12R-HETE (BioDeep_00000015329)
Main id: BioDeep_00000607970
代谢物信息卡片
12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
化学式: C20H32O3 (320.23513219999995)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m1/s1
描述信息
A HETE having a (12R)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:34144
- KEGG: C14822
- PubChem: 5283156
- Metlin: METLIN45653
- ChEMBL: CHEMBL1435825
- MeSH: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
- CAS: 82337-46-0
- MetaboLights: MTBLC34144
- PubChem: 17395820
- LipidMAPS: LMFA03060008
- KNApSAcK: C00000424
- NIKKAJI: J260.110I
- RefMet: 12R-HETE
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
99 个相关的代谢反应过程信息。
Reactome(53)
- Synthesis of 12-eicosatetraenoic acid derivatives:
12R-HpETE + GSH ⟶ 12R-HETE + GSSG + H2O - Synthesis of 12-eicosatetraenoic acid derivatives:
12R-HpETE + GSH ⟶ 12R-HETE + GSSG + H2O - Synthesis of 12-eicosatetraenoic acid derivatives:
12R-HpETE + GSH ⟶ 12R-HETE + GSSG + H2O - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12R-HpETE + GSH ⟶ 12R-HETE + GSSG + H2O - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
prostaglandin H2 ⟶ prostaglandin E2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H2O + lysoPC ⟶ GPCho + LCFA(-) - Fatty acid metabolism:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Arachidonic acid metabolism:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Fatty acid metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2 - Synthesis of 12-eicosatetraenoic acid derivatives:
12S-HpETE + GSH ⟶ 12S-HETE + GSSG + H2O
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(46)
- Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Piroxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Acetylsalicylic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Etodolac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Ketoprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Ibuprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Rofecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Diclofenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Sulindac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Celecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Ketorolac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Suprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Bromfenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Indomethacin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Mefenamic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Oxaprozin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Nabumetone Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Naproxen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Diflunisal Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Meloxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Valdecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Antipyrine Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Antrafenine Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Carprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Etoricoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Fenoprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Flurbiprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Magnesium Salicylate Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Lumiracoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Lornoxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Phenylbutazone Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Nepafenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Trisalicylate-Choline Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Tolmetin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Tiaprofenic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Tenoxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Salsalate Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Salicylate-Sodium Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Salicylic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Acetaminophen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4 - Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed Moustafa, Abraham Khalil, Noureldien H E Darwish, Dao-Qi Zhang, Amany Tawfik, Mohamed Al-Shabrawey. 12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29.
Prostaglandins & other lipid mediators.
2023 Dec; 171(?):106805. doi:
10.1016/j.prostaglandins.2023.106805. [PMID: 38141777] - Riyaz Mohamed, Jennifer C Sullivan. Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females.
Molecular medicine (Cambridge, Mass.).
2023 Dec; 29(1):163. doi:
10.1186/s10020-023-00762-y. [PMID: 38049738] - Naixin Zhang, Brian Harsch, Michael J Zhang, Dylan J Gyberg, Jackie A Stevens, Brandon M Wagner, Jenna Mendelson, Michael T Patterson, Devin A Orchard, Chastity L Healy, Jesse W Williams, DeWayne Townsend, Gregory C Shearer, Katherine A Murphy, Timothy D O'Connell. FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome.
Journal of lipid research.
2023 Apr; ?(?):100374. doi:
10.1016/j.jlr.2023.100374. [PMID: 37075982] - Annalisa Contursi, Stefania Tacconelli, Ulrika Hofling, Annalisa Bruno, Melania Dovizio, Patrizia Ballerini, Paola Patrignani. Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk.
Biochemical pharmacology.
2022 11; 205(?):115252. doi:
10.1016/j.bcp.2022.115252. [PMID: 36130648] - Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu, Tong Zhu. Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation.
Particle and fibre toxicology.
2022 10; 19(1):65. doi:
10.1186/s12989-022-00503-9. [PMID: 36280873] - Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice.
Scientific reports.
