Dexrazoxane hydrochloride (BioDeep_00000015369)

   


代谢物信息卡片


Dexrazoxane HCl (ICRF-187, ADR-529)

化学式: C11H17ClN4O4 (304.0938)
中文名称: 右雷佐生盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
InChI: 1H/t7-

描述信息

D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D054659 - Diketopiperazines
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

Dexrazoxane HCl (ICRF-187, ADR-529); Dexrazoxane hydrochloride



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Linfeng Zou, Bing Liang, YuanZhen Gao, Ting Ye, MengJiao Li, Yukun Zhang, Qi Lu, Xiaokun Hu, Huanting Li, Yang Yuan, Dongming Xing. Nicotinic Acid Riboside Regulates Nrf-2/P62-Related Oxidative Stress and Autophagy to Attenuate Doxorubicin-Induced Cardiomyocyte Injury. BioMed research international. 2022; 2022(?):6293329. doi: 10.1155/2022/6293329. [PMID: 35242876]
  • Huihui Hu, Caipeng Xie, Zeping Weng, Pei Yu, Yuqiang Wang, Luchen Shan. Dexrazoxane Alleviated Doxorubicin-Induced Nephropathy in Rats. Pharmacology. 2022; 107(3-4):206-215. doi: 10.1159/000521220. [PMID: 35021174]
  • Hana Bavlovič Piskáčková, Hana Jansová, Jan Kubeš, Galina Karabanovich, Nela Váňová, Petra Kollárová-Brázdová, Iuliia Melnikova, Anna Jirkovská, Olga Lenčová-Popelová, Jaroslav Chládek, Jaroslav Roh, Tomáš Šimůnek, Martin Štěrba, Petra Štěrbová-Kovaříková. Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity. Scientific reports. 2021 02; 11(1):4456. doi: 10.1038/s41598-021-83688-x. [PMID: 33627707]
  • Long Li, Xiaoqi Nie, Peng Zhang, Yongbiao Huang, Li Ma, Fang Li, Minxiao Yi, Wan Qin, Xianglin Yuan. Dexrazoxane ameliorates radiation-induced heart disease in a rat model. Aging. 2021 01; 13(3):3699-3711. doi: 10.18632/aging.202332. [PMID: 33406500]
  • Varsha G Desai, Taewon Lee, Carrie L Moland, Vikrant Vijay, Tao Han, Sherry M Lewis, Eugene H Herman, James C Fuscoe. Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice. Toxicology and applied pharmacology. 2019 01; 363(?):164-173. doi: 10.1016/j.taap.2018.11.016. [PMID: 30517846]
  • Eduard Jirkovský, Anna Jirkovská, Jan Bureš, Jaroslav Chládek, Olga Lenčová, Ján Stariat, Zuzana Pokorná, Galina Karabanovich, Jaroslav Roh, Petra Brázdová, Tomáš Šimůnek, Petra Kovaříková, Martin Štěrba. Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart. The Journal of pharmacology and experimental therapeutics. 2018 03; 364(3):433-446. doi: 10.1124/jpet.117.244848. [PMID: 29273587]
  • Joyce H Lee, Timothy J Wendorff, James M Berger. Resveratrol: A novel type of topoisomerase II inhibitor. The Journal of biological chemistry. 2017 12; 292(51):21011-21022. doi: 10.1074/jbc.m117.810580. [PMID: 29074616]
  • Sabry M Attia, Ali Y Alshahrani, Mohammed A Al-Hamamah, Mohammed M Attia, Quaiser Saquib, Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet. Dexrazoxane Averts Idarubicin-Evoked Genomic Damage by Regulating Gene Expression Profiling Associated With the DNA Damage-Signaling Pathway in BALB/c Mice. Toxicological sciences : an official journal of the Society of Toxicology. 2017 Nov; 160(1):161-172. doi: 10.1093/toxsci/kfx161. [PMID: 28973540]
