Irbesartan (BioDeep_00000001543)

 

Secondary id: BioDeep_00000397555

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one

化学式: C25H28N6O (428.2324478)
中文名称: 伊贝沙坦
谱图信息: 最多检出来源 Homo sapiens(blood) 13.94%

分子结构信息

SMILES: C12(C(N(Cc3ccc(c4c(c5[nH]nnn5)cccc4)cc3)C(=N1)CCCC)=O)CCCC2
InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

描述信息

Irbesartan is an angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It competes with angiotensin II for binding at the AT1 receptor subtype. Unlike ACE inhibitors, ARBs do not have the adverse effect of dry cough. The use of ARBs is pending revision due to findings from several clinical trials suggesting that this class of drugs may be associated with a small increased risk of cancer.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09C - Angiotensin ii receptor blockers (arbs), plain > C09CA - Angiotensin ii receptor blockers (arbs), plain
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2774
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

同义名列表

11 个代谢物同义名

2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one; 2-N-Butyl-3-((2-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one; 2-Butyl-3-{[2-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one; irbesartan; BMS 186295; Aprovel; Avapro; Karvea; SR-47436; BMS-186295; Irbesartan



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhenjie Chen, Jiajia Bai, Liwen Niu. Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis. The New England journal of medicine. 2024 Mar; 390(12):1154. doi: 10.1056/nejmc2401126. [PMID: 38507768]
  • Nural Pastacı Özsobacı, Metehan Karataş, Matem Tunçdemir, Derviş Özcelik. Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker on oxidative stress and metabolism of elements in kidney of STZ-induced diabetic rats. Archives of biochemistry and biophysics. 2024 Jan; 751(?):109851. doi: 10.1016/j.abb.2023.109851. [PMID: 38065251]
  • Jinxi Zhao, Shidong Wang, Xiaoran Li, Guangde Zhang, Yuan Xu, Xianling Zheng, Jian Guo, Zhenxian Zhang. A Prospective, Multicentered, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Keluoxin Capsules in the Treatment of Microalbuminuria in Patients with Type 2 Early Diabetic Kidney Disease. Journal of integrative and complementary medicine. 2023 Sep; ?(?):. doi: 10.1089/jicm.2022.0809. [PMID: 37733303]
  • Haozhen Wang, Ziyin Lu, Yang Li, Ting Liu, Linlin Zhao, Tianqi Gao, Xiuli Lu, Bing Gao. Virtual Screening of Novel 24-Dehydroxysterol Reductase (DHCR24) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062643. [PMID: 36985615]
  • Rui Li, Chuanzhou Liang, Sif B Svendsen, Vaidotas Kisielius, Kai Bester. Sartan blood pressure regulators in classical and biofilm wastewater treatment - Concentrations and metabolism. Water research. 2023 Feb; 229(?):119352. doi: 10.1016/j.watres.2022.119352. [PMID: 36450176]
  • Narendar Dudhipala, Swetha Ettireddy, Ahmed Adel Ali Youssef, Goverdhan Puchchakayala. Development and In vivo Pharmacokinetic and Pharmacodynamic Evaluation of an Oral Innovative Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan Formulation for Enhanced Bioavailability. Nanotheranostics. 2023; 7(1):117-127. doi: 10.7150/ntno.78102. [PMID: 36593793]
  • Y U Lu, Tsutomu Miyamoto, Hodaka Takeuchi, Fumi Tsunoda, Naoki Tanaka, Tanri Shiozawa. PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A. Oncology research. 2023; 31(3):239-253. doi: 10.32604/or.2023.026067. [PMID: 37305395]
  • Pei-Ying Pai, Yi-Yuan Lin, Shao-Hong Yu, Ching-Yuang Lin, Yi-Fan Liou, Xu-Bo Wu, James K S Wong, Chih-Yang Huang, Shin-Da Lee. Angiotensin II receptor blocker irbesartan attenuates sleep apnea-induced cardiac apoptosis and enhances cardiac survival and Sirtuin 1 upregulation. Sleep & breathing = Schlaf & Atmung. 2022 09; 26(3):1161-1172. doi: 10.1007/s11325-021-02499-6. [PMID: 34626328]
