Temocapril hydrochloride (BioDeep_00000015362)
代谢物信息卡片
Temocapril (hydrochloride)
化学式: C23H29ClN2O5S2 (512.1206)
中文名称: 盐酸替莫卡普利
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(C2=O)CC(=O)O)C3=CC=CS3.Cl
InChI: /m0./s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Keisuke Ohnishi, Miki Murase, Daisuke Nakano, Nicolas Pelisch, Hirofumi Hitomi, Hiroyuki Kobori, Satoshi Morimoto, Hirohito Mori, Tsutomu Masaki, Koji Ohmori, Masakazu Kohno, Atsuhiro Ichihara, Akira Nishiyama. Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats.
Journal of pharmacological sciences.
2013; 122(2):103-8. doi:
10.1254/jphs.13045fp. [PMID: 23698111] - Takayuki Kawata, Masao Daimon, Rei Hasegawa, Kiyomi Teramoto, Tomohiko Toyoda, Tai Sekine, Kyohei Yamamoto, Daigaku Uchida, Toshiharu Himi, Katsuya Yoshida, Issei Komuro. Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus.
International journal of cardiology.
2009 Feb; 132(2):286-8. doi:
10.1016/j.ijcard.2007.08.066. [PMID: 18083252] - Masanobu Kaihara, Yoshio Nakamura, Taro Sugimoto, Haruhito A Uchida, Hisanao Norii, Hisanao Norii, Yoshihisa Hanayama, Hirofumi Makino. Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats.
Acta medica Okayama.
2009 Feb; 63(1):35-42. doi:
10.18926/amo/31860. [PMID: 19247421] - Shigehiro Katayama, Ryuzo Kawamori, Yasuhiko Iwamoto, Ikuo Saito, Kizuku Kuramoto. In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diabetes (ATTEST) study.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Aug; 31(8):1499-508. doi:
10.1291/hypres.31.1499. [PMID: 18971523] - Tsukasa Nakamura, Teruo Inoue, Takeshi Sugaya, Yasuhiro Kawagoe, Tsukasa Suzuki, Yoshihiko Ueda, Hikaru Koide, Koichi Node. Beneficial effects of olmesartan and temocapril on urinary liver-type fatty acid-binding protein levels in normotensive patients with immunoglobin A nephropathy.
American journal of hypertension.
2007 Nov; 20(11):1195-201. doi:
10.1016/j.amjhyper.2007.06.003. [PMID: 17954367] - Susumu Ogawa, Kazuhisa Takeuchi, Takefumi Mori, Kazuhiro Nako, Yoshitaka Tsubono, Sadayoshi Ito. Effects of monotherapy of temocapril or candesartan with dose increments or combination therapy with both drugs on the suppression of diabetic nephropathy.
Hypertension research : official journal of the Japanese Society of Hypertension.
2007 Apr; 30(4):325-34. doi:
10.1291/hypres.30.325. [PMID: 17541211] - Yoshio Horita, Kouichi Taura, Takashi Taguchi, Akira Furusu, Shigeru Kohno. Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy.
Nephrology (Carlton, Vic.).
2006 Oct; 11(5):462-6. doi:
10.1111/j.1440-1797.2006.00665.x. [PMID: 17014562] - Toru Hiura, Hajime Yamazaki, Takako Saeki, Shotetsu Kawabe, Mitsuhiro Ueno, Shinichi Nishi, Shoji Miyamura, Fumitake Gejyo. Nephrotic syndrome and IgA nephropathy in polycystic kidney disease.
Clinical and experimental nephrology.
2006 Jun; 10(2):136-9. doi:
10.1007/s10157-005-0403-6. [PMID: 16791401] - Kazuya Maeda, Ichiro Ieiri, Kuninobu Yasuda, Akiharu Fujino, Hiroaki Fujiwara, Kenji Otsubo, Masaru Hirano, Takao Watanabe, Yoshiaki Kitamura, Hiroyuki Kusuhara, Yuichi Sugiyama. Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.
