704. doi:
10.1097/cad.0000000000000630. [PMID: 29782348] - Siqi Feng, Jingwei Zhang, Ying Wang, Runbin Sun, Dong Feng, Ying Peng, Na Yang, Yue Zhang, Haoxue Gao, Huilin Gu, Guangji Wang, Jiye Aa, Fang Zhou. Application of liquid chromatography-tandem mass spectrometry to study the effect of docetaxel on pharmacokinetics and tissue distribution of apatinib in mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Apr; 1083(?):198-203. doi:
10.1016/j.jchromb.2018.03.017. [PMID: 29549743] - Jun Wu, Junxian Yu, Jing Wang, Chenguang Zhang, Kun Shang, Xiaojun Yao, Bangwei Cao. Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Apr; 100(?):176-183. doi:
10.1016/j.biopha.2018.01.140. [PMID: 29428665] - Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan, Lu Pan. Effective treatment of apatinib in desmoplastic small round cell tumor: a case report and literature review.
BMC cancer.
2018 03; 18(1):338. doi:
10.1186/s12885-018-4135-x. [PMID: 29587657] - Xiaoyun Liu, Yifan Zhang, Qian Chen, Yan Zhan, Quanren Wang, Chaoying Hu, Chen Yu, Zitao Guo, Xiaoyan Chen, Dafang Zhong. Pharmacokinetic Drug Interactions of Apatinib With Rifampin and Itraconazole.
Journal of clinical pharmacology.
2018 03; 58(3):347-356. doi:
10.1002/jcph.1016. [PMID: 28967981] - F Teng, Z Y Xu, H Lyu, Y P Wang, L J Wang, T Huang, J C Sun, H T Zhu, Y X Ni, X D Cheng. [Triptolide reverses apatinib resistance in gastric cancer cell line MKN45 via inhibition of heat shock protein 70].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2018 Feb; 40(2):92-98. doi:
10.3760/cma.j.issn.0253-3766.2018.02.003. [PMID: 29502367] - Jun Zhao, Xiaoling Zhang, Chaojie Gong, Jialei Zhang. Targeted therapy with apatinib in a patient with relapsed small cell lung cancer: A case report and literature review.
Medicine.
2017 Dec; 96(50):e9259. doi:
10.1097/md.0000000000009259. [PMID: 29390367] - Jia-Qi Wu, Jing Zhai, Chong-Yong Li, Ai-Min Tan, Ping Wei, Li-Zong Shen, Ming-Fang He. Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer.
Journal of experimental & clinical cancer research : CR.
2017 Nov; 36(1):160. doi:
10.1186/s13046-017-0631-0. [PMID: 29141689] - Mingzi Zhang, Zhongkai Tian, Yehong Sun. Successful treatment of ovarian cancer with apatinib combined with chemotherapy: A case report.
Medicine.
2017 Nov; 96(45):e8570. doi:
10.1097/md.0000000000008570. [PMID: 29137078] - Yansong Lin, Chen Wang, Wen Gao, Ruixue Cui, Jun Liang. Overwhelming rapid metabolic and structural response to apatinib in radioiodine refractory differentiated thyroid cancer.
Oncotarget.
2017 Jun; 8(26):42252-42261. doi:
10.18632/oncotarget.15036. [PMID: 28178685] - Jung Eun Lee, Koung Li Kim, Danbi Kim, Yeongju Yeo, Hyounkoo Han, Myung Goo Kim, Sun Hwa Kim, Hyuncheol Kim, Ji Hoon Jeong, Wonhee Suh. Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization.
International journal of nanomedicine.
2017; 12(?):4813-4822. doi:
10.2147/ijn.s135133. [PMID: 28740387] - Xue-Ru Zhu, Mei-Ling Zhu, Qing Wang, Wen-Ji Xue, Yi-Wei Wang, Rui-Fen Wang, Si-Yu Chen, Lei-Zhen Zheng. A case report of targeted therapy with apatinib in a patient with advanced gastric cancer and high serum level of alpha-fetoprotein.
Medicine.
2016 Sep; 95(37):e4610. doi:
10.1097/md.0000000000004610. [PMID: 27631210] - Dan Lin, Zhe Wang, Junwei Li, Li Wang, Shuanghu Wang, Guo-Xin Hu, Xinshe Liu. The Effect of Apatinib on the Metabolism of Carvedilol Both in vitro and in vivo.
Pharmacology.
2016; 97(1-2):31-7. doi:
10.1159/000441228. [PMID: 26569478] - Dan Lou, Li-man Qiao, Chen Cheng, Hui Zhang, Guo-xin Hu. Determination and Pharmacokinetic Study of Apatinib in Rat Plasma by UPLC.
Journal of chromatographic science.
2016 Jan; 54(1):17-21. doi:
10.1093/chromsci/bmv099. [PMID: 26194841] - Ji Hoon Jeong, Hong Khanh Nguyen, Jung Eun Lee, Wonhee Suh. Therapeutic effect of apatinib-loaded nanoparticles on diabetes-induced retinal vascular leakage.
International journal of nanomedicine.
2016; 11(?):3101-9. doi:
10.2147/ijn.s108452. [PMID: 27462154] - Juefang Ding, Xiaoyan Chen, Zhiwei Gao, Xiaojian Dai, Liang Li, Cen Xie, Haoyuan Jiang, Lijia Zhang, Dafang Zhong. Metabolism and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor apatinib in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Jun; 41(6):1195-210. doi:
10.1124/dmd.112.050310. [PMID: 23509226] - Juefang Ding, Xiaoyan Chen, Xiaojian Dai, Dafang Zhong. Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 May; 895-896(?):108-15. doi:
10.1016/j.jchromb.2012.03.027. [PMID: 22503745]