  • Jing Zhao, Isabelle Tostivint, Lingdong Xu, Jihan Huang, Laetitia Gambotti, Jean-Jacques Boffa, Min Yang, Ling Wang, Zhuxing Sun, Xiaolan Chen, Amélie Liou-Schischmanoff, Alain Baumelou, Teng Ma, Guoyuan Lu, Ling Li, Dai Chen, Laurence Piéroni, Bingkai Liu, Xiao Qin, Weiming He, Yuejuan Wang, Harvest F Gu, Wei Sun. Efficacy of Combined Abelmoschus manihot and Irbesartan for Reduction of Albuminuria in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Multicenter Randomized Double-Blind Parallel Controlled Clinical Trial. Diabetes care. 2022 07; 45(7):e113-e115. doi: 10.2337/dc22-0607. [PMID: 35613364]
  • İlter İlhan, Halil Aşçi, Nursel Hasseyid, Hatice Kubra Doğan, Şerife Ağirca, Melike Altintaş, Muhammet Yusuf Tepebasi. Irbesartan decreased mitochondrial stress related apoptosis in cisplatin induced acute kidney injury via regulating BCL-2/BAX signaling. Molecular biology reports. 2022 Jul; 49(7):6125-6133. doi: 10.1007/s11033-022-07403-3. [PMID: 35366178]
  • Jian Gao, Zheng Liang, Fei Zhao, Xiaojing Liu, Ning Ma. Triptolide inhibits oxidative stress and inflammation via the microRNA-155-5p/brain-derived neurotrophic factor to reduce podocyte injury in mice with diabetic nephropathy. Bioengineered. 2022 05; 13(5):12275-12288. doi: 10.1080/21655979.2022.2067293. [PMID: 35603354]
  • Shaoqi Zuo, Haoyu Meng, Jiahui Liang, Huajun Zhen, Ying Zhu, Yanbin Zhao, Kun Zhang, Jiayin Dai. Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China. Environmental science & technology. 2022 02; 56(4):2312-2322. doi: 10.1021/acs.est.1c05520. [PMID: 35129343]
  • F P Zhang, X Jiang. The efficacy and safety of canagliflozin in the treatment of patients with early diabetic nephropathy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2022 Feb; 73(1):. doi: 10.26402/jpp.2022.1.06. [PMID: 35639038]
  • Sally E Abu-Risha, Mai A Mousa, Alaa E Elsisi. Protective role of irbesartan against cyclophosphamide-induced testicular damage in rats via up-regulating PPAR-γ signaling and ameliorating NF-κB/NLRP3/IL-18 inflammatory axis. Life sciences. 2022 Jan; 289(?):120218. doi: 10.1016/j.lfs.2021.120218. [PMID: 34890588]
  • Narendar Dudhipala, Swetha Ettireddy, Ahmed Adel Ali Youssef, Goverdhan Puchchakayala. Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan for Oral Applications: Design, Development, and In Vitro Characterization. Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247538. [PMID: 34946619]
  • Di Zhang, Qi-Fang Huang, Yan Li, Ji-Guang Wang. Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination. Blood pressure monitoring. 2021 Dec; 26(6):413-418. doi: 10.1097/mbp.0000000000000554. [PMID: 34128490]
  • Junting Weng, Min Chen, Rongjie Guo, Shuzhen Yang, Danjuan Liu, Dexiang Fang. The antihypertensive effect of irbesartan in spontaneously hypertensive rats is associated with improvement of the leptin-adiponectin imbalance. Adipocyte. 2021 12; 10(1):101-107. doi: 10.1080/21623945.2021.1886409. [PMID: 33570444]
  • Ann B Moser, Yanqiu Liu, Xiaohai Shi, Ulrike Schrifl, Shandi Hiebler, Ali Fatemi, Nancy E Braverman, Steven J Steinberg, Paul A Watkins. Drug discovery for X-linked adrenoleukodystrophy: An unbiased screen for compounds that lower very long-chain fatty acids. Journal of cellular biochemistry. 2021 10; 122(10):1337-1349. doi: 10.1002/jcb.30014. [PMID: 34056752]