Clinical pharmacology and therapeutics.
2006 May; 79(5):427-39. doi:
10.1016/j.clpt.2006.01.011. [PMID: 16678545] - Noriaki Emoto, Sunu Budhi Raharjo, Daiji Isaka, Shigeru Masuda, Suko Adiarto, Arco Y Jeng, Mitsuhiro Yokoyama. Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats.
Hypertension (Dallas, Tex. : 1979).
2005 Jun; 45(6):1145-52. doi:
10.1161/01.hyp.0000168944.29525.da. [PMID: 15897363] - Y Kanno, H Okada, Y Yamaji, Y Nakazato, H Suzuki. Angiotensin-converting-enzyme inhibitors slow renal decline in IgA nephropathy, independent of tubulointerstitial fibrosis at presentation.
QJM : monthly journal of the Association of Physicians.
2005 Mar; 98(3):199-203. doi:
10.1093/qjmed/hci036. [PMID: 15728401] - Yukiko Nagai, Li Yao, Hiroyuki Kobori, Kayoko Miyata, Yuri Ozawa, Akira Miyatake, Tokihito Yukimura, Takatomi Shokoji, Shoji Kimura, Hideyasu Kiyomoto, Masakazu Kohno, Youichi Abe, Akira Nishiyama. Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats.
Journal of the American Society of Nephrology : JASN.
2005 Mar; 16(3):703-11. doi:
10.1681/asn.2004080649. [PMID: 15647337] - Hirofumi Tomiyama, Kohki Motobe, Gulnisa Zaydun, Yutaka Koji, Minoru Yambe, Tomio Arai, Toshio Kushiro, Akira Yamashina. Insulin sensitivity and endothelial function in hypertension: a comparison of temocapril and candesartan.
American journal of hypertension.
2005 Feb; 18(2 Pt 1):178-82. doi:
10.1016/j.amjhyper.2004.08.033. [PMID: 15752944] - Masato Furuhashi, Nobuyuki Ura, Hideki Takizawa, Daisuke Yoshida, Norihito Moniwa, Hideyuki Murakami, Katsuhiro Higashiura, Kazuaki Shimamoto. Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity.
Journal of hypertension.
2004 Oct; 22(10):1977-82. doi:
10.1097/00004872-200410000-00021. [PMID: 15361770] - Shokei Kim-Mitsuyama, Yasukatsu Izumi, Yasuhiro Izumiya, Kaoru Yoshida, Minoru Yoshiyama, Hiroshi Iwao. Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Oct; 27(10):771-9. doi:
10.1291/hypres.27.771. [PMID: 15785013] - A K M Tarikuz Zaman, Satoshi Fujii, Daisuke Goto, Tomoo Furumoto, Tetsuya Mishima, Yukihito Nakai, Jie Dong, Shogo Imagawa, Burton E Sobel, Akira Kitabatake. Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity.
Journal of molecular and cellular cardiology.
2004 Aug; 37(2):525-35. doi:
10.1016/j.yjmcc.2004.05.006. [PMID: 15276022] - Masayuki Kanazawa, Masahiro Kohzuki, Hajime Kurosawa, Naoyoshi Minami, Osamu Ito, Takao Saito, Minoru Yasujima, Keishi Abe. Renoprotective effect of angiotensin-converting enzyme inhibitor combined with alpha1-adrenergic antagonist in spontaneously hypertensive rats with renal ablation.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Jul; 27(7):509-15. doi:
10.1291/hypres.27.509. [PMID: 15302988] - Kenichi Yasunari, Kensaku Maeda, Munehiro Nakamura, Takanori Watanabe, Junichi Yoshikawa, Akira Asada. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile.
Cardiovascular drug reviews.
