Milnacipran hydrochloride (BioDeep_00000015413)
代谢物信息卡片
Milnacipran ((1S-cis) hydrochloride)
化学式: C15H23ClN2O (282.1498818)
中文名称: 米那普仑盐酸盐, 左旋米那普仑盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl
InChI: /m0./s1
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
D049990 - Membrane Transport Modulators
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:31854
- KEGG: C73344
- KEGG: C13985
- KEGGdrug: D01107
- KEGGdrug: D10133
- PubChem: 163701
- PubChem: 6917778
- ChEMBL: CHEMBL1237129
- ChEMBL: CHEMBL2105732
- MeSH: Milnacipran
- MeSH: Levomilnacipran
- CAS: 101152-94-7
- CAS: 175131-61-0
- CAS: 175131-60-9
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Takuya Nagashima, Takashi Hayakawa, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asai. Identifying Antidepressants Less Likely to Cause Hyponatremia: Triangulation of Retrospective Cohort, Disproportionality, and Pharmacodynamic Studies.
Clinical pharmacology and therapeutics.
2022 06; 111(6):1258-1267. doi:
10.1002/cpt.2573. [PMID: 35258103] - Naoki Ito, Kazunori Sasaki, Eiji Hirose, Takayuki Nagai, Hiroko Isoda, Hiroshi Odaguchi. Preventive effect of a Kampo medicine, kososan, on recurrent depression in a mouse model of repeated social defeat stress.
Gene.
2022 Jan; 806(?):145920. doi:
10.1016/j.gene.2021.145920. [PMID: 34455026] - Islam M Mostafa, Mahmoud A Omar, Dalia M Nagy, Sayed M Derayea. Use of Hantzsch reaction for quantitation of milnacipran as a magic treatment for fibromyalgia syndrome in human plasma and urine.
Luminescence : the journal of biological and chemical luminescence.
2021 Feb; 36(1):73-78. doi:
10.1002/bio.3921. [PMID: 32706928] - Rasool Haddadi, Rojin Rashtiani. Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
Inflammopharmacology.
2020 Aug; 28(4):903-913. doi:
10.1007/s10787-020-00726-2. [PMID: 32518981] - Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A new sensitive approach for spectrofluorimetric assay of Milnacipran and Amisulpride in real plasma and pharmaceutical preparations via complexation with Eosin Y dye.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 May; 214(?):399-406. doi:
10.1016/j.saa.2019.02.071. [PMID: 30802797] - Islam M Mostafa, Sayed M Derayea, Dalia M Nagy, Mahmoud A Omar. An experimental ninhydrin design approach for the sensitive spectrofluorimetric assay of milnacipran in human urine and plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Dec; 205(?):292-297. doi:
10.1016/j.saa.2018.07.040. [PMID: 30029192] - Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto. Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats.
Biological & pharmaceutical bulletin.
2018; 41(2):213-219. doi:
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Clinical pharmacokinetics.
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Pharmaceutical development and technology.
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2013 Nov; 39(11):1851-63. doi:
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The international journal of neuropsychopharmacology.
2013 Jun; 16(5):937-43. doi:
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Biopharmaceutics & drug disposition.
2013 May; 34(4):227-35. doi:
10.1002/bdd.1840. [PMID: 23463628] - Akihiro Takano, Christer Halldin, Lars Farde. SERT and NET occupancy by venlafaxine and milnacipran in nonhuman primates: a PET study.
Psychopharmacology.
2013 Mar; 226(1):147-53. doi:
10.1007/s00213-012-2901-z. [PMID: 23090625] - Fanying Li, Christina Chin, Julie Wangsa, John Ho. Excretion and metabolism of milnacipran in humans after oral administration of milnacipran hydrochloride.
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2012 Sep; 40(9):1723-35. doi:
10.1124/dmd.112.045120. [PMID: 22653299] - Hiroyuki Kimura, Keizo Yoshida, Mikiko Ito, Tatsuya Tokura, Wataru Nagashima, Kenichi Kurita, Norio Ozaki. Plasma levels of milnacipran and its effectiveness for the treatment of chronic pain in the orofacial region.
Human psychopharmacology.
2012 May; 27(3):322-8. doi:
10.1002/hup.2230. [PMID: 22585592] - Michael Levine, Carrie A Truitt, Ayrn D O'Connor. Cardiotoxicity and serotonin syndrome complicating a milnacipran overdose.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2011 Dec; 7(4):312-6. doi:
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British journal of pharmacology.
2011 Jun; 163(4):792-803. doi:
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Biological & pharmaceutical bulletin.
2011; 34(5):740-7. doi:
10.1248/bpb.34.740. [PMID: 21532166] - Mervyn B Forman, Paul G Sutej, Edwin K Jackson. Hypertension, tachycardia, and reversible cardiomyopathy temporally associated with milnacipran use.
Texas Heart Institute journal.
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Cardiovascular toxicology.
2010 Dec; 10(4):275-82. doi:
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The Annals of pharmacotherapy.
2010 Sep; 44(9):1422-9. doi:
10.1345/aph.1p218. [PMID: 20716692] - Hisashi Higuchi. [Prediction of antidepressant response to milnacipran and fluvoxamine using pharmacogenetical methods].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
2010 Apr; 30(2):71-6. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2009 Nov; 33(8):1451-3. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2009 Oct; 37(10):2045-54. doi:
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Turk psikiyatri dergisi = Turkish journal of psychiatry.
2009; 20(4):403-5. doi:
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Journal of medicinal chemistry.
2008 Nov; 51(22):7265-72. doi:
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Neuroscience research.
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CNS spectrums.
2008 Jul; 13(7 Suppl 11):15-21. doi:
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Bioorganic & medicinal chemistry letters.
2008 Jun; 18(11):3230-5. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2007 Jun; 31(5):1034-7. doi:
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Bioorganic & medicinal chemistry letters.
2007 May; 17(10):2834-7. doi:
10.1016/j.bmcl.2007.02.054. [PMID: 17350257] - Katsunori Nonogaki, Kana Nozue, Tomifusa Kuboki, Yoshitomo Oka. Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 May; 292(5):R1775-81. doi:
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2005 Nov; 70(9):1389-97. doi:
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2004 Sep; 161(9):1575-80. doi:
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