  • Yiliyaer Nijiati, Lianlian Shan, Tao Yang, Maiwulanijiang Yizibula, Ainiwaer Aikemu. A 1H NMR spectroscopic metabolomic study of the protective effects of irbesartan in a rat model of chronic mountain sickness. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 204(?):114235. doi: 10.1016/j.jpba.2021.114235. [PMID: 34252817]
  • Hao Zhou, Wenyue Li, Ling Sun, Wenfang Li, Qian Liu. A rapid LC-MS/MS method for simultaneous determination of berberine and irbesartan in rat plasma: Application to the drug-drug pharmacokinetic interaction study after oral administration in rats. Biomedical chromatography : BMC. 2021 Sep; 35(9):e5144. doi: 10.1002/bmc.5144. [PMID: 33880775]
  • M Piazza, N M J Hanssen, F Persson, J L Scheijen, M P H van de Waarenburg, M M J van Greevenbroek, P Rossing, P Hovind, C D A Stehouwer, H-H Parving, C G Schalkwijk. Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. Diabetic medicine : a journal of the British Diabetic Association. 2021 09; 38(9):e14405. doi: 10.1111/dme.14405. [PMID: 32961617]
  • Yiliyaer Nijiati, Tao Yang, Mutalifu Aimaiti, Dilinuer Maimaitiyiming, Ainiwaer Aikemu. Irbesartan ameliorates chronic mountain sickness in a rat model via the cholesterol metabolism: An iTRAQ -based proteomics analysis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111802. doi: 10.1016/j.biopha.2021.111802. [PMID: 34147903]
  • Y Nijiati, D Maimaitiyiming, T Yang, H Li, A Aikemu. Research on the improvement of oxidative stress in rats with high-altitude pulmonary hypertension through the participation of irbesartan in regulating intestinal flora. European review for medical and pharmacological sciences. 2021 Jul; 25(13):4540-4553. doi: 10.26355/eurrev_202107_26247. [PMID: 34286497]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Alokkumar S Pathak, Mauricio Rojas, George A Stouffer. Expression of Cyr61 in ApoE-/- mice with chronic unilateral renal artery ligation. Scientific reports. 2021 02; 11(1):3606. doi: 10.1038/s41598-021-81646-1. [PMID: 33574403]
  • Rigas G Kalaitzidis, Olga Balafa, Evangelia Dounousi, Dimitrios Stagikas, Vasilios Tsimihodimos. Adherence to Treatment, Arterial Stiffness and Cognitive Function in Irbesartan- Treated Newly Diagnosed Hypertensive Patients. Current vascular pharmacology. 2021; 19(5):565-571. doi: 10.2174/1570161119666201120160104. [PMID: 33222674]
  • Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras. The Journal of biological chemistry. 2021 Jan; 296(?):100242. doi: 10.1074/jbc.ra120.015188. [PMID: 33380422]
  • Ibrahim A Darwish, Hany W Darwish, Ahmed H Bakheit, Hamad M Al-Kahtani, Zahi Alanazi. Irbesartan (a comprehensive profile). Profiles of drug substances, excipients, and related methodology. 2021; 46(?):185-272. doi: 10.1016/bs.podrm.2020.07.004. [PMID: 33461698]
  • Ling-Na Fang, Shao Zhong, Li-Ji Huang, Bing Lu, Li-Wen Shen, Feng-Yan Tang, He-Ping Sun, Li Zhang. Protective Effect of Irbesartan by Inhibiting ANGPTL2 Expression in Diabetic Kidney Disease. Current medical science. 2020 Dec; 40(6):1114-1120. doi: 10.1007/s11596-020-2304-z. [PMID: 33263178]
  • Bin Dai, Zi-Zhang Wang, Hui Zhang, Meng-Xiao Han, Guo-Xing Zhang, Jing-Wei Chen. Antihypertensive properties of a traditional Chinese medicine GAO-ZI-YAO in elderly spontaneous hypertensive rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110739. doi: 10.1016/j.biopha.2020.110739. [PMID: 32932045]
  • Dan Li, Bo Li, Li-Xia Peng, Rong Liu, Nan Zeng. Therapeutic Efficacy of Piperazine Ferulate Combined With Irbesartan in Diabetic Nephropathy: A Systematic Review and Meta-analysis. Clinical therapeutics. 2020 11; 42(11):2196-2212. doi: 10.1016/j.clinthera.2020.09.013. [PMID: 33158581]