2004; 22(3):189-98. doi:
10.1111/j.1527-3466.2004.tb00140.x. [PMID: 15492767] - Takayuki Kawamura, Kazunori Yoshida, Akira Sugawara, Makoto Nagasaka, Nobuyoshi Mori, Kazuhisa Takeuchi, Masahiro Kohzuki. Regulation of skeletal muscle peroxisome proliferator-activated receptor gamma expression by exercise and angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Jan; 27(1):61-70. doi:
10.1291/hypres.27.61. [PMID: 15055257] - Yukiko Takada, Hidetaka Tachizawa, Hiroko Kurihara, Motoe Takayanagi, Takahiro Sasamoto, Masahiro Akashi, Mitsuhiko Aiso, Yoriyuki Takamori, Naoyo Sano, Hajime Takikawa. Comparison of urinary excretion of pravastatin and temocapril in bile duct-ligated rats and Eisai hyperbilirubinemic rats (EHBR).
Journal of hepato-biliary-pancreatic surgery.
2004; 11(2):125-8. doi:
10.1007/s00534-003-0872-5. [PMID: 15127276] - Kazunori Yoshida, Takayuki Kawamura, Hong-Lan Xu, Lina Ji, Nobuyoshi Mori, Masahiro Kohzuki. Effects of exercise training on glomerular structure in fructose-fed spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2003 Nov; 26(11):907-14. doi:
10.1291/hypres.26.907. [PMID: 14714583] - Masayuki Tanemoto, Takaaki Abe, Noriyuki Obara, Michiaki Abe, Fumitoshi Satoh, Sadayoshi Ito. Successful treatment of severe hypertension with the combination of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker.
Hypertension research : official journal of the Japanese Society of Hypertension.
2003 Oct; 26(10):863-8. doi:
10.1291/hypres.26.863. [PMID: 14621191] - Taro Horino, Hiroyuki Ito, Noriyasu Tanimoto, Toshinori Yoshida, Atsushi Sasaoka, Tatsumi Chijiwa, Takanori Hosokawa, Kozo Hashimoto. [Successful treatment of combination therapy using an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker in a patient with IgA nephropathy].
Nihon Jinzo Gakkai shi.
2003; 45(2):104-8. doi:
NULL. [PMID: 12703406] - Takao Makino, Yuichi Hattori, Naoyuki Matsuda, Hisao Onozuka, Ichiro Sakuma, Akira Kitabatake. Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits: reversal of altered expression of beta-adrenoceptor kinase and G i alpha.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):370-9. doi:
10.1124/jpet.102.040956. [PMID: 12490614] - Takayuki Kawamura, Kazunori Yoshida, Akira Sugawara, Makoto Nagasaka, Nobuyoshi Mori, Kazuhisa Takeuchi, Masahiro Kohzuki. Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 Nov; 25(6):919-26. doi:
10.1291/hypres.25.919. [PMID: 12484517] - Satoru Kuriyama, Haruo Tomonari, Goro Tokudome, Makoto Horiguchi, Hirofumi Hayashi, Hideyuki Kobayashi, Masahiro Ishikawa, Tatsuo Hosoya. Antiproteinuric effects of combined antihypertensive therapies in patients with overt type 2 diabetic nephropathy.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 Nov; 25(6):849-55. doi:
10.1291/hypres.25.849. [PMID: 12484508] - Kazunori Yoshida, Hong-Lan Xu, Takayuki Kawamura, Lina Ji, Masahiro Kohzuki. Chronic angiotensin-converting enzyme inhibition and angiotensin II antagonism in rats with chronic renal failure.
Journal of cardiovascular pharmacology.
2002 Oct; 40(4):533-42. doi:
10.1097/00005344-200210000-00006. [PMID: 12352315] - Kohachiro Koga, Sho-ichi Yamagishi, Masayoshi Takeuchi, Yosuke Inagaki, Shinjiro Amano, Tamami Okamoto, Tsuyoshi Saga, Zenji Makita, Mitsuaki Yoshizuka. CS-886, a new angiotensin II type 1 receptor antagonist, ameliorates glomerular anionic site loss and prevents progression of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats.
