Roxatidine acetate hydrochloride (BioDeep_00000015364)

   


代谢物信息卡片


Roxatidine acetate hydrochloride

化学式: C19H29ClN2O4 (384.18157440000004)
中文名称: 盐酸罗沙替丁醋酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
InChI: 1H

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
Roxatidine Acetate Hydrochloride is a potent, selective, competitive and orally active histamine H2-receptor antagonist. Roxatidine Acetate Hydrochloride has antisecretory potency against gastric acid secretion. Roxatidine Acetate Hydrochloride can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine Acetate Hydrochloride has antitumor activity[1][2][3].

同义名列表

3 个代谢物同义名

Roxatidine acetate hydrochloride; HOE 760; Roxatidine (Acetate Hydrochloride)



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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文献列表

  • J D Collins, A W Pidgen. Pharmacokinetics of roxatidine in healthy volunteers. Drugs. 1988; 35 Suppl 3(?):41-7. doi: 10.2165/00003495-198800353-00009. [PMID: 2905248]
  • H B Lassman, I Ho, S K Puri, R Sabo, M R Scheffler. The pharmacodynamics and pharmacokinetics of multiple doses of the new H2-receptor antagonist, roxatidine acetate, in healthy men. Drugs. 1988; 35 Suppl 3(?):53-64. doi: 10.2165/00003495-198800353-00011. [PMID: 2905250]
  • R A Labs. Interaction of roxatidine acetate with antacids, food and other drugs. Drugs. 1988; 35 Suppl 3(?):82-9. doi: 10.2165/00003495-198800353-00015. [PMID: 2905254]
  • N Lameire, B Rosenkranz, L Maass, D Brockmeier. A pharmacokinetic study of roxatidine acetate in chronic renal failure. Drugs. 1988; 35 Suppl 3(?):48-52. doi: 10.2165/00003495-198800353-00010. [PMID: 2905249]
  • T Takabatake, H Ohta, Y Yamamoto, Y Ishida, H Hara, S Nakamura, Y Ushiogi, S Satoh, N Hattori. Pharmacokinetics of TZU-0460, a new H2-receptor antagonist, in patients with impaired renal function. European journal of clinical pharmacology. 1986; 30(6):709-12. doi: 10.1007/bf00608220. [PMID: 2876900]
  • K Naito, M Otsuka, S Harigaya, T Nagao, H Narita. Relationship between positive inotropic action and blood levels of denopamine in cats. Arzneimittel-Forschung. 1985; 35(5):833-5. doi: NULL. [PMID: 4026907]