2022 07; 12(1):11385. doi:
10.1038/s41598-022-15461-7. [PMID: 35790870] - Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S Kanwar. Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway.
JCI insight.
2022 03; 7(6):. doi:
10.1172/jci.insight.155487. [PMID: 35315361] - Shuli Chen, Haidong Zou. Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.
Current eye research.
2022 03; 47(3):329-335. doi:
10.1080/02713683.2021.1995003. [PMID: 35129022] - Mariya Misheva, Konstantinos Kotzamanis, Luke C Davies, Victoria J Tyrrell, Patricia R S Rodrigues, Gloria A Benavides, Christine Hinz, Robert C Murphy, Paul Kennedy, Philip R Taylor, Marcela Rosas, Simon A Jones, James E McLaren, Sumukh Deshpande, Robert Andrews, Nils Helge Schebb, Magdalena A Czubala, Mark Gurney, Maceler Aldrovandi, Sven W Meckelmann, Peter Ghazal, Victor Darley-Usmar, Daniel A White, Valerie B O'Donnell. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.
Nature communications.
2022 01; 13(1):139. doi:
10.1038/s41467-021-27766-8. [PMID: 35013270] - K M Bermingham, L Brennan, R Segurado, I J Gray, R E Barron, E R Gibney, M F Ryan, M J Gibney, J W Newman, Dr A M O'Sullivan. Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 10; 173(?):102338. doi:
10.1016/j.plefa.2021.102338. [PMID: 34500309] - Mélissa Simard, Geneviève Rioux, Sophie Morin, Cyril Martin, Sylvain L Guérin, Nicolas Flamand, Pierre Julien, Julie Fradette, Roxane Pouliot. Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.
The Journal of investigative dermatology.
2021 10; 141(10):2391-2401.e13. doi:
10.1016/j.jid.2021.02.755. [PMID: 33857488] - Ying-Chun Han, Ji-Chao Zhang, Cong-Cong Zhang, Jie DU. [Arachidonic acid Alox15/12-HETE signaling inhibits vascular calcification].
Sheng li xue bao : [Acta physiologica Sinica].
2021 Aug; 73(4):571-576. doi:
NULL. [PMID: 34405213] - Jonathan V Pascale, Pamela A Lucchesi, Victor Garcia. Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches.
Journal of cardiovascular pharmacology.
2021 06; 77(6):707-717. doi:
10.1097/fjc.0000000000001013. [PMID: 34016841] - Anne Abot, Eve Wemelle, Claire Laurens, Adrien Paquot, Nicolas Pomie, Deborah Carper, Arnaud Bessac, Xavier Mas Orea, Christophe Fremez, Maxime Fontanie, Alexandre Lucas, Jean Lesage, Amandine Everard, Etienne Meunier, Gilles Dietrich, Giulio G Muccioli, Cedric Moro, Patrice D Cani, Claude Knauf. Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice.
Gut.
2021 06; 70(6):1078-1087. doi:
10.1136/gutjnl-2019-320230. [PMID: 33020209] - Samantha D Pauls, Youjia Du, Luc Clair, Tanja Winter, Harold M Aukema, Carla G Taylor, Peter Zahradka. Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health.
Arteriosclerosis, thrombosis, and vascular biology.
2021 02; 41(2):883-897. doi:
10.1161/atvbaha.120.315133. [PMID: 33380172] - Layla Van Doren, Nga Nguyen, Christopher Garzia, Elizabeth K Fletcher, Ryan Stevenson, David Jaramillo, Athan Kuliopulos, Lidija Covic. Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis.
Arteriosclerosis, thrombosis, and vascular biology.
2021 01; 41(1):e33-e45. doi:
10.1161/atvbaha.120.315154. [PMID: 33267659] - Annalisa Contursi, Simone Schiavone, Melania Dovizio, Christine Hinz, Rosa Fullone, Stefania Tacconelli, Victoria J Tyrrell, Rosalia Grande, Paola Lanuti, Marco Marchisio, Mirco Zucchelli, Patrizia Ballerini, Angel Lanas, Valerie B O'Donnell, Paola Patrignani. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Journal of lipid research.
