GF 109203X (BioDeep_00000015298)
代谢物信息卡片
bisindolylmaleimide i
化学式: C25H24N4O2 (412.18991639999996)
中文名称: 双吲哚马来酰亚胺I
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
InChI: InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
描述信息
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Tawfik Addi, Stéphane Poitevin, Nathalie McKay, Kamel Eddine El Mecherfi, Omar Kheroua, Noémie Jourde-Chiche, Alix de Macedo, Bertrand Gondouin, Claire Cerini, Philippe Brunet, Françoise Dignat-George, Stéphane Burtey, Laetitia Dou. Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells.
Archives of toxicology.
2019 01; 93(1):121-136. doi:
10.1007/s00204-018-2328-3. [PMID: 30324315] - Jason S Yang, Steven Symington, John M Clark, Yeonhwa Park. Permethrin, a pyrethroid insecticide, regulates ERK1/2 activation through membrane depolarization-mediated pathway in HepG2 hepatocytes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Nov; 121(?):387-395. doi:
10.1016/j.fct.2018.09.009. [PMID: 30205134] - Soo Hee Lee, Dawon Kang, Seong-Ho Ok, Seong-Chun Kwon, Hyun-Jin Kim, Eun-Jin Kim, Jeong-Min Hong, Ji-Yoon Kim, Sung Il Bae, Seungmin An, Ju-Tae Sohn. Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels.
International journal of molecular sciences.
2018 Jun; 19(7):. doi:
10.3390/ijms19071876. [PMID: 29949899] - Feixue Li, Huihui Ma, Jing Liu. Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in LβT2 Mouse Pituitary Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 03; 162(1):43-52. doi:
10.1093/toxsci/kfx248. [PMID: 29149324] - Juan Zhang, Wen-Shu Zhao, Xin Wang, Lin Xu, Xin-Chun Yang. Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.
Cardiology.
2018; 140(3):133-140. doi:
10.1159/000490093. [PMID: 29996135] - HyunA Jo, Dahyun Hwang, Jeong-Keun Kim, Young-Hee Lim. Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Oct; 108(Pt A):203-213. doi:
10.1016/j.fct.2017.08.002. [PMID: 28780155] - M R Chae, S J Kang, K P Lee, B R Choi, H K Kim, J K Park, C Y Kim, S W Lee. Onion (Allium cepa L.) peel extract (OPE) regulates human sperm motility via protein kinase C-mediated activation of the human voltage-gated proton channel.
Andrology.
2017 Sep; 5(5):979-989. doi:
10.1111/andr.12406. [PMID: 28805023] - Fei-Xue Li, Jiao-Jiao Yu, Ying Liu, Xiao-Ping Miao, Thomas E Curry. Induction of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 During the Periovulatory Period in the Rat Ovary.
Reproductive sciences (Thousand Oaks, Calif.).
2017 07; 24(7):1033-1040. doi:
10.1177/1933719116676394. [PMID: 27872196] - H-H Cheng, C-T Chou, T-K Sun, W-Z Liang, J-S Cheng, H-T Chang, H-W Tseng, C-C Kuo, F-A Chen, D-H Kuo, P Shieh, C-R Jan. Naproxen-induced Ca2+ movement and death in MDCK canine renal tubular cells.
Human & experimental toxicology.
2015 Nov; 34(11):1096-105. doi:
10.1177/0960327115569810. [PMID: 25636639] - Kyung Soo Kim, Ji Hyun Jang, Haiyue Lin, Seong Woo Choi, Hang Rae Kim, Dong Hoon Shin, Joo Hyun Nam, Yin Hua Zhang, Sung Joon Kim. Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease.
Journal of immunology (Baltimore, Md. : 1950).
2015 Oct; 195(7):3345-54. doi:
10.4049/jimmunol.1500056. [PMID: 26324774] - Hsiang-Ruei Liao, Ching-Ru Chien, Jih-Jung Chen, Tzung-Yan Lee, Shinn-Zhi Lin, Ching-Ping Tseng. The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils.
Chemico-biological interactions.