Molecular medicine (Cambridge, Mass.).
2002 Oct; 8(10):591-9. doi:
10.1007/bf03402169. [PMID: 12477969] - Tetsuya Shiuchi, Tai-Xing Cui, Lan Wu, Hironori Nakagami, Yuko Takeda-Matsubara, Masaru Iwai, Masatsugu Horiuchi. ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO.
Hypertension (Dallas, Tex. : 1979).
2002 Sep; 40(3):329-34. doi:
10.1161/01.hyp.0000028979.98877.0c. [PMID: 12215475] - Hajime Masuda. [Effects of temocapril on the prevention of early diabetic nephropathy in OLETF rat, an animal model for type 2 diabetes].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.
2002 Sep; 77(5):419-28. doi:
NULL. [PMID: 12404757] - Kazuo Eguchi, Kazuomi Kario, Kazuyuki Shimada. Differential effects of a long-acting angiotensin converting enzyme inhibitor (temocapril) and a long-acting calcium antagonist (amlodipine) on ventricular ectopic beats in older hypertensive patients.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 May; 25(3):329-33. doi:
10.1291/hypres.25.329. [PMID: 12135309] - Masayuki Kanazawa, Masahiro Kohzuki, Kazunori Yoshida, Hajime Kurosawa, Naoyoshi Minami, Takao Saito, Minoru Yasujima, Keishi Abe. Combination therapy with an angiotensin-converting enzyme (ACE) inhibitor and a calcium antagonist: beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal ablation.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 May; 25(3):447-53. doi:
10.1291/hypres.25.447. [PMID: 12135325] - H Suzuki, K Asano, M Eiro, M Kuriki, S Hashimoto, T Katoh, T Watanabe, K Watanabe. Recovery from renal failure in malignant hypertension associated with primary aldosteronism: effect of an ACE inhibitor.
QJM : monthly journal of the Association of Physicians.
2002 Feb; 95(2):128-30. doi:
10.1093/qjmed/95.2.128. [PMID: 11861963] - Jian Teng, Noboru Fukuda, Ryo Suzuki, Hiroto Takagi, Yukihiro Ikeda, Yoshiko Tahira, Katsuo Kanmatsuse. Inhibitory effect of a novel angiotensin II type 1 receptor antagonist RNH-6270 on growth of vascular smooth muscle cells from spontaneously hypertensive rats: different anti-proliferative effect to angiotensin-converting enzyme inhibitor.
Journal of cardiovascular pharmacology.
2002 Feb; 39(2):161-71. doi:
10.1097/00005344-200202000-00002. [PMID: 11791001] - H L Xu, K Yoshida, X M Wu, M Kohzuki. [Effects of CS-866, an angiotensin II receptor antagonist, in 5/6 nephrectomized spontaneously hypertensive rats].
Nihon Jinzo Gakkai shi.
2001 Oct; 43(7):580-8. doi:
. [PMID: 11725555] - K Yoshida, M Kohzuki, H L Xu, X M Wu, M Kamimoto, T Sato. Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure.
Journal of hypertension.
2001 Mar; 19(3):503-10. doi:
10.1097/00004872-200103000-00019. [PMID: 11288821] - M Arakawa, M Sasaki, M Ohmori, K Harada, A Fujimura. Pharmacokinetics and pharmacodynamics of temocapril during repeated dosing in elderly hypertensive patients.
European journal of clinical pharmacology.
2001 Jan; 56(11):775-9. doi:
10.1007/s002280000237. [PMID: 11294366] - Y Miyashita, Y Ito, S Hasiguchi, M Totsuka, A Aoki, M Kurokawa, H Tomioka, K Shirai. Effect of temocapril hydrochloride on serum lipid levels in patients with hypertensive type 2 diabetes mellitus.
Journal of atherosclerosis and thrombosis.