2021; 62(?):100109. doi:
10.1016/j.jlr.2021.100109. [PMID: 34428433] - Miriam C Wolters, Julia Schmetzer, Christine V Möser, Lisa Hahnefeld, Carlo Angioni, Dominique Thomas, Nerea Ferreirós, Gerd Geisslinger, Ellen Niederberger. Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers.
Cells.
2020 09; 9(9):. doi:
10.3390/cells9092111. [PMID: 32948055] - Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska. Effect of renal replacement therapy on selected arachidonic acid derivatives concentration.
BMC nephrology.
2020 09; 21(1):394. doi:
10.1186/s12882-020-02053-8. [PMID: 32917166] - Changqing Dong, Shengmao Liu, Yingchun Cui, Qiaoyan Guo. 12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy.
European journal of pharmacology.
2020 Jul; 879(?):173122. doi:
10.1016/j.ejphar.2020.173122. [PMID: 32333927] - Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv, Hua-Ping Liang. Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.
Cell communication and signaling : CCS.
2020 05; 18(1):70. doi:
10.1186/s12964-020-0523-3. [PMID: 32366266] - Vanessa Moreira, José María Gutiérrez, Bruno Lomonte, Marco Aurélio Ramirez Vinolo, Rui Curi, Gérard Lambeau, Catarina Teixeira. 12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages.
Chemico-biological interactions.
2020 Feb; 317(?):108903. doi:
10.1016/j.cbi.2019.108903. [PMID: 31811862] - Vasundhara Kain, Ganesh V Halade. Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment.
Journal of cellular physiology.
2019 04; 234(4):3910-3920. doi:
10.1002/jcp.27165. [PMID: 30191990] - Saskia Kroschwald, Cheng-Ying Chiu, Dagmar Heydeck, Nadine Rohwer, Tatjana Gehring, Ulrike Seifert, Anke Lux, Michael Rothe, Karsten-Henrich Weylandt, Hartmut Kuhn. Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2018 08; 1863(8):866-880. doi:
10.1016/j.bbalip.2018.04.019. [PMID: 29702245] - Bibo Ke, Jerzy W Kupiec-Weglinski. Lipid Metabolites: The Alarm Signal to Trigger Liver Ischemia-reperfusion Injury.
Transplantation.
2018 06; 102(6):887-889. doi:
10.1097/tp.0000000000002206. [PMID: 29782474] - Chen Zhang, Cui Ma, Hongmin Yao, Lixin Zhang, Xiufeng Yu, Yumei Liu, Tingting Shen, Linlin Zhang, Fengying Zhang, Xinxin Chen, Daling Zhu. 12-Lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway.
American journal of physiology. Lung cellular and molecular physiology.
2018 04; 314(4):L606-L616. doi:
10.1152/ajplung.00049.2017. [PMID: 29074487] - Tamas Kriska, Michael J Thomas, John R Falck, William B Campbell. Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.
Journal of lipid research.
2018 04; 59(4):615-624. doi:
10.1194/jlr.m081448. [PMID: 29472381] - Yonghai Lu, Jinling Fang, Li Zou, Liang Cui, Xu Liang, Seng Gee Lim, Yock-Young Dan, Choon Nam Ong. Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases.
Metabolomics : Official journal of the Metabolomic Society.
2018 01; 14(3):26. doi:
10.1007/s11306-018-1326-z. [PMID: 30830341] - Qi Zhang, Xiang Wang, Guifang Yan, Juan Lei, Yu Zhou, Lei Wu, Ting Wang, Xiao Zhang, Duyun Ye, Yongsheng Li. Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(4):1377-1389. doi:
10.1159/000487563. [PMID: 29462800] - Xiao-Jing Zhang, Xu Cheng, Zhen-Zhen Yan, Jing Fang, Xiaozhan Wang, Weijun Wang, Zhen-Yu Liu, Li-Jun Shen, Peng Zhang, Pi-Xiao Wang, Rufang Liao, Yan-Xiao Ji, Jun-Yong Wang, Song Tian, Xue-Yong Zhu, Yan Zhang, Rui-Feng Tian, Lin Wang, Xin-Liang Ma, Zan Huang, Zhi-Gang She, Hongliang Li. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.