  • Christian D Peters, Krista D Kjaergaard, Kent L Christensen, Bo M Bibby, Bente Jespersen, Jens D Jensen. High-sensitivity Troponin T in hemodialysis patients: a randomized placebo-controlled sub-study investigating angiotensin-II-blockade, variation over time and associations with clinical outcome. BMC nephrology. 2020 10; 21(1):452. doi: 10.1186/s12882-020-02103-1. [PMID: 33115436]
  • Gan Mi Wang, Liang Jin Li, Wen Lu Tang, James M Wright. Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension. The Cochrane database of systematic reviews. 2020 10; 10(?):CD012569. doi: 10.1002/14651858.cd012569.pub2. [PMID: 33089502]
  • Yong Zhong, Rong Tang, Yang Lu, Wei Wang, Chenggen Xiao, Ting Meng, Xiang Ao, Xiaozhao Li, Ling Peng, Patrick Kwadwo Nuro-Gyina, Qiaoling Zhou. Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension. International immunopharmacology. 2020 Oct; 87(?):106789. doi: 10.1016/j.intimp.2020.106789. [PMID: 32683300]
  • Eleni Karatza, Vangelis Karalis. Delay differential equations for the description of Irbesartan pharmacokinetics: A population approach to model absorption complexities leading to dual peaks. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Oct; 153(?):105498. doi: 10.1016/j.ejps.2020.105498. [PMID: 32736091]
  • Naoki Nakagawa, Nobuyuki Sato, Yasuaki Saijo, Hideo Morimoto, Satoshi Koyama, Yuji Ogawa, Kazumi Uekita, Junichi Maruyama, Takafumi Ohta, Yasuhiro Nakamura, Toshiharu Takeuchi, Naoyuki Hasebe. Assessment of suitable antihypertensive therapies: Combination with high-dose amlodipine/irbesartan vs triple combination with amlodipine/irbesartan/indapamide (ASAHI-AI study). Journal of clinical hypertension (Greenwich, Conn.). 2020 09; 22(9):1577-1584. doi: 10.1111/jch.13977. [PMID: 32762115]
  • Zhanying Liu, Lin Zhang, Ruijie Zhai, Jiarong Lan. Comparison of Irbesartan and Benazepril Hydrochloride on Urine Protein Reduction in Chronic Glomerulonephritis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2020 Sep; 30(9):1000-1001. doi: 10.29271/jcpsp.2020.09.1000. [PMID: 33036695]
  • Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122125. doi: 10.1016/j.jchromb.2020.122125. [PMID: 32371329]
  • Aimin Tan, Xuan Gui, Molly Wong, Hui Deng, Guifen Gu, Constantine Fanaras, John C Fanaras. Simultaneous quantification of candesartan and irbesartan in rabbit eye tissues by liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2020 May; 34(5):e4808. doi: 10.1002/bmc.4808. [PMID: 32100318]
  • Juyoung Shin, Hun-Sung Kim, Tong Min Kim, Hyunah Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon. The short-term effects of angiotensin II receptor blockers on albuminuria and renal function in Korean patients. Basic & clinical pharmacology & toxicology. 2020 May; 126(5):424-431. doi: 10.1111/bcpt.13369. [PMID: 31765038]
  • Navpreet Kaur, Poonam Singh Thakur, Ganesh Shete, Rahul Gangwal, Abhay T Sangamwar, Arvind Kumar Bansal. Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling. AAPS PharmSciTech. 2020 Mar; 21(3):102. doi: 10.1208/s12249-020-01643-x. [PMID: 32152915]
  • Miao Ye, Wen Xu, Da-Qing He, Xian Wu, Wen-Fang Lai, Xiao-Qin Zhang, Yu Lin, Wei Xu, Xu-Wen Li. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis. Journal of natural products. 2020 02; 83(2):362-373. doi: 10.1021/acs.jnatprod.9b00857. [PMID: 32031812]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Mohamed Saleh Elgawish, Moustafa K Soltan, Mahmoud M Sebaiy. An LC-MS/MS spectrometry method for the simultaneous determination of Rosuvastatin and Irbesartan in rat plasma: Insight into pharmacokinetic and drug-drug interaction studies. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):226-234. doi: 10.1016/j.jpba.2019.05.069. [PMID: 31181484]