2015 Jul; 236(?):90-101. doi:
10.1016/j.cbi.2015.05.004. [PMID: 25980585] - Jin-Ichi Ito, Rui Lu, Yuko Nagayasu, Shinji Yokoyama. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes.
Biochimica et biophysica acta.
2014 Sep; 1841(9):1234-40. doi:
10.1016/j.bbalip.2014.04.010. [PMID: 24814947] - Karolina Varga, Katalin Pászty, Rita Padányi, Luca Hegedűs, Jean-Philippe Brouland, Béla Papp, Agnes Enyedi. Histone deacetylase inhibitor- and PMA-induced upregulation of PMCA4b enhances Ca2+ clearance from MCF-7 breast cancer cells.
Cell calcium.
2014 Feb; 55(2):78-92. doi:
10.1016/j.ceca.2013.12.003. [PMID: 24439526] - Sophia Koutsogiannaki, Silvia Franzellitti, Elena Fabbri, Martha Kaloyianni. Oxidative stress parameters induced by exposure to either cadmium or 17β-estradiol on Mytilus galloprovincialis hemocytes. The role of signaling molecules.
Aquatic toxicology (Amsterdam, Netherlands).
2014 Jan; 146(?):186-95. doi:
10.1016/j.aquatox.2013.11.005. [PMID: 24316436] - Mykola Mamenko, Oleg L Zaika, Nabila Boukelmoune, Jonathan Berrout, Roger G O'Neil, Oleh Pochynyuk. Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.
The Journal of biological chemistry.
2013 Jul; 288(28):20306-14. doi:
10.1074/jbc.m113.466797. [PMID: 23709216] - Nouval Shahab, Shunichi Kajioka, Ryosuke Takahashi, Maya Hayashi, Shinsuke Nakayama, Kazuyuki Sakamoto, Masahiro Takeda, Noriyuki Masuda, Seiji Naito. Novel effect of 2-aminoethoxydiphenylborate through inhibition of calcium sensitization induced by Rho kinase activation in human detrusor smooth muscle.
European journal of pharmacology.
2013 May; 708(1-3):14-20. doi:
10.1016/j.ejphar.2013.03.006. [PMID: 23528358] - Olivia Reetz, Ulf Strauss. Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 31(4-5):532-41. doi:
10.1159/000350074. [PMID: 23571312] - Nobutomo Ikarashi, Naoki Ogiue, Eri Toyoda, Marina Nakamura, Risako Kon, Yoshiki Kusunoki, Takashi Aburada, Makoto Ishii, Yoshikazu Tanaka, Yoshiaki Machida, Wataru Ochiai, Kiyoshi Sugiyama. Elucidating the mechanism by which Gypsum fibrosum, a traditional Chinese medicine, maintains cutaneous water content.
Biological & pharmaceutical bulletin.
2013; 36(10):1615-21. doi:
10.1248/bpb.b13-00494. [PMID: 23912684] - Narasimha M Midde, Adrian M Gomez, Jun Zhu. HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2012 Sep; 7(3):629-39. doi:
10.1007/s11481-012-9369-9. [PMID: 22570010] - A Bakillah, R Guillot, P Urios, A-M Grigorova-Borsos, M Sternberg. Stimulating effect of growth hormone on type IV collagen production by endothelial cells cultured in normal and high glucose.
Amino acids.
2012 Aug; 43(2):697-707. doi:
10.1007/s00726-011-1118-5. [PMID: 22002796] - Shenglan Wang, Yi Dai, Kimiko Kobayashi, Wanjun Zhu, Yoko Kogure, Hiroki Yamanaka, You Wan, Wensheng Zhang, Koichi Noguchi. Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.
The European journal of neuroscience.
2012 Aug; 36(3):2293-301. doi:
10.1111/j.1460-9568.2012.08142.x. [PMID: 22616675] - Bing S Huang, Roselyn A White, Frans H H Leenen. Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Jul; 303(2):R236-45. doi:
10.1152/ajpregu.00381.2011. [PMID: 22647294] - Adelaide Del Viscovo, Agnese Secondo, Alba Esposito, Fernando Goglia, Maria Moreno, Lorella M T Canzoniero. Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells.