Nature medicine.
2018 01; 24(1):73-83. doi:
10.1038/nm.4451. [PMID: 29227475] - Jan Philipp Schuchardt, Annika I Ostermann, Lisa Stork, Sabrina Fritzsch, Heike Kohrs, Theresa Greupner, Andreas Hahn, Nils Helge Schebb. Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood.
Prostaglandins, leukotrienes, and essential fatty acids.
2017 Jun; 121(?):76-87. doi:
10.1016/j.plefa.2017.06.007. [PMID: 28651702] - Oscar D Rangel-Huerta, Concepcion M Aguilera, Antonio Perez-de-la-Cruz, Fernando Vallejo, Francisco Tomas-Barberan, Angel Gil, Maria D Mesa. A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study.
Molecular nutrition & food research.
2017 02; 61(2):. doi:
10.1002/mnfr.201600120. [PMID: 27689343] - Ashok-Kumar Dilly, Keqin Tang, Yande Guo, Sangeeta Joshi, Prasanna Ekambaram, Krishna Rao Maddipati, Yinlong Cai, Stephanie C Tucker, Kenneth V Honn. Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.
Experimental cell research.
2017 02; 351(1):1-10. doi:
10.1016/j.yexcr.2016.12.011. [PMID: 28011194] - A L Peters, M A T Vervaart, R van Bruggen, D de Korte, R Nieuwland, W Kulik, A P J Vlaar. Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury.
Vox sanguinis.
2017 Jan; 112(1):25-32. doi:
10.1111/vox.12453. [PMID: 28097705] - Hong-Zhao Xu, Wan-Ning Wang, Yuan-Yuan Zhang, Yan-Li Cheng, Zhong-Gao Xu. Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Journal of nephrology.
2016 Dec; 29(6):775-782. doi:
10.1007/s40620-016-0296-3. [PMID: 27021232] - Qiaoxia Bian, Weihui Wang, Nannan Wang, Yan Peng, Wen Ma, Ronghua Dai. Arachidonic acid metabolomic study of BPH in rats and the interventional effects of Zishen pill, a traditional Chinese medicine.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):149-157. doi:
10.1016/j.jpba.2016.05.027. [PMID: 27262108] - L Malan, J Baumgartner, P C Calder, C M Smuts. Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy.
Prostaglandins, leukotrienes, and essential fatty acids.
2016 07; 110(?):35-41. doi:
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Atherosclerosis.
2016 06; 249(?):30-5. doi:
10.1016/j.atherosclerosis.2016.03.019. [PMID: 27062407] - Hong-Zhao Xu, Yan-Li Cheng, Wan-Ning Wang, Hao Wu, Yuan-Yuan Zhang, Chong-Sen Zang, Zhong-Gao Xu. 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
International journal of molecular sciences.
2016 May; 17(5):. doi:
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Clinical journal of the American Society of Nephrology : CJASN.
2015 Sep; 10(9):1534-41. doi:
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The American journal of clinical nutrition.
2015 Sep; 102(3):608-15. doi:
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Biochimica et biophysica acta.
2015 Apr; 1851(4):340-55. doi:
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Archives of biochemistry and biophysics.
2015 Apr; 571(?):50-7. doi:
10.1016/j.abb.2015.02.029. [PMID: 25731857] - Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain.
Journal of lipid research.
2015 Mar; 56(3):502-514. doi:
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Diabetologia.
2015 Mar; 58(3):549-57. doi:
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American journal of physiology. Heart and circulatory physiology.
2015 Feb; 308(4):H269-80. doi:
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The British journal of dermatology.
2015 Feb; 172(2):337-44. doi:
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Nephron.
2015; 130(2):141-50. doi:
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Redox biology.
