Peretinoin (BioDeep_00000015366)
代谢物信息卡片
化学式: C20H30O2 (302.224568)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(=CCCC(=CC=CC(=CC(=O)O)C)C)C)C
InChI: InChI=1S/C20H30O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h8-9,11,13-15H,6-7,10,12H2,1-5H3,(H,21,22)/b14-8+,17-11+,18-13+,19-15+
描述信息
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masaya Funaki, Juria Kitabayashi, Tetsuro Shimakami, Naoto Nagata, Yuriko Sakai, Kai Takegoshi, Hikari Okada, Kazuhisa Murai, Takayoshi Shirasaki, Takeru Oyama, Taro Yamashita, Tsuguhito Ota, Yoh Takuwa, Masao Honda, Shuichi Kaneko. Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Scientific reports.
2017 12; 7(1):16978. doi:
10.1038/s41598-017-17285-2. [PMID: 29208982] - Kiwamu Okita, Namiki Izumi, Osamu Matsui, Katsuaki Tanaka, Shuichi Kaneko, Hisataka Moriwaki, Kenji Ikeda, Yukio Osaki, Kazushi Numata, Kohei Nakachi, Norihiro Kokudo, Kazuho Imanaka, Shuhei Nishiguchi, Takuji Okusaka, Yoichi Nishigaki, Susumu Shiomi, Masatoshi Kudo, Kenichi Ido, Yoshiyasu Karino, Norio Hayashi, Yasuo Ohashi, Masatoshi Makuuchi, Hiromitsu Kumada. Peretinoin after curative therapy of hepatitis C-related hepatocellular carcinoma: a randomized double-blind placebo-controlled study.
Journal of gastroenterology.
2015 Feb; 50(2):191-202. doi:
10.1007/s00535-014-0956-9. [PMID: 24728665] - Tetsuro Shimakami, Masao Honda, Takayoshi Shirasaki, Riuta Takabatake, Fanwei Liu, Kazuhisa Murai, Takayuki Shiomoto, Masaya Funaki, Daisuke Yamane, Seishi Murakami, Stanley M Lemon, Shuichi Kaneko. The acyclic retinoid Peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro.
Scientific reports.
2014 Apr; 4(?):4688. doi:
10.1038/srep04688. [PMID: 24732793] - Haruka Kamiyama, Katsura Kakoki, Sayuri Shigematsu, Mai Izumida, Yuka Yashima, Yuetsu Tanaka, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto, Tetsuro Sano, Yoshihiro Shidoji, Yoshinao Kubo. CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit.
AIDS research and human retroviruses.
2013 Feb; 29(2):279-88. doi:
10.1089/aid.2012.0174. [PMID: 22845664] - Masahito Shimizu, Hiroyasu Sakai, Yohei Shirakami, Junpei Iwasa, Yoichi Yasuda, Masaya Kubota, Koji Takai, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki. Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice.
Cancer prevention research (Philadelphia, Pa.).
2011 Jan; 4(1):128-36. doi:
10.1158/1940-6207.capr-10-0163. [PMID: 21071580] - Mitsutoshi Kimura, Makiko Watanabe, Naoto Ishibashi, Shingo Yanagida, Masahiko Ogihara. Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70\% partially hepatectomized rats, in vivo.
European journal of pharmacology.
2010 Sep; 643(2-3):267-73. doi:
10.1016/j.ejphar.2010.06.037. [PMID: 20619257] - Takashi Tsujino, Tomoya Nagata, Fumitaka Katoh, Hiroshi Yamasaki. Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication.
Cancer detection and prevention.
2007; 31(4):332-8. doi:
10.1016/j.cdp.2007.06.001. [PMID: 17935907]