American journal of physiology. Endocrinology and metabolism.
2012 Jun; 302(11):E1419-30. doi:
10.1152/ajpendo.00389.2011. [PMID: 22414808] - Peng Sun, Peng Yue, Wen-Hui Wang. Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney.
American journal of physiology. Renal physiology.
2012 Mar; 302(6):F679-87. doi:
10.1152/ajprenal.00368.2011. [PMID: 22169010] - Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology.
2012 Jan; 258(2):275-87. doi:
10.1016/j.taap.2011.11.007. [PMID: 22155090] - Hiroshi Asano, Takahiro Horinouchi, Yosuke Mai, Osamu Sawada, Shunsuke Fujii, Tadashi Nishiya, Masabumi Minami, Takahiro Katayama, Toshihiko Iwanaga, Koji Terada, Soichi Miwa. Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase.
Journal of pharmacological sciences.
2012; 118(2):275-87. doi:
10.1254/jphs.11166fp. [PMID: 22302021] - Takeshi Kanno, Akito Tanaka, Tomoyuki Nishizaki. Linoleic acid derivative DCP-LA stimulates vesicular transport of α7 ACh receptors towards surface membrane.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 30(1):75-82. doi:
10.1159/000339049. [PMID: 22759957] - Wen-Jing Jin, Cai-Feng Chen, Hui-Yu Liao, Lu-Lu Gong, Xiao-Hui Yuan, Bin-Bin Zhao, Ding Zhang, Xia Feng, Jing-Jun Liu, Yu Wang, Guo-Feng Chen, Hui-Ping Yan, You-Wen He. Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy.
PloS one.
2012; 7(3):e33356. doi:
10.1371/journal.pone.0033356. [PMID: 22428029] - Javier Vargas-Medrano, Vicente Castrejon-Tellez, Fernando Plenge, Ivan Ramirez, Manuel Miranda. PKCβ-dependent phosphorylation of the glycine transporter 1.
Neurochemistry international.
2011 Dec; 59(8):1123-32. doi:
10.1016/j.neuint.2011.08.006. [PMID: 21864610] - Hesham M El-Shewy, Souzan A Abdel-Samie, Abdelmohsen M Al Qalam, Mi-Hye Lee, Kazuyuki Kitatani, Viviana Anelli, Ayad A Jaffa, Lina M Obeid, Louis M Luttrell. Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Molecular endocrinology (Baltimore, Md.).
2011 Dec; 25(12):2144-56. doi:
10.1210/me.2011-0101. [PMID: 22016563] - Tomoaki Inoue, Kunihisa Kobayashi, Toyoshi Inoguchi, Noriyuki Sonoda, Masakazu Fujii, Yasutaka Maeda, Yoshinori Fujimura, Daisuke Miura, Ken-Ichi Hirano, Ryoichi Takayanagi. Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB.
The Journal of biological chemistry.
2011 Sep; 286(37):32045-53. doi:
10.1074/jbc.m111.285650. [PMID: 21828047] - Blake T Dotta, Carly A Buckner, Dianne Cameron, Robert F Lafrenie, Michael A Persinger. Biophoton emissions from cell cultures: biochemical evidence for the plasma membrane as the primary source.
General physiology and biophysics.
2011 Sep; 30(3):301-9. doi:
10.4149/gpb_2011_03_301. [PMID: 21952440] - M T Harper, A W Poole. PKC inhibition markedly enhances Ca2+ signaling and phosphatidylserine exposure downstream of protease-activated receptor-1 but not protease-activated receptor-4 in human platelets.
Journal of thrombosis and haemostasis : JTH.
2011 Aug; 9(8):1599-607. doi:
10.1111/j.1538-7836.2011.04393.x. [PMID: 21649850] - Yi Chang, Yu-Wan Lin, Su-Jane Wang. Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
10.1007/s00210-011-0630-1. [PMID: 21541760] - Angel Luis García-Villalón, Nuria Fernández, Luis Monge, Godofredo Diéguez. Coronary response to diadenosine tetraphosphate after ischemia-reperfusion in the isolated rat heart.
European journal of pharmacology.