2001; 8(1):25-9. doi:
10.5551/jat1994.8.25. [PMID: 11686312] - H Shionoiri, T Kosaka, E Kita, T Takizawa, I Takasaki. Comparison of long-term therapeutic effect of an ACE inhibitor, temocapril, with that of a diuretic on microalbuminuria in non-diabetic essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2000 Nov; 23(6):593-600. doi:
10.1291/hypres.23.593. [PMID: 11131271] - R Suzuki, A Shimada, K Konishi, T Saruta. Rapid remission of nephrotic-range proteinuria in a case of histologically proven diabetic nephropathy treated with an ACE inhibitor.
Diabetes care.
2000 May; 23(5):708-10. doi:
10.2337/diacare.23.5.708. [PMID: 10834440] - K Hori, S Saito, H Takahashi, H Sato, H Maeda, Y Sato. Tumor-selective blood flow decrease induced by an angiotensin converting enzyme inhibitor, temocapril hydrochloride.
Japanese journal of cancer research : Gann.
2000 Feb; 91(2):261-9. doi:
10.1111/j.1349-7006.2000.tb00940.x. [PMID: 10761715] - K Watanabe, M Sekiya, T Tsuruoka, J Funada, H Kameoka. Effect of insulin resistance on left ventricular hypertrophy and dysfunction in essential hypertension.
Journal of hypertension.
1999 Aug; 17(8):1153-60. doi:
10.1097/00004872-199917080-00015. [PMID: 10466471] - H Yoshikawa. [Renal angiotensin converting enzyme (ACE) expression in diabetic rats: the effect of ACE inhibitors].
Nihon Jinzo Gakkai shi.
1999 Aug; 41(5):486-92. doi:
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Journal of cardiovascular pharmacology.
1999 Apr; 33(4):527-33. doi:
10.1097/00005344-199904000-00003. [PMID: 10218721] - K Püchler, B Sierakowski, I Roots. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients.
British journal of clinical pharmacology.
1998 Oct; 46(4):363-7. doi:
10.1046/j.1365-2125.1998.t01-1-00785.x. [PMID: 9803985] - Z Xie, M Gao, M Horimoto, H Togashi, H Saito, T Koyama. Rearrangement of the ventricular capillary network in stroke-prone spontaneously hypertensive rats (SHRSP) following a late start of treatment with the angiotensin converting enzyme blocker temocapril.
Japanese heart journal.
1998 Sep; 39(5):699-706. doi:
10.1536/ihj.39.699. [PMID: 9926001] - Y Miyazaki, H Murakami, A Hirata, M Fukuoka, A Masuda, N Ura, K Shimamoto. Effects of the angiotensin converting enzyme inhibitor temocapril on insulin sensitivity and its effects on renal sodium handling and the pressor system in essential hypertensive patients.
American journal of hypertension.
1998 Aug; 11(8 Pt 1):962-70. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
1998 Jun; 21(2):81-7. doi:
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British journal of clinical pharmacology.
1997 Dec; 44(6):531-6. doi:
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Journal of cardiovascular pharmacology.
1997 Nov; 30(5):643-8. doi:
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The Journal of urology.
1997 Feb; 157(2):739-42. doi:
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Nihon Jinzo Gakkai shi.
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Journal of cardiovascular pharmacology.
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Clinical and experimental pharmacology & physiology.
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Clinical pharmacokinetics.
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European journal of clinical pharmacology.
1993; 44(4):383-5. doi:
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Biopharmaceutics & drug disposition.
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Clinical and experimental pharmacology & physiology.
1992 Mar; 19(3):193-200. doi:
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European journal of clinical pharmacology.
1992; 43(6):657-9. doi:
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Journal of chromatography.
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Journal of immunoassay.
1991; 12(1):15-28. doi:
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Clinical and experimental pharmacology & physiology.
1990 Nov; 17(11):745-53. doi:
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Journal of chromatography.
1989 Nov; 496(1):129-35. doi:
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1988 Nov; 48(3):349-56. doi:
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