  • Weizhong Huangfu, Fuhou Chang, Minjie Wang, Ruiying Gao. ALDH2 improved irbesartan treatment efficacy among rats with hypertension. Pakistan journal of pharmaceutical sciences. 2019 Sep; 32(5(Special)):2495-2499. doi: . [PMID: 31894041]
  • Rohit Ramchandra, Daniel T Xing, Marcus Matear, Gavin Lambert, Andrew M Allen, Clive N May. Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure. American journal of physiology. Regulatory, integrative and comparative physiology. 2019 09; 317(3):R386-R396. doi: 10.1152/ajpregu.00026.2019. [PMID: 31241978]
  • Barbara Ruggiero, Matias Trillini, Lida Tartaglione, Silverio Rotondi, Elena Perticucci, Rocco Tripepi, Carolina Aparicio, Veruska Lecchi, Annalisa Perna, Francesco Peraro, Davide Villa, Silvia Ferrari, Antonio Cannata, Sandro Mazzaferro, Francesca Mallamaci, Carmine Zoccali, Antonio Bellasi, Mario Cozzolino, Giuseppe Remuzzi, Piero Ruggenenti, Donald E Kohan. Effects of Sevelamer Carbonate in Patients With CKD and Proteinuria: The ANSWER Randomized Trial. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2019 09; 74(3):338-350. doi: 10.1053/j.ajkd.2019.01.029. [PMID: 31027883]
  • Jasper Tromp, Li Shen, Pardeep S Jhund, Inder S Anand, Peter E Carson, Akshay S Desai, Christopher B Granger, Michel Komajda, Robert S McKelvie, Marc A Pfeffer, Scott D Solomon, Lars Køber, Karl Swedberg, Michael R Zile, Bertram Pitt, Carolyn S P Lam, John J V McMurray. Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction. Journal of the American College of Cardiology. 2019 08; 74(5):601-612. doi: 10.1016/j.jacc.2019.05.052. [PMID: 31370950]
  • Ying Zuo, Ting Li, Zhen Lei. Should we add atorvastatin to irbesartan for improving renoprotective effects in early diabetic nephropathy? A meta-analysis of randomized controlled trials. Pharmacological research. 2019 08; 146(?):104286. doi: 10.1016/j.phrs.2019.104286. [PMID: 31152787]
  • Jin Hee Jeong, Coral Hanevold, Ryan A Harris, Gaston Kapuku, Jennifer Pollock, David Pollock, Gregory Harshfield. Angiotensin II receptor blocker attenuates stress pressor response in young adult African Americans. Journal of clinical hypertension (Greenwich, Conn.). 2019 08; 21(8):1191-1199. doi: 10.1111/jch.13625. [PMID: 31328876]
  • Nermin T El-Said, Eman A Mohamed, Ragia A Taha. Irbesartan suppresses cardiac toxicity induced by doxorubicin via regulating the p38-MAPK/NF-κB and TGF-β1 pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2019 06; 392(6):647-658. doi: 10.1007/s00210-019-01624-3. [PMID: 30734091]
  • G-D Ren, Y -Y Cui, W-L Li, F-F Li, X-Y Han. Research on cardioprotective effect of irbesartan in rats with myocardial ischemia-reperfusion injury through MAPK-ERK signaling pathway. European review for medical and pharmacological sciences. 2019 Jun; 23(12):5487-5494. doi: 10.26355/eurrev_201906_18218. [PMID: 31298402]
  • Xingang Zhao, Dongbin Yang, Weiwei Xu, Wen Xu, Zhengdong Guo. Effect of Irbesartan on Oxidative Stress and Serum Inflammatory Factors in Renal Tissues of Type 2 Diabetic Rats. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2019 May; 29(5):422-425. doi: 10.29271/jcpsp.2019.05.422. [PMID: 31036110]
  • Ryoko Umebayashi, Haruhito A Uchida, Yuka Okuyama, Yuki Kakio, Yoshihisa Hanayama, Kenichi Shikata, Jun Wada. The clinical efficacy of angiotensin II type1 receptor blockers on inflammatory markers in patients with hypertension: a multicenter randomized-controlled trial; MUSCAT-3 study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2019 May; 24(3):255-261. doi: 10.1080/1354750x.2018.1548033. [PMID: 30444137]
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