2011 Jun; 660(2-3):394-401. doi:
10.1016/j.ejphar.2011.04.006. [PMID: 21513710] - Lise Sofie H Nissen-Meyer, Mark C Popescu, El Hassan Hamdani, Farrukh A Chaudhry. Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Apr; 31(17):6565-75. doi:
10.1523/jneurosci.3694-10.2011. [PMID: 21525297] - Ben Fogelgren, Shin-Yi Lin, Xiaofeng Zuo, Kimberly M Jaffe, Kwon Moo Park, Ryan J Reichert, P Darwin Bell, Rebecca D Burdine, Joshua H Lipschutz. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.
PLoS genetics.
2011 Apr; 7(4):e1001361. doi:
10.1371/journal.pgen.1001361. [PMID: 21490950] - Peiying Yu, Weixing Han, Van Anthony M Villar, Hewang Li, Francis B Arnaldo, Gisela P Concepcion, Robin A Felder, Mark T Quinn, Pedro A Jose. Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk.
Free radical biology & medicine.
2011 Apr; 50(7):832-40. doi:
10.1016/j.freeradbiomed.2010.12.027. [PMID: 21193028] - Gábor Harmati, Ferenc Papp, Norbert Szentandrássy, László Bárándi, Ferenc Ruzsnavszky, Balázs Horváth, Tamás Bányász, János Magyar, György Panyi, Zoltán Krasznai, Péter P Nánási. Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectifier K+ currents.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Feb; 383(2):141-8. doi:
10.1007/s00210-010-0584-8. [PMID: 21120453] - Kalpana Gupta, Amitabha Chakrabarti, Sonia Rana, Ritu Ramdeo, Bryan L Roth, Munna L Agarwal, William Tse, Mukesh K Agarwal, David N Wald. Securinine, a myeloid differentiation agent with therapeutic potential for AML.
PloS one.
2011; 6(6):e21203. doi:
10.1371/journal.pone.0021203. [PMID: 21731671] - I M Liu, J T Cheng. Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):987876. doi:
10.1093/ecam/nen078. [PMID: 19095661] - Dana Galuska, Sergej Pirkmajer, Romain Barrès, Karin Ekberg, John Wahren, Alexander V Chibalin. C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells.
PloS one.
2011; 6(12):e28294. doi:
10.1371/journal.pone.0028294. [PMID: 22162761] - Natália Pereira de Almeida Nogueira, Cintia Fernandes de Souza, Francis Monique de Souza Saraiva, Pedro Elias Sultano, Sergio Ranto Dalmau, Roberta Eitler Bruno, Renata de Lima Sales Gonçalves, Gustavo Augusto Travassos Laranja, Luís Henrique Monteiro Leal, Marsen Garcia Pinto Coelho, Claudio A Masuda, Marcus F Oliveira, Marcia Cristina Paes. Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS.
PloS one.
2011; 6(10):e25935. doi:
10.1371/journal.pone.0025935. [PMID: 22022475] - Fei Liu, Kangmin He, Xinxing Yang, Ning Xu, Zhangyi Liang, Ming Xu, Xinsheng Zhao, Qide Han, Youyi Zhang. α1A-adrenergic receptor induces activation of extracellular signal-regulated kinase 1/2 through endocytic pathway.
PloS one.
2011; 6(6):e21520. doi:
10.1371/journal.pone.0021520. [PMID: 21738688] - Antonio Velayos-Baeza, Clotilde Levecque, Kazuhiro Kobayashi, Zoe G Holloway, Anthony P Monaco. The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage.
The Journal of biological chemistry.
2010 Dec; 285(51):40148-62. doi:
10.1074/jbc.m110.145961. [PMID: 20943657] - Jing-Shan Tong, Qing-Hua Zhang, Zhen-Bo Wang, Sen Li, Cai-Rong Yang, Xue-Qi Fu, Yi Hou, Zhao-Yi Wang, Jun Sheng, Qing-Yuan Sun. ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway.
PloS one.