  • Yang QuanJun, Yang GenJin, Wan LiLi, Han YongLong, Huo Yan, Li Jie, Huang JinLu, Lu Jin, Gan Run, Guo Cheng. Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study. PloS one. 2017; 12(1):e0169567. doi: 10.1371/journal.pone.0169567. [PMID: 28072830]
  • Anna Tycova, Marek Vido, Petra Kovarikova, Frantisek Foret. Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization-Analysis of dexrazoxane in blood plasma. Journal of chromatography. A. 2016 Sep; 1466(?):173-9. doi: 10.1016/j.chroma.2016.08.042. [PMID: 27613146]
  • Vikrant Vijay, Carrie L Moland, Tao Han, James C Fuscoe, Taewon Lee, Eugene H Herman, G Ronald Jenkins, Sherry M Lewis, Connie A Cummings, Yuan Gao, Zhijun Cao, Li-Rong Yu, Varsha G Desai. Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice. Toxicology and applied pharmacology. 2016 Mar; 295(?):68-84. doi: 10.1016/j.taap.2016.02.003. [PMID: 26873546]
  • Olga Lenčová-Popelová, Eduard Jirkovský, Hana Jansová, Anna Jirkovská-Vávrová, Lucie Vostatková-Tichotová, Yvona Mazurová, Michaela Adamcová, Jaroslav Chládek, Miloš Hroch, Zuzana Pokorná, Vladimír Geršl, Tomáš Šimůnek, Martin Štěrba. Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane. Journal of molecular and cellular cardiology. 2016 Feb; 91(?):92-103. doi: 10.1016/j.yjmcc.2015.12.021. [PMID: 26724189]
  • Pranitha Kamat, Stijn Vandenberghe, Stephan Christen, Anjan K Bongoni, Bernhard Meier, Robert Rieben, Ahmed A Khattab. Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs. PloS one. 2016; 11(12):e0168541. doi: 10.1371/journal.pone.0168541. [PMID: 28002439]
  • Fangyi Sun, Xiaoyong Qi, Cuizhi Geng, Xingtao Li. Dexrazoxane protects breast cancer patients with diabetes from chemotherapy-induced cardiotoxicity. The American journal of the medical sciences. 2015 May; 349(5):406-12. doi: 10.1097/maj.0000000000000432. [PMID: 25723884]
  • Sheng Zhang, Tingting Meng, Jingjing Liu, Xiaobei Zhang, Jin Zhang. Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2. Medicine. 2015 Jan; 94(4):e445. doi: 10.1097/md.0000000000000445. [PMID: 25634181]
  • Jolana Cermanova, Zuzana Kadova, Eva Dolezelova, Marie Zagorova, Vaclav Safka, Milos Hroch, Tomas Laho, Magdalena Holeckova, Jaroslav Mokry, Petra Kovarikova, Jan Bures, Martin Sterba, Stanislav Micuda. Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats. Shock (Augusta, Ga.). 2014 Oct; 42(4):372-9. doi: 10.1097/shk.0000000000000210. [PMID: 25140599]
  • Yoshihiko Ichikawa, Mohsen Ghanefar, Marina Bayeva, Rongxue Wu, Arineh Khechaduri, Sathyamangla V Naga Prasad, R Kannan Mutharasan, Tejaswitha Jairaj Naik, Hossein Ardehali. Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. The Journal of clinical investigation. 2014 Feb; 124(2):617-30. doi: 10.1172/jci72931. [PMID: 24382354]
  • Jennifer S Dickey, Yanira Gonzalez, Baikuntha Aryal, Steven Mog, Asako J Nakamura, Christophe E Redon, Ulrich Baxa, Elliot Rosen, Gang Cheng, Jacek Zielonka, Palak Parekh, Karen P Mason, Joy Joseph, Balaraman Kalyanaraman, William Bonner, Eugene Herman, Emily Shacter, V Ashutosh Rao. Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. PloS one. 2013; 8(8):e70575. doi: 10.1371/journal.pone.0070575. [PMID: 23940596]