2015; 4(?):40-7. doi:
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Liver international : official journal of the International Association for the Study of the Liver.
2014 Oct; 34(9):1428-44. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Aug; 96(?):256-62. doi:
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Talanta.
2014 Aug; 126(?):170-6. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Jul; 69(?):94-101. doi:
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Archives of toxicology.
2014 Mar; 88(3):691-9. doi:
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Molecular nutrition & food research.
2014 Mar; 58(3):580-90. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Oct; 84(?):53-8. doi:
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The British journal of nutrition.
2013 Sep; 110(5):891-900. doi:
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The international journal of biochemistry & cell biology.
2013 Aug; 45(8):1620-8. doi:
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European journal of cancer (Oxford, England : 1990).
2013 Aug; 49(12):2747-59. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2013 Jul; 89(1):19-29. doi:
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Journal of endocrinological investigation.
2013 Jun; 36(6):385-9. doi:
10.3275/8654. [PMID: 23095287] - Greg S McMahon, Chris I Jones, Paul D Hayes, A Ross Naylor, Alison H Goodall. Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial.
Thrombosis and haemostasis.
2013 Jun; 109(6):1099-107. doi:
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Cell death & disease.
2013 Apr; 4(?):e569. doi:
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Lipids.
2013 Feb; 48(2):167-75. doi:
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Prostaglandins & other lipid mediators.
2013 Jan; 100-101(?):15-21. doi:
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Journal of vascular research.
2013; 50(5):372-82. doi:
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PloS one.
2013; 8(12):e81228. doi:
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PloS one.
2013; 8(2):e57254. doi:
10.1371/journal.pone.0057254. [PMID: 23437353] - Santiago E Farias, Kim A Heidenreich, Max V Wohlauer, Robert C Murphy, Ernest E Moore. Lipid mediators in cerebral spinal fluid of traumatic brain injured patients.
The Journal of trauma.
2011 Nov; 71(5):1211-8. doi:
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Endocrinology.
2011 Oct; 152(10):3811-9. doi:
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The Journal of biological chemistry.
2011 Sep; 286(39):33832-40. doi:
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Biochimica et biophysica acta.
2011 Jun; 1811(6):361-9. doi:
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PloS one.
2011; 6(9):e24422. doi:
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American journal of physiology. Heart and circulatory physiology.
2010 Dec; 299(6):H1891-901. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Dec; 25(12):4061-7. doi:
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The Journal of steroid biochemistry and molecular biology.
2010 Jul; 121(1-2):265-7. doi:
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Diabetes.
2010 Apr; 59(4):872-82. doi:
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The Journal of biological chemistry.
2010 Mar; 285(10):6891-903. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2010 Feb; 30(2):283-9. doi:
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Journal of applied physiology (Bethesda, Md. : 1985).
2009 Oct; 107(4):1285-92. doi:
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Integrative cancer therapies.
2009 Sep; 8(3):242-53. doi:
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Biochemistry.
2009 Jul; 48(26):6259-67. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Jun; 24(6):1744-52. doi:
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Platelets.
2009 Jun; 20(4):242-9. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2009 Mar; 29(3):387-93. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Nov; 295(5):R1473-8. doi:
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Biochemical pharmacology.
2008 Sep; 76(5):654-61. doi:
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The Journal of experimental medicine.
2008 Apr; 205(4):759-66. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2008 Apr; 294(4):G948-62. doi:
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American journal of physiology. Heart and circulatory physiology.
2008 Apr; 294(4):H1933-8. doi:
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Journal of the American Society of Nephrology : JASN.
2008 Mar; 19(3):559-69. doi:
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American journal of hypertension.
2008 Feb; 21(2):219-23. doi:
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British journal of pharmacology.
2007 Aug; 151(7):1033-40. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2007 Jul; 77(1):21-8. doi:
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Annals of surgical oncology.
2007 Feb; 14(2):862-8. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2006 Dec; 75(6):403-11. doi:
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Endocrinology.
2006 Nov; 147(11):5431-42. doi:
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