2010 Nov; 5(11):e15408. doi:
10.1371/journal.pone.0015408. [PMID: 21079811] - Théo Araújo-Santos, Deboraci Brito Prates, Bruno Bezerril Andrade, Danielle Oliveira Nascimento, Jorge Clarêncio, Petter F Entringer, Alan B Carneiro, Mário A C Silva-Neto, José Carlos Miranda, Cláudia Ida Brodskyn, Aldina Barral, Patrícia T Bozza, Valéria Matos Borges. Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E₂ production in murine macrophages.
PLoS neglected tropical diseases.
2010 Nov; 4(11):e873. doi:
10.1371/journal.pntd.0000873. [PMID: 21072234] - Hans Fischer, Nataliya Lutay, Bryndís Ragnarsdóttir, Manisha Yadav, Klas Jönsson, Alexander Urbano, Ahmed Al Hadad, Sebastian Rämisch, Petter Storm, Ulrich Dobrindt, Ellaine Salvador, Diana Karpman, Ulf Jodal, Catharina Svanborg. Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
PLoS pathogens.
2010 Sep; 6(9):e1001109. doi:
10.1371/journal.ppat.1001109. [PMID: 20886096] - Pedro M Guerreiro, Adelino V M Canario, Deborah M Power, J Larry Renfro. Piscine PTHrP regulation of calcium and phosphate transport in winter flounder renal proximal tubule primary cultures.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Aug; 299(2):R603-11. doi:
10.1152/ajpregu.00509.2009. [PMID: 20484696] - Kathleen Frondorf, Karen M Henkels, Michael A Frohman, Julian Gomez-Cambronero. Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.
The Journal of biological chemistry.
2010 May; 285(21):15837-47. doi:
10.1074/jbc.m109.070524. [PMID: 20304930] - Carmen Castaneda-Sceppa, Supriya Subramanian, Francisco Castaneda. Protein kinase C mediated intracellular signaling pathways are involved in the regulation of sodium-dependent glucose co-transporter SGLT1 activity.
Journal of cellular biochemistry.
2010 Apr; 109(6):1109-17. doi:
10.1002/jcb.22489. [PMID: 20069550] - Kathleen Köck, Anna Koenen, Bernd Giese, Martin Fraunholz, Karen May, Werner Siegmund, Elke Hammer, Uwe Völker, Gabriele Jedlitschky, Heyo K Kroemer, Markus Grube. Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
The Journal of biological chemistry.
2010 Apr; 285(15):11336-47. doi:
10.1074/jbc.m109.056457. [PMID: 20159975] - Y Z De Marinis, E Zhang, S Amisten, J Taneera, E Renström, P Rorsman, L Eliasson. Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.
Diabetologia.
2010 Apr; 53(4):717-29. doi:
10.1007/s00125-009-1635-x. [PMID: 20020096] - Ansar A Khan, Bieuwke S Dragt, Robert J Porte, Geny M M Groothuis. Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression.
Toxicology in vitro : an international journal published in association with BIBRA.
2010 Apr; 24(3):822-9. doi:
10.1016/j.tiv.2009.12.011. [PMID: 20006981] - Azahel Rangel, Sergio Sánchez-Armass, Ulises Meza. Protein kinase C-mediated inhibition of recombinant T-type Cav3.2 channels by neurokinin 1 receptors.
Molecular pharmacology.
2010 Feb; 77(2):202-10. doi:
10.1124/mol.109.058727. [PMID: 19805509] - Suzanne Heemskerk, Janny G P Peters, Jochem Louisse, Seil Sagar, Frans G M Russel, Rosalinde Masereeuw. Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha.
Journal of biomedicine & biotechnology.
2010; 2010(?):525180. doi:
10.1155/2010/525180. [PMID: 20300455] - Svetlana I Galkina, Vladimir I Stadnichuk, Julian G Molotkovsky, Julia M Romanova, Galina F Sud'ina, Thomas Klein. Microbial alkaloid staurosporine induces formation of nanometer-wide membrane tubular extensions (cytonemes, membrane tethers) in human neutrophils.
Cell adhesion & migration.
2010 Jan; 4(1):32-8. doi:
10.4161/cam.4.1.10314. [PMID: 20009568] - Emilia Lecuona, Haiying Sun, Christine Vohwinkel, Aaron Ciechanover, Jacob I Sznajder. Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions.
American journal of respiratory cell and molecular biology.
2009 Dec; 41(6):671-9. doi:
10.1165/rcmb.2008-0365oc. [PMID: 19286978] - Manabu Kubokawa, Toshiyuki Kojo, You Komagiri, Kazuyoshi Nakamura. Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.
The Journal of membrane biology.
2009 Oct; 231(2-3):79-92. doi:
10.1007/s00232-009-9207-z. [PMID: 19865787] - Wen Liu, Yuan Wei, Peng Sun, Wen-Hui Wang, Thomas R Kleyman, Lisa M Satlin. Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C.
American journal of physiology. Renal physiology.
2009 Oct; 297(4):F904-15. doi:
10.1152/ajprenal.90685.2008. [PMID: 19656909] - Rui Zhao, Qing-wang Li, Jian Li, Tao Zhang. Protective effect of Lycium barbarum polysaccharide 4 on kidneys in streptozotocin-induced diabetic rats.
Canadian journal of physiology and pharmacology.
2009 Sep; 87(9):711-9. doi:
10.1139/y09-068. [PMID: 19794522] - Zaheer Sarwar, Fadi Annaba, Alka Dwivedi, Seema Saksena, Ravinder K Gill, Waddah A Alrefai. Modulation of ileal apical Na+-dependent bile acid transporter ASBT by protein kinase C.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Sep; 297(3):G532-8. doi:
10.1152/ajpgi.00052.2009. [PMID: 19571234] - Usha Gundimeda, Jason Eric Schiffman, Simcha Neeli Gottlieb, Brandon Ian Roth, Rayudu Gopalakrishna. Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase.
Carcinogenesis.
2009 Sep; 30(9):1553-61. doi:
10.1093/carcin/bgp164. [PMID: 19578042] - Talha Akbulut, Kevin R Regner, Richard J Roman, Ellis D Avner, John R Falck, Frank Park. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
American journal of physiology. Renal physiology.
2009 Sep; 297(3):F662-70. doi:
10.1152/ajprenal.00146.2009. [PMID: 19570883] - Dapeng Wang, Hongxin Wang, Guoqiang Wu, Yuhong Yang, Jing Yang, Chunna Liu, Tak Ming Wong. Protein kinase C mediates the effects of delta-opioid receptor stimulation on survival and apoptosis in neonatal cardiomyocytes cultured in serum-deprived condition.
Die Pharmazie.
2009 Jul; 64(7):466-71. doi:
. [PMID: 19694185] - Karl D Pendergrass, Tanya M Gwathmey, Ryan D Michalek, Jason M Grayson, Mark C Chappell. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus.
Biochemical and biophysical research communications.
2009 Jun; 384(2):149-54. doi:
10.1016/j.bbrc.2009.04.126. [PMID: 19409874] - K Staiger, U Schatz, H Staiger, P Weyrich, C Haas, A Guirguis, F Machicao, H-U Häring, M Kellerer. Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.
Microvascular research.
2009 Jun; 78(1):40-4. doi:
10.1016/j.mvr.2009.01.014. [PMID: 19327373] - Jacob Eriksen, Søren G F Rasmussen, Trine Nygaard Rasmussen, Christian Bjerggaard Vaegter, Joo Hwan Cha, Mu-Fa Zou, Amy Hauck Newman, Ulrik Gether. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 May; 29(21):6794-808. doi:
10.1523/jneurosci.4177-08.2009. [PMID: 19474307] - Sofia Cristóvão-Ferreira, Sandra H Vaz, Joaquim A Ribeiro, Ana M Sebastião. Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT-1.
Journal of neurochemistry.
2009 Apr; 109(2):336-47. doi:
10.1111/j.1471-4159.2009.05963.x. [PMID: 19200339] - Toni L Richards, Nancy R Zahniser. Rapid substrate-induced down-regulation in function and surface localization of dopamine transporters: rat dorsal striatum versus nucleus accumbens.
Journal of neurochemistry.
2009 Mar; 108(6):1575-84. doi:
10.1111/j.1471-4159.2009.05910.x. [PMID: 19183252] - Alejandra Espinosa, Alejandra García, Steffen Härtel, Cecilia Hidalgo, Enrique Jaimovich. NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells.
The Journal of biological chemistry.
2009 Jan; 284(4):2568-75. doi:
10.1074/jbc.m804249200. [PMID: 19028699] - Yudan Liu, Xihua Chen. Cholinergic excitation of dopaminergic cells depends on sequential activation of protein kinase C and the L-type calcium channel in ventral tegmental area slices.
Brain research.
2008 Dec; 1245(?):41-51. doi:
10.1016/j.brainres.2008.09.062. [PMID: 18929546] - Yukio Ikeda, Tadashi Suehiro, Kaoru Arii, Yoshitaka Kumon, Kozo Hashimoto. High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes.
Metabolism: clinical and experimental.
2008 Dec; 57(12):1725-32. doi:
10.1016/j.metabol.2008.07.032. [PMID: 19013297] - Katherine R Tuttle. Protein kinase C-beta inhibition for diabetic kidney disease.
Diabetes research and clinical practice.
2008 Nov; 82 Suppl 1(?):S70-4. doi:
10.1016/j.diabres.2008.09.041. [PMID: 18977550] - Angus J Cameron, Katarzyna J Procyk, Michael Leitges, Peter J Parker. PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.
International journal of cancer.
2008 Aug; 123(4):769-79. doi:
10.1002/ijc.23560. [PMID: 18508315] - Barbara E Slack, Jan K Blusztajn. Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes.
Journal of cellular biochemistry.
2008 Aug; 104(5):1818-31. doi:
10.1002/jcb.21745. [PMID: 18348264] - Rachel Ross, Penny Y T Wang, Madhu Chari, Carol K L Lam, Liora Caspi, Hiraku Ono, Evan D Muse, Xiaosong Li, Roger Gutierrez-Juarez, Peter E Light, Gary J Schwartz, Luciano Rossetti, Tony K T Lam. Hypothalamic protein kinase C regulates glucose production.
Diabetes.
2008 Aug; 57(8):2061-5. doi:
10.2337/db08-0206. [PMID: 18511848] - S Aisling Aherne, Nora M O'Brien. Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells.
Molecular nutrition & food research.
2008 Jun; 52(6):664-73. doi:
10.1002/mnfr.200700385. [PMID: 18465778] - Y H Wang, C X Shi, F Dong, J W Sheng, Y F Xu. Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor.
British journal of pharmacology.
2008 May; 154(2):429-39. doi:
10.1038/bjp.2008.95. [PMID: 18414380] - Wimolpak Sriwai, Huiping Zhou, Karnam S Murthy. G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA.
The Biochemical journal.
2008 May; 411(3):543-51. doi:
10.1042/bj20071299. [PMID: 18237278] - Yeshao Wen, Jiali Gu, George E Vandenhoff, Xiaoping Liu, Jerry L Nadler. Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.
American journal of physiology. Heart and circulatory physiology.
2008 Apr; 294(4):H1933-8. doi:
10.1152/ajpheart.00260.2007. [PMID: 18296557] - DaZheng Wu, Zhibi Hu. Rutaecarpine induces chloride secretion across rat isolated distal colon.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):256-66. doi:
10.1124/jpet.107.131961. [PMID: 18187619] - Christopher J Delvecchio, John P Capone. Protein kinase C alpha modulates liver X receptor alpha transactivation.
The Journal of endocrinology.
2008 Apr; 197(1):121-30. doi:
10.1677/joe-07-0525. [PMID: 18372238] - Lynn Huang, Hung-Chi Cheng, Richard Isom, Chia-Sui Chen, Roy A Levine, Bendicht U Pauli. Protein kinase Cepsilon mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis.
The Journal of biological chemistry.
2008 Mar; 283(12):7616-27. doi:
10.1074/jbc.m705839200. [PMID: 18184652] - Yu Jin Lee, Ho Jae Han. Albumin-stimulated DNA synthesis is mediated by Ca2+/PKC as well as EGF receptor-dependent p44/42 MAPK and NF-kappaB signal pathways in renal proximal tubule cells.
American journal of physiology. Renal physiology.
2008 Mar; 294(3):F534-41. doi:
10.1152/ajprenal.00408.2007. [PMID: 18160626] - Edwin K Jackson, Delbert G Gillespie, Chongxue Zhu, Jin Ren, Lefteris C Zacharia, Zaichuan Mi. Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.
Hypertension (Dallas, Tex. : 1979).
2008 Mar; 51(3):719-26. doi:
10.1161/hypertensionaha.107.096297. [PMID: 18250367] - Munju Cho, Seoyoung Park, Jungsug Gwak, Dong-Eun Kim, Sung Su Yea, Jae-Gook Shin, Sangtaek Oh. Bisindoylmaleimide I suppresses adipocyte differentiation through stabilization of intracellular beta-catenin protein.
Biochemical and biophysical research communications.
2008 Feb; 367(1):195-200. doi:
10.1016/j.bbrc.2007.12.147. [PMID: 18174026] - Huda Ismail Abdullah, Paulina L Pedraza, John C McGiff, Nicholas R Ferreri. CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism.
American journal of physiology. Renal physiology.
2008 Feb; 294(2):F345-54. doi:
10.1152/ajprenal.00509.2006. [PMID: 18032544] - Tim D Plant, Christian Zöllner, Frauke Kepura, Shaaban S Mousa, Jenny Eichhorst, Michael Schaefer, Jens Furkert, Christoph Stein, Alexander Oksche. Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C.
Molecular pain.
2007 Nov; 3(?):35. doi:
10.1186/1744-8069-3-35. [PMID: 18001466] - Babu V Bassa, Jung W Noh, Shobha H Ganji, Mi-Kyung Shin, Daeyoung D Roh, Vaijinath S Kamanna. Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.
Biochimica et biophysica acta.
2007 Nov; 1771(11):1364-71. doi:
10.1016/j.bbalip.2007.09.004. [PMID: 17950662] - Hui-Fang Bao, Zhi-Ren Zhang, You-You Liang, Joshua J Ma, Douglas C Eaton, He-Ping Ma. Ceramide mediates inhibition of the renal epithelial sodium channel by tumor necrosis factor-alpha through protein kinase C.
American journal of physiology. Renal physiology.
2007 Oct; 293(4):F1178-86. doi:
10.1152/ajprenal.00153.2007. [PMID: 17634398] - Pamela W Anderson, Janet B McGill, Katherine R Tuttle. Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy.
Current opinion in nephrology and hypertension.
2007 Sep; 16(5):397-402. doi:
10.1097/mnh.0b013e3281ead025. [PMID: 17693752] - Hideyuki Takahashi, Hideo Namiki. Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors.
The Biochemical journal.
2007 Jul; 405(2):331-40. doi:
10.1042/bj20070299. [PMID: 17373912] - Rajesh Gopalrao Katare, Zou Zhitian, Mikiko Sodeoka, Shiro Sasaguri. A novel bisindolylmaleimide derivative enhances functional recovery of heart after long-term hypothermic heart preservation.
Transplantation.
2007 Jun; 83(12):1588-94. doi:
10.1097/01.tp.0000267019.93796.aa. [PMID: 17589342] - Sandra Halwachs, Carsten Kneuer, Walther Honscha. Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators.
Biochimica et biophysica acta.
2007 Jun; 1768(6):1671-9. doi:
10.1016/j.bbamem.2007.03.023. [PMID: 17482559] - Su-Lan Liao, Yen-Chuan Ou, Shih-Yun Chen, An-Na Chiang, Chun-Jung Chen. Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes.
Neurochemistry international.
2007 Jun; 50(7-8):905-15. doi:
10.1016/j.neuint.2006.09.016. [PMID: 17084486] - P Amador, J García-Herrera, M C Marca, J de la Osada, S Acín, M A Navarro, M T Salvador, M P Lostao, M J Rodríguez-Yoldi. Inhibitory effect of TNF-alpha on the intestinal absorption of galactose.
Journal of cellular biochemistry.
2007 May; 101(1):99-111. doi:
10.1002/jcb.21168. [PMID: 17177295]